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annotation rule: PRU01293

General rule information [?]

Accession PRU01293
Dates 1-DEC-2020 (Created)
3-JUN-2021 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51948; COV_NSP12_RDRP
Name Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain
Function The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity.

Propagated annotation [?]

Description [?]

+ AltName: Full=RNA-directed RNA polymerase; EC;

Comments [?]

Catalytic activity [RNA-directed RNA polymerase]: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=;
Similarity Belongs to the coronaviruses polyprotein 1ab family.

Gene Ontology [?]

GO:0000166; Molecular function: nucleotide binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0003968; Molecular function: RNA-directed 5'-3' RNA polymerase activity.
GO:0003723; Molecular function: RNA binding.
GO:0016740; Molecular function: transferase activity.
GO:0039694; Biological process: viral RNA genome replication.

Keywords [?]

Features [?]

From: PS51948
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Nsp12 RNA-dependent RNA polymerase #        
ACT_SITE     395     395             S   1
ACT_SITE     396     396             D   1
ACT_SITE     397     397             D   1

Additional information [?]

Size range 560-570 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P0C6Y1 (R1AB_IBVB)
Viruses; Orthocoronavirinae
Comments None


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UniProtKB rule member sequences [?]