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annotation rule: PRU01293 |
Accession | PRU01293 |
Dates | 1-DEC-2020 (Created) 3-JUN-2021 (Last updated, Version 2) |
Data class | Domain |
Predictors | PROSITE; PS51948; COV_NSP12_RDRP |
Name | Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain |
Function | The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity. |
+ AltName: Full=RNA-directed RNA polymerase; EC 2.7.7.48; |
Catalytic activity | [RNA-directed RNA polymerase]: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; |
Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
From: PS51948 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | Nsp12 RNA-dependent RNA polymerase # | |||||||||
ACT_SITE | 395 | 395 | S | 1 | ||||||||
ACT_SITE | 396 | 396 | D | 1 | ||||||||
ACT_SITE | 397 | 397 | D | 1 |
Size range | 560-570 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P0C6Y1 (R1AB_IBVB) |
Scope | Viruses; Orthocoronavirinae |
Comments | None |
Viruses | [32] |