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| annotation rule: PRU01293 |
General rule information
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| Accession | PRU01293 |
| Dates | 1-DEC-2020 (Created) 3-JUN-2021 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51948; COV_NSP12_RDRP |
| Name | Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain |
| Function | The Nsp12 RNA-dependent RNA polymerase, that includes an RdRp catalytic domain conserved in all RNA viruses, possesses some minimal activity on its own, but the addition of the Nsp7 and Nsp8 cofactors greatly stimulates polymerase activity. |
Propagated annotation
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Description
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| + AltName: Full=RNA-directed RNA polymerase; EC 2.7.7.48; |
Comments
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| Catalytic activity | [RNA-directed RNA polymerase]: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; |
| Similarity | Belongs to the coronaviruses polyprotein 1ab family. |
Gene Ontology
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GO:0000166; Molecular function: nucleotide binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0003968; Molecular function: RNA-directed 5'-3' RNA polymerase activity.
GO:0003723; Molecular function: RNA binding.
GO:0016740; Molecular function: transferase activity.
GO:0039694; Biological process: viral RNA genome replication.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0003968; Molecular function: RNA-directed 5'-3' RNA polymerase activity.
GO:0003723; Molecular function: RNA binding.
GO:0016740; Molecular function: transferase activity.
GO:0039694; Biological process: viral RNA genome replication.
Keywords
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Nucleotide-binding
Nucleotidyltransferase
Viral RNA replication
RNA-directed RNA polymerase
RNA-binding
Transferase
Nucleotidyltransferase
Viral RNA replication
RNA-directed RNA polymerase
RNA-binding
Transferase
Features
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| From: PS51948 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | Nsp12 RNA-dependent RNA polymerase # | |||||||||
| ACT_SITE | 395 | 395 | S | 1 | ||||||||
| ACT_SITE | 396 | 396 | D | 1 | ||||||||
| ACT_SITE | 397 | 397 | D | 1 | ||||||||
Additional information
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| Size range | 560-570 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P0C6Y1 (R1AB_IBVB) |
| Scope | Viruses; Orthocoronavirinae |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Viruses [32]
- Retrieve set of proteins with 3D structure for this domain