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Entry: PS51964

General information about the entry

Entry name [info] SARS_ORF8_IG
Accession [info] PS51964
Entry type [info] MATRIX
Date [info] 29-SEP-2021 CREATED;
29-SEP-2021 DATA UPDATE;
29-SEP-2021 INFO UPDATE.
PROSITE Doc. [info] PDOC51964
Associated ProRule [info] PRU01309

Name and characterization of the entry

Description [info] SARS ORF8 accessory protein immunoglobulin (Ig)-like domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=103;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=98;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=4.3734336; R2=0.0076399; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=672; N_SCORE=9.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=279; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-64; D=-6; I=-6; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-15;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         I=-150; B1=0; BI=-380; BD=-380;
/M: SY='E';  M= -80, -99, -60,  77, -87, -99, -80,  42, -68, -75, -75, -80, -79, -62, -77, -80, -78, -67, -96, -86; D=-150;
/I:         I=-150; DM=-380;
/M: SY='C';  M= -81, 122, -94, -89, -91, -95, -89, -98, -73, -89, -86, -82,-105, -86,  43, -81, -81, -87,-111, -94; D=-150;
/I:         I=-150; DM=-380;
/M: SY='S';  M= -63, -81, -74, -76, -90, -73, -80, -86, -75, -90, -85, -63, -80, -71, -81,  72,  54, -78,-103, -84; D=-150;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L';  M= -79, -87,-102, -95, -63,-104, -94,  32, -94,  44, -51, -97, -97, -91, -94, -90, -75,  40, -93, -74; D=-150;
/I:         I=-150; DM=-380;
/M: SY='Q';  M= -76,-102, -71, -51,-107, -84, -64, -93, -57, -88, -74, -67, -84, 114, -57, -66, -79, -95, -89, -78; D=-150;
/I:         I=-150; DM=-380;
/M: SY='S';  M= -70, -90, -69,  33, -90, -81, -28, -90, -59, -30, -81, -69, -83, -60,  48,  54, -67, -85, -96, -81; D=-150;
/I:         I=-150; DM=-380;
/M: SY='C';  M= -78, 137, -98, -98, -88, -93, -98, -95, -94, -86, -86, -84,-109,-101,-100, -81, -78, -83,-118, -99; D=-150;
/I:         I=-150; DM=-380;
/M: SY='C';  M=  28,  72, -82, -81, -86, -81, -88, -76, -80, -80, -77, -73, -84, -47, -86, -60,  64, -17,-103, -86; D=-150;
/I:         I=-150; DM=-380;
/M: SY='Q';  M= -69, -93, -65,  34, -59, -79, -69, -93, -61, -90, -81, -66, -80,  82, -65,  43, -68, -90, -93, -80; D=-150;
/I:         I=-150; DM=-380;
/M: SY='H';  M= -82, -90, -60, -72, -87, -76,  99, -31, -70, -89, -76,  79, -88, -66, -72, -68, -72, -92,-114, -68; D=-150;
/I:         I=-150; DM=-380;
/M: SY='Q';  M= -75, -96, -71, -54,-101, -84, -67, -91,  31, -88, -76, -65, -81,  99, -54, -47,   4, -90, -90, -79; D=-150;
/I:         I=-150; DM=-380;
/M: SY='P';  M= -81,-106, -81, -70,-101, -83, -84, -89, -77, -99, -85, -88, 113, -80, -90, -61, -73, -94, -94, -98; D=-150;
/I:         I=-150; DM=-380;
/M: SY='Y';  M= -84, -95, -81, -83,   2, -90,  67, -76, -79, -71, -66, -78, -94, -73, -75, -27, -79, -80, -52, 104; D=-150;
/I:         I=-150; DM=-380;
/M: SY='V';  M= -68, -84, -91, -80, -73, -95, -90, -19, -81, -58, -59, -86, -91,  44, -82, -77, -67,  79, -99, -76; D=-150;
/I:         I=-150; DM=-380;
/M: SY='V';  M= -71, -81, -96, -89, -42, -97, -89,  16, -88,  36,  14, -92, -37, -86, -88, -83, -69,  60, -91, -70; D=-150;
/I:         I=-150; DM=-380;
/M: SY='D';  M= -76,  15,  75,  69, -97, -82, -66, -97, -61, -92, -90, -41, -74, -56, -70, -68, -71, -91,-103, -85; D=-150;
/I:         I=-150; DM=-380;
/M: SY='D';  M= -79, -91, 100, -47, -95, -75, -65, -92, -67, -38, -89,  25, -80, -67, -75, -67, -68, -91,-112, -81; D=-150;
/I:         I=-150; DM=-380;
/M: SY='P';  M= -78,-103, -78, -67, -98, -80, -81, -86, -20, -96, -82, -84, 113, -77, -83, -71, -71, -91, -91, -94; D=-150;
/I:         I=-150; DM=-380;
/M: SY='C';  M= -72, 137, -92, -92, -82, -88, -92, -24, -88, -79, -79, -79,-101, -94, -94, -25, -72, -74,-111, -92; D=-150;
/I:         I=-150; DM=-380;
/M: SY='P';  M= -78,-101, -79, -67, -94, -81, -81, -83, -10, -38, -79, -84, 110, -76, -81, -74, -71, -88, -90, -92; D=-150;
/I:         MD=-15; DM=-380;
/M: SY='I';  M= -27, -86, -90, -89, -68, -95, -93,  76, -84, -53, -55, -80, -84, -84, -47, -73,  39,  -4, -91, -73;
/I:         MD=-15; DM=-380;
/M: SY='H';  M= -77, -93, -71, -71, -83,  27, 116, -92, -74, -35, -69, -60, -84,   9, -71, -70, -81, -56,-104, -60;
/I:         MD=-15; DM=-380;
/M: SY='Y';  M= -82, -86, -87, -86,  75, -89,  25, -62, -81, -25,  21, -81, -93, -80, -78, -47, -76, -67, -50,  85;
/I:         MD=-15; DM=-380;
/M: SY='Y';  M= -81,  25, -82, -77, -46, -90, -57, -72, -72, -71, -66, -81, -94,  47, -28, -76, -78, -26, -53, 102;
/I:         MD=-15; DM=-380;
/M: SY='S';  M= -62, -83, -74, -72, -87, -70, -76, -83, -74, -29, -80, -66,  50, -68, -79,  77, -10, -79, -95, -83;
/I:         MD=-15; DM=-380;
/M: SY='K';  M= -77, -93,  41,  37, -96, -83, -69, -96,  66, -94, -85,  -5, -77, -56, -26, -70, -72, -91, -94, -83;
/I:         MD=-15; DM=-380;
/M: SY='W';  M= -87,   2,-111, -91, -58, -89,-109, -15, -85, -68, -82,-103, -93,  -5, -87, -87, -96, -90, 156, -46;
/I:         MD=-15; DM=-380;
/M: SY='Y';  M= -84, -89, -76, -83,  42, -85, -59, -71, -29, -23, -67,  50, -95, -76, -76, -76, -74, -76, -57,  88;
/I:         MI=0; MD=-15; IM=0;
/M: SY='I';  M= -76, -89, -99, -97, -63,-103, -99,  84, -92, -25, -50, -91, -89, -90, -95, -86, -71,  28, -90, -71;
/M: SY='R';  M= -81, -98, -76, -63, -93, -90, -68, -96,  26, -90, -79, -70, -88,  17,  89, -75, -79, -91, -90, -78;
/M: SY='Y';  M= -76, -89, -93, -91, -55, -98,   1,  32, -87, -58, -59, -89, -94, -85, -87, -83, -72,  54, -73,  70;
/M: SY='G';  M= -70, -91, -70, -85, -98,  70, -77,-103, -37,-102, -90,  56, -87, -77, -84, -65, -78, -99, -96, -93;
/M: SY='T';  M=  50, -81, -80, -76, -85, -74, -82, -80, -77, -84, -78, -73,  12, -76, -83,  -3,  51, -69, -92,  -8;
/M: SY='R';  M= -83, -99, -81, -69, -90, -94, -69, -51, -21, -87,  -8, -73, -91, -57,  96, -78, -82, -88, -92, -78;
/M: SY='K';  M= -75, -94, -76, -68, -98,  39, -80,-100,  73, -99, -87, -66, -83, -65, -54, -41, -78, -95, -91, -87;
/M: SY='S';  M= -65, -83, -67, -75, -93, -39, -72, -92, -72, -96, -88,  57, -84, -68, -78,  72, -30, -87,-104, -86;
/M: SY='A';  M=  63, -79, -82, -78, -40, -72, -86, -80, -79, -82, -78, -74, -82, -78, -84, -57,  51, -69, -95, -84;
/M: SY='P';  M= -85,-104, -84, -77, -68, -90, -69, -86, -70, -87, -79, -36,  77, -75,  29, -81, -79, -90, -72,  69;
/M: SY='L';  M= -78, -86, -87, -87, -68, -89, -81, -61, -87,  56, -57,  11, -96, -81, -88,  29, -72, -66, -94, -76;
/I:         MI=0; MD=-15; IM=0;
/M: SY='I';  M=  35, -89, -98, -93, -76, -90, -98,  57, -92, -39, -63, -89, -92, -89, -95, -78, -74,  15, -96, -81;
/M: SY='W';  M= -84,-107, -69,  57, -89, -94, -80,-100, -65, -94, -89, -82, -85,  45,   5, -81, -87, -98,  98, -74;
/M: SY='L';  M= -88, -90,-105, -97, -61,-107, -89, -53, -99,  71, -49,-105,-105, -92, -96, -98, -84, -60, -92, -74;
/M: SY='C';  M= -82, 133,-102,-102, -84, -98,-102, -99, -98, -90, -90, -88,-113,-106,-104, -85, -82, -87,-122,-103;
/M: SY='V';  M= -14,-110,-109,  -5,-103,-117,-117, -74,-107, -64, -90,-113,-114,-105,-112,-102, -95,  41,-126,-107;
/M: SY='D';  M=-103,-122,  60, -84,-128,  16,-101,-130,-102,-127,-123, -81,-110,-100,-110, -96,-103,-126,-133,-115;
/M: SY='E';  M=  35, -94,   8,  62,-101, -84, -80, -94, -71, -93, -89, -77, -82, -65, -79, -72, -78, -46,-102, -93;
/M: SY='Y';  M=  38, -89, -38, -88, -66, -80, -81, -69, -89,  28, -65, -91, -96, -84, -90, -77, -79, -44, -81,  47;
/M: SY='G';  M= -69, -96, -83, -44,-103,  82, -91,-111, -89,-106, -95, -71, -88, -86, -96, -70, -88,-104, -94, -98;
/M: SY='K';  M= -42, -91, -76, -69, -92, -79,  11, -96,  56, -96, -86, -66, -84, -64, -21,  53, -67, -80, -98, -83;
/M: SY='K';  M= -79, -94, -83, -32, -88, -96, -84, -68,  54, -80, -76, -78, -90, -67,  31, -80, -76,  38, -98, -83;
/M: SY='S';  M= -72, -87, -89, -87, -74, -86, -86,  -1, -87,  32, -64, -80, -90, -80, -89,  54, -46, -19, -97, -79;
/M: SY='P';  M= -59,-106, -85, -74,-103, -84, -87, -92, -81, -88, -89, -88, 103, -83, -92,   0, -74, -95, -98,-100;
/M: SY='I';  M= -85, -93,-104,-101,  58,-105, -97,  73, -96, -52, -57, -94, -95, -97, -98, -91, -78, -24, -77, -58;
/M: SY='H';  M= -81,-100, -71, -59, -94, -86,  99, -97, -47, -86, -73, -63, -85,  86, -62, -70, -81, -98,-100, -45;
/M: SY='Y';  M=-105,-115,-104,-107, -52,-111, -69, -90, -99, -87, -83,-105,-117, -94, -96, -99, -99, -95, -60, 101;
/M: SY='I';  M= -95,-111, -96,  21, -87,-118,-106,  64, -97, -71, -74,-102,-100, -55,-103,-100, -91, -60,-107, -92;
/M: SY='D';  M= -80, -93,  75, -56, -89, -83, -67, -85, -28, -79,  58, -60, -84, -63,  52, -74, -74, -85,-101, -77;
/M: SY='W';  M= -84, -96,-105, -97,  37, -97,-100,  65, -91, -36, -60, -96, -92, -90, -93, -90, -81, -51, 113, -52;
/M: SY='H';  M= -68, -91, -74, -82, -92,  74,  83,-103, -80, -94, -81, -62, -82, -74, -82, -65, -82, -97, -94, -75;
/M: SY='N';  M= -73, -79, -55, -72, -88, -69, -63, -84, -64, -91, -81,  96, -82, -67, -73, -55,  51, -82,-108, -84;
/M: SY='Y';  M= -82, -92, -88, -87, -40, -91, -55, -63, -80, -58,  81, -85, -93, -74, -77, -81, -78, -69, -51, 105;
/M: SY='T';  M= -66, -77, -78, -79, -77, -85, -86, -57, -76, -69, -68, -68, -78, -79, -82, -19,  83,  40,-102, -78;
/M: SY='Q';  M= -70, -87, -86, -73, -64, -93, -83,  23, -75, -58,   6, -81, -88,  66, -76, -75, -69,  60, -93, -73;
/M: SY='S';  M=   2, -78, -71, -72, -82, -67, -73, -83, -71, -86, -80, -21, -78, -66, -76,  75,  33, -75, -92,  -7;
/M: SY='C';  M= -75, 139, -95, -95, -85, -91, -95, -92, -91, -83, -83, -81,-106, -99, -97, -78, -75, -80,-115, -96;
/M: SY='T';  M= -71, -82, -71,  32, -73, -87, -78, -66, -74,  36, -62, -73, -81, -69, -79,  11,  51, -66, -93, -76;
/M: SY='P';  M= -82,-108, -83, -71,-102, -84, -86, -90, -79, -99, -86, -89, 112, -82, -91, -79, -75, -95, -95, -99;
/I:         MI=0; MD=-15; IM=0;
/M: SY='F';  M= -82, -86,-102, -96,  78,-100, -89, -23, -94,   9, -59, -94, -99, -98, -92, -88, -77,  36, -71, -50;
/M: SY='T';  M= -70, -81, -66,  32, -86, -86, -81, -65, -70, -82, -78, -65, -74, -70, -79, -56,  88, -71,-102, -83;
/M: SY='I';  M= -82, -95,-103,-101, -65,-107,-103,  92, -96, -48, -52, -93, -90, -92, -99, -90, -75, -35, -90, -73;
/M: SY='N';  M= -78, -84, -52, -73, -93, -67, -60, -91, -65,-100, -87, 107, -90, -66, -73, -32, -63, -95,-113, -88;
/M: SY='C';  M= -78, 136, -98, -98, -88, -94, -98, -95, -94, -86, -86, -84,-109,-102,-101, -81, -78, -83,-118, -99;
/M: SY='Q';  M= -77,-103, -73, -52,-108, -86, -66, -94, -58, -89, -76, -68, -85, 113, -58, -67, -80, -96, -90, -79;
/M: SY='E';  M=  -1, -95,  55,  60,-101, -84, -73, -99, -67, -96, -92,  -3, -80, -63, -76, -71, -33, -92,-106, -90;
/M: SY='P';  M= -83,-108, -83, -72,-102, -85, -85, -90, -79,-100, -87, -90, 111, -83, -92, -80, -75, -95, -96,-100;
/M: SY='K';  M=   8, -91, -79, -68, -91, -84, -82, -76,  61, -85, -78, -75,  47, -68, -60, -73, -72,  11, -93, -85;
/M: SY='L';  M= -74, -87, -93, -93, -64,  38, -89, -56, -91,  43, -58, -86, -94, -87, -92, -81, -78,  25, -91, -78;
/M: SY='G';  M= -65, -92, -81, -93, -99,  87, -87,-107, -86,-103, -92, -67, -85, -84, -93, -66, -85,-101, -90, -94;
/M: SY='S';  M=  36, -82, -78, -76, -93, -69, -80, -89, -75, -92, -86, -68, -84, -70, -22,  70, -60, -80, -98, -86;
/M: SY='L';  M= -86, -88,-103, -95, -59,-105, -87, -51, -97,  73, -47,-102,-103, -89, -94, -96, -82, -58, -90, -72;
/M: SY='V';  M= -76, -90,-103, -99, -70,-106,-105,  59, -95, -54, -58, -96, -95, -95, -98, -88, -73,  60,-100, -78;
/M: SY='V';  M=  35, -84, -97, -90, -80, -88, -99, -49, -89, -66, -67, -92, -94, -90, -92, -75, -70,  67,-103, -84;
/M: SY='R';  M= -86,-103, -83, -71, -95, -96, -71,-102, -43, -94, -83, -76, -95, -59,  97, -80, -85, -96, -95, -82;
/M: SY='C';  M= -81, 132,-101,-100, -88, -96,-101, -97, -96, -88, -89, -88,-111,-103,-102, -84, -81, -86,  30, -96;
/M: SY='W';  M= -70, -93, -87, -84, -77, -77, -89, -90, -82, -43, -88, -77, -88, -75, -86,  68, -68, -90, 113, -67;
/M: SY='Y';  M= -92, -96, -95, -95,  68, -99,   7, -73, -89, -67, -70, -91,-103, -89, -86, -87, -86, -78, -53,  89;
/M: SY='Y';  M= -89, -97,  38, -80,  13, -96, -68, -72, -86,  14, -68, -82, -99, -83, -86, -86, -82, -77, -66,  79;
/M: SY='H';  M= -84,-100, -66,  56, -73, -95,  74, -89, -72, -84, -78, -76, -86, -64, -75, -80, -83, -26, -84,  54;
/M: SY='D';  M= -85,-101,  79,  42,-106, -88, -73,-105, -31,-101, -98, -61, -83, -21, -30, -76, -78,-100,-112, -90;
/M: SY='F';  M= -83, -21, -97, -99,  81,  36, -88, -80, -94, -72, -78, -84, -98, -98, -95, -28, -85, -82, -71, -53;
/M: SY='H';  M= -34, -89, -89, -85, -70, -93,  68, -31, -87,  39,  16, -82, -49, -79, -85, -10, -77,  -5, -98, -69; D=-150;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='E';  M=  21, -92, -30,  74, -99, -85, -77, -95, -66, -92, -87, -75, -77, -53, -75, -69,   4, -85, -99, -91; D=-150;
/I:         I=-150; DM=-380;
/M: SY='Y';  M= -91, -96, -91, -92,  59, -97,  46, -75, -87, -69, -69, -87,-101, -85, -84, -86, -85, -80, -56,  89; D=-150;
/I:         I=-150; DM=-380;
/M: SY='H';  M= -88,-101, -75, -71, -89, -92, 112,-104, -62, -89, -76, -66, -91, -62,  52, -78, -86,-101,-111, -63; D=-150;
/I:         I=-150; DM=-380;
/M: SY='D';  M= -87,-100, 100, -50,-107, -83, -72,-105, -74,-103,-103, -54, -86, -73, -82, -74, -76,-102,-122, -89; D=-150;
/I:         I=-150; DM=-380;
/M: SY='V';  M= -74, -88,-103, -98, -72,-105,-105,  31, -95, -57, -60, -97, -97, -96, -97, -87, -71,  74,-104, -80; D=-150;
/I:         I=-150; DM=-380;
/M: SY='R';  M= -87, -99, -86, -76, -58, -98,  34, -84, -54,  12, -71, -79, -96, -66,  80, -83, -85, -84, -95, -75; D=-150;
/I:         I=-150; DM=-380;
/M: SY='V';  M= -71, -85,-102, -96, -73,-103,-105, -38, -94, -59, -62, -98, -98, -97, -95, -85, -70,  84,-108, -81; D=-150;
/I:         I=-150; DM=-380;
/M: SY='V';  M= -73, -87,   4, -88, -75,-101,-100, -42, -92, -62, -64, -91, -97, -94, -94, -84, -70,  79,-109, -82; D=-150;
/I:         I=-150; DM=-380;
/M: SY='L';  M= -87, -89,-104, -96, -57,-106, -88, -52, -98,  72, -48,-103,-104, -90, -95, -97, -83, -59, -91, -73; D=-150;
/I:         I=-150; DM=-380;
/M: SY='D';  M= -85, -95,  82, -57,   7, -84, -74, -95, -76, -94, -94,  23, -88, -77, -83, -72,   6, -94,-108, -81; D=-150;
/I:         I=-150; DM=-380;
/M: SY='F';  M= -94, -94, -98, -91,  88,-101, -87, -76,  27, -69, -76, -51,-101, -93, -78, -90, -86, -78, -69, -48; D=-150;
/I:         I=-150; DM=-380;
/M: SY='I';  M= -87,-101, -96, -89, -79,-105, -93,  65,  -1, -61, -66, -65, -95, -81,  37, -80, -82, -44, -96, -81; D=-150;
/I:         I=-150; E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2021_04 which contains 565'928 sequence entries.


Total number of hits 6 in 6 different sequences
Number of true positive hits 6 in 6 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotic viruses
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] SARS ORF8 Ig-like
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
6 sequences

NS8A_SARS   (Q7TFA0    ), NS8B_SARS   (Q80H93    ), NS8_BC279   (Q0Q469    ), 
NS8_BCHK3   (Q3LZX5    ), NS8_BCRP3   (Q3I5I8    ), NS8_SARS2   (P0DTC8    )
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PDB
[Detailed view]
2 PDB

7JTL; 7JX6

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