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PROSITE entry PS52033


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General information about the entry

Entry name [info] CYSTATIN_LXN
Accession [info] PS52033
Entry type [info] MATRIX
Date [info] 08-NOV-2023 CREATED;
08-NOV-2023 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC52033
Associated ProRule [info] PRU01377

Name and characterization of the entry

Description [info] Latexin (LXN)-type cystatin domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=102;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=102;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3404832; R2=0.0108875; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=796; N_SCORE=11.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=383; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -15, -81,  -3,  17, -11,  -3, -24, -30, -41, -24,   0, -25,  26,  -4,  -5,  19,  -3, -16,  -5, -40;
/M: SY='A';  M=  33, -29, -48,  25, -28,  23, -11, -44, -40, -35,   6, -64, -24, -26,   3, -11,   4, -20, -80, -13;
/M: SY='Q';  M=  -9, -78, -21,  24, -50, -40,   0, -65,  -9, -46,  32,  -1,  12,  47,   4,   5,   3,   6, -82, -31;
/M: SY='N';  M= -45, -24,  14,  38, -70, -10,  -2, -52, -32,   3, -31,  41, -21, -28, -46,  32, -36, -71,  22,   2;
/M: SY='I';  M= -17, -77, -34, -47, -33, -45, -76,  62, -75,  33, -46,  16, -15, -72, -52, -32, -62,   9,  -2, -35;
/M: SY='P';  M= -37, -88, -30, -32, -88, -54, -69, -79, -62, -87, -75,   9, 106, -18, -25,  23, -59, -81, -85, -82;
/M: SY='D';  M= -22, -22,  69,   1, -82, -14, -28, -77,  -4, -26, -21, -21,  50, -58,   4,  -6, -27, -52, -89, -74;
/M: SY='S';  M= -14, -72, -24,   1, -76,  12,   4, -76, -16, -46, -24,  42,  -8, -54, -28,  65,   1, -72, -84, -35;
/M: SY='H';  M= -29, -78, -16, -40,  38, -74,  91, -47, -45,   4,  -3,   3,  16, -41, -20, -26, -13, -49,  -3,  38;
/I:         I=-19; MD=-49;
/M: SY='G';  M= -35, -15, -67, -30, -27,  50, -63, -54,  17, -46, -68, -33,   0,  -2,  17,   0, -30, -56, -69,  48; D=-19;
/I:         I=-19; MD=-49;
/M: SY='H';  M=  15, -22, -35,  -3, -46, -39,  65, -77, -41, -30, -29,  50,  33,  -2, -29, -25, -14, -59, -16, -39; D=-19;
/I:         I=-19; MD=-49;
/M: SY='V';  M=  24, -83, -87, -81, -24, -50, -85,  26, -79,   1, -21, -50,  -5, -18, -37, -22, -68,  29,   9, -72; D=-19;
/I:         I=-19; MD=-49;
/M: SY='P';  M= -35,-105,  -3,   3,-101, -95, -90, -20, -49, -50, -43, -85,  28,   0, -39,   8, -83, -62,  -5, -95; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='F';  M=   9, -89, -95, -54,  31, -92, -87,  10, -90,  24, -62, -91,  -5, -87, -91, -28, -53, -23, -83, -15; D=-19;
/I:         I=-19; DM=-49;
/M: SY='W';  M= -35, -22, -69, -27, -37, -17,  18, -70, -35,  -5, -63, -34,  10,  28,  46,   3,  14, -53, 107, -55;
/M: SY='R';  M= -17, -34,   8,   0, -39, -50,  37, -76, -29, -20, -63,  26,  11,  41,  65, -59, -39, -74, -12,   1;
/M: SY='A';  M=  59, -69, -74, -44, -19, -35, -69, -33, -37,  49,  12, -37, -18, -31, -46, -41, -36, -38, -75, -63;
/M: SY='A';  M=  82, -66, -67,  -3, -74,   8, -70, -66, -63, -12, -61, -63, -69, -60, -27, -25, -25, -44, -78, -72;
/M: SY='W';  M=  -7, -29, -69, -39,   0, -35, -30,  -2, -11,  -3, -20, -19,  -7,  34,  52,  -5, -15, -23,  80, -56;
/M: SY='V';  M=  19, -70, -18, -41, -58, -26, -74,  18, -45,  10,   3, -37, -76, -39, -44, -33, -17,  63, -80, -11;
/M: SY='A';  M=  70, -19, -40, -66, -74,  36, -73, -44, -67, -41, -62, -62, -14, -65, -72,  -7, -24,  15, -80, -73;
/M: SY='C';  M=   6,  58, -65,   4, -26, -48, -28, -56, -40,  13, -22, -17, -45,  35, -43,  46, -54,  19, -81, -65;
/M: SY='H';  M= -31, -24, -15, -27, -76,   8,  93, -58, -40, -40, -66,   6,  -6,  15, -63,  50, -58, -77, -90, -34;
/M: SY='Y';  M= -29,  -8, -78, -47,  61, -58,  -3, -13, -47, -42, -55, -75, -85, -35, -43, -46, -69, -48,  -5, 101;
/M: SY='I';  M= -68, -77, -84, -53,  14, -88, -13,  50, -48,  40,  22, -79,   8, -35, -45, -75, -40,  26, -77, -57;
/M: SY='N';  M=  -7, -74, -25, -24, -75, -31, -57, -22, -24, -67,  64,  85, -11, -10, -16, -19, -19, -33, -89, -71;
/M: SY='W';  M=   0, -29, -79, -46,   7, -57, -31, -35, -71, -20, -62, -75,  -7, -29, -73, -18,  18, -33, 118,  68;
/M: SY='R';  M= -52, -84, -24,  30, -79, -20,  36, -80,   2, -40, -67,   6, -24,  54,  59, -27, -47, -52, -81, -19;
/M: SY='Y';  M=   5, -79,   3,   5, -45, -28,  18, -47,  24, -30,  -3,  17, -73,  30,  18, -10, -31, -52, -74,  35;
/M: SY='G';  M=   9, -28, -65, -69, -81,  61, -23, -54, -42, -80, -73,  -9, -71, -32, -18,  48,   8, -39, -83, -75;
/M: SY='S';  M= -20, -25, -62, -42, -76,  -1, -68, -45, -63, -55, -69, -20, -68, -31, -69,  72,  63, -38, -88, -71;
/M: SY='P';  M= -28, -87, -39,  49, -82, -74, -28, -74, -32, -13, -69, -69,  92,  -8, -40, -17, -63, -48, -84, -78;
/M: SY='H';  M= -25,  -9,   8, -42,  16, -21,  60, -48, -62, -53, -67,  36,   5, -60, -15,  43, -20, -35, -79,  17;
/M: SY='R';  M=  -2,  14, -25, -19, -50, -18, -21, -72,  23, -21, -65, -58, -72,   2,  48,  15,  37, -33, -83, -69;
/M: SY='H';  M= -17, -77, -73, -47, -16,   5,  38, -28, -34,  35, -53, -33, -17, -22,  -5,  14, -24,   8,  30, -24;
/M: SY='Y';  M= -53, -17, -18, -36,  61, -80, -57, -42, -25, -16, -12, -23,  -9,  -7,  27, -45, -68, -53, -53,  78;
/M: SY='N';  M=   2, -76, -22, -31, -11, -23,  27, -11, -29, -15, -10,  28, -15,   2, -10,  16,   2,  -2,  -5,  17;
/M: SY='M';  M= -38, -74, -59, -76, -13, -84,  -4,  -8, -72,  54,  65, -77, -82, -69,   1, -29, -32,  23, -78, -26;
/M: SY='A';  M=  43, -32,  -3, -10, -79,   8,  28, -75, -12, -59, -67, -39,  -8,  35,  10, -10,   2, -35, -82, -28;
/M: SY='Q';  M=   0, -81, -32,  25, -48, -72, -19, -73,   8, -38, -65,   6, -18,  74,  20, -27,   4, -30, -16, -22;
/M: SY='V';  M= -62,  -3, -82, -58, -58, -85, -28,  27, -48,  24,   5, -26, -24, -36, -41, -31, -59,  68, -86, -64;
/M: SY='H';  M=  19,   2, -63,  -1, -75, -26,  34, -37,  34, -24, -65, -21, -38,  15,   9,  23,   1, -51, -81, -17;
/I:         I=-7; MD=-17;
/M: SY='K';  M= -35, -94, -48, -12, -32, -42,  12, -95,  33, -67, -84,  23, -22,  11,  -1,   1, -51, -92, -97, -82; D=-7;
/I:         I=-7; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='A';  M=  49, -86, -88, -84, -58, -25, -89, -24, -84, -38, -78, -41, -89, -38, -88,   8, -24, -25,   9, -44; D=-7;
/I:         I=-7; DM=-17;
/M: SY='T';  M=   2, -76,  -8, -25, -74, -16,   1, -33, -13, -33, -67,  -8, -45, -59,  25,  39,  40, -32,  -2, -19; D=-7;
/I:         I=-7; DM=-17;
/M: SY='V';  M=   9, -75, -43, -67, -12, -38, -72, -12,   2,   4,  -8,  -5, -48,  13,   6,  -5, -25,  41,   5, -64; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Q';  M= -39, -82, -38,  42, -78, -75, -63, -72,  41, -21, -66, -36, -37,  51,  19,   5, -17, -15,  24, -69; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Q';  M= -38, -81,  26,  12, -28, -43,  14,  -2, -17, -51, -29,   8, -17,  48, -45,  -9, -49,  28,  24, -20; D=-7;
/I:         I=-7; DM=-17;
/M: SY='W';  M= -43, -81,  13, -26, -62, -79, -73,  57, -44, -20, -22,  25, -78,   5, -20, -31, -15,   9,  73, -20; D=-7;
/I:         I=-7; DM=-17;
/M: SY='P';  M=  -5, -84,  -3,   7, -79, -55, -68, -22,  -1, -33, -67, -66,  77,  18,  -8, -14,   1, -25, -83, -31; D=-7;
/I:         I=-7; DM=-17;
/M: SY='R';  M= -50,   8,  13,  10, -82,  32, -65, -50,  21, -80, -73,   7, -41,   2,  36, -18,  15, -49,  11, -73; D=-7;
/I:         I=-7; DM=-17;
/M: SY='K';  M= -30, -78, -64,  16, -19,  -7, -68, -12,  40, -37, -63, -12, -37, -25,   8,   6,   4,  24, -81, -33; D=-7;
/I:         I=-7; DM=-17;
/M: SY='G';  M= -45, -81,  50,  11, -85,  73, -14, -56, -34, -60, -30, -14, -34, -62, -71, -24, -49, -82, -84, -77; D=-7;
/I:         I=-7; DM=-17;
/M: SY='C';  M= -18,  65,  47,   3, -76, -46,  63, -80, -30, -76,  -6,  18, -22,  10,  22, -22, -63, -56, -14,  -7; D=-7;
/I:         I=-7; DM=-17;
/M: SY='K';  M= -11, -78,  -7,  -1, -13, -71, -28, -34,  71, -39, -66, -13, -70,  14,  10,   5,  -9, -71, -77, -34; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Y';  M= -33, -79, -78, -39,  18, -54, -25,  20, -44,  13, -49, -76, -37, -70, -45, -70, -35,  27, -54,  88; D=-7;
/I:         I=-7; DM=-17;
/M: SY='H';  M= -16, -32,  39,  22, -26, -72,  69, -34,  -3, -57, -28,   6, -73,  22,   3, -18, -63, -45, -75,  44; D=-7;
/I:         I=-7; DM=-17;
/M: SY='L';  M= -69, -74, -84, -80,  51, -86, -73,   3, -77,  60, -41, -16, -86, -76, -36, -51, -34,  20,   2, -20; D=-7;
/I:         I=-7; DM=-17;
/M: SY='D';  M= -21, -15,  49,  35, -74, -31,  22, -47,  13, -40, -65, -56, -43,  38, -58, -32, -10,  14, -83,   2; D=-7;
/I:         I=-7; DM=-17;
/M: SY='F';  M= -75,  -3, -85, -82,  94, -85, -63, -53, -54,  -8, -17, -79, -88, -80, -38, -75, -37, -22,  32,  70; D=-7;
/I:         I=-7; DM=-17;
/M: SY='T';  M= -20, -72,  10,   3, -36, -69, -27, -44, -38, -34, -65, -55, -18, -60, -40,  43,  68,  -3, -85, -14; D=-7;
/I:         I=-7; DM=-17;
/M: SY='T';  M=   0, -16, -75, -30, -63, -50, -78,  22, -71,   2,   5, -69, -16, -71, -76, -34,  54,  49, -86, -67; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M= -65, -18,  -5,  57, -45, -15, -65, -24,  31,  28, -19, -64, -71,   4, -57, -50, -21, -18, -81, -68; D=-7;
/I:         I=-7; DM=-17;
/M: SY='D';  M= -40, -22,  53,  27, -39, -38,  -4, -26, -15,  34, -21, -36, -75,  -8,  -4, -11, -36, -64,  -1, -65; D=-7;
/I:         I=-7; DM=-17;
/M: SY='Y';  M= -25, -81, -46, -16,   8, -40,  75, -20, -46, -38,   6, -31, -36, -11, -36, -13, -14,  -9,  18,  75; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M= -53, -80,   5,  35, -72, -35,  -1,  20,   9,  -6, -61,  29,   3, -10,  -1,  -5, -29,  -4, -85, -69; D=-7;
/I:         I=-7; DM=-17;
/M: SY='M';  M= -46, -33,  -6, -23, -25, -25,  13,  -9, -27,   5,  35,  14,  31,  27, -66,  27,  11, -63, -82, -35; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M= -26, -79, -26,  44, -40,   5,   6, -43,  21, -48, -67,  28,  34, -33,   2,  -6, -60,   3, -83, -71; D=-7;
/I:         I=-7; DM=-17;
/M: SY='S';  M= -53, -89, -49,  16, -93, -14, -80, -90, -15, -74, -86,  -6, -17, -47, -77,  41,  30, -66,   5, -86; D=-7;
/I:         I=-7; MI=0; MD=-17; IM=0; DM=-17;
/M: SY='Q';  M= -49, -94,  -7,  50, -97, -39,  -4, -93,   7, -88, -79, -19, -28,  74, -21, -45, -73, -90, -91, -79; D=-7;
/I:         I=-7; DM=-17;
/M: SY='E';  M= -26, -78, -29,  57, -74, -42,   9, -71, -36, -73, -21,  35,   0,   3,  36,   6, -12,  -4,  12,  -9;
/M: SY='I';  M=   8, -72, -42, -47, -30, -76, -71,  45, -27,  28,  26,   9, -19, -67, -30, -27,   9,  19, -79, -38;
/M: SY='G';  M= -30, -77, -73, -38,  -1,  58, -73,  30, -40,   4,   2, -37, -23,  -3, -55, -47, -28,  13,  -6, -64;
/M: SY='N';  M= -44, -75, -41, -28, -72, -52,  -3, -35,  28, -50, -65,  52,  40,   0,  -2,  29,  20,  -9, -80,   3;
/M: SY='C';  M= -44, 138, -40, -79, -24, -54,  -7, -75, -33, -50, -69, -70, -40, -81, -80, -67, -65, -29,  70, -70;
/M: SY='S';  M= -34, -72, -62, -16,  -9, -66,  52, -21, -22,  -8, -59, -54, -69,  22, -25,  58,  46, -39,   2, -30;
/M: SY='A';  M=  72, -67, -73, -40, -65, -31, -70, -39, -67,   8,  47, -68, -72, -25, -70, -21, -57,  13, -77, -27;
/M: SY='E';  M= -44, -79,  -3,  48, -35, -48,  38, -21, -12, -29, -64, -31, -69,  31,  33, -18,  35, -41, -83, -32;
/M: SY='V';  M= -45, -72, -83, -52, -35, -86, -83,  31, -44,   4, -11, -78, -80, -75, -22, -43, -16,  79, -86, -63;
/M: SY='F';  M= -22, -75, -43, -77,  50, -25, -74,  14, -75,  49, -45, -76, -83, -16, -23, -49,  -4,   6, -70, -52;
/M: SY='W';  M= -77, -86, -86, -44,  79, -82, -68, -63, -46, -58, -62, -82, -14, -33, -74, -76, -43, -69, 119,  70;
/M: SY='H';  M= -68, -84, -37, -24, -67, -45,  63, -51,  15, -23, -63,   3,  35,  28,  44, -10, -41, -75, -75,  39;
/M: SY='P';  M= -67, -82, -38, -12, -75, -52,  32, -70,  25,   5, -31,  40,  65,  -4,   7, -16, -22, -47, -85, -70;
/M: SY='Q';  M= -23, -80, -20,  25, -82,  38,   3, -47,   6, -42, -21, -23, -17,  51,  -8,   1,  10, -74, -82, -71;
/M: SY='K';  M= -49, -81, -12,  34, -78, -25,   8, -36,  63, -22, -66,  -8, -69,  26,  10,  -2, -43, -74, -80, -36;
/M: SY='P';  M= -36, -83, -63,   7, -85,   6, -68, -79,  -9, -83, -73, -28,  87,  -7,  -1,  10,  25, -77, -84, -79;
/I:         I=-31; MD=-79;
/M: SY='R';  M= -82, -98, -28, -26, -95, -55,  32, -93,   3, -52, -82, -45, -12,  11,  47, -38,  12, -63,-101, -82; D=-31;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='P';  M=  -1, -84, -40, -35, -78, -55, -72, -30, -26, -21,  -6, -71,  97, -39, -26, -25,  -6, -10, -83, -77;
/M: SY='A';  M=  50, -74, -11,   1, -77, -43, -66, -47,  40, -41, -65, -17, -71,  -3,  20, -21, -10, -18, -81, -38;
/M: SY='V';  M= -37, -75, -40, -77, -32, -85, -85,  21, -77, -29, -51, -78,  27, -79, -80, -68,  12,  77, -11, -67;
/M: SY='N';  M= -66, -79,   7,  18, -42, -44,  21, -79,  32, -35, -69,  68, -72,  46, -53, -11,  -6, -78, -86, -37;
/M: SY='Y';  M= -40, -30, -81, -78, -25, -58,  -1,  34, -75,  -4, -50, -45, -46,   1, -55, -50, -64,  50, -66,  68;
/M: SY='H';  M= -46, -77,  12, -17, -20, -70,  54, -74,  -4, -57, -29,  24, -19,   9, -16,  23,  52, -55, -87, -18;
/M: SY='C';  M= -40, 131, -81, -54,   0, -79, -15, -56, -76, -70, -10, -35, -91, -80, -35,  -6, -65, -31,  -9, -12;
/M: SY='T';  M= -13, -76, -15,   9, -21, -51, -67, -67, -26, -23, -23, -10,   9,  28, -20,  15,  58, -17, -86, -70;
/M: SY='H';  M= -43, -35,  24,  -7, -19,   2,  31, -51, -14, -10, -65, -39,   7,   1,  27,   6, -33, -16, -10,   5;
/M: SY='L';  M= -31, -78, -24,  34, -26, -44, -68, -12, -18,  36, -56,  10,   5, -22, -48,   0,   4, -32, -17, -67;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='H';  M= -29, -24,  14,   9, -77,   3,  45,   0,  33, -22, -36, -38, -15,  32, -26, -44, -26, -16, -86, -68;
/M: SY='E';  M= -17, -24,  39,  51, -86, -19, -24, -84,   5, -83, -76,  23, -43,  15, -60,  20,   5, -78, -90, -75;
/M: SY='K';  M= -39, -29, -27, -15, -28, -78, -22,  12,  42,  11, -60, -22,  15,  24, -59,   0,  -9, -46, -82, -37;
/M: SY='E';  M=   0, -80, -28,  39, -82, -21, -31, -48,  35, -37, -25,  10, -23,  -2, -35,  25, -12, -53, -86, -75;
/M: SY='E';  M= -55, -85, -13,  52, -25, -46, -16, -43,  31, -78, -12,  10, -72,  37,  18, -25, -21, -78, -82, -10;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 10 in 5 different sequences
Number of true positive hits 10 in 5 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] Cystatin LXN-type
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
5 sequences

LXN_HUMAN   (Q9BS40), LXN_MOUSE   (P70202), LXN_RAT (Q64361), 
OCX32_CHICK (Q90YI1), TIG1_HUMAN  (P49788)
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PDB
[Detailed view]
2 PDB

1WNH; 2BO9