PROSITE entry PS52033
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General information about the entry
| Entry name [info] | CYSTATIN_LXN |
| Accession [info] | PS52033 |
| Entry type [info] | MATRIX |
| Date [info] |
08-NOV-2023 CREATED;
08-NOV-2023 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52033 |
| Associated ProRule [info] | PRU01377 |
Name and characterization of the entry
| Description [info] | Latexin (LXN)-type cystatin domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=102; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=102; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3404832; R2=0.0108875; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=796; N_SCORE=11.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=383; N_SCORE=6.5; MODE=1; TEXT='RR'; /DEFAULT: M0=-26; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='P'; M= -15, -81, -3, 17, -11, -3, -24, -30, -41, -24, 0, -25, 26, -4, -5, 19, -3, -16, -5, -40; /M: SY='A'; M= 33, -29, -48, 25, -28, 23, -11, -44, -40, -35, 6, -64, -24, -26, 3, -11, 4, -20, -80, -13; /M: SY='Q'; M= -9, -78, -21, 24, -50, -40, 0, -65, -9, -46, 32, -1, 12, 47, 4, 5, 3, 6, -82, -31; /M: SY='N'; M= -45, -24, 14, 38, -70, -10, -2, -52, -32, 3, -31, 41, -21, -28, -46, 32, -36, -71, 22, 2; /M: SY='I'; M= -17, -77, -34, -47, -33, -45, -76, 62, -75, 33, -46, 16, -15, -72, -52, -32, -62, 9, -2, -35; /M: SY='P'; M= -37, -88, -30, -32, -88, -54, -69, -79, -62, -87, -75, 9, 106, -18, -25, 23, -59, -81, -85, -82; /M: SY='D'; M= -22, -22, 69, 1, -82, -14, -28, -77, -4, -26, -21, -21, 50, -58, 4, -6, -27, -52, -89, -74; /M: SY='S'; M= -14, -72, -24, 1, -76, 12, 4, -76, -16, -46, -24, 42, -8, -54, -28, 65, 1, -72, -84, -35; /M: SY='H'; M= -29, -78, -16, -40, 38, -74, 91, -47, -45, 4, -3, 3, 16, -41, -20, -26, -13, -49, -3, 38; /I: I=-19; MD=-49; /M: SY='G'; M= -35, -15, -67, -30, -27, 50, -63, -54, 17, -46, -68, -33, 0, -2, 17, 0, -30, -56, -69, 48; D=-19; /I: I=-19; MD=-49; /M: SY='H'; M= 15, -22, -35, -3, -46, -39, 65, -77, -41, -30, -29, 50, 33, -2, -29, -25, -14, -59, -16, -39; D=-19; /I: I=-19; MD=-49; /M: SY='V'; M= 24, -83, -87, -81, -24, -50, -85, 26, -79, 1, -21, -50, -5, -18, -37, -22, -68, 29, 9, -72; D=-19; /I: I=-19; MD=-49; /M: SY='P'; M= -35,-105, -3, 3,-101, -95, -90, -20, -49, -50, -43, -85, 28, 0, -39, 8, -83, -62, -5, -95; D=-19; /I: I=-19; MI=0; MD=-49; IM=0; DM=-49; /M: SY='F'; M= 9, -89, -95, -54, 31, -92, -87, 10, -90, 24, -62, -91, -5, -87, -91, -28, -53, -23, -83, -15; D=-19; /I: I=-19; DM=-49; /M: SY='W'; M= -35, -22, -69, -27, -37, -17, 18, -70, -35, -5, -63, -34, 10, 28, 46, 3, 14, -53, 107, -55; /M: SY='R'; M= -17, -34, 8, 0, -39, -50, 37, -76, -29, -20, -63, 26, 11, 41, 65, -59, -39, -74, -12, 1; /M: SY='A'; M= 59, -69, -74, -44, -19, -35, -69, -33, -37, 49, 12, -37, -18, -31, -46, -41, -36, -38, -75, -63; /M: SY='A'; M= 82, -66, -67, -3, -74, 8, -70, -66, -63, -12, -61, -63, -69, -60, -27, -25, -25, -44, -78, -72; /M: SY='W'; M= -7, -29, -69, -39, 0, -35, -30, -2, -11, -3, -20, -19, -7, 34, 52, -5, -15, -23, 80, -56; /M: SY='V'; M= 19, -70, -18, -41, -58, -26, -74, 18, -45, 10, 3, -37, -76, -39, -44, -33, -17, 63, -80, -11; /M: SY='A'; M= 70, -19, -40, -66, -74, 36, -73, -44, -67, -41, -62, -62, -14, -65, -72, -7, -24, 15, -80, -73; /M: SY='C'; M= 6, 58, -65, 4, -26, -48, -28, -56, -40, 13, -22, -17, -45, 35, -43, 46, -54, 19, -81, -65; /M: SY='H'; M= -31, -24, -15, -27, -76, 8, 93, -58, -40, -40, -66, 6, -6, 15, -63, 50, -58, -77, -90, -34; /M: SY='Y'; M= -29, -8, -78, -47, 61, -58, -3, -13, -47, -42, -55, -75, -85, -35, -43, -46, -69, -48, -5, 101; /M: SY='I'; M= -68, -77, -84, -53, 14, -88, -13, 50, -48, 40, 22, -79, 8, -35, -45, -75, -40, 26, -77, -57; /M: SY='N'; M= -7, -74, -25, -24, -75, -31, -57, -22, -24, -67, 64, 85, -11, -10, -16, -19, -19, -33, -89, -71; /M: SY='W'; M= 0, -29, -79, -46, 7, -57, -31, -35, -71, -20, -62, -75, -7, -29, -73, -18, 18, -33, 118, 68; /M: SY='R'; M= -52, -84, -24, 30, -79, -20, 36, -80, 2, -40, -67, 6, -24, 54, 59, -27, -47, -52, -81, -19; /M: SY='Y'; M= 5, -79, 3, 5, -45, -28, 18, -47, 24, -30, -3, 17, -73, 30, 18, -10, -31, -52, -74, 35; /M: SY='G'; M= 9, -28, -65, -69, -81, 61, -23, -54, -42, -80, -73, -9, -71, -32, -18, 48, 8, -39, -83, -75; /M: SY='S'; M= -20, -25, -62, -42, -76, -1, -68, -45, -63, -55, -69, -20, -68, -31, -69, 72, 63, -38, -88, -71; /M: SY='P'; M= -28, -87, -39, 49, -82, -74, -28, -74, -32, -13, -69, -69, 92, -8, -40, -17, -63, -48, -84, -78; /M: SY='H'; M= -25, -9, 8, -42, 16, -21, 60, -48, -62, -53, -67, 36, 5, -60, -15, 43, -20, -35, -79, 17; /M: SY='R'; M= -2, 14, -25, -19, -50, -18, -21, -72, 23, -21, -65, -58, -72, 2, 48, 15, 37, -33, -83, -69; /M: SY='H'; M= -17, -77, -73, -47, -16, 5, 38, -28, -34, 35, -53, -33, -17, -22, -5, 14, -24, 8, 30, -24; /M: SY='Y'; M= -53, -17, -18, -36, 61, -80, -57, -42, -25, -16, -12, -23, -9, -7, 27, -45, -68, -53, -53, 78; /M: SY='N'; M= 2, -76, -22, -31, -11, -23, 27, -11, -29, -15, -10, 28, -15, 2, -10, 16, 2, -2, -5, 17; /M: SY='M'; M= -38, -74, -59, -76, -13, -84, -4, -8, -72, 54, 65, -77, -82, -69, 1, -29, -32, 23, -78, -26; /M: SY='A'; M= 43, -32, -3, -10, -79, 8, 28, -75, -12, -59, -67, -39, -8, 35, 10, -10, 2, -35, -82, -28; /M: SY='Q'; M= 0, -81, -32, 25, -48, -72, -19, -73, 8, -38, -65, 6, -18, 74, 20, -27, 4, -30, -16, -22; /M: SY='V'; M= -62, -3, -82, -58, -58, -85, -28, 27, -48, 24, 5, -26, -24, -36, -41, -31, -59, 68, -86, -64; /M: SY='H'; M= 19, 2, -63, -1, -75, -26, 34, -37, 34, -24, -65, -21, -38, 15, 9, 23, 1, -51, -81, -17; /I: I=-7; MD=-17; /M: SY='K'; M= -35, -94, -48, -12, -32, -42, 12, -95, 33, -67, -84, 23, -22, 11, -1, 1, -51, -92, -97, -82; D=-7; /I: I=-7; MI=0; MD=-17; IM=0; DM=-17; /M: SY='A'; M= 49, -86, -88, -84, -58, -25, -89, -24, -84, -38, -78, -41, -89, -38, -88, 8, -24, -25, 9, -44; D=-7; /I: I=-7; DM=-17; /M: SY='T'; M= 2, -76, -8, -25, -74, -16, 1, -33, -13, -33, -67, -8, -45, -59, 25, 39, 40, -32, -2, -19; D=-7; /I: I=-7; DM=-17; /M: SY='V'; M= 9, -75, -43, -67, -12, -38, -72, -12, 2, 4, -8, -5, -48, 13, 6, -5, -25, 41, 5, -64; D=-7; /I: I=-7; DM=-17; /M: SY='Q'; M= -39, -82, -38, 42, -78, -75, -63, -72, 41, -21, -66, -36, -37, 51, 19, 5, -17, -15, 24, -69; D=-7; /I: I=-7; DM=-17; /M: SY='Q'; M= -38, -81, 26, 12, -28, -43, 14, -2, -17, -51, -29, 8, -17, 48, -45, -9, -49, 28, 24, -20; D=-7; /I: I=-7; DM=-17; /M: SY='W'; M= -43, -81, 13, -26, -62, -79, -73, 57, -44, -20, -22, 25, -78, 5, -20, -31, -15, 9, 73, -20; D=-7; /I: I=-7; DM=-17; /M: SY='P'; M= -5, -84, -3, 7, -79, -55, -68, -22, -1, -33, -67, -66, 77, 18, -8, -14, 1, -25, -83, -31; D=-7; /I: I=-7; DM=-17; /M: SY='R'; M= -50, 8, 13, 10, -82, 32, -65, -50, 21, -80, -73, 7, -41, 2, 36, -18, 15, -49, 11, -73; D=-7; /I: I=-7; DM=-17; /M: SY='K'; M= -30, -78, -64, 16, -19, -7, -68, -12, 40, -37, -63, -12, -37, -25, 8, 6, 4, 24, -81, -33; D=-7; /I: I=-7; DM=-17; /M: SY='G'; M= -45, -81, 50, 11, -85, 73, -14, -56, -34, -60, -30, -14, -34, -62, -71, -24, -49, -82, -84, -77; D=-7; /I: I=-7; DM=-17; /M: SY='C'; M= -18, 65, 47, 3, -76, -46, 63, -80, -30, -76, -6, 18, -22, 10, 22, -22, -63, -56, -14, -7; D=-7; /I: I=-7; DM=-17; /M: SY='K'; M= -11, -78, -7, -1, -13, -71, -28, -34, 71, -39, -66, -13, -70, 14, 10, 5, -9, -71, -77, -34; D=-7; /I: I=-7; DM=-17; /M: SY='Y'; M= -33, -79, -78, -39, 18, -54, -25, 20, -44, 13, -49, -76, -37, -70, -45, -70, -35, 27, -54, 88; D=-7; /I: I=-7; DM=-17; /M: SY='H'; M= -16, -32, 39, 22, -26, -72, 69, -34, -3, -57, -28, 6, -73, 22, 3, -18, -63, -45, -75, 44; D=-7; /I: I=-7; DM=-17; /M: SY='L'; M= -69, -74, -84, -80, 51, -86, -73, 3, -77, 60, -41, -16, -86, -76, -36, -51, -34, 20, 2, -20; D=-7; /I: I=-7; DM=-17; /M: SY='D'; M= -21, -15, 49, 35, -74, -31, 22, -47, 13, -40, -65, -56, -43, 38, -58, -32, -10, 14, -83, 2; D=-7; /I: I=-7; DM=-17; /M: SY='F'; M= -75, -3, -85, -82, 94, -85, -63, -53, -54, -8, -17, -79, -88, -80, -38, -75, -37, -22, 32, 70; D=-7; /I: I=-7; DM=-17; /M: SY='T'; M= -20, -72, 10, 3, -36, -69, -27, -44, -38, -34, -65, -55, -18, -60, -40, 43, 68, -3, -85, -14; D=-7; /I: I=-7; DM=-17; /M: SY='T'; M= 0, -16, -75, -30, -63, -50, -78, 22, -71, 2, 5, -69, -16, -71, -76, -34, 54, 49, -86, -67; D=-7; /I: I=-7; DM=-17; /M: SY='E'; M= -65, -18, -5, 57, -45, -15, -65, -24, 31, 28, -19, -64, -71, 4, -57, -50, -21, -18, -81, -68; D=-7; /I: I=-7; DM=-17; /M: SY='D'; M= -40, -22, 53, 27, -39, -38, -4, -26, -15, 34, -21, -36, -75, -8, -4, -11, -36, -64, -1, -65; D=-7; /I: I=-7; DM=-17; /M: SY='Y'; M= -25, -81, -46, -16, 8, -40, 75, -20, -46, -38, 6, -31, -36, -11, -36, -13, -14, -9, 18, 75; D=-7; /I: I=-7; DM=-17; /M: SY='E'; M= -53, -80, 5, 35, -72, -35, -1, 20, 9, -6, -61, 29, 3, -10, -1, -5, -29, -4, -85, -69; D=-7; /I: I=-7; DM=-17; /M: SY='M'; M= -46, -33, -6, -23, -25, -25, 13, -9, -27, 5, 35, 14, 31, 27, -66, 27, 11, -63, -82, -35; D=-7; /I: I=-7; DM=-17; /M: SY='E'; M= -26, -79, -26, 44, -40, 5, 6, -43, 21, -48, -67, 28, 34, -33, 2, -6, -60, 3, -83, -71; D=-7; /I: I=-7; DM=-17; /M: SY='S'; M= -53, -89, -49, 16, -93, -14, -80, -90, -15, -74, -86, -6, -17, -47, -77, 41, 30, -66, 5, -86; D=-7; /I: I=-7; MI=0; MD=-17; IM=0; DM=-17; /M: SY='Q'; M= -49, -94, -7, 50, -97, -39, -4, -93, 7, -88, -79, -19, -28, 74, -21, -45, -73, -90, -91, -79; D=-7; /I: I=-7; DM=-17; /M: SY='E'; M= -26, -78, -29, 57, -74, -42, 9, -71, -36, -73, -21, 35, 0, 3, 36, 6, -12, -4, 12, -9; /M: SY='I'; M= 8, -72, -42, -47, -30, -76, -71, 45, -27, 28, 26, 9, -19, -67, -30, -27, 9, 19, -79, -38; /M: SY='G'; M= -30, -77, -73, -38, -1, 58, -73, 30, -40, 4, 2, -37, -23, -3, -55, -47, -28, 13, -6, -64; /M: SY='N'; M= -44, -75, -41, -28, -72, -52, -3, -35, 28, -50, -65, 52, 40, 0, -2, 29, 20, -9, -80, 3; /M: SY='C'; M= -44, 138, -40, -79, -24, -54, -7, -75, -33, -50, -69, -70, -40, -81, -80, -67, -65, -29, 70, -70; /M: SY='S'; M= -34, -72, -62, -16, -9, -66, 52, -21, -22, -8, -59, -54, -69, 22, -25, 58, 46, -39, 2, -30; /M: SY='A'; M= 72, -67, -73, -40, -65, -31, -70, -39, -67, 8, 47, -68, -72, -25, -70, -21, -57, 13, -77, -27; /M: SY='E'; M= -44, -79, -3, 48, -35, -48, 38, -21, -12, -29, -64, -31, -69, 31, 33, -18, 35, -41, -83, -32; /M: SY='V'; M= -45, -72, -83, -52, -35, -86, -83, 31, -44, 4, -11, -78, -80, -75, -22, -43, -16, 79, -86, -63; /M: SY='F'; M= -22, -75, -43, -77, 50, -25, -74, 14, -75, 49, -45, -76, -83, -16, -23, -49, -4, 6, -70, -52; /M: SY='W'; M= -77, -86, -86, -44, 79, -82, -68, -63, -46, -58, -62, -82, -14, -33, -74, -76, -43, -69, 119, 70; /M: SY='H'; M= -68, -84, -37, -24, -67, -45, 63, -51, 15, -23, -63, 3, 35, 28, 44, -10, -41, -75, -75, 39; /M: SY='P'; M= -67, -82, -38, -12, -75, -52, 32, -70, 25, 5, -31, 40, 65, -4, 7, -16, -22, -47, -85, -70; /M: SY='Q'; M= -23, -80, -20, 25, -82, 38, 3, -47, 6, -42, -21, -23, -17, 51, -8, 1, 10, -74, -82, -71; /M: SY='K'; M= -49, -81, -12, 34, -78, -25, 8, -36, 63, -22, -66, -8, -69, 26, 10, -2, -43, -74, -80, -36; /M: SY='P'; M= -36, -83, -63, 7, -85, 6, -68, -79, -9, -83, -73, -28, 87, -7, -1, 10, 25, -77, -84, -79; /I: I=-31; MD=-79; /M: SY='R'; M= -82, -98, -28, -26, -95, -55, 32, -93, 3, -52, -82, -45, -12, 11, 47, -38, 12, -63,-101, -82; D=-31; /I: I=-31; MI=0; MD=-79; IM=0; DM=-79; /M: SY='P'; M= -1, -84, -40, -35, -78, -55, -72, -30, -26, -21, -6, -71, 97, -39, -26, -25, -6, -10, -83, -77; /M: SY='A'; M= 50, -74, -11, 1, -77, -43, -66, -47, 40, -41, -65, -17, -71, -3, 20, -21, -10, -18, -81, -38; /M: SY='V'; M= -37, -75, -40, -77, -32, -85, -85, 21, -77, -29, -51, -78, 27, -79, -80, -68, 12, 77, -11, -67; /M: SY='N'; M= -66, -79, 7, 18, -42, -44, 21, -79, 32, -35, -69, 68, -72, 46, -53, -11, -6, -78, -86, -37; /M: SY='Y'; M= -40, -30, -81, -78, -25, -58, -1, 34, -75, -4, -50, -45, -46, 1, -55, -50, -64, 50, -66, 68; /M: SY='H'; M= -46, -77, 12, -17, -20, -70, 54, -74, -4, -57, -29, 24, -19, 9, -16, 23, 52, -55, -87, -18; /M: SY='C'; M= -40, 131, -81, -54, 0, -79, -15, -56, -76, -70, -10, -35, -91, -80, -35, -6, -65, -31, -9, -12; /M: SY='T'; M= -13, -76, -15, 9, -21, -51, -67, -67, -26, -23, -23, -10, 9, 28, -20, 15, 58, -17, -86, -70; /M: SY='H'; M= -43, -35, 24, -7, -19, 2, 31, -51, -14, -10, -65, -39, 7, 1, 27, 6, -33, -16, -10, 5; /M: SY='L'; M= -31, -78, -24, 34, -26, -44, -68, -12, -18, 36, -56, 10, 5, -22, -48, 0, 4, -32, -17, -67; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='H'; M= -29, -24, 14, 9, -77, 3, 45, 0, 33, -22, -36, -38, -15, 32, -26, -44, -26, -16, -86, -68; /M: SY='E'; M= -17, -24, 39, 51, -86, -19, -24, -84, 5, -83, -76, 23, -43, 15, -60, 20, 5, -78, -90, -75; /M: SY='K'; M= -39, -29, -27, -15, -28, -78, -22, 12, 42, 11, -60, -22, 15, 24, -59, 0, -9, -46, -82, -37; /M: SY='E'; M= 0, -80, -28, 39, -82, -21, -31, -48, 35, -37, -25, 10, -23, -2, -35, 25, -12, -53, -86, -75; /M: SY='E'; M= -55, -85, -13, 52, -25, -46, -16, -43, 31, -78, -12, 10, -72, 37, 18, -25, -21, -78, -82, -10; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 10 in 5 different sequences |
| Number of true positive hits | 10 in 5 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Cystatin LXN-type |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
5 sequences
LXN_HUMAN (Q9BS40), LXN_MOUSE (P70202), LXN_RAT (Q64361), OCX32_CHICK (Q90YI1), TIG1_HUMAN (P49788)» more
|
| PDB [Detailed view] |
2 PDB
1WNH; 2BO9 |