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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01377


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01377
General rule information [?]

Accession PRU01377
Dates 28-JUL-2023 (Created)
28-JUL-2023 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52033; CYSTATIN_LXN
Name Latexin (LXN)-type cystatin domain
Function The LXN-type cystatin domains are packed against each other through the helices and linked by a connecting segment encompassing a third alpha- helix. The two domains are arranged so that there is a cleft in this part of the structure that can accommodate a peptide chain.
Scope(s) Eukaryota
Euteleostomi
Example(s) Q64361;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the protease inhibitor I47 (latexin) family.

Keywords [?]

Protease inhibitor

Gene Ontology [?]

GO:0008191; Molecular function:metalloendopeptidase inhibitor activity

Features [?]

From: PS52033
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Cystatin LXN-type #"

Additional information [?]

Size range 97-116 amino acids
Related rules None
Fusion None
Repeats 2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]