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PROSITE entry PS52035


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General information about the entry

Entry name [info] PEPTIDASE_M14
Accession [info] PS52035
Entry type [info] MATRIX
Date [info] 24-JAN-2024 CREATED;
24-JAN-2024 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC52035
Associated ProRule [info] PRU01379

Name and characterization of the entry

Description [info] Peptidase family M14 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=290;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=285;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2143202; R2=0.0063441; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1385; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=676; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-30; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='Y';  M= -22, -79,  21,  18, -47,   5,  12, -41,  25, -73, -66, -16, -41,  18,  29,   8, -11, -50, -71,  46;
/M: SY='Y';  M= -72, -86, -69, -45, -37, -77,  48,  -3, -37, -61, -56, -37,  61, -63, -66, -67, -66, -65, -45, 109;
/M: SY='H';  M= -34, -80, -40, -59,  13, -73, 106, -70, -59, -46, -30,  15, -76,  37, -12, -60, -24, -47, -65,  70;
/M: SY='T';  M= -57, -72,  -4, -21, -77, -62,  12, -73,  -2, -77, -69,  51,  38, -54,  10,  48,  51, -54, -88, -69;
/M: SY='Y';  M= -60,  15, -11, -28,   9, -79, -23, -54, -45,  32,   8,  -9, -82,  -8, -41, -69, -66, -59,  56,  95;
/M: SY='E';  M= -10, -76,  19,  59, -53, -33, -58, -79,   0, -78, -71,  24,   5,  29, -56,  42,  -3, -74, -83, -71;
/M: SY='E';  M= -13, -77,  46,  54, -51, -32, -60, -52, -33, -70, -13, -16, -66,  36,   6,  -7,  20,   7, -85, -69;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='M';  M= -42,  -4, -83, -79, -29, -58,  34,  66, -76,  27,  73, -74, -48, -71, -76, -56, -24,  -6, -79, -57; D=-33;
/I:         I=-33; DM=-84;
/M: SY='Q';  M= -28, -77,   6,  36, -62, -46,   3, -32, -31, -25,  13,   1, -71,  46,  11, -11, -15,  17, -71,  45; D=-33;
/I:         I=-33; DM=-84;
/M: SY='A';  M=  30, -25,  13,  19, -77, -38,  11, -33,  12, -57,  13,  10,  19,  19,   4,  20,  -7, -52, -82, -68;
/M: SY='W';  M= -10, -81, -22, -10,  48, -75,   9, -41, -13,  -2, -20, -73, -77, -65, -31, -30, -36, -31, 125,  46;
/M: SY='M';  M= -44, -71, -82, -76, -30, -82, -66,  29, -73,  58,  89, -76, -78, -68, -73, -71,   9, -28, -71,   4;
/M: SY='R';  M= -10, -78,  36,  16, -75, -34, -19, -31,  29, -24, -32,   8, -70,  32,  52,  -5, -34, -43, -80, -28;
/M: SY='Q';  M=  -9, -75,  -6,  11, -38, -14, -21, -34,  12,  16, -28, -10, -12,  43,  24,   7,  -2, -22, -77, -34;
/M: SY='L';  M= -29, -71, -83, -76,   6, -84, -72,  24, -58,  57,  47, -77, -80, -70, -12, -71, -18,  38, -74, -39;
/M: SY='A';  M=  48, -70,  -4,  21, -71, -47, -28, -17, -43, -45, -37,  13, -69,  34, -51,  -8,  10,  23,   5, -40;
/M: SY='S';  M=   3, -73, -16,  35, -51, -20, -29, -22,   3, -42, -15,  16, -66,  33,   3,  52,   1, -66, -81, -67;
/M: SY='M';  M= -10, -76,  15,  46, -72, -70, -27, -45,  17, -17,  55,  13, -32,  20,  30,  -5, -29, -45, -80, -39;
/M: SY='Y';  M= -38,  58, -64, -44,  55, -36,  63, -54, -34, -61, -24,  45,  11, -45, -65, -44, -36, -39, -60,  65;
/M: SY='P';  M= -14, -80, -12, -35, -78, -13, -66, -48, -33, -50, -23, -11,  96, -12, -37,  30, -12, -32, -81, -40;
/I:         I=-19; MD=-49;
/M: SY='D';  M= -37, -44,  36,  12, -19, -19,  23, -81, -25, -69, -73,  29,   2,  16,   6,  31,   0, -78,  22, -67; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='H';  M= -69, -77, -78, -58,  16, -84,  50,  44, -72,  38,  33, -20, -38, -39, -35, -72, -64,   5, -68,  38; D=-19;
/I:         I=-19; DM=-49;
/M: SY='V';  M=  26,  30, -35, -71,  11, -24, -74,   6, -70, -28, -24, -66, -35, -70, -73,  -5,  32,  54, -77,   0;
/M: SY='R';  M= -45, -75, -57,  16, -39, -33,  30, -74,  19, -40, -27, -19, -68,  24,  53,  44,  23, -70, -78, -11;
/I:         I=-45; MD=-115;
/M: SY='R';  M= -65, -21, -71, -46, -43, -35,   6,   7,  31,  27,  16, -65, -22,   3,  36, -64,   4,  12, -75,   7; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='Y';  M= -62, -76,  -8,  31,  12, -46,  12,  35, -22, -24, -29, -63, -72, -40,   4,  -1,   6,  19, -68,  46;
/M: SY='S';  M=   2, -71,  -2,   7, -25, -36,  28, -57,  -6, -27, -27,  35, -19,  22, -43,  45,   4,   7, -82, -42;
/M: SY='I';  M= -20, -74, -37, -50, -48, -29, -73,  69, -75,  40, -40, -37, -78, -71, -77, -47, -38,  20, -71,  26;
/M: SY='G';  M= -24,  58, -33, -76, -24,  90, -73, -82, -48, -34, -71, -55, -73, -70, -77, -53, -67, -56, -77, -75;
/M: SY='R';  M= -49, -76, -26,  -9, -71, -23,  18, -17,  48, -48, -21,  -7, -69,  24,  49,   8,  18, -17, -77,  -5;
/M: SY='S';  M= -46, -65, -57, -40, -74, -56, -62, -71, -58, -74, -69, -47, -26, -24, -64,  91,  61, -63, -85, -68;
/M: SY='Y';  M= -25, -73, -74, -12,  53, -51,  39, -37, -71,  21, -47, -72, -80, -69, -70, -44, -51,  45, -58,  66;
/M: SY='E';  M= -13, -79,  15,  82, -31,  -4, -57, -75, -27,  -4, -65, -39, -64,  40, -13, -32, -62, -72, -79, -68;
/M: SY='G';  M= -28, -77, -34, -70, -54,  90, -20, -87,  -4, -72, -73,  -2, -70, -30, -43, -10, -48, -81, -75, -35;
/M: SY='R';  M= -30, -79, -51, -56, -27, -72,   8, -74, -15, -19, -61,  42, -76,  -5,  92, -41, -29, -72, -74,  13;
/M: SY='P';  M= -33, -80,  37,  23, -80, -46,  -5, -32,  16, -77, -27,  11,  73, -17,  -9,   5,  11, -72, -84, -52;
/M: SY='I';  M= -66,  12, -86, -80,   2, -87, -76,  69, -52,  47,  45, -79, -80, -74, -77, -75, -61,  17, -74, -55;
/M: SY='W';  M= -46, -81,   7, -31, -18, -73, -46, -29,   5,  -5, -58,   2,  53, -61, -49, -25, -16, -37,  82,  79;
/M: SY='V';  M=  34, -26, -75, -28, -52,  -8, -68, -19, -47,  31,  -4, -72, -76, -67, -71, -31, -40,  46,   2,  40;
/M: SY='L';  M= -66, -72, -85, -78,   7, -86, -70,  21, -51,  71,  33, -81, -83, -72, -75, -76, -62,  20, -70,   5;
/M: SY='K';  M= -62, -77, -55,  30, -74, -73,  14, -73,  67, -54, -64, -53, -10,  24,  32, -54,  41, -39, -77, -11;
/M: SY='I';  M= -19, -73, -83, -79,  30, -83, -77,  68, -51,  22,  22, -75, -78, -74, -77, -20, -30,  38, -72, -53;
/M: SY='S';  M= -36, -71, -39, -62, -53,  49, -65, -76, -23, -78, -71, -17,  -3, -22, -41,  67,  39, -70,  26, -69;
/I:         I=-10; MD=-26;
/M: SY='T';  M=  21, -72,  36, -45, -52,  10, -63, -68,  13, -73, -67,  21, -69, -20,   1,  14,  38,  -2, -83, -31; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P';  M= -42,   6, -17, -39, -43,  12,  28, -79,  16, -78,   0,  30,  43, -11,  12,   4,   7, -77,  24, -38; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P';  M= -51, -84,  -1, -11, -83,  23,  28, -40,  -7, -44, -71,  -1,  75, -63, -30,  14, -42, -34, -87, -76; D=-10;
/I:         I=-10; MD=-26;
/M: SY='G';  M= -15, -83, -26,  -5, -33,  48, -54, -88, -23, -87, -54,   5, -14,   0, -26,  31,  -7, -82, -88, -79; D=-10;
/I:         I=-10; MD=-26;
/M: SY='E';  M= -41, -89, -28,  23, -89, -72,  -5, -36, -19, -35, -42,  23, -50, -15, -59,  13,  16, -24,-102, -84; D=-10;
/I:         I=-10; MD=-26;
/M: SY='H';  M= -40, -97,  19, -46, -54, -45,  60, -45, -40, -37, -82,  12,  15, -75, -13, -14, -42, -61,-106, -53; D=-10;
/I:         I=-10; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='P';  M=  14, -90, -72,  25, -88, -11, -78, -63, -13, -26, -77, -75,  43, -67,  14, -27, -21, -47, -91, -57; D=-10;
/I:         I=-10; DM=-26;
/M: SY='N';  M=   3, -45, -15, -11, -81,  34,  10, -69, -26, -35, -29,  43,  20, -47,  -3,  24, -40, -69, -87, -75; D=-10;
/I:         I=-10; DM=-26;
/M: SY='K';  M= -64, -79, -54,  37, -76, -73,  -6, -49,  72, -32, -64,  -7, -67, -29,  60, -24, -41, -40, -78, -66;
/M: SY='P';  M= -51, -85, -62, -23, -78, -70, -63, -74,  51, -34, -67,  -5,  98, -55,  20, -36, -60, -76, -77, -22;
/M: SY='A';  M=  42, -71, -58,  37, -69, -37, -63, -13,  10, -65, -18, -30, -40, -23,   2,   9,  20,   8, -76,   8;
/M: SY='I';  M= -62, -73, -85, -81,  32, -34, -81,  69, -78,   5, -22, -77, -79, -40, -79, -71, -59,  60, -73, -34;
/M: SY='W';  M= -68, -78, -82, -71,  52, -81,  13,   3,  22,  21,   2, -74, -79, -67,  -7, -72, -66,  23, 110, -42;
/M: SY='I';  M= -66, -75, -84, -80,  24, -86, -67,  59, -76,  33,  53, -78, -80, -72, -75, -73, -49,  20, -61,  57;
/M: SY='D';  M= -58, -72,  53, -15, -68, -60,   2,  24, -39, -31, -58, -16, -69,   7, -66,  28,  45,  27, -88, -65;
/M: SY='C';  M=  61,  71, -68, -68, -78,  54, -72, -75, -67, -58, -68, -58, -71, -65, -73,  14, -19, -64, -80, -75;
/M: SY='G';  M= -38, -76, -59, -66, -79,  74, -27, -82, -54, -42, -70,  46, -72, -30,  46,  -8, -21, -78, -79, -72;
/M: SY='M';  M= -37, -72, -78, -73,  32, -79, -13,  56, -70, -18,  60, -55, -75,  14, -72,   6, -12,  41, -73, -52;
/M: SY='H';  M= -71, -82, -55, -55, -67, -73, 146, -87, -60, -69, -55, -44, -72, -49, -54, -60, -69, -86,-101,  -8;
/M: SY='A';  M=  61, -27, -29, -64, -81,  53, -71, -76, -66, -78, -69, -60,  59, -64, -73,  -6, -58, -68, -78, -77;
/M: SY='R';  M= -63, -79,  15, -13, -77,  34, -55, -83, -40, -80, -70,  54, -73, -49,  81, -42, -29, -79,   2, -23;
/M: SY='E';  M= -36, -82, -33, 109, -84, -77, -55, -85, -43, -77, -74, -58, -57, -36, -53, -57, -29, -77, -82, -75;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='W';  M= -19, -81, -76, -69, -56, -70,  23, -65, -67, -69, -67, -35,  25, -66, -72,   5,  48,  -2, 142, -45;
/M: SY='I';  M=  11, -73, -74, -74, -57, -75, -73,  67, -71,  10,  24,  24,  12, -69, -75, -23, -56,  30, -79, -62;
/M: SY='S';  M=  27, -68, -62, -65, -77,  56, -67, -75, -63, -77, -70, -51, -66, -59, -69,  62,  41, -67, -80, -72;
/M: SY='P';  M= -49, -76,  -7,  -5, -74, -70,  -3, -25, -32, -54, -62, -58,  57,  14,  41,  33,  29,  18, -83, -68;
/M: SY='W';  M=  39, -77, -60,  47,  -4, -42, -11, -71, -58, -69,  -1, -64,   5,  18, -63,  23, -60, -45, 103, -28;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='T';  M= -23, -69, -73, -43,  42,  -4, -71,   3, -70,  21,  34, -65, -73, -69, -73,   3,  49,  23,  -9, -53;
/M: SY='C';  M=   7,  70, -81, -76, -12, -21, -72, -12, -74,  40,  69, -73, -79, -71, -75, -65, -15,  31, -79, -60;
/M: SY='L';  M= -44,  -6, -63,   8, -59, -75,  -5,   8,   2,  45, -15,  18, -73,  44, -60, -13,  13, -12, -78, -40;
/M: SY='W';  M= -21,   8, -71, -71, -21,  36,  32, -54, -41, -30, -62, -10, -77, -28,  -5, -35, -31, -62, 108,  75;
/M: SY='F';  M=   5, -71, -82, -77,  72, -79, -72,  26, -75,  41,  -2, -75, -79, -75, -76, -56,  12,  -2,   1, -43;
/M: SY='A';  M=  46, -69, -79, -73, -31, -47, -74,  37, -72,  43,  15, -73, -76, -69, -55, -33, -43,  24, -76, -61;
/M: SY='W';  M= -40, -80,  24,  35, -45, -15,   4, -79,  20, -75, -67,  37, -69,  35,  37, -14, -60, -77,  38,  35;
/I:         I=-16; MD=-41;
/M: SY='F';  M= -64, -78, -11,  32,  50, -33,   5, -54,  12, -43, -62, -23, -72,  48,  -8,  16, -22, -69, -14,  43; D=-16;
/I:         I=-16; MD=-41;
/M: SY='L';  M= -15, -37, -87, -81,  10, -86, -73,  36, -80,  68,  -6, -83, -84, -75, -79, -76, -65, -13, -71,   4; D=-16;
/I:         I=-16; MD=-41;
/M: SY='C';  M= -13,  69, -81, -76, -45, -59, -78,  23, -75,  28,   3, -73, -33, -18, -72, -65,  29,  36, -85, -66; D=-16;
/I:         I=-16; MD=-41;
/M: SY='S';  M= -11, -33,  -2,  18, -77,  -6, -16, -51, -17, -25,  -9,   1, -16,  33,   4,  37,  26, -69, -84, -43; D=-16;
/I:         I=-16; MD=-41;
/M: SY='N';  M= -37, -48,   5,  19, -40,   3,   4, -87, -25, -87, -79,  53, -20,  -5, -11,  17,  -4, -83,   6, -46; D=-16;
/I:         I=-16; MD=-41;
/M: SY='Y';  M= -72,-102, -65, -96,  24, -56,  -2, -78, -90, -36, -72, -93,-105, -87, -87, -89, -88, -83, -21,  97; D=-16;
/I:         I=-16; MD=-41;
/M: SY='G';  M= -39, -26, -25, -46,-100,  44, -85, -72,   5, -42, -89,  -7, -92,  -5, -13, -61, -49, -95,-100, -93; D=-16;
/I:         I=-16; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='K';  M= -74, -91,  17, -22, -46,   4, -71, -64,  42, -56, -79,  -8, -81,  27,   8, -16,  -9, -86, -89, -25; D=-16;
/I:         I=-16; DM=-41;
/M: SY='D';  M= -65, -32,  72,   1, -86, -31, -18, -44, -41, -85, -79,  55, -74, -11, -66,  35, -41, -53, -98, -76; D=-16;
/I:         I=-16; DM=-41;
/M: SY='P';  M=  -7, -82, -31,  -8, -44, -40, -39, -22,  11, -56, -69, -30,  75, -12, -14,  22,   6, -34, -84, -75; D=-16;
/I:         I=-16; DM=-41;
/M: SY='R';  M=  14, -78,   6,   8, -74, -72,  26, -28, -31, -54, -36, -44, -36,  -4,  47,  12,  17,  -4,  23, -33; D=-16;
/I:         I=-16; DM=-41;
/M: SY='I';  M=  35, -74, -42, -25, -18, -53, -39,  51, -73, -19,  47, -45, -38, -70, -76, -33, -44,  29, -78, -15; D=-16;
/I:         I=-16; DM=-41;
/M: SY='T';  M= -11, -38, -49, -58, -74, -20, -11, -36,   4, -42, -62,  -8, -70,  46,  22, -24,  68,  -2, -84, -40; D=-16;
/I:         I=-16; DM=-41;
/M: SY='K';  M=   1, -77,   9,  25, -76, -69, -12, -49,  37, -19,  -6,  21, -35,  18,  32,   4,  -9, -47, -83, -68; D=-16;
/I:         I=-16; DM=-41;
/M: SY='L';  M= -53, -73, -87, -80,   4, -55, -72,  15, -80,  78,  -1, -84, -86, -74, -78, -78, -66, -23, -71, -17; D=-16;
/I:         I=-16; DM=-41;
/M: SY='L';  M= -21, -74, -82, -74,   9, -84, -70,   7, -64,  55, -42, -77, -83, -68,  39, -72, -37,  27, -73,  -4; D=-16;
/I:         I=-16; DM=-41;
/M: SY='E';  M= -64, -79,  56,  60, -83, -67,  10, -83,   8, -81, -73,  55, -66,  23,  13, -16, -47, -80, -88, -70;
/M: SY='N';  M= -42, -13,  21,  -2, -75, -40,  18, -50,  36, -33, -17,  49, -69,   8,  24,  24,  12, -52, -84, -44;
/M: SY='F';  M= -23, -71, -76, -73,  62, -78, -65, -34, -67,  18,  46, -68, -77, -69,  -2, -33,  46,   5,   5,  35;
/M: SY='D';  M= -64, -29,  78,  -2, -75, -70, -30,   3, -29, -70, -67,  25, -71, -54,  41, -17,   0,   5, -90, -32;
/M: SY='W';  M= -72, -78, -88, -83,  79, -86,   4,  60, -79,  10, -25, -79, -82, -79, -78, -76, -67, -25,  85, -17;
/M: SY='Y';  M= -66, -79, -34, -65,  14, -76,  72,   5,  28, -26, -53, -62, -76, -60, -58,  -2, -62,  15,  40,  78;
/M: SY='I';  M= -65, -74, -87, -82,  23, -89, -80,  69, -80,  42, -26, -81, -81, -77, -80, -75, -60,  44, -73, -53;
/M: SY='M';  M= -44, -72, -81, -15,  -1, -85, -74,  42, -75,  45,  58, -78, -79, -71, -75, -72, -45,  48, -76, -56;
/M: SY='P';  M= -68, -92, -70, -59, -34, -72, -72, -23, -66, -33, -67, -76, 121, -69, -77, -66, -61, -74, -79, -49;
/M: SY='M';  M= -56,  19, -45, -67, -62, -70, -21, -17, -64, -16,  72,  18, -73, -20, -24,  39,  26,  45, -85, -63;
/M: SY='M';  M=  -9, -70, -81, -76,  -4, -80, -69,  11, -73,  47,  74, -75, -78, -70, -74, -67,  16,  34, -74,  -8;
/M: SY='N';  M= -63, -69, -37, -59, -79, -52, -45, -78, -50, -85, -72, 122, -75, -52, -58, -11, -48, -80, -98, -74;
/M: SY='P';  M= -67, -90, -71, -59, -81, -72, -73,  -2, -34, -75, -37, -75, 118, -69, -76, -66, -60,  -6, -81, -80;
/M: SY='D';  M= -69, -82, 114, -35, -34, -67, -56, -85, -57, -84, -83, -25, -69, -57, -66, -57, -12, -82,   6, -69;
/M: SY='G';  M= -33, -78, -66, -76, -85, 100, -72, -92, -71, -87, -76, -52, -70, -22, -78, -51, -70, -85, -76, -79;
/M: SY='Y';  M= -48, -19, -74, -75,  49, -34, -54, -47, -69, -38, -52,  -9, -83, -69, -31, -19, -61,  39, -46,  98;
/M: SY='E';  M=  12, -28,  -9,  52,   0, -75, -24,  34, -29, -55, -55, -35, -70,  -6, -65, -19, -41,  42, -78, -28;
/M: SY='Y';  M= -36, -77, -70, -41,  34, -78,  21, -20,  -4,   6, -51,  -2, -80, -62,  19, -66, -26,   5,   7,  87;
/I:         I=-13; MD=-33;
/M: SY='T';  M=  17, -71,  -9, -67, -77,  50, -72, -40, -66, -74, -69, -54, -69, -65, -52,  22,  64, -20, -85, -73; D=-13;
/I:         I=-13; MD=-33;
/M: SY='W';  M= -11, -82, -66, -65,   8, -71,  69,  -5, -37, -32, -62,  47, -77,  29, -26, -47, -22, -70, 111,  -8; D=-13;
/I:         I=-13; MD=-33;
/M: SY='T';  M= -19, -83, -28,  37, -85, -45,  26, -81, -14, -23, -75,  -6, -76, -19, -70,  17,  43, -76, -96, -77; D=-13;
/I:         I=-13; MD=-33;
/M: SY='T';  M= -65, -91, -49, -30, -94,   5, -10, -88,   4, -89,   6,   5, -43,   4, -35,   8,  31, -44,-101, -86; D=-13;
/I:         I=-13; MD=-33;
/M: SY='D';  M= -81, -96,  63, -35,-103,  12, -74,-102, -75, -93, -96,  51, -12, -57, -84, -39, -75,-101,-112, -93; D=-13;
/I:         I=-13; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='R';  M= -38, -97, -35, -72, -41, -45, -74, -92, -12, -52, -81, -39, -65, -65,  77, -21, -34, -55, -93, -43; D=-13;
/I:         I=-13; DM=-33;
/M: SY='M';  M= -78, -87, -93, -36,   9, -51, -82, -19, -87,  33,  63, -66, -41, -82, -87,  -8, -42,  -8, -87, -36; D=-13;
/I:         I=-13; DM=-33;
/M: SY='W';  M= -79,-103, -96, -88, -56,  32, -88, -86, -81, -83, -81, -87, -88, -18, -84, -81, -90, -94, 144,  42; D=-13;
/I:         I=-13; DM=-33;
/M: SY='R';  M= -68, -84, -64, -53, -77, -78, -12, -83,  -7, -56, -65, -22, -77, -32, 111, -44, -66, -77, -78, -64;
/M: SY='K';  M=  -4,  61, -43, -29,  -9, -51, -64, -74,  73, -73, -67,   2, -70, -18, -45, -11,  17, -70,  54,   1;
/M: SY='N';  M= -58, -22, -10, -59, -75, -56, -52, -72, -54, -44, -68, 100, -70, -55, -62,  29,  50, -70, -94, -71;
/M: SY='R';  M=  32, -76, -66, -22, -68, -70, -10, -11, -18,   3, -58, -47, -30, -51,  80,  -4, -29, -61, -76, -13;
/M: SY='Q';  M=   4, -27, -33, -22, -43, -61,  -6, -70, -29, -52,  -5,  44, -69,  66,   4,  52,  -2, -34, -81, -33;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='G';  M=  -9, -76, -62, -72, -83,  95, -68, -88, -67, -85, -74,  23, -69, -15, -74, -41, -65, -82, -76, -77;
/M: SY='V';  M=   1, -71, -30,   5,  24, -76, -29,  29, -34, -20, -51, -65, -72, -32,  12, -51,  39,  47, -75, -18;
/M: SY='D';  M= -68, -80, 112, -15, -87, -64, -53, -86, -54, -85, -82,  38, -68, -54, -52, -55, -57, -83,-103, -72;
/M: SY='L';  M= -37, -17, -81, -72, -49, -44, -70, -10, -75,  77, -36, -80,  55, -71, -76, -63, -63, -46, -74, -60;
/I:         I=-10; MD=-26;
/M: SY='N';  M= -65, -71,  39, -54, -43, -54, -46, -79, -51, -85, -73, 116, -74, -52, -59, -48, -50, -80, -97, -72; D=-10;
/I:         I=-10; MD=-26;
/M: SY='R';  M= -51, -84, -12, -33, -78, -77,   6, -84, -17, -77, -66, -31, -76, -43, 109, -61, -30, -77, -79, -64; D=-10;
/I:         I=-10; MD=-26;
/M: SY='N';  M= -14, -72,  27, -12, -28, -16,   2, -76, -52, -78, -13,  92, -71,  39, -59,   9, -14, -75, -88, -68; D=-10;
/I:         I=-10; MD=-26;
/M: SY='W';  M= -79, -86, -93, -85,  89, -82, -78, -63, -78, -57, -63, -29, -87, -82, -79, -80, -78, -70, 134,  32; D=-10;
/I:         I=-10; MD=-26;
/M: SY='P';  M=  -3, -83,  33, -48, -42,  15, -67, -76, -13, -45, -17,   1,  68,  -6, -23, -37,   6, -54, -83, -15; D=-10;
/I:         I=-10; MD=-26;
/M: SY='D';  M=  23, -79,  44, -35,  41, -74, -67, -43, -72, -23, -29, -64, -80, -70, -75,  10,   0, -37, -71,  42; D=-10;
/I:         I=-10; MD=-26;
/M: SY='Q';  M= -46, -92, -69,  30, -86,   5,  23, -81,  10,   3, -72, -21, -83,  38, -68, -20, -75, -41, -93, -79; D=-10;
/I:         I=-10; MD=-26;
/M: SY='W';  M= -97,-111, -34, -96,  15, -94, -10, -95, -91, -92, -93,  18,-102, -92, -95, -94, -44,-103, 133, -57; D=-10;
/I:         I=-10; MD=-26;
/M: SY='W';  M= -42,  36,  18, -26, -98,  16, -91,-101, -86,-101, -54,  -1, -96, -85, -47, -16, -24, -58,  53, -91; D=-10;
/I:         I=-10; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='G';  M= -82,  16, -48,   8,-101,  30, -92, -62, -18, -84, -30, -42, -94, -82, -50,  -8, -25, -98,  29, -95; D=-10;
/I:         I=-10; DM=-26;
/M: SY='N';  M= -30, -99, -39,   0, -94, -24, -87,  -9, -32, -88, -84,   9,  -4, -22, -29, -19, -30,  -1,-104, -40; D=-10;
/I:         I=-10; DM=-26;
/M: SY='G';  M= -34,-100, -54, -89,-102,  56, -88, -71, -58,-104, -94, -12,   3, -46,  -8, -19, -85, -89, -99, -58; D=-10;
/I:         I=-10; DM=-26;
/M: SY='A';  M=  31, -88, -81, -84, -46, -37, -19, -66, -51, -91, -53,  19, -90, -80, -87,  17,  22, -52,-104, -89; D=-10;
/I:         I=-10; DM=-26;
/M: SY='S';  M= -40, -93, -80, -80, -98, -31,  21, -99, -75, -99, -90,  -8, -12, -44,   9,  55, -10, -92,-106, -88; D=-10;
/I:         I=-10; DM=-26;
/M: SY='S';  M= -45, -94, -11, -47, -93, -47, -19, -61, -50, -53, -51,   6,  -1, -36, -19,  35,  10, -77,-103, -24; D=-10;
/I:         I=-10; DM=-26;
/M: SY='N';  M= -56, -93,   2, -35, -54, -52,  -8, -57, -66, -30, -86,  62, -94, -43, -63,  15, -44, -53,-110, -88; D=-10;
/I:         I=-10; DM=-26;
/M: SY='P';  M= -25, -11, -60, -54,-105, -56,   5, -97, -54,-102, -91, -89,  85, -62, -25, -38, -82, -67,-104, -98; D=-10;
/I:         I=-10; DM=-26;
/M: SY='C';  M= -83, 110, -24, -74, -93, -61, -11, -20, -94, -67, -87, -38,-106, -33, -99, -20, -82, -53,-118, -96; D=-10;
/I:         I=-10; DM=-26;
/M: SY='S';  M= -42, -91, -16, -80, -33, -80, -84, -85, -83, -36, -41, -61,  22, -78, -88,  62, -52, -34,-100, -38; D=-10;
/I:         I=-10; DM=-26;
/M: SY='E';  M= -81, -98,  33,  60, -48, -90, -31, -48, -21, -65, -87,  -8, -38, -41, -12, -49, -50, -57,-100, -52; D=-10;
/I:         I=-10; DM=-26;
/M: SY='T';  M= -52, -86, -14, -38, -81, -37, -81, -22, -44, -42, -76,   0, -29, -77, -47,   4,  57, -14,  -7, -15; D=-10;
/I:         I=-10; DM=-26;
/M: SY='Y';  M= -71, -92, -82, -83,  32, -66,   0, -48, -27, -41, -64, -25, -42, -26, -75, -63, -56, -74, -50, 101; D=-10;
/I:         I=-10; DM=-26;
/M: SY='C';  M=  11,  49,  -7, -34, -43,  -7,  43, -78, -68, -21, -72, -32, -19, -39,  19,  -9, -11, -30, -93, -49; D=-10;
/I:         I=-10; DM=-26;
/M: SY='G';  M= -64, -87, -25, -37, -86,  72, -73, -93, -10, -54, -80,  12, -40,  -3, -39, -21, -73, -89, -19, -15; D=-10;
/I:         I=-10; DM=-26;
/M: SY='P';  M= -12, -83,  26,   8, -53, -70,  -1, -29, -17, -41,   7, -21,  79, -32, -12,   4, -12, -60,  33, -42; D=-10;
/I:         I=-10; DM=-26;
/M: SY='S';  M=  11, -71,  10,  16, -19, -18, -25, -25,   6, -14, -62,  41, -68, -10, -59,  42,   6, -46,  11,   2;
/M: SY='P';  M=  48, -75, -26,  -8, -54, -12, -67, -66,   0, -43, -64, -23,  81, -34, -14, -26, -36, -11, -79, -73;
/M: SY='F';  M= -34, -75,  12,  45,  59, -21, -22, -33, -17,  -5, -39,  19, -36,   2, -62, -10,  -3, -30,  22, -25;
/M: SY='S';  M=  -3, -70, -16,  14, -59, -29, -62, -42, -46,   7, -59, -55, -38,   2,  18,  66,   8,   1, -81, -65;
/M: SY='E';  M=  19, -12, -50,  65, -12,  10,  58, -73, -52, -43, -64, -56, -65,  32, -21,  11, -59, -30, -78, -37;
/M: SY='P';  M= -37, -81, -67, -58, -76, -70, -70, -23,  -5, -57, -27, -40, 103,   3, -54, -17,  16,  15, -13, -74;
/M: SY='E';  M= -42,  -1, -36, 101, -82, -73, -56, -82, -45, -76, -72, -56, -58,  -4, -54,   4,   9, -74, -82, -73;
/M: SY='T';  M=  21, -66, -69, -68, -63, -46, -74,  26, -66, -30, -33, -60, -68, -66, -71,   9,  73,  45, -84, -65;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='K';  M=  -5, -79, -11, -40, -64, -72,   7, -10,  64, -21, -26, -57, -71,   9,  48, -31, -61, -32,  60,  22;
/M: SY='A';  M=  67, -68,   4, -40, -39,  -6, -24, -39, -61, -27, -60, -44, -70,   9, -18,  20, -38,  -1, -74,  10;
/M: SY='V';  M=  -7, -70, -81, -76,   5, -80, -44,  42, -73,  34,  35, -46, -77, -72, -47, -46,  -5,  55, -12, -55;
/M: SY='M';  M=  31, -17, -70, -62, -38, -56, -18,  26,  26,  -2,  44, -63, -72, -29,  33, -15, -11,   6, -75, -13;
/M: SY='D';  M= -10, -76,  62,  20, -81, -46, -11, -78,  11, -59, -69,  44, -67,  55, -26,  24, -26, -75, -85, -47;
/M: SY='W';  M= -35, -79, -82, -48,  68, -77,  26, -28, -44,  15,  19, -20, -43, -50, -56, -72, -69, -33, 122,  27;
/M: SY='I';  M=  13, -72, -82, -77, -14, -80, -75,  68, -74,  33,  55, -75, -41, -71, -76, -67, -19,  19, -75, -57;
/M: SY='R';  M=  -9, -33, -13,   6, -32, -57,  42, -28,  37,  -6,   0,  -6, -70,  20,  54, -42,   5, -40, -78, -35;
/M: SY='S';  M=  -5, -73, -10,  17, -71, -21, -56, -72,  20, -17, -64,  41, -68,  -4,  37,  45,  -4, -68, -78,  -2;
/I:         I=-4; MD=-9;
/M: SY='H';  M= -82, -93, -78,  -9, -75, -92,  70, -23, -40,  19, -22,  -5, -55,   2, -25, -38, -43, -32, -96, -12; D=-4;
/I:         I=-4; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='N';  M= -38, -97, -50,  -2, -94, -19, -80, -39,  26, -21, -81,  32, -91,  -7, -14, -77, -45, -40,-102, -89; D=-4;
/I:         I=-4; DM=-9;
/M: SY='N';  M=   9, -32, -26, -14, -11,  10, -12,  15,   0, -41, -59,  29, -70,  17,  22,  12,   9,  -6, -76, -14;
/M: SY='P';  M= -59, -26,   0,  13, -79,  21,  33, -79,  19, -62, -68,  30,  39,  29,  17,  21,  -9, -67, -82, -68;
/M: SY='F';  M= -67,  26, -81, -45,  75, -83, -74,  52, -72, -24,  -4, -75,  35, -76, -15, -70, -41,  27, -63, -44;
/M: SY='V';  M=  11, -72,  33, -35, -44, -58,  -1, -10,  46,  -8, -16, -58, -71, -28, -11, -30, -28,  47, -80, -36;
/M: SY='L';  M=  35,  19, -76, -72,  15,  16, -70, -13, -70,  40,  32, -69, -76, -68, -43, -25, -18,  -3,  27, -13;
/M: SY='Y';  M= -25, -74, -73, -72,  66, -34,  26, -14, -69, -18,  -1, -66, -78, -66, -68,  31, -59,  -1, -49,  84;
/M: SY='C';  M=  17,  51, -81, -76, -24, -35, -75,  48, -75,  46, -10, -74, -78, -72, -77, -66, -22,  25, -76, -34;
/M: SY='D';  M=  -9, -72,  86, -44, -80, -60, -57, -66, -56, -78, -73,  42, -66, -55, -64,  33,  46, -70, -94, -70;
/M: SY='F';  M= -68,  16, -84, -36,  57, -84, -70,  33, -76,  54,  49, -79, -81, -73, -75, -75, -64, -16,  41,  -8;
/M: SY='H';  M= -70, -82,  -3, -53, -70, -40, 144, -87, -59, -70, -56, -23, -71, -24, -54, -59, -68, -86,-103, -40;
/M: SY='S';  M=   4, -70, -32,  19, -78,  58, -65, -76, -60, -78, -71, -50, -65, -55, -67,  67,   8, -37, -80, -72;
/M: SY='Y';  M= -66, -81,  18, -64,  17,  35,  69, -69, -65, -64, -59, -58, -13, -11, -65, -60, -34, -71,   8,  95;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='S';  M=   7, -74, -11,   5, -80,   9, -31, -81, -19, -82, -75,   2,  -1, -45, -66,  73, -31, -74, -17, -36; D=-5;
/I:         I=-5; DM=-13;
/M: SY='Q';  M= -64, -82, -42,  -2, -77,  -6,  -3, -68, -20,   2, -11,  33, -75,  87, -19, -14, -63, -15, -82, -38; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -63,  -4, -33, -31, -58, -82, -25,  -4, -50,  27,  53, -71, -79,  33,  -1, -23, -45,  49, -79,  -3; D=-5;
/I:         I=-5; DM=-13;
/M: SY='I';  M=  20, -74, -84, -79,  48, -33, -77,  48, -77,  22,   2, -40, -80, -76, -79, -68, -47,  23,   3, -52; D=-5;
/I:         I=-5; DM=-13;
/M: SY='M';  M= -34,  28, -75, -74, -16, -50, -66,  -3, -71,  49,  65,  23, -80, -54, -50,   7, -20, -22, -77,  -9; D=-5;
/I:         I=-5; DM=-13;
/M: SY='Y';  M= -31, -82, -75, -77,  38, -37, -50, -52, -69, -58, -56, -16, -84, -68, -44, -40, -18, -23,  59, 110; D=-5;
/I:         I=-5; DM=-13;
/M: SY='P';  M= -65, -90, -38, -27, -86,  36, -72, -78, -37, -83,  14, -69, 108, -68, -76, -64, -64, -81, -82, -83; D=-5;
/I:         I=-5; DM=-13;
/M: SY='Y';  M= -53,  55, -73, -40,  40, -78, -51, -63, -13, -59, -58, -14, -83, -67, -66, -66,  -6, -65,  54, 106; D=-5;
/I:         I=-5; DM=-13;
/M: SY='D';  M= -34, -77,  57,   4, -79,  54, -43, -83, -18, -82, -76,  -9, -69, -57, -56,  42, -49, -57, -82,   0; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='Y';  M= -56, -83, -66, -72, -10,  -2,  66, -70, -46, -66,  -3,  41, -82, -62, -57, -65, -68, -74,  36,  99; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='S';  M= -32, -73,   2, -22, -82, -67, -71, -77, -59, -81, -76, -54, -71, -62, -72,  68,  68, -69, -95, -76; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='C';  M= -74,  82, -62,  51, -33, -49, -66, -86,   6, -81, -77,  17, -82, -62, -16, -70, -71, -82, -79,  46; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='S';  M= -11, -71, -44, -62, -73, -61, -39, -69,  12,   8, -64,  48, -72, -30, -61,  70,  -2, -67, -86, -70; D=-5;
/I:         I=-5; MI=0; MD=-13; IM=0; DM=-13;
/M: SY='P';  M=  13, -77,  25, -56, -26, -70,   7, -38,   5,  26, -39, -63,  67, -25,  15, -30, -47, -26, -76,  -7;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='P';  M=  -1,  33, -40,  -2, -34, -58, -68, -11, -27, -49, -36,  -1,  68, -38, -42,  21,  27,   2,  -8, -34; D=-26;
/I:         I=-26; DM=-67;
/M: SY='P';  M= -26, -82, -11,  24, -74, -46, -66, -17,  -7,   5, -47, -34,  87,  -6, -45,   5, -59, -28, -80, -49; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -36, -76,  71,   8, -82, -63,  12, -79, -52, -80, -72,  66, -24,  26, -10,  -2,  22, -76, -93, -69; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -13, -78,  62,  18,  -9, -53,  44, -51,  -4,   7, -61,  -2, -33,  24, -25, -18, -41, -47,   5,  -5; D=-26;
/I:         I=-26; DM=-67;
/M: SY='E';  M=  25, -75,  24,  57, -77, -19, -21, -69,   1, -30,  -8, -25,   0,   8,   5, -20, -11, -12, -82, -69; D=-26;
/I:         I=-26; DM=-67;
/M: SY='E';  M=  -9, -22,   3,  44, -11, -27, -63,  11, -57, -11,  17,  25, -69, -31,  -8, -19,  22,  19, -81, -64; D=-26;
/I:         I=-26; DM=-67;
/M: SY='F';  M= -68, -24, -76, -70,  66, -24,  28, -16, -66,  48, -23, -24, -81,  26,   6, -69, -65, -18, -62,   4;
/M: SY='Q';  M= -26, -78,  18,  37, -60, -34,  20, -48,  20, -32,   2,  13,   2,  51,  32,   7, -41, -71, -79, -39;
/M: SY='W';  M= -13, -76,   0,  48, -10, -72,  10, -40,  -5,  16, -32, -29, -69,  27, -39,  -4,  12, -41,  54,  29;
/M: SY='L';  M= -47, -71, -82, -76,  38, -83,  -9,   3, -74,  61,  30, -77, -81, -71, -45, -31, -44,  25, -65,  24;
/M: SY='A';  M=  65, -70, -64,  -6, -32,  17, -67, -28, -47, -30, -37, -25,  37, -59,  -8,  15, -55, -52, -76, -46;
/M: SY='K';  M= -46, -27,  -9,  16, -45, -57,  19,   4,  54, -22,   2, -15, -69,  22,  29,   8, -30, -19, -75,  -2;
/M: SY='A';  M=  32, -72, -39, -27, -29,  22, -68,   9,  19,  10, -55, -25, -70,   8, -35,   9,  -7,  -7,  31, -63;
/M: SY='Y';  M=  34, -71, -72, -70,  32, -43, -59,   1, -37,  22,  27,  -1, -76, -64, -68,  -4, -15, -22, -58,  65;
/M: SY='A';  M=  66,   3, -11,  -5, -73,  -7, -69, -29, -30, -65, -61, -41, -46, -59, -67,  31, -12,  22, -81, -70;
/I:         I=-9; MD=-22;
/M: SY='K';  M= -12, -78,  35, -24, -28, -23, -10, -63,  57, -46, -14,  17, -13,  31,  -6,  10, -37, -55, -79, -28; D=-9;
/I:         I=-9; MD=-22;
/M: SY='A';  M=  54, -71,   3,  10, -19, -19, -40, -47, -36, -30, -41,  24, -71, -23,  -6,  -8,  -5,  -2, -80, -27; D=-9;
/I:         I=-9; MD=-22;
/M: SY='H';  M= -18, -12, -69, -45,  -2, -76,  60,  36, -26,  32,  10,  26, -77,  -6, -41, -22, -21, -15, -80, -56; D=-9;
/I:         I=-9; MD=-22;
/M: SY='P';  M=   6, -80,  -5,   2,   4,  -8,   3, -50,  10, -49, -67,   9,  53, -22,  40, -19,  -8, -72, -78, -40; D=-9;
/I:         I=-9; MD=-22;
/M: SY='S';  M=  12, -76,   2, -43, -71, -68,   4,  -8,   9,  -1,  13, -13, -60,  23,  -5,  38,   2, -40,  23, -50; D=-9;
/I:         I=-9; MD=-22;
/M: SY='M';  M= -24, -78, -27, -76,  43, -83, -72, -12, -33,   0,  69, -44, -83, -72,   9, -28,  10,  12, -76, -30; D=-9;
/I:         I=-9; MD=-22;
/M: SY='H';  M= -39, -85, -12, -47, -40, -75,  68, -34, -22, -76, -28,   3, -32,  22,  -1,  26,   7, -77, -80,  43; D=-9;
/I:         I=-9; MD=-22;
/M: SY='G';  M= -74, -93,   1,  -7, -32,  41,   8, -89,  -9, -21, -30, -50, -85,   1,   2, -50, -13, -87, -12, -79; D=-9;
/I:         I=-9; MD=-22;
/M: SY='T';  M= -28, -91, -75,   5, -94,   6, -83, -46, -45, -72, -84,   2,  -6, -27, -16, -26,  46, -67,-102, -90; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='F';  M= -41, -58, -22,  -8,  23, -67, -79, -40,  17, -73, -81, -26, -37, -14,  18,  -2,  -6, -69, -90, -40; D=-9;
/I:         I=-9; DM=-22;
/M: SY='Y';  M= -38, -36, -65, -16, -10, -30,  -7, -69,   6, -65, -75, -59,  17,  -6, -35, -54, -46, -58, -69,  72; D=-9;
/I:         I=-9; DM=-22;
/M: SY='T';  M= -74,   0,   2, -24, -67,   8,  16, -26,  14, -82, -27,  15, -47, -43,  -5, -31,  19, -50, -90,  11; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -39, -86, -36, -10, -39,  42,  -4, -36, -58, -73,  31, -33, -82, -46, -62, -33,   6,  -1, -80,  37; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -46, -85, -63, -78, -44,  50, -75,  24, -33, -65, -68, -32,  19, -55, -46,   7, -27, -17, -77,  29; D=-9;
/I:         I=-9; DM=-22;
/M: SY='P';  M= -12, -76, -16, -12, -73, -45, -36,  -5, -54, -46, -25,   5,  47,   1, -57,  41,  38, -23, -83,  -1; D=-9;
/I:         I=-9; DM=-22;
/M: SY='C';  M= -18,  64, -27, -32, -74,  -3, -66,  24, -21, -61, -64,  52, -41,  12,   7,   8, -18,  -8, -88, -72; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M=  -1,  27,  13, -52,   4,  40, -69, -28, -21, -41, -69, -34,  13, -52, -49,  36,  -1, -43, -78, -11; D=-9;
/I:         I=-9; DM=-22;
/M: SY='F';  M=  27, -73,  15, -10,  34, -46, -27, -31,   3, -67, -65,   9, -26, -44, -31,  22,  16,  -7, -76,  -8; D=-9;
/I:         I=-9; DM=-22;
/M: SY='T';  M=  -7, -74,   7, -22, -45, -71,   4, -29,   7, -25, -61, -11,   5,  -5,  17,   6,  51,  11, -83, -24; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -44, -81,  32, -69, -57,  -7, -77,  39, -36,  20,  -5, -47, -38, -69, -28, -26, -66,   4, 104, -56; D=-9;
/I:         I=-9; DM=-22;
/M: SY='Y';  M= -33, -82, -39,  11, -40,  10,  33, -36, -37, -36, -22, -34, -31,  20, -62, -47, -47, -44, -48, 102; D=-9;
/I:         I=-9; DM=-22;
/M: SY='P';  M=  -1, -77,  -4,  17, -72, -52, -62, -13,   6, -16, -43,  -4,  41,  35,  -9,  30, -22,  -7, -79, -18; D=-9;
/I:         I=-9; DM=-22;
/M: SY='A';  M=  40, -23, -65, -16, -30, -42,  -8,   7, -28, -22, -59,   0, -22, -60, -33,  40,  24,  11, -82, -66; D=-9;
/I:         I=-9; DM=-22;
/M: SY='S';  M=  26, -73,  -8, -36,  -3, -17, -63, -69,  18, -17, -64,   9,  34, -29, -38,  45,  -1, -66, -76,  -2; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M=  -7, -78, -60,  18, -83,  87, -69, -47,  -9, -83, -74,  -3, -69, -62, -70, -52, -46, -79, -78, -78; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -31, -71, -16, -65, -74,  66,  13, -48, -63, -21, -66, -21, -68, -60, -32,  53,  26, -52, -80, -69;
/M: SY='M';  M=  17, -68, -22, -65,  25,  -8, -62, -24, -64, -28,  71, -56, -69, -59, -67,  59,  30, -49, -72,  -6;
/M: SY='D';  M=  14,  -4,  41, -39, -54,  16, -63,  -1, -17,  -9, -11,   5, -71,  37,   2, -11,  -8,   6, -81, -66;
/M: SY='D';  M= -66, -79,  98, -39, -81, -66, -54, -80,  -8, -37, -74,  22, -51, -52,  38, -35,   0, -77, -94, -69;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='W';  M= -50, -28, -65, -78,  56, -76, -76, -39, -72, -28,  11, -13, -81, -73, -74, -74, -48,   5, 145,  37;
/M: SY='A';  M=  45,  10, -67, -68,  34, -63, -65,   0, -65,  -7,  45,  43, -73, -63, -69,  15, -26,  10, -74, -57;
/M: SY='Y';  M= -36, -13, -74, -73, -16,  -7, -21,  -3, -18, -39,  11, -32, -80, -63, -29, -66, -65,  -2,  84, 105;
/M: SY='H';  M= -37, -77,  52, -15, -44,  16,  66, -36,   0,   4, -30,  -4, -71,   0,  30, -20, -28, -37, -84, -60;
/M: SY='Q';  M=  -1, -75,   3,   8, -27, -69,  48,  -8, -28,   8,  -3, -13, -70,  53, -15,  13,  -8, -20,  43,   2;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='G';  M= -17, -77,  -2, -46, -21,  65,  47, -48, -25, -59, -68, -22, -71, -36, -13,  -3,  20, -74,  -1,   8; D=-36;
/I:         I=-36; DM=-90;
/M: SY='I';  M=  -1, -72, -39, -65, -35,  -9,  -8,  50,  -2, -23, -51,  49, -73,  12, -38, -14, -16,  33, -81, -63;
/M: SY='C';  M= -19,  95, -33, -39, -71, -73, -30,  10,  49, -18, -60, -50,  17,  -8,  26, -15, -36, -48, -82, -69;
/M: SY='Y';  M= -69, -25, -72, -44,  57, -78,  30, -24, -41,   6,  14,  -1,  16, -66, -16, -67, -29,  -5,  35,  78;
/M: SY='S';  M=  34,  31, -55,  40, -76,  -5, -63, -70, -58, -73, -68, -53, -38, -52, -64,  73, -27, -16, -82, -71;
/M: SY='Y';  M= -26, -19, -79, -78,  73, -81, -56,  28, -73,   0, -20, -47, -83, -72, -71, -70, -64, -19, -43,  92;
/M: SY='T';  M= -12,  28, -60, -59, -69, -68, -66, -61, -58, -22, -59, -30, -63,  36, -64,  -4,  99, -54, -86, -66;
/M: SY='F';  M= -21,   2, -82, -77,  58, -81, -70,  42, -75,  31,  40, -75, -24, -73, -75, -29, -19,  17, -63,  13;
/M: SY='E';  M= -39, -81, -36, 102, -77, -42, -54, -83,  21, -76, -71, -57, -58, -37, -33, -57, -61, -76, -75,   7;
/M: SY='L';  M= -31,   7, -78, -39, -25, -79, -68,  -6, -73,  69,  49, -73, -78, -67, -73,  -4,  14,  -9, -75, -56;
/M: SY='R';  M= -59, -78, -62, -57, -71,   6, -58, -77, -43, -76, -67, -11,  50, -51,  77,  40,   8, -73, -74,  16;
/I:         I=-11; MD=-29;
/M: SY='C';  M= -39,  82,  71, -57,  35,   3, -66, -75, -69, -34, -71, -56,  19, -70, -75, -41, -33, -73, -80,   5; D=-11;
/I:         I=-11; MD=-29;
/M: SY='C';  M= -68,  66, -52, -53, -28, -13, -72, -32,  27, -46, -30,   0, -79, -42,  11, -18,  45, -35, -87, -16; D=-11;
/I:         I=-11; MD=-29;
/M: SY='G';  M= -60, -90,   0, -82, -96,  69, -83, -98, -80, -97, -44, -64, -83, -79, -55,   9,   8, -92, -94, -90; D=-11;
/I:         I=-11; MD=-29;
/M: SY='S';  M= -37,  11, -35, -55, -36, -23,   2, -24, -19, -70, -13,  24, -86, -27,   9,  26,  -4, -79, -90,  14; D=-11;
/I:         I=-11; MD=-29;
/M: SY='Y';  M= -15, -94,  -8, -42, -17, -46,   6, -52, -75, -66, -77, -16, -92, -75,   3,  -5, -18, -82, -24,  72; D=-11;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='G';  M= -69, -93,   8, -30, -58,  67, -81, -65, -40, -97, -88, -23,  24, -46, -73, -39, -46, -94, -92, -89; D=-11;
/I:         I=-11; DM=-29;
/M: SY='F';  M= -38, -82, -24, -69,  84, -83, -67, -67,  41, -61, -64, -45, -83,  -8,   3, -71, -23, -69, -59,  25; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Y';  M= -50, -80, -81, -41,  38, -30,  -8, -13,  -6,  37,   3, -47, -85, -26, -28, -55, -35,  -3, -15,  39; D=-11;
/I:         I=-11; DM=-29;
/M: SY='P';  M= -50, -16, -27, -71, -66, -13, -39, -49, -52,  48, -54, -33,  72, -35, -34, -74, -69, -47,  16, -71; D=-11;
/I:         I=-11; DM=-29;
/M: SY='P';  M= -53, -89, -45, -48, -66, -75,  33, -57, -13, -31, -70, -29,  95, -67, -22,  -6,   3, -40, -87, -44; D=-11;
/I:         I=-11; DM=-29;
/M: SY='P';  M=  27, -80,  14,  47, -84, -13,  20, -80, -11, -79, -70, -58,  49,  42,  -2, -21, -49, -75, -82, -72; D=-11;
/I:         I=-11; DM=-29;
/M: SY='E';  M= -17, -77,  -3,  50,   8, -47, -60,  -4,   1, -38, -24,  -8, -68,  18, -19,  37, -21, -65,  26,  14; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Q';  M= -46, -12, -33,  22, -39, -27,  26, -70, -16, -38, -63,  34,  -3,  69,  -7,   0,  16, -22, -77,  12; D=-11;
/I:         I=-11; DM=-29;
/M: SY='I';  M= -42, -76, -81, -48,  11, -50, -78,  78, -76,  30, -41, -74, -28, -41, -79, -21,  12, -22, -74, -57; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Q';  M= -22, -78,  10,  30, -50, -36, -64,  16,  18, -25, -23, -61,  31,  38, -14,  -4, -58,  19, -78, -17;
/M: SY='P';  M=  -9, -82,   2,   6, -78, -45, -17, -62, -17, -35, -65, -44,  79,  35,  38, -17, -13, -45, -79, -19;
/M: SY='T';  M= -22, -71, -38,  19,  19, -73, -63, -25, -58,   6, -55, -59, -69,  -8,   4,   4,  68, -16, -71,  27;
/M: SY='W';  M=   7,  62, -20,  17, -66,  32, -75, -26,  -9, -70, -23, -63, -72, -63, -68, -14,   5, -14, 108, -60;
/M: SY='E';  M= -16, -78, -35,  66, -47, -71,   6, -72,  23, -16, -64,  -9, -65,  50,   5,   8, -17, -36, -80, -66;
/M: SY='E';  M=  -8, -77,   8,  73, -73, -47, -30, -15,   2, -15,  29,  10, -66, -12,  -1, -26, -60, -22, -81, -42;
/M: SY='N';  M= -23, -71, -35, -66, -42,  34,   9,  -3, -61, -50, -11,  70, -71, -61, -52, -26,  53, -20, -81,   4;
/M: SY='W';  M= -11, -78, -44, -45,  23, -48, -38, -20,  18,  12,  37, -36, -77, -17,  42, -25, -64, -31,  82,  34;
/M: SY='E';  M=  36, -38,  30,  36, -21, -66,  15, -47,  -7,   5, -11,  31, -70, -40,  -5, -26, -58, -17, -82, -65;
/M: SY='A';  M=  57, -26, -69, -66,  11,  20, -67, -61, -34, -49,  30, -61, -24, -62, -69,  34, -20,  -1, -73,  -4;
/M: SY='C';  M=  -3,  48, -83, -77, -15, -81, -75,  26, -76,  47,  41, -77, -80, -73, -77, -45, -32,  45, -79, -59;
/M: SY='K';  M= -13, -74,  -7, -30, -43, -18, -32,  18,  39,  35,   5, -11, -74,  -6,  -1, -38, -29,   8, -78, -62;
/M: SY='T';  M=  23, -70, -61, -18, -12, -28, -24, -17,  -5, -49, -35,  26, -70,  20, -51,  16,  45,   3, -73,  33;
/M: SY='F';  M= -31, -73, -85, -80,  59, -44, -69,  40, -77,  39,  45, -78, -81, -75, -76, -73, -63,  13, -61,  30;
/M: SY='M';  M=  15, -29, -79, -74, -18,   9, -71,  21, -40,  50,  52, -72, -77, -48, -73, -65,  -9,  -2,  -1, -59;
/M: SY='E';  M=  -4, -78,  41,  54, -79, -57, -26, -62,  19, -59, -26,  18, -67,  27,  24,  -4, -46, -31,  19, -68;
/M: SY='H';  M= -10, -77, -37,   0,  43, -36,  67, -63,  12, -12,  38, -38, -73,  39, -38, -47, -19, -65,   4,  44;
/M: SY='V';  M=  12,  40, -37, -58, -56, -76, -21,   3, -40,  23, -30, -30, -78, -49, -57, -21,   1,  59, -80,   0;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 167 in 157 different sequences
Number of true positive hits 167 in 157 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Peptidase M14
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
157 sequences

AEBP1_HUMAN (Q8IUX7), AEBP1_MOUSE (Q640N1), AEBP1_RAT   (A2RUV9), 
BCN5_CLOPF  (P08696), CBP1_SABMA  (P86516), CBPA1_ANOGA (O02350), 
CBPA1_BOVIN (P00730), CBPA1_DROME (Q9VL86), CBPA1_DROPS (Q29NC4), 
CBPA1_HUMAN (P15085), CBPA1_MOUSE (Q7TPZ8), CBPA1_PIG   (P09954), 
CBPA1_RAT   (P00731), CBPA2_HUMAN (P48052), CBPA2_MOUSE (Q504N0), 
CBPA2_RAT   (P19222), CBPA3_HUMAN (P15088), CBPA3_MOUSE (P15089), 
CBPA3_RAT   (P21961), CBPA4_HUMAN (Q9UI42), CBPA4_MOUSE (Q6P8K8), 
CBPA5_HUMAN (Q8WXQ8), CBPA5_MACFA (Q4R7R2), CBPA5_MOUSE (Q8R4H4), 
CBPA6_HUMAN (Q8N4T0), CBPA6_MOUSE (Q5U901), CBPB1_AEDAE (A0A1S4F020), 
CBPB1_BOVIN (P00732), CBPB1_CANLF (P55261), CBPB1_HUMAN (P15086), 
CBPB1_PIG   (P09955), CBPB1_RAT   (P19223), CBPB2_BOVIN (Q2KIG3), 
CBPB2_HUMAN (Q96IY4), CBPB2_MOUSE (Q9JHH6), CBPB2_RAT   (Q9EQV9), 
CBPB_ASTAS  (P04069), CBPB_HELZE  (Q3T905), CBPC1_CAEEL (O76373), 
CBPC1_CHICK (E1C3P4), CBPC1_DANRE (Q4U2V3), CBPC1_HUMAN (Q9UPW5), 
CBPC1_MOUSE (Q641K1), CBPC1_XENLA (Q6DD21), CBPC1_XENTR (A9JRL3), 
CBPC2_DANRE (A6H8T7), CBPC2_HUMAN (Q5U5Z8), CBPC2_MACFA (Q4R632), 
CBPC2_MOUSE (Q8CDK2), CBPC2_XENTR (Q0P4M4), CBPC3_BOVIN (E1B9D8), 
CBPC3_HUMAN (Q8NEM8), CBPC3_MOUSE (Q8CDP0), CBPC4_HUMAN (Q96MI9), 
CBPC4_MOUSE (Q09M05), CBPC5_AILME (D2GXM8), CBPC5_BOVIN (Q58CX9), 
CBPC5_DANRE (Q68EI3), CBPC5_HUMAN (Q8NDL9), CBPC5_MOUSE (Q09M02), 
CBPC5_RAT   (B2GV17), CBPC5_XENTR (B0JZV4), CBPC6_CAEEL (Q09296), 
CBPC6_HUMAN (Q5VU57), CBPC6_MOUSE (Q09LZ8), CBPD_ANAPL  (Q90240), 
CBPD_DROME  (P42787), CBPD_HUMAN  (O75976), CBPD_LOPSP  (P83852), 
CBPD_MOUSE  (O89001), CBPD_RAT(Q9JHW1), CBPE_BOVIN  (P04836), 
CBPE_CAEEL  (O17754), CBPE_HUMAN  (P16870), CBPE_LOPAM  (P37892), 
CBPE_MACFA  (Q4R4M3), CBPE_MOUSE  (Q00493), CBPE_PANTR  (A5A6K7), 
CBPE_RAT(P15087), CBPM_HUMAN  (P14384), CBPM_MOUSE  (Q80V42), 
CBPM_PONAB  (Q5RFD6), CBPN_BOVIN  (Q2KJ83), CBPN_HUMAN  (P15169), 
CBPN_MOUSE  (Q9JJN5), CBPN_RAT(Q9EQV8), CBPO_BOVIN  (Q0II73), 
CBPO_DANRE  (B8JLQ9), CBPO_HUMAN  (Q8IVL8), CBPS_STRGR  (P18143), 
CBPS_STRMP  (P39041), CBPT_THEVU  (P29068), CBPZ1_PLAF7 (Q8I2A6), 
CBPZ_CHICK  (Q8QGP3), CBPZ_HUMAN  (Q66K79), CBPZ_MOUSE  (Q8R4V4), 
CBPZ_RAT(O54858), CBPZ_SIMVI  (P42788), CPXM1_HUMAN (Q96SM3), 
CPXM1_MOUSE (Q9Z100), CPXM2_HUMAN (Q8N436), CPXM2_MOUSE (Q9D2L5), 
ECM14_AJECG (C0NM08), ECM14_AJECH (C6H4F1), ECM14_AJECN (A6RCF5), 
ECM14_AJEDR (C5G6U8), ECM14_ARTBC (D4AKU7), ECM14_ARTGP (E4UPZ6), 
ECM14_ARTOC (C5FPR9), ECM14_ASPCL (A1CSU3), ECM14_ASPFC (B0XRS8), 
ECM14_ASPFN (B8NBP9), ECM14_ASPFU (Q4X1U0), ECM14_ASPNC (A2QZA2), 
ECM14_ASPOR (Q2TZK2), ECM14_ASPTN (Q0C9B4), ECM14_BLAGS (C5JZS0), 
ECM14_COCP7 (C5PHW9), ECM14_COCPS (E9DD69), ECM14_EMENI (Q5B011), 
ECM14_LEPMJ (E5A0U8), ECM14_NEOFI (A1DGH9), ECM14_PARBA (C1HE31), 
ECM14_PARBD (C1GDH9), ECM14_PARBP (C0SAI5), ECM14_PENRW (B6H233), 
ECM14_SCHPO (O74818), ECM14_SCLS1 (A7EUC0), ECM14_TALMQ (B6Q972), 
ECM14_TALSN (B8M2K0), ECM14_TRIVH (D4DIW7), ECM14_UNCRE (C4JEE1), 
ECM14_YEAST (P38836), ENP1_LYSSH  (Q03415), MCPAL_ARTBC (D4B5N0), 
MCPAL_ARTOC (C5FH26), MCPAL_TRIVH (D4D675), MCPA_ARTBC  (D4AS12), 
MCPA_ARTOC  (C5FVN6), MCPA_TRIEQ  (B8XGR3), MCPA_TRIRU  (A6XGK3), 
MCPA_TRITO  (B6V865), MCPA_TRIVH  (D4DL57), MCPB_ARTBC  (D4B1S6), 
MCPB_ARTOC  (C5FYJ7), MCPB_TRIEQ  (B8XGR2), MCPB_TRIRU  (A6XHF7), 
MCPB_TRITO  (B6V866), MCPB_TRIVH  (D4D4Z1), MPAA_ECO57  (P0ACV7), 
MPAA_ECOLI  (P0ACV6), MPAA_VIBC1  (A7N805), NNAD_DROME  (Q9VY99), 
SOL1_ARATH  (Q9M9H7), SURO1_CAEEL (Q9XU75), Y1242_ZYMMO (P30795), 
YQGT_BACSU  (P54497)
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PDB
[Detailed view]
136 PDB

1ARL; 1ARM; 1AYE; 1BAV; 1CBX; 1CPB; 1CPS; 1CPX; 1DTD; 1EE3; 1ELL; 1ELM; 1F57; 1H8L; 1HDQ; 1HDU; 1HEE; 1IY7; 1KWM; 1M4L; 1NSA; 1OBR; 1PCA; 1PYT; 1QMU; 1UWY; 1YME; 1Z5R; 1ZG7; 1ZG8; 1ZG9; 1ZLH; 1ZLI; 2ABZ; 2BO9; 2BOA; 2C1C; 2CTB; 2CTC; 2JEW; 2NSM; 2PCU; 2PIY; 2PIZ; 2PJ0; 2PJ1; 2PJ2; 2PJ3; 2PJ4; 2PJ5; 2PJ6; 2PJ7; 2PJ8; 2PJ9; 2PJA; 2PJB; 2PJC; 2RFH; 2V77; 3CPA; 3D4U; 3D66; 3D67; 3D68; 3DGV; 3FJU; 3FVL; 3FX6; 3GLJ; 3I1U; 3KGQ; 3LMS; 3MN8; 3OSL; 3PRT; 3QNV; 3V38; 3V7Z; 3WAB; 3WC5; 3WC6; 3WC7; 4A94; 4AXV; 4BD9; 4CPA; 4DJL; 4DUK; 4F8Z; 4GM5; 4IAV; 4IHM; 4IK2; 4P10; 4UEE; 4UEZ; 4UIA; 4UIB; 4Z65; 5CPA; 5HVF; 5HVG; 5HVH; 5HXD; 5J1Q; 5JC6; 5LRG; 5LRJ; 5LRK; 5LYD; 5LYF; 5LYI; 5LYL; 5MRV; 5OM9; 5ZEQ; 6CPA; 6F6Q; 6F75; 6F79; 6GO2; 6I6Z; 6SN6; 6T9Y; 6TNK; 6Z28; 7AQP; 7ARU; 7CPA; 7EQX; 7EQZ; 7NEE; 7NEU; 7Q87; 8CPA; 8QVO
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