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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01379


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01379
General rule information [?]

Accession PRU01379
Dates 11-AUG-2023 (Created)
29-AUG-2023 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS52035; PEPTIDASE_M14
Name Peptidase family M14 domain
Function M14 metallocarboxypeptidases are a diverse and important class of peptidases that catalyze the removal of the C-terminal residue from polypeptides by means of a coordinated Zn(2+) cofactor.
Scope(s) Eukaryota
Bacteria
Example(s) Q09M02;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTORName=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case
SIMILARITYBelongs to the peptidase M14 family.

Keywords [?]

Carboxypeptidase
Hydrolase
Metalloprotease
Protease
end case
case <FTGroup:1>
Metal-binding
Zinc
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
case <FTTag:act_site> and <FTGroup:1>
GO:0004181; Molecular function:metallocarboxypeptidase activity
GO:0006508; Biological process:proteolysis

Features [?]

From: PS52035
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M14 #"
ACT_SITE 256 256 /note="Proton donor/acceptor" act_site E
BINDING 62 62 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 1
BINDING 65 65 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 E 1
BINDING 182 182 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"
/ligand_note="catalytic"		 H 1

Additional information [?]

Size range 234-454 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]