We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS52051

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PURL: https://purl.expasy.org/prosite/signature/PS52051

Direct ScanProsite submission

General information about the entry

Entry name [info]	CXC_MSL2
Accession [info]	PS52051
Entry type [info]	MATRIX
Date [info]	05-FEB-2025 CREATED; 05-FEB-2025 DATA UPDATE; 05-FEB-2025 INFO UPDATE.
PROSITE Doc. [info]	PDOC52051
Associated ProRule [info]	PRU01396

Name and characterization of the entry

Description [info]

CXC MSL2-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=47;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.9816434; R2=0.0081472; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1046; N_SCORE=12.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=310; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-51; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -26, -83, -73, -11, -75,  -9, -75,  -4,   5,  -6, -19,   3,  34,  -5, -20, -30, -12,  24, -89, -76;
/M: SY='E';  M=  -9, -86, -62,  45, -43, -65, -69, -38,  44, -54, -10, -66,  15,   2,  17, -59,  -8, -42, -85, -76;
/M: SY='K';  M= -47, -87, -71, -60, -54, -27, -69, -39,  63, -36, -71, -64,  16, -56,  52,  -1, -67, -38, -84, -74;
/M: SY='K';  M= -48, -89, -27, -17, -88, -49,  21, -78,  66, -87, -75, -45,  33,   7,  29, -18, -62, -85, -20, -74;
/M: SY='G';  M= -64, -84, -73, -77, -80,  60, -23,  10,  -5, -29, -70,  -3, -26, -71, -15, -19,  11, -29, -87, -78;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='R';  M= -72, -89, -69, -58, -87, -42, -64, -91,  59, -86, -75, -62, -79, -50,  83,  -9, -70, -85, -84, -74;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='G';  M= -34, -86, -74, -84, -92,  91, -80, -99, -76, -95, -84, -60, -78, -75, -24, -59, -77, -92, -83, -87;
/I:         I=-36; MD=-90;
/M: SY='R';  M= -49, -88, -75, -75, -83, -34, -75,  -9, -22, -44, -16,  38, -87,  -6,  39, -31,  21,  -5, -97, -59; D=-36;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='A';  M=  55, -75, -73, -68, -55, -26, -75, -72, -32, -77, -72, -23, -76, -14, -10,  35,  11, -12,   1, -76;
/M: SY='T';  M= -51, -75, -38, -70, -15,  13, -74, -72, -19, -77, -73,   5, -73, -68, -73,  35,  71, -21, -91, -73;
/M: SY='Q';  M= -16, -24, -70, -61, -84, -14, -22, -40,  17, -41, -15, -36,  29,  59, -45,  12,  12, -17, -87, -75;
/M: SY='N';  M=  19, -21, -65, -45, -40,  -5, -68, -47, -46, -14, -10,  57, -79,   0, -44,  -2,  23, -32, -89, -43;
/M: SY='P';  M= -72, -92, -69, -63, -91, -30, -72, -80,  11, -89, -77,  30,  96,   9, -70, -50, -39, -31, -90, -86;
/M: SY='G';  M= -58, -81, -69, -72, -87,  57, -73, -85, -20, -88, -80,  -5,   5, -29, -74,  56, -16, -39, -88, -81;
/M: SY='K';  M= -46, -82, -73, -42, -75, -52,  -9, -52,  48,   0, -63, -44,   6, -31,  11,  -5,  -5,  27, -88, -72;
/I:         I=-38; MD=-97;
/M: SY='L';  M= -42, -33, -81, -78, -65, -86, -76, -58, -23,  54, -22,   4, -88, -73,   6, -15,  22, -61, -89, -71; D=-38;
/I:         I=-38; MD=-97;
/M: SY='T';  M= -72, -81, -78, -81, -87, -88, -88, -76, -77, -82, -79, -67, -79, -82, -86, -56,  94, -37,-108, -85; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='C';  M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92;
/M: SY='R';  M= -73,  70, -79, -70, -19, -69, -22, -16, -31, -26, -67, -70, -87, -23,  78, -26, -71, -14, -87, -54;
/M: SY='G';  M= -61, -82, -65, -78, -89,  77, -72, -93, -71, -93, -82,  48, -78, -71, -47, -14,  -2, -88, -88, -84;
/M: SY='Q';  M= -67, -86, -62, -54, -81, -73, -11, -81, -15, -80, -70,  34, -77,  93, -56,  13,  11, -81, -80,  23;
/M: SY='R';  M= -76, -92, -72, -60, -86, -86, -62, -92,   7, -85, -74, -65, -84, -49, 104, -70, -75, -86, -85, -72;
/M: SY='C';  M= -71, 143, -91, -91, -79, -87, -90, -85, -87, -42, -76, -77,-101, -94, -93, -74, -71, -74,-109, -90;
/M: SY='P';  M= -46, -96, -76, -66, -87, -77, -76, -64, -69, -67, -77, -78, 106, -44, -16,  -6, -22, -83,   0, -22;
/I:         I=-31; MD=-79;
/M: SY='C';  M= -72, 143, -92, -92, -82, -88, -92, -89, -88, -80, -80, -78,-103, -96, -94, -75, -72, -77,-112, -93; D=-31;
/I:         I=-31; MD=-79;
/M: SY='Y';  M= -83, -91, -84, -86,  37, -90, -51, -66, -78, -62, -61, -84, -95, -75, -75, -78, -77, -71, -40, 117; D=-31;
/I:         I=-31; MD=-79;
/M: SY='S';  M= -12, -69, -64, -58, -69, -64, -66,  -7,  55, -62,  -3, -55, -68, -54, -51,  63, -12,  40, -81, -65; D=-31;
/I:         I=-31; MD=-79;
/M: SY='N';  M=  12, -70,  27,  20, -78, -32, -53, -71, -11, -77, -69,  88, -69, -31, -58,  20, -13, -14, -89, -71; D=-31;
/I:         I=-31; MD=-79;
/M: SY='F';  M= -40, -77,  11,   4,  55,  42, -52, -74,   7, -69, -67, -11, -72,   2,  33,  13, -62, -72, -67, -18; D=-31;
/I:         I=-31; MI=-79; MD=-79; IM=-79; DM=-79;
/M: SY='N';  M= -26, -74, -51, -53, -73, -12, -55, -72,  70, -22, -64,  78, -70, -17, -20, -53, -13, -38, -80, -17; D=-31;
/I:         I=-31; DM=-79;
/M: SY='S';  M=  14, -68, -59, -23, -65, -17, -63, -68, -43, -74, -68, -52,  40, -53, -39,  87, -23, -11, -82, -69;
/M: SY='C';  M= -62, 149, -80, -78, -72, -77, -79, -79, -32, -70, -69, -67, -91, -80,  -4, -64, -62, -67, -99, -81;
/I:         I=-20; MD=-51;
/M: SY='A';  M=  44, -70, -19,  31, -48, -66,   6,  -2,  -6,  -9, -33, -12, -68, -36, -11,  -3,  22,  -4, -77,  -1; D=-20;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='D';  M= -51, -14,  86,   5, -79,  14,  30, -80, -11, -52, -41,  36, -69, -22, -24,  -9, -58, -53, -90, -26;
/M: SY='C';  M= -36, 148, -82, -82,  -8, -77, -80, -77, -78, -68, -69, -69, -92, -85, -83, -65, -63, -66, -93, -17;
/M: SY='H';  M= -21, -77, -61, -56, -68, -47,  92, -13,  41, -25, -58,   3,  19, -34,  21,   4, -59,  -3, -82, -12;
/M: SY='C';  M= -36, 148, -83, -83, -72, -79, -83, -76, -79, -42, -69, -70, -93, -86, -85, -66, -63, -34,-101, -83;
/M: SY='V';  M= -52,  15, -70, -41,   3, -79, -31, -14,  11, -18, -54,  -3, -77,  20,  50, -63, -12,  57, -80, -61;
/M: SY='G';  M= -19,   2, -62, -75, -84,  87, -69, -89, -68, -87, -77,  44, -72, -67, -76, -35, -29, -83, -81, -80;
/M: SY='C';  M= -37, 147, -82, -82, -75, -79,  -7, -81, -45, -73, -72, -69, -46, -84, -83, -66, -64, -70,-103, -83;
/M: SY='K';  M= -25, -81, -61, -51, -81,   7,  36, -83,  72, -79, -68, -15, -70,  17,  53, -58, -13, -78, -79, -66;
/M: SY='N';  M= -38, -71, -40, -60, -80, -54, -47, -78, -31, -63, -72, 119, -76, -53, -59, -48, -50, -80, -98, -75;
/M: SY='P';  M= -67, -92, -69, -38, -86, -70, -73, -77, -66, -86, -74, -73, 118, -68, -77,  -5, -19, -81,  19, -82;
/M: SY='H';  M= -41, -81, -66, -64,  29, -77, 112, -68, -61,  -2, -54, -18, -79, -45,  17, -65, -42, -40, -71,  52;
/M: SY='K';  M= -64, -79, -19,  -3, -78, -11, -61, -31,  74, -59,  19,  25,  -6, -14,   0, -41,  13, -62, -80, -59;
/M: SY='E';  M=-130,-151,-101,  42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144;
/M: SY='D';  M=-138,-151,  49,-101,-158,-134,-123,-156,-125,-155,-154,-105,-137,-124,-133,-126,-127,-153,-173,-141;
/M: SY='Y';  M=-141,-152,-141,-144, -89,-148,-107,-127,-135,-123,-120,-142,-153,-131,-132,-136,-136,-132, -97,  64;
/M: SY='V';  M=-122,-136,-153,-147,-124,-154,-156, -89,-145,-110,-112,-149,-149,-148,-146,-136,-121,  33,-158,-132;
/M: SY='E';  M=-130,-151,-101,  42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	4 in 4 different sequences
Number of true positive hits	4 in 4 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CXC MSL2-type
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

4 sequences

MSL2_CHICK  (A0A1D5NVS8), MSL2_DROME  (P50534), MSL2_HUMAN  (Q9HCI7),

MSL2_MOUSE  (Q69ZF8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

3 PDB

pdb_00002lua; pdb_00004rkg; pdb_00004rkh