PROSITE entry PS52051
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PURL: https://purl.expasy.org/prosite/signature/PS52051
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General information about the entry
| Entry name [info] | CXC_MSL2 |
| Accession [info] | PS52051 |
| Entry type [info] | MATRIX |
| Date [info] |
05-FEB-2025 CREATED;
05-FEB-2025 DATA UPDATE; 05-FEB-2025 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52051 |
| Associated ProRule [info] | PRU01396 |
Name and characterization of the entry
| Description [info] | CXC MSL2-type domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=47; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.9816434; R2=0.0081472; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1046; N_SCORE=12.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=310; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-51; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='P'; M= -26, -83, -73, -11, -75, -9, -75, -4, 5, -6, -19, 3, 34, -5, -20, -30, -12, 24, -89, -76; /M: SY='E'; M= -9, -86, -62, 45, -43, -65, -69, -38, 44, -54, -10, -66, 15, 2, 17, -59, -8, -42, -85, -76; /M: SY='K'; M= -47, -87, -71, -60, -54, -27, -69, -39, 63, -36, -71, -64, 16, -56, 52, -1, -67, -38, -84, -74; /M: SY='K'; M= -48, -89, -27, -17, -88, -49, 21, -78, 66, -87, -75, -45, 33, 7, 29, -18, -62, -85, -20, -74; /M: SY='G'; M= -64, -84, -73, -77, -80, 60, -23, 10, -5, -29, -70, -3, -26, -71, -15, -19, 11, -29, -87, -78; /M: SY='C'; M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92; /M: SY='R'; M= -72, -89, -69, -58, -87, -42, -64, -91, 59, -86, -75, -62, -79, -50, 83, -9, -70, -85, -84, -74; /M: SY='C'; M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92; /M: SY='G'; M= -34, -86, -74, -84, -92, 91, -80, -99, -76, -95, -84, -60, -78, -75, -24, -59, -77, -92, -83, -87; /I: I=-36; MD=-90; /M: SY='R'; M= -49, -88, -75, -75, -83, -34, -75, -9, -22, -44, -16, 38, -87, -6, 39, -31, 21, -5, -97, -59; D=-36; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='A'; M= 55, -75, -73, -68, -55, -26, -75, -72, -32, -77, -72, -23, -76, -14, -10, 35, 11, -12, 1, -76; /M: SY='T'; M= -51, -75, -38, -70, -15, 13, -74, -72, -19, -77, -73, 5, -73, -68, -73, 35, 71, -21, -91, -73; /M: SY='Q'; M= -16, -24, -70, -61, -84, -14, -22, -40, 17, -41, -15, -36, 29, 59, -45, 12, 12, -17, -87, -75; /M: SY='N'; M= 19, -21, -65, -45, -40, -5, -68, -47, -46, -14, -10, 57, -79, 0, -44, -2, 23, -32, -89, -43; /M: SY='P'; M= -72, -92, -69, -63, -91, -30, -72, -80, 11, -89, -77, 30, 96, 9, -70, -50, -39, -31, -90, -86; /M: SY='G'; M= -58, -81, -69, -72, -87, 57, -73, -85, -20, -88, -80, -5, 5, -29, -74, 56, -16, -39, -88, -81; /M: SY='K'; M= -46, -82, -73, -42, -75, -52, -9, -52, 48, 0, -63, -44, 6, -31, 11, -5, -5, 27, -88, -72; /I: I=-38; MD=-97; /M: SY='L'; M= -42, -33, -81, -78, -65, -86, -76, -58, -23, 54, -22, 4, -88, -73, 6, -15, 22, -61, -89, -71; D=-38; /I: I=-38; MD=-97; /M: SY='T'; M= -72, -81, -78, -81, -87, -88, -88, -76, -77, -82, -79, -67, -79, -82, -86, -56, 94, -37,-108, -85; D=-38; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='C'; M= -71, 144, -91, -91, -81, -86, -91, -88, -86, -78, -79, -77,-101, -94, -93, -73, -71, -75,-111, -92; /M: SY='R'; M= -73, 70, -79, -70, -19, -69, -22, -16, -31, -26, -67, -70, -87, -23, 78, -26, -71, -14, -87, -54; /M: SY='G'; M= -61, -82, -65, -78, -89, 77, -72, -93, -71, -93, -82, 48, -78, -71, -47, -14, -2, -88, -88, -84; /M: SY='Q'; M= -67, -86, -62, -54, -81, -73, -11, -81, -15, -80, -70, 34, -77, 93, -56, 13, 11, -81, -80, 23; /M: SY='R'; M= -76, -92, -72, -60, -86, -86, -62, -92, 7, -85, -74, -65, -84, -49, 104, -70, -75, -86, -85, -72; /M: SY='C'; M= -71, 143, -91, -91, -79, -87, -90, -85, -87, -42, -76, -77,-101, -94, -93, -74, -71, -74,-109, -90; /M: SY='P'; M= -46, -96, -76, -66, -87, -77, -76, -64, -69, -67, -77, -78, 106, -44, -16, -6, -22, -83, 0, -22; /I: I=-31; MD=-79; /M: SY='C'; M= -72, 143, -92, -92, -82, -88, -92, -89, -88, -80, -80, -78,-103, -96, -94, -75, -72, -77,-112, -93; D=-31; /I: I=-31; MD=-79; /M: SY='Y'; M= -83, -91, -84, -86, 37, -90, -51, -66, -78, -62, -61, -84, -95, -75, -75, -78, -77, -71, -40, 117; D=-31; /I: I=-31; MD=-79; /M: SY='S'; M= -12, -69, -64, -58, -69, -64, -66, -7, 55, -62, -3, -55, -68, -54, -51, 63, -12, 40, -81, -65; D=-31; /I: I=-31; MD=-79; /M: SY='N'; M= 12, -70, 27, 20, -78, -32, -53, -71, -11, -77, -69, 88, -69, -31, -58, 20, -13, -14, -89, -71; D=-31; /I: I=-31; MD=-79; /M: SY='F'; M= -40, -77, 11, 4, 55, 42, -52, -74, 7, -69, -67, -11, -72, 2, 33, 13, -62, -72, -67, -18; D=-31; /I: I=-31; MI=-79; MD=-79; IM=-79; DM=-79; /M: SY='N'; M= -26, -74, -51, -53, -73, -12, -55, -72, 70, -22, -64, 78, -70, -17, -20, -53, -13, -38, -80, -17; D=-31; /I: I=-31; DM=-79; /M: SY='S'; M= 14, -68, -59, -23, -65, -17, -63, -68, -43, -74, -68, -52, 40, -53, -39, 87, -23, -11, -82, -69; /M: SY='C'; M= -62, 149, -80, -78, -72, -77, -79, -79, -32, -70, -69, -67, -91, -80, -4, -64, -62, -67, -99, -81; /I: I=-20; MD=-51; /M: SY='A'; M= 44, -70, -19, 31, -48, -66, 6, -2, -6, -9, -33, -12, -68, -36, -11, -3, 22, -4, -77, -1; D=-20; /I: I=-20; MI=0; MD=-51; IM=0; DM=-51; /M: SY='D'; M= -51, -14, 86, 5, -79, 14, 30, -80, -11, -52, -41, 36, -69, -22, -24, -9, -58, -53, -90, -26; /M: SY='C'; M= -36, 148, -82, -82, -8, -77, -80, -77, -78, -68, -69, -69, -92, -85, -83, -65, -63, -66, -93, -17; /M: SY='H'; M= -21, -77, -61, -56, -68, -47, 92, -13, 41, -25, -58, 3, 19, -34, 21, 4, -59, -3, -82, -12; /M: SY='C'; M= -36, 148, -83, -83, -72, -79, -83, -76, -79, -42, -69, -70, -93, -86, -85, -66, -63, -34,-101, -83; /M: SY='V'; M= -52, 15, -70, -41, 3, -79, -31, -14, 11, -18, -54, -3, -77, 20, 50, -63, -12, 57, -80, -61; /M: SY='G'; M= -19, 2, -62, -75, -84, 87, -69, -89, -68, -87, -77, 44, -72, -67, -76, -35, -29, -83, -81, -80; /M: SY='C'; M= -37, 147, -82, -82, -75, -79, -7, -81, -45, -73, -72, -69, -46, -84, -83, -66, -64, -70,-103, -83; /M: SY='K'; M= -25, -81, -61, -51, -81, 7, 36, -83, 72, -79, -68, -15, -70, 17, 53, -58, -13, -78, -79, -66; /M: SY='N'; M= -38, -71, -40, -60, -80, -54, -47, -78, -31, -63, -72, 119, -76, -53, -59, -48, -50, -80, -98, -75; /M: SY='P'; M= -67, -92, -69, -38, -86, -70, -73, -77, -66, -86, -74, -73, 118, -68, -77, -5, -19, -81, 19, -82; /M: SY='H'; M= -41, -81, -66, -64, 29, -77, 112, -68, -61, -2, -54, -18, -79, -45, 17, -65, -42, -40, -71, 52; /M: SY='K'; M= -64, -79, -19, -3, -78, -11, -61, -31, 74, -59, 19, 25, -6, -14, 0, -41, 13, -62, -80, -59; /M: SY='E'; M=-130,-151,-101, 42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144; /M: SY='D'; M=-138,-151, 49,-101,-158,-134,-123,-156,-125,-155,-154,-105,-137,-124,-133,-126,-127,-153,-173,-141; /M: SY='Y'; M=-141,-152,-141,-144, -89,-148,-107,-127,-135,-123,-120,-142,-153,-131,-132,-136,-136,-132, -97, 64; /M: SY='V'; M=-122,-136,-153,-147,-124,-154,-156, -89,-145,-110,-112,-149,-149,-148,-146,-136,-121, 33,-158,-132; /M: SY='E'; M=-130,-151,-101, 42,-154,-146,-123,-155,-111,-147,-143,-127,-125,-104,-121,-127,-131,-147,-150,-144; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 4 in 4 different sequences |
| Number of true positive hits | 4 in 4 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | CXC MSL2-type |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
4 sequences
MSL2_CHICK (A0A1D5NVS8), MSL2_DROME (P50534), MSL2_HUMAN (Q9HCI7), MSL2_MOUSE (Q69ZF8)» more
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| PDB [Detailed view] |
3 PDB
pdb_00002lua; pdb_00004rkg; pdb_00004rkh |