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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01396


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01396
General rule information [?]

Accession PRU01396
Dates 19-SEP-2024 (Created)
19-SEP-2024 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS52051; CXC_MSL2
Name CXC MSL2-type domain
Function The MSL2-type CXC dpmain has a DNA binding function as it can mediate the DNA binding of the MSL2-MSL1 heteromer.
Scope(s) Eukaryota
Metazoa
Example(s) Q69ZF8;

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the MSL2 family.

Keywords [?]

Metal-binding
Zinc
end case
Nucleus
Chromosome

Gene Ontology [?]

GO:0072487; Cellular component:MSL complex
case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS52051
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="CXC MSL2-type #"
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [C] 1
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [C] 2
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [C] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [C] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [C] 3
BINDING 25 25 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [C] 1
BINDING 27 27 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [C] 2
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [C] 2
BINDING 34 34 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [C] 3
BINDING 37 37 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [C] 2
BINDING 39 39 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [C] 3
BINDING 42 42 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#3"		 [C] 3

Additional information [?]

Size range 52-52 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]