PROSITE entry PS52064

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PURL: https://purl.expasy.org/prosite/signature/PS52064

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General information about the entry

Entry name [info]	UBM
Accession [info]	PS52064
Entry type [info]	MATRIX
Date [info]	28-JAN-2026 CREATED; 28-JAN-2026 DATA UPDATE; 28-JAN-2026 INFO UPDATE.
PROSITE Doc. [info]	PDOC52064
Associated ProRule [info]	PRU01409

Name and characterization of the entry

Description [info]

Ubiquitin-binding motif (UBM) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=36;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=33;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2780006; R2=0.0078158; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1244; N_SCORE=12.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=541; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-65; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='I';  M= -15,-152,  14,  41,  -4, -64,-141,  71,-138, -28,-128,  16,-147,  13,-143,  12, -26, -42,-150,   9;
/M: SY='T';  M= -16,-148,  32,  42,-149, -47,  -1,  -6, -48, -44,-139,  30,-142, -14,   7,  29,  57, -22,-162,-143;
/M: SY='L';  M= -65,  -3,  34,-137, -18,   7,-139, -28,  -8,  58,-124,  18, -39,  34,  -2,-140,-138, -17,-151,  -8;
/M: SY='P';  M=   1,-159,-141,   1, -13,-144,  -5,-144,-139, -23,-141,-144, 115,-139,-148,  10, -22, -52,-155,-149;
/I:         I=-26; MD=-67;
/M: SY='S';  M=  40,-149,  25,   8,  13, -47,-142,-147,-139, -29,-144,  -7,  -4, -16,-144,  65, -16, -56,-158,-143; D=-26;
/I:         I=-26; MD=-67;
/M: SY='M';  M= -34, -16,  39,-147,  17,-158,-153,-141, -12,-144,  69,-146,   8, -37,-153,  17,   1,  20,-167,-147; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='P';  M=-142,  10,   2,  16,-150, -60,-148,  25,-140,   4,-139, -41,  41,-141,  14,  28,  35, -56,-165,-150; D=-26;
/I:         I=-26; DM=-67;
/M: SY='Q';  M= -64,-154,  58,  55,-154,  21,-132, -13, -52,-151,-144,  45,-143,  60, -50,-129,  17,-148,-157,  -5;
/M: SY='I';  M=-137,-149,-159,-153, -11,-159,-154,  67,-151,  20,  44,-152,  10,-149,-153,  -6,-133,  67,-154,-134;
/M: SY='D';  M= -15,-154, 112,  24, -52,-140,-133,-158,-132,-157,-155,-117,-143,-129,-140,  22,  -5,-153,-171,-146;
/M: SY='P';  M=  11,-152, -13,  20,-150,-140,-136,-146, -66,-149,   7,   4,  75,  49,-138,  45,  18, -63,-153,  16;
/M: SY='E';  M=  20,-150,  -1,  70,-153,  19,-137,-150,-129,  -8,-142,-131,-141,  18,  -5,  48, -17,-144,-156,-146;
/M: SY='V';  M=  -4,-146, -30,   8,  75,-156,-149,-113,-147, -38,-126,-149,-154,-149,-149,-140,  -2,  79,-143,  -4;
/M: SY='F';  M=-145,-147,-160,-154,  84,-160,-144,-116,-153,  72,  47,-154,-158,-151,-151,-148,  18,-122,-137,-116;
/M: SY='E';  M=  48,-150, -13,  65,-143,-141,-132,-146,  29, -63,-140,  36,-143,  13,-130, -37,-133, -38,-147,  50;
/M: SY='A';  M=  67,-145,-129,  63,-153,-137,-139,-143,-131,-146,-141, -13,-140,  29,-137,  18,  34, -13,-157,-147;
/M: SY='L';  M=-144,-147,-162,-154,-119,-164,-146,   0,-155,  97,  16,-160,-161,-148,-152,-154,-140,-116,-149,-131;
/M: SY='P';  M=-144,-169,-145,-133,-162,-146,-147,-150,-141, -64,-147,-151, 134,-144,-153,-141,-137,-155,-157,-160;
/M: SY='P';  M= -18,-154,  26,  61,-156,-144,-138,-146,  23, -92,-145,  27,  74,-128,-134,  -5,   0,   1,-160,-150;
/M: SY='D';  M=   6,-154,  82,  65,  23,-144,-135,-153,-131,-151,-148,-127,  28, -16,-139, -15,  14,-148,-159,-141;
/M: SY='I';  M=-140,-149, -15,  13, -17,-161,-149,  65,-148,  54,  38,-149,-152,-144,-150,-146,   2,  23,-152,-133;
/M: SY='Q';  M= -32,-157,-135,-123,-153,-147,-129,-149,  30,  -5,-135,  27,-148,  96,  79,-132,-138,-148,-152,-140;
/M: SY='Q';  M=  37,-151,  -3,  38,-144,-141,  22,-149,  18, -43,-139,  31,-144,  50,  17,  -4, -22,-144,-149,  41;
/M: SY='E';  M=-138,-157,  61,  98,-158, -50,-131,-156,-124, -23,-147,-128,-138,  41,-132, -23,-137,-152,-160,-148;
/M: SY='I';  M=   6,-149,-157,-151,-130,-158,-155,  75,  12,  29,-117,-151,-153,-147,-147,-144,-134,  59,-154,-137;
/M: SY='L';  M=-143,-151,  34, -10,  -9,-153,-138,   4, -22,  63, -14,  24,-152,  49,   5,-142,-138, -50,-152,-134;
/M: SY='A';  M=  58,-146,   8,-133, -13, -21,  17,  11,  -7,-140,  32,   4,-145,  39,-137,  35,  -9,-134,-153, -34;
/M: SY='Q';  M=   3,-151,  46,  33, -12, -36,-134, -70,-130,  -2,-137,  17,-144,  80,-134,  17,   0, -29,-156,-140;
/M: SY='W';  M=  -8,  16,-143,  17,  12,-150,  52,-135, -27,  36,  36,-141,-151,  30,  29,  -8,-139,-137,  59,  34;
/M: SY='R';  M=  -4,-153,  25,  26,-149, -37,-137,  -1,  -3, -62,-137,   8, -44,  -9,  72, -27, -62,  30,-158,-143;
/M: SY='R';  M=  -8,-151, -42,  29,-144, -17, -25,   0, -10,  23,-132,-136,  -5,  18,  45,  37, -16, -22,-155,-141;
/M: SY='Q';  M=  15,-154,-129,  58,  -5,-146,   8, -48,  22, -38,-138,  -7,-143,  78,  34, -41, -22,-145,-152,-139;
/M: SY='Q';  M=-136,-152,-134,  10,-147, -36,-132,-143,  57,  -4,  57,  16,-145,  57,  37,  22,  -9,-143,-153, -44;
/M: SY='R';  M=   1, -18,  20,-130,   0, -54, -10,-146,  10, -73,  12, -17, -32,  20,  77,  22,-135, -27,-150,  13;
/M: SY='Q';  M=   2,-151,  11,  11, -12,-147,  33, -19,  16,   7,  21,  -4, -32,  34,  33,  -4, -59,  10,-155,-136;
/M: SY='R';  M=  -2,-153, -80,   3,   3, -17,-135, -36,-124,  -6,-133,  -8,  -9,  55,  68, -34, -23,   6,-147,  20;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_01 which contains 574'627 sequence entries.

Total number of hits	52 in 27 different sequences
Number of true positive hits	52 in 27 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	UBM
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

27 sequences

ERCC5_HUMAN (P28715), ERCC5_MOUSE (P35689), ERCC5_XENLA (P14629),

HUWE1_HUMAN (Q7Z6Z7), HUWE1_MOUSE (Q7TMY8), HUWE1_RAT   (P51593), 
POLH_ARATH  (Q8H2D5), POLI_DROME  (Q9VHV1), POLI_HUMAN  (Q9UNA4), 
POLI_MOUSE  (Q6R3M4), PTR1_SCHPO  (O13834), RAD13_SCHPO (P28706), 
RAD2_YEAST  (P07276), REV1_ARATH  (A3EWL3), REV1_CHICK  (Q4KWZ7), 
REV1_DROME  (Q9W0P2), REV1_HUMAN  (Q9UBZ9), REV1_MOUSE  (Q920Q2), 
REV1_PONAB  (Q5R4N7), REV1_SCHPO  (O94623), REV1_YEAST  (P12689), 
TOM1_EREGS  (Q756G2), TOM1_NEUCR  (Q9P4Z1), TOM1_YEAST  (Q03280), 
UPL1_ARATH  (Q8GY23), UPL2_ARATH  (Q8H0T4), UVH3_ARATH  (Q9ATY5)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

22 PDB

pdb_00002khu; pdb_00002khw; pdb_00002ktf; pdb_00002kwu; pdb_00002kwv; pdb_00002l0f; pdb_00002l0g; pdb_00002mbb; pdb_00002mul; pdb_00003ai4; pdb_00005vzm; pdb_00006asr; pdb_00006axd; pdb_00007jq9; pdb_00007mop; pdb_00007mwd; pdb_00007mwe; pdb_00007mwf; pdb_00008tlq; pdb_00008tlt; pdb_00009dns; pdb_00009dnt
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