PROSITE entry PS52079

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PURL: https://purl.expasy.org/prosite/signature/PS52079

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General information about the entry

Entry name [info]	FOXP_ZIP
Accession [info]	PS52079
Entry type [info]	MATRIX
Date [info]	28-JAN-2026 CREATED; 28-JAN-2026 DATA UPDATE; 28-JAN-2026 INFO UPDATE.
PROSITE Doc. [info]	PDOC52079
Associated ProRule [info]	PRU01424

Name and characterization of the entry

Description [info]

Forkhead box protein P (FoxP) family leucine zipper (ZIP) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9723291; R2=0.0116649; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=560; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=389; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-7; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='R';  M= -1, -9,-23,-12, -6,-19,-11, -9,-16,  0,-15, -9, -4, -3, -3,  9, -2, -1,-11,-25,-15, -7;
/M: SY='L';  M= -8,-14,-11,-16, -7, -8,-23,-10, -3,-15,  5,  2,-13,-18, -3,-12,-10, -5, -5,-20, -7, -5;
/M: SY='D';  M=-13, 15,-15, 23,  2,-27, -3, -6,-31,-10,-23,-20,  4, -7, -6,-14, -4,-10,-24,-33,-19, -3;
/M: SY='D';  M=-15, 15,-29, 24, 19,-24,-12,  0,-28,  0,-16,-16,  4,-12,  4,  0, -5,-11,-24,-29,-14, 11;
/I:         I=-5; MD=-25;
/M: SY='R';  M= -1, -5,-22, -6,  1,-23,-10, -7,-19, 11,-20, -9, -1, -9,  8, 13,  2, -4,-13,-24,-14,  3; D=-5;
/I:         I=-5; MI=-25; MD=-25; IM=-25; DM=-25;
/M: SY='S';  M=  3, -1,-12, -3, -4,-19,  0,-12,-16,-10,-17,-13,  3,-14, -6,-10, 11,  3,-11,-30,-17, -6; D=-5;
/I:         I=-5; DM=-25;
/M: SY='T';  M= -3, -5,-18,-13,-12, -5,-17, -7,  2,-13,  0,  1,  2,-19,-10,-10, -1,  3,  0,-26, -7,-12; D=-5;
/I:         I=-5; DM=-25;
/M: SY='A';  M= 14, -7,-16,-13, -6,-17,  1,-15,-14, -9,-10, -7, -6,-12, -6,-11,  5,  6, -7,-22,-16, -6; D=-5;
/I:         I=-5; DM=-25;
/M: SY='Q';  M=-10,  1,-29,  2, 24,-36,-20,  6,-22, 10,-20, -5,  0, -9, 47, 11,  0, -7,-28,-22,-12, 35;
/M: SY='W';  M=-12,-26,  2,-30,-22,  5,-27,-21, -5,-22, -3, -5,-25,-28,-20,-21,-21,-14, -6, 21,  8,-20;
/I:         I=-6; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='R';  M=-13,-10,-25,-11,  1,-13,-21, -6,-17, 14, -8, -4, -6,-17,  7, 30,-10, -6,-12,-19, -7,  2; D=-6;
/I:         I=-6; DM=-29;
/M: SY='V';  M=  0, -9,-18,-14,-10,-11,-19,-14,  1, -8, -2,  3, -7,-18, -8, -5, -1,  4,  6,-27,-11,-10;
/M: SY='Q';  M= -8,  1,-28,  0, 14,-37, -8,  6,-22,  5,-22, -4,  3,-12, 45,  5,  3, -9,-29,-22,-13, 29;
/M: SY='M';  M= -7,-13,-25,-15, -1,-15,-23, -9,  0, -1, -1,  6,-10,-16,  6,  4, -9, -8, -3,-22, -8,  0;
/I:         I=-4; MD=-19;
/M: SY='E';  M= -8, 12,-27, 17, 28,-27, -8,  3,-27,  2,-21,-17,  5, -7, 10, -4,  1, -7,-26,-27,-14, 19; D=-4;
/I:         I=-4; MI=-19; MD=-19; IM=-19; DM=-19;
/M: SY='L';  M= -6,-24,-15,-27,-19,  4,-25,-18,  9,-16, 16,  8,-22,-25,-17,-10,-18, -8,  9,-11,  0,-19; D=-4;
/I:         I=-4; DM=-19;
/M: SY='V';  M= -1,-24,-13,-26,-25, -3,-23,-27, 22,-19,  5,  6,-22,-25,-24,-19, -5,  2, 35,-28,-10,-25; D=-4;
/I:         I=-4; DM=-19;
/M: SY='Q';  M=-13, -1,-28,  2, 17,-21,-20, 11,-22,  8,-14, -6, -1,-12, 21, 11, -6,-11,-23,-22, -6, 18; D=-4;
/I:         I=-4; DM=-19;
/M: SY='Q';  M= -4, -2,-15, -4,  3,-22, -6, -1,-21,  1,-19,-10,  1,-15,  9, -2,  2, -6,-19,-23, -9,  5; D=-4;
/I:         I=-4; DM=-19;
/M: SY='L';  M=-10,-27,-20,-28,-18,  6,-28,-17, 20,-26, 40, 21,-26,-26,-14,-18,-26,-10,  9,-19,  0,-16; D=-4;
/I:         I=-4; DM=-19;
/M: SY='E';  M= -8,  5,-28, 14, 47,-26,-18, -3,-25,  5,-17,-17, -2,  2, 14, -3,  0, -8,-25,-29,-19, 30; D=-4;
/I:         I=-4; DM=-19;
/M: SY='Q';  M= -7,  4,-23,  4,  6,-23,-16,  7,-19,  4,-18,-10,  5,-12,  9,  5,  3,  0,-16,-27, -9,  6; D=-4;
/I:         I=-4; DM=-19;
/M: SY='Q';  M=-12, -1,-30, -1, 16,-34,-20,  4,-24, 20,-22, -5,  0,-11, 40, 24, -4,-10,-26,-20,-10, 27;
/M: SY='L';  M=-10,-30,-20,-31,-21,  9,-31,-21, 22,-30, 46, 20,-29,-29,-20,-21,-28,-10, 13,-20,  0,-21;
/M: SY='A';  M= 14, -6,-14,-12, -9,-15,-12,-17, -5, -8,-11, -8, -2,-14, -9,-12, 11, 12,  3,-28,-15, -9;
/M: SY='K';  M=-10,-10,-25,-10,  1,-16,-23,-10, -9, 12, -5, -1, -9,-18,  3, 10,-12, -8, -6,-21, -7,  1;
/M: SY='E';  M=-11, 12,-30, 23, 58,-31,-19,  0,-31,  9,-21,-21,  1, -1, 19, -1,  0,-10,-30,-31,-20, 38;
/M: SY='R';  M=-14, -5,-29, -5,  5,-25,-19, -5,-30, 37,-25,-10,  0,-15, 10, 48, -8, -9,-20,-21,-10,  5;
/M: SY='Q';  M= -6,  3,-26,  5, 24,-29,-16,  5,-22,  6,-19, -9,  2, -9, 27,  3,  4, -6,-24,-27,-13, 25;
/M: SY='R';  M=-17, -8,-30, -9,  1,-21,-21, -3,-25, 31,-20, -8, -1,-17,  8, 53,-11,-10,-17,-20, -9,  1;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='Q';  M= -3, -3,-26, -5,  2,-26, -4, 10,-19, -1,-18, -3,  2,-15, 21,  0, -1,-10,-21,-21, -8, 10;
/M: SY='A';  M= 30, -9,-14,-14, -5,-17, -6,-18, -8,-11, -4, -7,-11,-13,-10,-18,  2, -3,  0,-22,-17, -8;
/M: SY='M';  M=-10,-20,-20,-30,-20,  0,-20, -1, 20,-11, 21, 58,-20,-20, -1,-10,-20,-10, 10,-20,  0,-10;
/M: SY='M';  M= -9,-11,-25,-15, -2,-16,-21,  4, -3,  1, -1, 20,-10,-16, 18,  5,-11,-10, -9,-19, -2,  7;
/M: SY='A';  M= 15, -5,-17,-13, -6,-16,-11, -8,-13, -3,-11, -6, -3,-13,  0, -4,  4,  4, -8,-22,-12, -3;
/M: SY='H';  M=-16, -1,-29,  0,  7,-23,-21, 70,-25, -6,-18, -2,  5,-17, 15,  0, -8,-16,-25,-29, 10,  8;
/M: SY='L';  M=-10,-29,-21,-31,-21, 11,-30,-19, 22,-28, 43, 22,-28,-28,-19,-20,-28,-10, 11,-19,  1,-21;
/M: SY='H';  M=  0, -6,-22, -9, -2,-17,-16, 18,-14, -3,-14, -4, -1,-16,  5,  0, -1, -8,-11,-25, -4, -1;
/M: SY='M';  M=-10, -8,-25, -7, -9, -9, -9, -9, -5,-12,  3,  9,-10,-16, -8,-10,-12,-10, -7,-23, -7, -9;
/M: SY='K';  M= -6, -6,-18, -9, -1,-19,-18,-11,-21, 18,-21,-10, -3,-11,  2, 18, -2, -1,-14,-23,-11, -1;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_01 which contains 574'627 sequence entries.

Total number of hits	23 in 23 different sequences
Number of true positive hits	23 in 23 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	FoxP leucine zipper (ZIP)
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

23 sequences

FOXP1_BOVIN (A4IFD2), FOXP1_CHICK (Q58NQ4), FOXP1_HUMAN (Q9H334),

FOXP1_MOUSE (P58462), FOXP1_RAT   (Q498D1), FOXP1_XENLA (Q5W1J5), 
FOXP2_GORGO (Q8MJ99), FOXP2_HUMAN (O15409), FOXP2_HYLLA (Q5QL03), 
FOXP2_MACMU (Q8MJ97), FOXP2_MOUSE (P58463), FOXP2_PANPA (Q8HZ00), 
FOXP2_PANTR (Q8MJA0), FOXP2_PONPY (Q8MJ98), FOXP2_RAT   (P0CF24), 
FOXP2_XENLA (Q4VYS1), FOXP3_HUMAN (Q9BZS1), FOXP3_MACFA (Q6U8D7), 
FOXP3_MOUSE (Q99JB6), FOXP4_HUMAN (Q8IVH2), FOXP4_MOUSE (Q9DBY0), 
FOXP4_XENLA (Q4VYR7), FXP1B_DANRE (Q2LE08)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

5 PDB

pdb_00004i1l; pdb_00007tdw; pdb_00007tdx; pdb_00008sro; pdb_00008srp