ProRule PRU01424
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01424
General rule information
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| Accession | PRU01424 |
| Dates | -- (Created)
-- (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52079; FOXP_ZIP |
Name | Forkhead box protein P (FoxP) family leucine zipper (ZIP) domain |
| Function | FoxP subfamily members contain a zinc finger (ZF) that likely binds DNA, and a Leucine Zipper (ZIP), known to form antiparallel coiled-coil dimers, in addition to their forkhead domain. |
| Scope(s) |
Eukaryota Euteleostomi |
| Example(s) | Q2LE08; |
Propagated annotation
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Comments
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| DOMAIN | The leucine zipper (ZIP) is required for dimerization and transcriptional repression. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
| GO:0000978; Molecular function:RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0001227; Molecular function:DNA-binding transcription repressor activity, RNA polymerase II-specific |
Features
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| From: PS52079 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="FoxP leucine zipper (ZIP) #" | |||||||||
Additional information
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| Size range | 41-41 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [23] All [ 23 ]
- Retrieve set of proteins with 3D structure for this domain