PROSITE entry PS52082

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PURL: https://purl.expasy.org/prosite/signature/PS52082

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General information about the entry

Entry name [info]	5_PPASE
Accession [info]	PS52082
Entry type [info]	MATRIX
Date [info]	10-JUN-2026 CREATED; 10-JUN-2026 DATA UPDATE; 10-JUN-2026 INFO UPDATE.
PROSITE Doc. [info]	PDOC52082
Associated ProRule [info]	PRU01427

Name and characterization of the entry

Description [info]

5-phosphatase (5-PPase) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=311;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=306;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8866731; R2=0.0064192; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1420; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=719; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-31; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='T';  M=  12, -75,  -6, -64,  -8, -69, -70,   0, -28, -42,   8,  -5,  25, -25, -30,  36,  44, -30, -84, -68;
/M: SY='N';  M= -13, -79,   2,  39, -36, -68, -60, -76,   1, -78, -49,  43,  38,  -3,   7,  15,   8, -40, -84, -24;
/M: SY='P';  M= -15, -82,   8,   8,   0, -29,   8,  12,   4, -21, -63, -29,  68,   8, -66, -62,   4, -37, -81, -67;
/M: SY='D';  M=  -6, -79,  57, -27, -37, -69, -60, -21,  35, -35,   3, -52,  37,  37,  20, -20,   2, -68, -81, -67;
/M: SY='N';  M=  -4, -73,  39,  -2, -68,   2, -18, -66, -20, -65,  59,  60, -69,  29,  -5,   9, -37, -36, -78,  16;
/M: SY='W';  M= -64, -73, -80, -76,  26, -82,  19,  58, -73,  34,  -2, -72, -76, -71, -74, -67,  24,  26,  61,  -3;
/M: SY='R';  M=   6,  -2, -58, -51, -76, -63, -57, -75,  47, -74, -65,  -7, -67,  14,  62,  50,  20, -68, -78, -65;
/M: SY='I';  M= -60, -72, -84, -80,   3, -86, -78,  73, -76,  -1,  38, -77, -77, -74, -77, -71, -56,  64, -73,   0;
/M: SY='F';  M= -32,  35, -77, -73,  84, -78,  41,  -1, -68,  31, -47, -68, -79, -71,   2, -20,   8, -51, -60, -37;
/M: SY='V';  M=  -7, -69, -79, -74,  25, -79, -76,  47, -70,   7,  -5, -72, -76, -71, -15, -32,  11,  65, -75, -54;
/M: SY='G';  M=  20,  -1, -70, -72, -16,  66, -73,  20, -69, -27, -57, -59, -71, -67, -74,   7, -13,  28, -76, -66;
/M: SY='T';  M= -50, -61, -57, -60, -68, -65, -67, -60, -57, -65, -61, -46, -59, -60, -65,  28, 110, -52, -87, -66;
/M: SY='W';  M=  19, -85, -89, -75,  31, -69, -81, -66, -70, -63,  10, -82, -77, -69, -72, -21, -73, -72, 158,  30;
/M: SY='N';  M= -62, -68, -36, -56, -77, -51, -43, -76, -47, -83, -69, 123, -73,   2, -56, -44, -47, -78, -95, -72;
/M: SY='V';  M= -16,  14, -81, -74, -54, -78, -74,   6, -72,   3,  78, -74, -76, -70, -73, -12, -53,  78, -82, -59;
/M: SY='G';  M=  26, -72, -55, -64, -80,  76, -61, -81, -16, -81, -70,  64, -69,   2, -65, -27, -58, -75, -78, -74;
/M: SY='G';  M= -28, -73, -26, -21, -78,  70,  21, -79, -18, -77,   2,  -4,  -5,  -8, -64,  52, -20, -74, -78, -69;
/M: SY='Q';  M=  16,  -8, -61,  11, -65,  20,  -5, -18,  25,  28, -53,  -5, -70,  30,   0, -26, -25, -15, -76, -64;
/M: SY='F';  M=  -7, -72, -66, -59,  44, -67, -63, -33,  33, -59,  40, -59,  38, -56,  24,  37,   9,   3, -70, -54;
/M: SY='P';  M=  15, -80,   4,  33, -82, -64, -61, -74, -32, -78, -69,  19,  95,  15, -36,  -5, -56, -51, -81, -75;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='P';  M= -59, -79,  17, -13, -78, -40, -18, -75,  -3, -80, -71,   4,  88, -57, -37,  41,  22, -74, -82, -17; D=-23;
/I:         I=-23; DM=-58;
/M: SY='D';  M= -13, -76,  48,  40, -77, -36,   3, -72,  44, -25, -67, -51, -23,  -6, -26,  17,  11, -27, -83, -68; D=-23;
/I:         I=-23; DM=-58;
/M: SY='D';  M=   7,  -3,  60,  -3, -80,   9, -57, -79,  20, -80, -73,  54, -34, -14, -57,  21, -18, -74, -86, -35; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='L';  M= -64, -71, -80, -72, -17, -84,   8,  32, -70,  70,  -2, -76, -80,  11, -15, -72, -61,  21, -73, -53;
/M: SY='T';  M= -57, -73,  33,  44, -75, -23,  35, -69,  39, -70,   0, -16, -63, -12, -20,  11,  47, -12, -84, -64;
/M: SY='D';  M= -20, -74,  62,  29, -75, -37,  -5, -77, -17, -56, -70,  49,   7,   1, -25,  45, -51, -74, -83,   0;
/M: SY='W';  M= -72, -88, -95, -79,  21, -76, -87, -58, -73,  29,   4, -89, -80, -72, -75, -37, -77, -68, 161, -32;
/M: SY='L';  M= -64, -70, -83, -77,  23, -83, -70,  31, -76,  74,   4, -78, -81, -71, -75,  -8, -60,   4, -69, -50;
/M: SY='H';  M= -11, -73, -22, -17,  34,  18,  38, -29,  -8,  26, -53,   3, -72,  31,   0,   5,  -1, -60, -71, -53;
/M: SY='P';  M= -34,  46,   4,  -3, -70, -28, -31, -37, -28,   1, -60, -29,  60,  -1, -65,  32,  46, -24, -83, -69;
/M: SY='N';  M=  13, -71,  -7,  -1,  16,   0,  11,   2,  16, -41,  24,  35, -34, -57, -35,   4, -25,  17, -73,   1;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='I';  M= -11, -94, -15,   7, -88, -35, -20,  17, -15, -49, -77,   4, -90, -76, -32, -24, -23,  -6,-102, -86; D=-19;
/I:         I=-19; DM=-49;
/M: SY='D';  M= -26, -90,  42,   3, -90, -13,  25, -30, -67, -84, -79, -25, -83,   9,   4,   0, -16,  -8,-101, -80; D=-19;
/I:         I=-19; DM=-49;
/M: SY='D';  M= -23, -80,  42, -11, -76,  -6, -66, -48,  -9, -36, -72,   4, -20,  -2, -68,  18,  36, -48, -86,  12; D=-19;
/I:         I=-19; DM=-49;
/M: SY='H';  M= -25, -76,   4,  24, -15, -16,  40,  13, -22, -14, -58,  20, -11,  38, -24,  15, -14, -23, -77,   4; D=-19;
/I:         I=-19; DM=-49;
/M: SY='P';  M=  -9,  14,  20, -14, -73, -20,   5, -68,  34, -11, -14,  -9,  72, -58, -59, -58,  14, -37, -80, -16; D=-19;
/I:         I=-19; DM=-49;
/M: SY='P';  M=  31, -11, -66, -58,  -7, -66,  58, -63, -61, -33, -30, -63,  82,  24, -66, -22,  -3,  -9, -73,  17;
/M: SY='D';  M= -63, -78, 106, -20, -82, -18,  44, -77, -56, -78, -76, -39, -67, -54, -63,   4, -56, -13, -99, -66;
/M: SY='I';  M= -65, -73, -86, -81,  51, -87, -78,  78, -78,  27,   5, -78, -78, -76, -79, -73, -59,  30, -67, -47;
/M: SY='Y';  M= -13, -75, -76, -75,  28, -78, -52,   8, -69, -19,  27, -74, -80, -67, -68, -66, -61,  38, -43, 105;
/M: SY='V';  M=  56,  25, -77, -70, -61, -68, -79,  15, -70, -48, -49, -71, -47, -70, -73, -56, -52,  75, -82, -65;
/M: SY='I';  M= -63, -15, -85, -80,  15, -87, -78,  74, -78,  40,   2, -78, -78, -75, -78, -73, -58,  43, -73, -53;
/M: SY='G';  M=  10, -76, -62, -69, -79,  90,  75, -87, -67, -80, -69, -50, -68, -62, -71, -50, -66, -80, -78, -67;
/M: SY='F';  M= -64,  30, -80, -76,  70, -82, -70, -27, -74,  55, -41, -73, -80, -75, -74, -66,  34,  19, -64, -43;
/M: SY='Q';  M= -59, -84, -51,  21, -89, -68, -48, -76, -40, -71, -59, -50, -65, 127, -41, -49, -62, -77, -73, -62;
/M: SY='E';  M= -59, -81, -10, 106, -84,  10, -55, -85, -44, -78, -73, -55, -57, -36, -54, -56, -61, -78, -80, -74;
/M: SY='V';  M= -33, -69,   0, -70,  28, -23, -69,  33, -69,  21,  37,  13, -74, -68, -72,  -4,   9,  43, -75, -54;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='V';  M= -29, -80,   4, -14, -74,  28, -79,  -5, -75, -29, -63,   8, -82, -74, -80,  -6, -64,  54, -93, -76; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -70, -89,  -7,  18, -40,  16,   4, -81, -70, -29,  26,   7,  54, -22, -77,   5, -31, -81, -91, -79; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -69, -82, -81, -76, -68,   4, -77, -19,  22,  44,  -2, -73, -85, -70, -71,  33, -67, -63, -86, -72; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -13, -81, -59,  -6, -83, -70, -66, -14,  -5, -68, -76,  76, -80, -63, -34,  14,  10, -76,  35, -77; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  40, -88, -85, -82, -15, -12, -79,  -2, -81, -78, -11, -26,  -9,  -7, -84,  -7, -73, -72, -82,  32; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='N';  M= -76, -94,  -5,  12, -17,   9, -78, -89,   1, -60, -86,  23,   0, -24, -76,  13, -73, -33, -98, -85; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -21, -89, -67,   8, -93, -78,  12, -85, -71, -91, -83,  46,  27, -23, -39,  24, -10, -21,-103, -86; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -30, -86, -15, -84,  -2, -55, -84,  22, -36,  28,  12, -26, -91, -81, -85,   0, -72,   3, -89, -71; D=-2;
/I:         I=-2; DM=-4;
/M: SY='V';  M= -47, -84, -22, -53,  27,   2, -84,  -5, -83,  27, -58, -81, -90, -83, -31, -36, -28,  29, -84, -66; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='N';  M= -15, -85, -18, -73, -17, -30, -72, -25, -37,  -8, -73,  42, -44,   5, -76,  38, -65, -49, -91, -16; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M=  17, -82,  -1,   5, -28, -72,  -6, -84, -28, -67, -79,  39, -80, -25,  -8,  22,  18, -79, -95, -78; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -73, -90,  71, -25, -90, -11, -70, -13, -69, -89, -85,   0,   8, -68, -19,  26, -67, -83, -99, -29; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M=  26,  18, -32, -62, -72, -26, -65, -68, -10, -14, -65,  23,  42, -61, -67,  41,  29, -40, -81,  -7; D=-2;
/I:         I=-2; DM=-4;
/M: SY='M';  M=   0, -74, -45, -36, -68,  -8, -67, -17, -14,  -7,  52, -30,  41,   4, -67,  29,  23,  -2, -80, -23; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -14,   2,  32, -31,   5,  -1, -63, -23,  36, -46,  26,  20, -35,  29, -56, -14, -15,   1, -80, -64; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M= -17, -80,  13,  58, -78, -10, -21, -77, -35, -47, -68,  -2, -29,  34,  42,  -3, -23, -31, -81, -16; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M= -46, -81,  18, -12,  21, -18, -60, -21,  25, -15, -61, -37, -12,  35,  47, -22, -32, -35, -71,  15; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M= -65, -81,  17,  62,  -1, -34, -22, -35, -18, -17,  20,   7,  29, -10, -62, -36,   5, -69,  44, -25; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -20,  31, -44, -73, -53, -35, -86, -74, -21, -58, -72, -37, -79, -18,  -2, -41, -19, -49, 155, -19; D=-2;
/I:         I=-2; DM=-4;
/M: SY='C';  M=  19,  63, -65,  32,  21,  -4, -69, -26, -65,  14, -59, -27, -74, -62, -28,  14,   0, -40, -78, -63; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M=  -5, -77,  44,  42, -77, -43, -62, -68,  -1, -37, -16, -25, -37, -52,  30,  10,  15,   4, -86, -70; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M=   0,  -8, -67,  11, -31, -76,  -7, -23,  28,  21,   6, -65, -74,  -9,  -9, -10,  21,  16, -81, -65; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='I';  M= -44, -75, -82, -80,  -2, -85, -20,  55, -78,  53, -40,   5, -47, -74, -78, -49, -62,  24, -77, -58; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Q';  M= -18, -79,   2,  14, -12,  -2, -59, -38, -10, -30,  27,   6, -72,  52,  47, -19,  -3, -50, -79, -65; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M= -12, -20,  28,  42, -79, -28,  27, -77,  42, -50,  10,   9, -67,  23,  -3,   4, -10, -73, -83, -67; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M=  12,   9, -32, -29, -32,   6, -64, -33, -18, -20, -16,   8, -71, -60, -14,  28,  48, -29,  30,  24; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -37, -72, -85, -78, -20, -85, -69,  11, -78,  73,  28, -82, -84, -72, -76, -50, -63,  10, -70,  21; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -33,-102, -19, -80, -27, -55, -82,-101,  -5,-100, -12,  35, -99,  20,  -7, -12, -42, -99,-106, -47; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='Y';  M= -65, -81,  15, -15, -66, -26,   8, -17,  10,  -3, -62, -12, -15,  27, -39,  21, -16,  -3,  13,  31; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M= -57, -74, -16,  22, -72,   0, -61, -40, -13, -33, -17,  20,  -5, -54,  24,  41,  47, -67, -81,  -6; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=   5, -73,  39, -31, -77,  10, -59,   1,  23, -73, -66,  29,  18,  22, -15,  43, -28, -65, -81, -68;
/M: SY='P';  M=   1, -74,  -7,  30, -22, -28,   4,  -4,   1, -13,  29,  19,  43,  -2, -35,  10, -55,   9, -79, -64;
/M: SY='K';  M= -38, -76,  40,  21, -79,  15,  39, -77,  41, -76, -67,   2, -23,  26,   6,  12,  15, -47, -82, -65;
/M: SY='Y';  M= -72, -78, -74, -75,  70, -79,  23, -54, -68, -49,   6, -71, -83, -66, -65, -68, -66, -60, -33, 117;
/M: SY='V';  M= -31,  10, -65,   2, -63, -13, -68,   3,  18,  -2,  -5, -60, -70, -15,  10,  -7,  41,  48, -81, -64;
/M: SY='L';  M=  14,  29, -12, -60, -61, -11, -64, -53,  25,  47, -48, -63,   0,   3,  30, -60, -14, -15, -76, -63;
/M: SY='L';  M= -43, -70, -83, -77, -16, -28, -72,  42, -76,  60,  50, -78, -79, -71, -75, -72, -59,  41, -74, -55;
/M: SY='A';  M=  45,  32, -65, -62, -73,  41,  -6, -37,   3, -69, -63, -55, -68, -13,  -3,  33,  -3,  -1,   8, -68;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='S';  M= -31,  -1, -62, -16,  -3, -64,  37, -19,  -5, -28,   4,   3, -71, -22, -15,  67, -10,  11, -82, -61; D=-29;
/I:         I=-29; DM=-75;
/M: SY='K';  M=   5, -72, -54,  35, -72, -39,  11, -19,  43, -29, -59,  -5, -65,  30,   6,   5,  27,   7, -79, -64;
/M: SY='Q';  M=  18, -73, -59, -48, -18, -64,  14, -13, -21, -32, -58, -16, -68,  88,  25,  29,  17, -62, -75, -60;
/M: SY='M';  M= -64, -71, -80, -72, -47, -80,  15,   3, -70,  62,  93, -73, -76,  -9, -69, -70,  -6, -12,  34, -51;
/M: SY='W';  M=  26, -72, -66,  -8, -65,  14, -70, -49,  12, -60, -58,  -6, -70,  27, -61,  -8, -30,  53,  86, -60;
/M: SY='G';  M= -20, -71, -56, -64, -76,  70, -61, -72, -60, -34, -66,  58, -68,  14, -66,  14,  21, -22, -80, -71;
/M: SY='I';  M= -61, -72, -79, -76, -51, -82, -75,  67, -73,  30,  38, -16,   8, -71, -76, -67,   2,  47, -78, -58;
/M: SY='C';  M=  -3,  44, -70, -65,  40, -17,  30, -25, -11,  21,  21, -62, -75,  11,  11,   3, -14, -56, -63,  42;
/M: SY='L';  M= -63, -72, -79, -69, -48, -83, -69,  51, -70,  64,  19, -74, -78,  43, -70, -33, -60,   8, -73, -56;
/M: SY='F';  M=  11,  30, -72, -70,  49, -38, -64, -14, -68,  24,  -6, -65, -74, -67, -70,  20,  35,   0, -62,  42;
/M: SY='V';  M= -59, -70,  26, -68, -10, -79, -73,  34, -71,  26, -43,  15, -77, -71, -74, -66, -55,  72, -82, -59;
/M: SY='W';  M= -74, -78, -87, -80,  93, -80, -67, -52, -75,  13, -51, -81, -84, -77, -74, -75, -70, -59, 117,  57;
/M: SY='V';  M=  32,  38, -73, -67, -60, -13,   8,  20,  12, -51,  27, -66, -73, -63,   1, -58, -56,  57, -77,   0;
/M: SY='R';  M= -13, -77, -60, -49, -73, -70, -56, -71,  66, -25,  26,   7, -21,   4,  75, -57, -15, -68, -75, -63;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='P';  M= -28, -78, -31,  13, -68, -40, -12, -22,  51, -73, -64,  10,  55, -11,  32,  16, -56, -69, -70,  34;
/M: SY='Y';  M= -62, -77,  54,  50,  -8, -67, -50, -74,   6, -71, -66,  27, -67,  33, -10,  11, -29, -73, -67,  57;
/M: SY='H';  M= -26,  -8,   4, -32, -58, -74,  97, -22,  -5,  45, -45, -57, -74,  15, -16, -30, -61,   2, -83, -51;
/M: SY='R';  M=   7,   0, -64,  18, -59, -74,  19,  23,   5,  31, -49, -63, -71,  17,  34, -31,   1, -22,  10, -20;
/M: SY='P';  M= -18, -75,   5, -28, -69, -28, -10, -62,  28, -43, -62,  21,  59,  -6, -20, -12,  33,  13,  59, -27;
/M: SY='H';  M= -40, -75, -63, -57,  35, -70,  70, -63,  16, -38, -56, -28, -72,  26,  33,  27, -11, -10, -62,  56;
/M: SY='I';  M= -58,  35, -74, -75, -58,  23, -77,  72, -21, -16, -46,   0, -10, -70, -74, -18, -57,  39, -79, -63;
/I:         I=-33; MD=-84;
/M: SY='K';  M= -57, -75, -10, -51, -80,  -8, -59, -79,  57, -79, -69, -10, -68,  31,  38,  54,   5, -74, -80, -68; D=-33;
/I:         I=-33; MI=-84; MD=-84; IM=-84; DM=-84;
/M: SY='H';  M= -25, -79,  55,  42, -72, -71,  67, -24, -27,  -7,  -6,  35, -70,   3, -17, -59, -61, -37, -87, -20; D=-33;
/I:         I=-33; DM=-84;
/M: SY='V';  M= -62, -74, -83, -75, -21, -86, -80,  53,   7,  25,  -4, -77,  -5, -73, -71, -72, -59,  62, -79, -60; D=-33;
/I:         I=-33; DM=-84;
/M: SY='C';  M=   7,  40,  20,  30, -69, -30, -61,   2,  10, -32, -63,  16, -71,   9,  -3,   8, -26, -24, -78,  13; D=-33;
/I:         I=-33; DM=-84;
/M: SY='T';  M=  -7,  -7, -27, -10, -63,  -5, -70,  -8,  -5, -42, -18, -60, -70, -64, -67,   7,  58,  43, -80,  11; D=-33;
/I:         I=-33; DM=-84;
/M: SY='D';  M=  28, -70,  62,   8, -78, -59,  10, -75,   5, -75, -69, -17, -65, -50,   7,  47,  26, -67, -85, -67;
/M: SY='T';  M=  -8,  50, -61, -64, -16,  -2, -65, -11, -61, -17, -59,  17, -31, -61, -27,  47,  65, -19, -82, -65;
/M: SY='V';  M= -57, -70, -73, -67, -56, -28,  27,   0,  17,  11,  -2, -67, -74,  -9, -27, -62,   7,  73, -80, -13;
/M: SY='K';  M= -57, -76, -54,  32, -77,  30, -61, -70,  64, -74, -66,  -4,  28, -48,   5, -10,   2,   2, -77, -70;
/M: SY='T';  M= -54,  60, -61, -62, -68, -68, -66, -16, -55, -63, -60,  14, -67, -60,  26,  21,  85,   9, -87, -66;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='G';  M= -57,  -3, -70, -75,   2,  81,   9,  -9, -67, -75, -70, -58,  -6, -68,   2, -56, -21, -74,  64, -64; D=-20;
/I:         I=-20; DM=-51;
/M: SY='I';  M= -66, -76, -82, -77,  37,  -1, -73,  53, -75,  35,  52, -75,  39, -73, -78, -71, -28, -26, -70, -53; D=-20;
/I:         I=-20; DM=-51;
/M: SY='M';  M=   8, -71, -65,  -5, -32,  65, -64, -60, -18, -60,  75, -57, -68, -59, -35,  18, -58,   5, -74, -24;
/M: SY='G';  M= -54,  30,  -2, -67, -12,  73, -63, -24, -61, -44, -67,  52, -71, -62,   1,   1, -59, -24, -78, -69;
/M: SY='Y';  M=  16,  13,  -4, -59, -21, -25, -59,   5,  29, -17,   9, -58, -70,   3,  12, -54,  42, -32, -65,  54;
/M: SY='W';  M=  -9, -73, -70,  -4,   9, -37,  -5,  26, -65,  29,  31,  -7, -72,   6, -68, -14,  30, -49,  95, -50;
/M: SY='G';  M= -30, -75, -61, -67, -79,  86, -65, -82,  11, -37, -70,  11, -69, -59,  14,   6, -62, -78, -75, -73;
/M: SY='N';  M= -62, -71, -44, -55, -75, -57,   9, -23,   7, -77, -66, 103,   9, -50,  31, -12,   6, -71, -89, -68;
/M: SY='K';  M= -60, -75, -56, -44, -77, -68, -59, -72, 104, -75, -64, -49, -64, -42, -27,   9, -55, -11, -74, -65;
/M: SY='G';  M= -50, -77, -65, -76, -14, 102, -71, -88, -70, -83, -74, -51, -69, -68, -77, -50, -68, -83, -72, -74;
/M: SY='A';  M=  60,  11, -68, -65,  41,  35, -66, -64, -65, -64, -62, -59, -70,  -3, -68,  30, -54, -20, -67,  -1;
/M: SY='V';  M= -56, -69, -84, -78, -51, -84, -79,  46, -75,   1,  59, -77, -77, -74, -76, -69, -54,  83, -82, -58;
/M: SY='G';  M=  41, -69, -63, -63, -73,  49,  12, -65, -59, -67,  26,  -7, -68,  -3,  -1,  32,  10,  -2, -79, -67;
/M: SY='I';  M= -36, -69, -76, -73,   8, -81, -77,  60, -68, -15, -26, -68, -72, -71, -17, -59,  53,  58, -78, -57;
/M: SY='R';  M= -55,  11, -58, -25, -76, -64, -55, -79, -36, -76, -66,  -4, -70,   4,  89,  66, -51, -72, -79, -65;
/M: SY='W';  M= -69, -75, -88, -80,  82, -28, -70,  12, -74,  17,  76, -78, -79, -74, -74, -74, -67, -50, 104, -33;
/M: SY='M';  M= -31,  43, -12,  -3, -66, -69, -59, -57,  24,  15,  48,  22, -70,  41,   4,   6,  22, -15, -80, -63;
/M: SY='F';  M= -34, -72, -80, -22,  68, -83, -68,  33, -74,  38,  -7, -77, -80, -73, -74, -71, -61,  33, -58,  36;
/M: SY='H';  M=   0,  -5,  18,  -4,  35, -27,  87, -68, -59, -29, -58,  51, -73, -56, -61, -32, -60, -69, -65,  60;
/M: SY='N';  M= -14, -75,  51,   7, -79,  49, -57, -80, -32, -80, -72,  54, -67,  34, -61,   9, -18, -77,  35, -69;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='T';  M= -58,  30, -59, -15, -66, -71,  -1, -32,  28, -67, -62, -52, -65,   0,   4, -12,  87, -59, -78,  20; D=-19;
/I:         I=-19; DM=-47;
/M: SY='S';  M=  -9, -70, -26, -59, -33, -35, -61, -15,   0, -68,  -3, -52, -28, -53,  27,  78,  -4, -13, -78,  -3; D=-19;
/I:         I=-19; DM=-47;
/M: SY='F';  M= -72, -73, -88, -82,  97, -85, -68,  21, -78,  16,  58, -78, -83, -80, -76, -75, -66, -17, -52,  -1; D=-19;
/I:         I=-19; DM=-47;
/M: SY='C';  M= -58, 119,  37, -67, -73,  26, -72, -71, -71, -17, -67, -58, -80, -71, -77,  20, -59, -13, -92, -76; D=-19;
/I:         I=-19; DM=-47;
/M: SY='F';  M= -73, -73, -88, -84, 109, -85, -70,  10, -80, -10, -49, -79, -86, -86, -77, -75, -66,   4, -47,  11; D=-19;
/I:         I=-19; DM=-47;
/M: SY='V';  M= -57, -70, -84, -79, -54, -86, -85,  54, -76,  -7, -42, -78, -78, -77, -79, -68,  -4,  83, -84, -61; D=-19;
/I:         I=-19; DM=-47;
/M: SY='N';  M= -60,  91, -12, -63, -76, -20, -56, -74, -58, -77, -70,  94, -75, -60, -66,  -8,  31, -43, -96, -75; D=-19;
/I:         I=-19; DM=-47;
/M: SY='C';  M=  -3,  96, -66, -66, -70, -62, -69,  -8, -66, -19, -64, -55, -72, -62, -70,  75,  16, -59, -87, -70; D=-19;
/I:         I=-19; DM=-47;
/M: SY='H';  M= -71, -82, -56, -56, -68, -74, 142, -10, -58, -67, -54, -46, -72, -50,  -3, -61, -69, -78,-101, -40; D=-19;
/I:         I=-19; DM=-47;
/M: SY='L';  M= -69, -71, -87, -79,  46, -86, -68, -36, -79,  79,  45, -83, -85, -73, -76, -78, -65, -43, -66, -47; D=-19;
/I:         I=-19; DM=-47;
/M: SY='T';  M=  48, -67, -64, -63,  20, -61, -68, -24, -63, -66, -63,  -6,  29, -62, -69,  34,  62, -56, -77, -63; D=-19;
/I:         I=-19; DM=-47;
/M: SY='A';  M=  59, -69,  -3, -57, -77, -56,  57, -73, -61, -74, -66, -54,  35, -56, -65,  56,  -9, -64, -84, -66; D=-19;
/I:         I=-19; DM=-47;
/M: SY='H';  M= -60, -81,  38,  -8, -83,  73,  81, -91, -32, -84, -73,  -3, -71, -60, -68, -56, -68, -87, -87, -67; D=-19;
/I:         I=-19; DM=-47;
/M: SY='Q';  M=   9, -77,  20,  33, -73, -40, -15, -24, -57, -10,  14,  30, -13,  52, -61,   6, -42, -16, -82, -21; D=-19;
/I:         I=-19; DM=-47;
/M: SY='E';  M= -57, -76,   0,  53, -78,   0, -60, -76,  23, -77, -71,   0, -66, -12,   0,  51, -11, -18, -82, -27; D=-19;
/I:         I=-19; DM=-47;
/M: SY='N';  M= -11, -75,   9,  34, -80, -65, -55, -74,  48, -77, -68,  68,  10,  16,  -7, -53,  -4, -27, -84, -71; D=-19;
/I:         I=-19; DM=-47;
/M: SY='V';  M= -15, -70, -68, -68, -16,   6, -64,   7,   6,  15, -49,  14, -74, -63, -32,   9,  -3,  45, -69,  41;
/M: SY='D';  M=  18, -72,  62,  22, -71, -27,  25, -66,   8, -11, -63,  36, -67, -52, -26, -26,   7, -11, -84, -24;
/M: SY='E';  M=  -2, -78, -19,  66, -79, -10, -53, -78, -12, -35, -65,  23, -65,  47,  60, -54, -60, -73, -78, -68;
/M: SY='R';  M= -66,  31, -65, -31, -68, -76, -57, -12, -33, -17, -60,  -7, -75, -19, 100, -61,  -6, -67,  53, -60;
/M: SY='N';  M= -63, -73, -21,  16, -70, -65,  26, -64,  33,   8, -58,  82, -71,  14,  28, -54, -55, -13, -83, -64;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='Q';  M=  10, -72,  20,  37, -69, -62,  18, -69, -13, -12,  -8,  27, -66,  50, -55,  41, -21, -67, -77,   9;
/M: SY='D';  M=  13, -75,  90,  22, -81, -61,  10, -74, -53, -77, -72,  53, -67,  -5, -60, -52, -55, -13, -93, -69;
/M: SY='Y';  M= -25, -75, -73, -74,  60, -76, -51, -46, -68, -17, -49,   6, -11, -68, -68, -65, -61,  29, -42, 101;
/M: SY='N';  M=   6, -72,  28, -29, -29, -64,  22, -25,  24, -14,  24,  32, -68,  28,  18,  23,   2, -51, -78, -24;
/M: SY='H';  M= -61, -75,  30,  45, -67, -12,  64, -73, -49, -34, -63,  17, -66, -48,  32, -13,  44, -69, -78,  26;
/M: SY='I';  M= -63, -76, -78, -76, -51, -85, -76,  94, -66, -38, -40, -15, -74, -68,  21, -67,   3,  11, -73,  -1;
/M: SY='L';  M=   2,  25, -75, -68, -13, -76,   9,   0, -61,  55,  13, -69, -78, -62,  34,  -7, -19, -15, -70,  19;
/M: SY='R';  M= -20, -77,  22, -12, -78, -66,  39, -80,  39, -76, -65,  20, -68,  43,  69,  17, -57, -75, -80, -62;
/M: SY='K';  M=  -9,   8, -58, -14,   3, -23,  38, -67,  49,  -4, -14,  33, -70, -23,  33,   4, -16, -66, -72,  10;
/I:         I=-8; MD=-21;
/M: SY='M';  M=  -3, -73, -74,  -4,  -7, -79, -68,   5, -67,  48,  52, -71, -76,   2, -17, -36,  29, -16, -77, -59; D=-8;
/I:         I=-8; MD=-21;
/M: SY='S';  M=  -9,  22, -26, -15,   4, -69, -65, -61, -17,  -9, -61, -27,  -6,  27,  28,  42,   9,   9, -80, -64; D=-8;
/I:         I=-8; MD=-21;
/M: SY='F';  M= -75, -14, -87, -83,  88, -16, -74, -57, -22,  27, -55, -78, -89, -81, -19,  -8, -71, -61, -61, -41; D=-8;
/I:         I=-8; MD=-21;
/M: SY='P';  M= -18, -22, -73, -21,   6,  15, -17, -73, -70, -13, -68, -70,  70, -16, -35,  10, -19, -54, -77,  13; D=-8;
/I:         I=-8; MD=-21;
/M: SY='R';  M= -68, -84,  22, -29, -77, -12, -67,  -7,  -7, -21,  10,  -7,  -5, -15,  55,   2, -65,   0, -88, -72; D=-8;
/I:         I=-8; MD=-21;
/M: SY='G';  M= -73, -93, -17, -33, -92,  38, -17, -47,  10, -60, -81,  10,  11, -29,  -8, -27, -75,  -6, -96, -86; D=-8;
/I:         I=-8; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='Q';  M= -33, -20, -25,   8, -90, -13, -80, -86,  -8,  -1, -78, -33, -89,  18,   2, -10,  -3, -84, -99, -86; D=-8;
/I:         I=-8; DM=-21;
/M: SY='L';  M= -30, -93,   8,  17, -78, -44,  10, -75, -27,  30, -69, -78, -90, -45, -41, -10, -47, -61, -96, -30; D=-8;
/I:         I=-8; DM=-21;
/M: SY='S';  M= -46, -88,  11, -41, -91,  -3, -74, -89, -31, -59, -83, -12,   0, -28,  29,  50, -36, -51, -97, -83; D=-8;
/I:         I=-8; DM=-21;
/M: SY='P';  M=   8, -81, -15, -68, -18, -38, -74,   2, -26,   8, -62, -24,  60, -16, -75,  17, -12, -25, -84, -72; D=-8;
/I:         I=-8; DM=-21;
/M: SY='R';  M= -38, -78, -27,  24,  32, -40, -13,  -8,  37, -21,  -8, -28,  30,   0,  38,   3, -60, -43, -72, -58; D=-8;
/I:         I=-8; DM=-21;
/M: SY='D';  M= -62, -75,  62,  29, -77, -32, -15, -73,  18, -37,  19,  48, -67, -51,  -1, -14,  34, -71, -88, -68; D=-8;
/I:         I=-8; DM=-21;
/M: SY='I';  M= -65, -77,  12, -69, -22, -83, -72,  78, -16,  -3, -43, -11, -76,  10, -71, -69, -59,  28, -73,  17; D=-8;
/I:         I=-8; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='F';  M=  -2, -12,  10, -16,  37, -27,  26, -36,  -9,  17,  30,  14,   1, -17, -26, -13,   1, -60, -71,   4; D=-8;
/I:         I=-8; DM=-21;
/M: SY='D';  M= -45,  26,  48,  35, -81, -23,   8, -82,  21, -80, -72,  19,   3, -15,  40,  22, -57, -77, -86, -70; D=-8;
/I:         I=-8; DM=-21;
/M: SY='H';  M= -11, -74, -59,  -1,  57, -70, 112, -68,  -5, -61, -56, -52, -70, -54, -23,   8,   8, -29, -74, -40;
/M: SY='D';  M= -63,  32,  95,   9, -80, -66,  14, -74, -55, -76, -73,   3,  -8, -54, -18, -15,  21, -13, -96, -68;
/M: SY='H';  M= -16, -73, -62, -13,   1, -70,  78, -53, -35,  10,  19,  21, -73, -23,  27,   9, -57,  24, -73,  28;
/M: SY='V';  M= -27,  -1, -82, -77,  -5, -83, -75,  38, -75,  37, -39, -77, -79, -74, -76, -68, -23,  70, -73,  15;
/M: SY='F';  M= -35, -71, -86, -82, 101, -83, -72,  40, -78,  10, -44, -77, -82, -82, -77, -72, -63,   8, -51, -30;
/I:         I=-45; MD=-115;
/M: SY='W';  M= -74, -92,-100, -82,  33, -79, -96, -60, -76, -38, -66, -93, -83, -77, -78, -81, -80,  16, 163, -32; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='F';  M= -69,  55, -83, -79,  88, -82,  -5,  -5, -76,  47,  16, -75, -83, -78, -75, -71, -13, -47, -57, -36;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='D';  M= -53, -80, 116, -32, -87, -63, -53, -85, -54, -84, -83,  15, -67, -54, -63, -55, -57, -82,-103, -71;
/M: SY='F';  M= -70, -70, -86, -79,  87, -84, -67, -39, -78,  65,  25, -80, -84, -77, -75, -76, -65, -45, -55, -35;
/M: SY='N';  M= -62, -67, -35, -57, -77, -50, -43, -76, -48, -84, -70, 125, -73, -50, -56, -44, -47, -78, -96, -72;
/M: SY='Y';  M= -71,  32, -77, -77,  78, -80, -48, -52, -71, -48, -50, -74, -84, -70, -68, -69, -65, -13, -35, 111;
/M: SY='R';  M= -65, -82, -63, -52, -76, -75, -52, -82, -25, -75, -64, -56, -75, -40, 114,  -4, -63, -76, -76, -63;
/M: SY='I';  M= -63, -72, -85, -80, -46, -88, -78,  73, -78,  54, -34, -79, -79, -74, -78, -74, -58,  40, -75, -56;
/M: SY='D';  M=  -8,  -9,  76,  40,  -8,  -5, -56, -77, -53, -51, -71,  28, -66,   6, -35,  14,  -2, -72, -85, -66;
/M: SY='M';  M= -40,  32,  27,   7,  -8,   2, -63, -53, -64,  41,  50, -58, -71, -59, -68,  38,   9, -55, -77, -60;
/M: SY='P';  M= -58, -74,  30,  -1, -13, -20, -62,  12,  -4, -24, -61,   4,  50, -56, -15,  38,  26, -31, -77, -12;
/I:         I=-4; MD=-9;
/M: SY='S';  M=  -6, -77,  19, -33, -74, -12, -63, -16, -57, -76, -70,  35, -75, -59,  34,  41,  12, -29, -84,   9; D=-4;
/I:         I=-4; MD=-9;
/M: SY='Y';  M= -10, -74, -12,  25,  37, -46, -57, -55, -60,  -6, -55,   6, -22,   5, -17, -35,  15,   9,  37,  64; D=-4;
/I:         I=-4; MI=0; MD=-9; IM=0; DM=-9;
/M: SY='E';  M= -82, -98,  27,  35, -99,  -9,  32, -95, -73, -63, -88,  30, -88,  -3, -80, -37, -79, -32,-109, -87; D=-4;
/I:         I=-4; DM=-9;
/M: SY='E';  M= -24, -74,   6,  68,   4, -68,  22, -71,  24, -71, -66,  10,  11, -46, -53,  17,  24, -24, -79, -63;
/M: SY='V';  M=  29,  51, -76, -72, -58, -73, -79,  25, -69, -22, -49, -69, -74, -71, -38, -57,  33,  66,  37, -62;
/M: SY='R';  M= -63, -74, -28, -28, -16, -76,   7,  10,  46,  15, -51,   9, -72, -21,  55, -61, -13,  24, -76, -59;
/M: SY='D';  M=  -4, -74,  36,  29, -22,  -9, -56, -69,  28,  -6, -62,  30, -25,  14,   7,  14, -30, -44, -76,  -8;
/M: SY='L';  M= -19,  -8, -72, -39,  31, -76,  -5, -48,  16,  57, -43, -68, -77,  22,   9, -22, -62, -53,  19,  30;
/M: SY='I';  M= -61, -72, -84, -80, -49, -86, -81,  81, -77,  31, -36, -77, -77, -74, -78, -22, -56,  50, -77, -57;
/M: SY='K';  M= -22,  -7,  21,  32,   2, -22, -58, -68,  37, -71, -65,  27, -67,   8,  14,  37, -29,  -2, -78, -63;
/M: SY='Q';  M= -42, -76, -28, -20, -77, -66, -13, -74,  30, -45,   5,  49, -69,  74,  59,   0, -13, -72, -78, -63;
/M: SY='K';  M= -61, -76,  -5,   9, -79,   6,  14, -79,  59, -77, -66,  51, -66,  50,  34, -52,   2, -76, -79, -65;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='D';  M= -33,  10,  66,  29, -75, -67, -55, -75, -13, -45,   9,  40, -22,  27, -33, -11,   6, -73, -84,   8; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -72, -82, -78, -19,  43, -82,  43,  16, -65,  15, -52, -74, -80, -17,  17, -73, -70, -17, 109,  42; D=-9;
/I:         I=-9; DM=-22;
/M: SY='D';  M= -12, -79,  65,   7, -81, -42,   9, -78,  41, -25, -69, -20,  -2,  26,   9,   5, -59, -75, -85, -68; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M=  -4, -78, -12,  19, -70,  -7, -65, -38,  32, -70, -22, -59,   1,  18,  13,   8,   5,   0,  77, -19; D=-9;
/I:         I=-9; DM=-22;
/M: SY='L';  M= -69, -72, -86, -78, -44, -88,  -7, -35, -79,  86,  15, -84, -86, -72, -76, -79, -65, -23, -74, -55; D=-9;
/I:         I=-9; DM=-22;
/M: SY='L';  M= -39, -74, -85, -76,  18, -84, -69, -14, -43,  66,  45, -81, -83, -70,   0, -75, -65,  -2,  56, -10; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M=  11,  -5,  11,  67, -83, -67, -12, -81, -11, -78, -71,  -8,  -1,  47, -15,  27, -57, -74, -83, -71; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='W';  M= -38, -79, -66, -63,  48, -32,  64, -66,  39, -64, -60,   9, -76, -58,   4, -17, -28, -19,  65,  52; D=-9;
/I:         I=-9; DM=-22;
/M: SY='D';  M= -69, -83, 108,  10, -88, -67, -55, -88, -53, -86, -83,  12, -69, -54,   8, -58, -60, -84,-101, -73; D=-9;
/I:         I=-9; DM=-22;
/M: SY='Q';  M= -60, -85, -55,  12, -89, -70, -51, -74, -43, -72, -60, -53, -68, 122, -45, -16, -63, -27, -76, -64; D=-9;
/I:         I=-9; DM=-22;
/M: SY='L';  M= -70, -73, -33, -23,  -1, -87, -67, -38, -77,  82, -34, -82, -85, -71, -75, -77, -66, -45, -67,  25; D=-9;
/I:         I=-9; DM=-22;
/M: SY='N';  M= -63,  -5, -58, -60, -33, -70, -13,  -2,  27,  -7, -59,  63, -74,  -7,  40, -18,  26,  -2, -83, -65; D=-9;
/I:         I=-9; DM=-22;
/M: SY='Q';  M= -33, -78, -15, -16,   4, -79, -66,  28,  10,  17,  28, -15, -76,  31,  30, -32,   1, -28, -77, -60; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M=  17, -81,  14,  77, -84, -45, -59, -78, -49, -35, -69, -59, -66,  54,   1, -57, -64, -39, -83, -73; D=-9;
/I:         I=-9; DM=-22;
/M: SY='M';  M= -38, -81,  31, -55, -69, -77, -60, -10,  39, -11,  70, -60, -75,   8,  55, -66, -64, -33, -80, -24; D=-9;
/I:         I=-9; DM=-22;
/M: SY='K';  M=  -8,  14, -28,  28, -78, -45,  -5, -42,  48, -48, -14,  46, -71, -51,  29, -23,  -9, -30, -85, -70; D=-9;
/I:         I=-9; DM=-22;
/M: SY='E';  M=  20, -76, -13,  39, -79, -24, -12, -76,  38, -48, -67,  25, -68,  24,  29,  -9,  -6, -49, -81, -69; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -59, -81, -14, -19, -81,  76,   5, -86, -16, -37, -73,  -4, -73,  -4,   2, -31, -18, -82,  22, -73; D=-9;
/I:         I=-9; DM=-22;
/M: SY='K';  M= -19, -24,  10,  12, -79, -69,  11, -75,  50, -49, -67,  17,  -1,  29,  29,  -3,  20, -47, -83, -68; D=-9;
/I:         I=-9; DM=-22;
/M: SY='V';  M=  33, -71, -72,   4, -61, -38, -76,  44, -70,   3, -48, -11, -75, -68, -74, -35, -26,  53, -82, -65; D=-9;
/I:         I=-9; DM=-22;
/M: SY='F';  M= -76, -74, -89, -83, 111, -85, -70, -49, -81,  18, -49, -80, -11, -88, -78, -77, -69, -55, -47, -26; D=-9;
/I:         I=-9; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='K';  M= -53, -79,  37,   2,  -7, -11,  -5, -25,  41,  -8,  11, -55,  -6,  38,  34, -37, -62, -23, -77, -62; D=-9;
/I:         I=-9; DM=-22;
/M: SY='G';  M= -55, -77,   2, -20, -32,  77,  10, -85, -58, -81, -72,  12, -70, -20,  20,  13, -26, -80, -77, -24; D=-9;
/I:         I=-9; DM=-22;
/M: SY='W';  M= -73, -75, -89, -80,  98, -81, -69, -47, -76,  22,  46, -80, -83, -78, -74, -75, -69, -54, 103,   1;
/M: SY='H';  M= -42, -74, -56,   6, -11, -68,  56, -64,  18, -35,  -6,  14, -69,  51,  13,  18,  18,  -9, -69,  42;
/M: SY='E';  M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74;
/M: SY='G';  M=   8, -76, -62,  24, -72,  62, -66, -67, -63,  12,  22, -61,  58,  -7, -69, -56, -62, -67, -75, -71;
/M: SY='E';  M= -24, -76,  15,  49, -12, -69,  10, -12,  28, -38, -63,  21,  33,  37, -27, -54,  24, -66, -79, -64;
/M: SY='I';  M= -63, -74, -85, -81, -47, -89, -81,  88, -78,  36, -35, -78, -77, -75, -80, -73, -58,  36, -75, -57;
/M: SY='T';  M= -57, -69, -11, -57, -12, -34,  29, -64,   4, -32,  -6,  28, -67,  11,   1,  17,  72, -61, -72,  39;
/M: SY='F';  M= -76, -71, -88, -83, 122, -83, -67, -49, -79, -40, -51, -77, -86, -89, -76, -74, -67, -54, -40,  -2;
/M: SY='P';  M=  43, -77, -66, -19, -11, -28, -67, -38,   3, -17, -62, -66,  93, -15, -18, -56, -58, -52, -75, -70;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='T';  M= -51, -61, -57, -60, -68, -66, -67, -60, -57, -64, -61, -46, -59, -60, -65,  18, 111, -52, -88, -66;
/M: SY='Y';  M= -71, -82,   2, -70,   1, -77, -38, -57, -65, -54, -51, -69, -82, -61, -63, -66, -65, -62, -29, 131;
/M: SY='K';  M= -64, -80, -58, -45, -80, -70, -59, -79,  94, -79, -66, -53,  55, -43,  41, -59, -59, -76, -74, -68;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='Y';  M= -71, -78, -78, -77,  76, -79, -50, -51, -70, -49, -51, -75, -84, -70, -68, -70, -66,  -3,  67, 109;
/M: SY='D';  M= -58, -76,  79,  57, -81, -64, -55, -79,  11, -78, -74, -12, -63, -17, -32,  39, -15, -44, -88, -69;
/M: SY='R';  M= -41, -76, -62,  26, -32, -75, -62,  12, -31,   7, -53,  -2,  38, -23,  56, -28,  -7,  20, -75,  -5;
/M: SY='G';  M= -57, -74,  32, -15,  18,  66,  37, -77, -27, -35, -68,  58, -70, -58, -65, -14, -60, -76, -78, -62;
/M: SY='S';  M= -32, -68, -57, -14, -75, -59, -61, -70,  -3, -74, -67, -49,  41, -20,   7,  76,  57, -64, -82, -68;
/M: SY='D';  M= -18, -75,  72,  13, -80,  -2, -56, -79,  -2, -78, -72,  23, -12, -13,  34,  14,  16, -74, -86, -69;
/I:         I=-16; MD=-40;
/M: SY='D';  M= -10, -76,  58,  23,   3,  -8, -56, -27, -22, -49, -68,  51, -69,  26,   3, -14,   2, -70, -83, -65; D=-16;
/I:         I=-16; MD=-40;
/M: SY='Y';  M= -66,  -5, -71, -70, -11,  12,  15, -63, -20, -16, -56, -66, -79,  -8, -30, -21,  -9, -66,  73, 104; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='D';  M=  -7, -79,  90,  28, -84, -22,  -7, -83,  19, -61, -75,  -1, -11, -51, -14, -27, -58, -78, -91, -71; D=-16;
/I:         I=-16; DM=-40;
/M: SY='T';  M= -53, -68, -57,   7, -72, -41, -64, -66, -16, -25, -63, -51,   5,  13, -12,  45,  83, -60, -84, -67; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='S';  M= -53, -71, -29, -34,   6,  32, -60, -69,  13, -13, -64,  -3, -32, -56, -61,  67,  -7, -67, -69,  33; D=-16;
/I:         I=-16; DM=-40;
/M: SY='M';  M=   8, -73,  25,  60, -69, -34,  -3,  -4, -33, -57,  70,   6, -65, -50, -60,   7, -55,  14, -82, -64;
/I:         I=-38; MD=-97;
/M: SY='K';  M= -64, -79, -57, -47, -80, -16, -59, -81,  94, -80, -68,   9, -29, -10,  28, -57, -14, -76, -76, -68; D=-38;
/I:         I=-38; MI=-97; MD=-97; IM=-97; DM=-97;
/M: SY='C';  M= -43,  63, -61,  -2, -69, -74,  -9, -33,  55, -68, -14, -55, -69,  29,  15, -54,  52, -35, -77,  13; D=-38;
/I:         I=-38; DM=-97;
/M: SY='R';  M= -68, -83, -58,   0, -78, -75, -53, -84, -29, -78, -67,  36, -76, -43, 106, -60, -65, -79, -80, -66; D=-38;
/I:         I=-38; DM=-97;
/M: SY='T';  M=  26,  59, -70, -67, -62, -37, -74,  21,  -4, -15, -52, -62, -70, -66, -34, -52,  59,  41, -83, -65;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='A';  M=  81, -62, -63, -59, -75, -49, -65, -68, -60, -70, -64, -55, -65, -55, -65,  66, -45, -56, -78, -69;
/M: SY='W';  M= -75,-100,-101, -80, -39, -74, -95, -72, -72, -70, -72, -94, -79, -71, -75, -81, -86, -86, 176,  27;
/M: SY='C';  M= -57, 127, -69, -70, -70, -73, -73, -69, -63, -67, -65, -57, -75, -71,  -1, -50,  78, -59, -94, -73;
/M: SY='D';  M= -66, -80, 117, -32, -87, -63, -53, -85, -55, -84, -83, -35, -67, -54, -63,  -3, -56, -82,-102, -70;
/M: SY='R';  M= -67, -83, -63, -51, -76, -77, -52, -83, -24, -75, -64, -56, -75, -40, 117, -61, -66, -76, -76, -62;
/M: SY='I';  M= -17, -73, -84, -81, -51, -86, -85,  92, -77, -35, -38, -76, -75, -75, -80, -69, -56,  55, -77, -59;
/M: SY='L';  M= -67,  -1, -85, -77, -42, -86, -70,  23, -78,  86, -29, -82, -83, -71, -76, -77, -63, -37, -72, -54;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='W';  M= -40, -85, -84, -76,  22, -75, -63,  -4, -69, -55,  43, -79, -79, -67, -70, -23, -71, -63, 141,  87;
/M: SY='K';  M= -63, -76, -55, -49, -44, -67,  15, -76,  73, -52, -64,  44, -69, -44,  61,  -5, -25, -74,  27,  -1;
/M: SY='G';  M= -19, -73,  15, -58, -73,  54, -61, -34,  -4, -22, -65,  -3,  -9,  15,   1,  49, -54, -34, -76, -17;
/M: SY='Y';  M= -23, -75,   8,  20, -62, -15, -42, -46,  34, -72, -64,  37, -68,   8,  37,  19, -10, -70, -67,  54;
/M: SY='P';  M=  29, -73, -23, -56, -29,  31,  16, -71,   6, -47, -63,  21,  45,  29,   8, -50,  22, -41, -78, -67;
/M: SY='M';  M= -61,  15, -25,   3, -60, -18,   3,  20,  21,   8,  35, -61,  12,  11,  11, -25,   3,   4,  27,  -1;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='P';  M= -60, -77, -20,  32, -75, -15,  24, -45,  23, -73, -13,  12,  50, -13,  10,  20,  20, -26, -80, -15; D=-11;
/I:         I=-11; DM=-29;
/M: SY='H';  M= -63, -14,  -8, -57,  -9,   8,  64, -30,  -3,  23, -54,   1,  -2,  57, -59, -21,  13, -64, -77, -17; D=-11;
/I:         I=-11; DM=-29;
/M: SY='L';  M= -49,  -8,  -1, -27,   9, -26, -16,  12, -41,  14, -64, -80, -91, -32, -85,  -8, -75,   5, -89, -30; D=-11;
/I:         I=-11; DM=-29;
/M: SY='H';  M=   5, -20, -81, -10, -95, -51,  26, -90, -30, -27, -83,   3, -24, -20, -27,   9, -44, -45,-106, -88; D=-11;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='I';  M= -28,  13, -92, -88, -84,  -8, -93,  28, -11, -36, -72, -83,   6, -85, -88,  12, -74,  10, -99, -86; D=-11;
/I:         I=-11; DM=-29;
/M: SY='T';  M= -73,  17, -80, -24, -87,  11, -85, -11, -80, -52, -76,  -9, -88,  18, -85,   3,  26,   9,-101, -86; D=-11;
/I:         I=-11; DM=-29;
/M: SY='C';  M= -36,  68, -89, -84, -79, -92, -86, -26, -85,   1, -72, -12,  36,   1, -90, -78,   0, -19, -96,  -5; D=-11;
/I:         I=-11; DM=-29;
/M: SY='H';  M= -77, -86, -80, -75,  -9, -88,  43, -26, -43,  32,  10,  -3, -88,  28, -38, -43,   9, -38, -83,  16; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Y';  M= -66, -83, -71, -16, -63, -45, -19, -74, -18,  -8,  -2, -17, -82, -14, -71,  59, -61, -74, -73,  61; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Y';  M= -77, -91,  -1, -75, -43, -14,  21, -72, -69, -70, -66, -23, -89, -68,   7, -37, -74, -28,   6, 103; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Y';  M= -59, -76,  14, -23, -48,  16,  28, -66, -33, -18, -59,   3,  -8, -14,  -3,  34, -17, -42, -57,  84;
/M: SY='S';  M=  -8,  56, -28, -63,  13,  -9, -66,   3, -16, -61, -59, -10, -71, -20,   8,  58,  -6,  27, -78, -61;
/M: SY='C';  M= -22,  61, -15, -60, -71,  23,  53, -34, -12, -25, -61,  -9, -71, -55,  56,   7,  27, -36, -83, -63;
/M: SY='M';  M=   3,  -5,  27,   8, -68,   8, -58, -61, -21, -59,  83,  26,  37, -56, -63,   4,   6, -36, -79, -15;
/M: SY='E';  M=  16, -76,  59,  66, -80, -19, -56, -23, -17, -75, -70,  31,   6, -10, -58, -26, -30, -70, -84, -71;
/M: SY='I';  M= -28, -72, -13,  -4, -48, -78, -66,  54, -68,  36, -42, -68, -74, -26, -71,   5,  -1,  25, -69,  40;
/M: SY='C';  M= -61,  64, -66, -58, -21, -45, -60, -58,  56,  -3,  23, -58, -72,  -7,  24, -35,  29,   0, -69,  37;
/M: SY='T';  M=  13,  -4, -34, -13,  42, -37, -66,  22, -64,  -6,  35, -60, -69,   6, -68, -52,  65, -23, -70, -15;
/M: SY='S';  M= -43, -66, -57, -60, -75,  34, -61, -75, -59, -78, -71, -45, -64, -52, -64,  98,   1, -68, -81, -68;
/M: SY='D';  M= -67, -81, 114,  13, -88, -65, -53, -85, -53, -83, -81, -37, -66,  15, -61, -55, -58, -82, -99, -70;
/M: SY='H';  M= -67, -80, -53, -53, -68, -69, 146, -85, -58, -69, -54, -43, -69, -47, -52,  -4, -65, -84,-102, -38;
/M: SY='R';  M= -60, -77, -59, -48, -76, -69, -56, -77,  72, -39, -64, -51, -68,   3,  78,  32, -56, -72, -75, -64;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='P';  M= -66, -91,   3, -53, -86, -68, -69, -74, -62, -84, -71, -70, 125, -66, -75, -63, -59, -79, -80, -83;
/M: SY='V';  M= -53, -66, -83, -77, -53, -84, -84,  -7, -75,  -7, -41, -79, -79, -77, -76, -67, -51, 100, -87, -61;
/M: SY='F';  M= -33,  10, -69, -67,  53, -11,  29, -54, -14,   6,   9,  -8, -75, -28,   2,  10,   6,  -7,  19,  52;
/M: SY='A';  M=  67,  53, -67, -65, -68,  27, -67, -63, -65,  16, -57,   9, -71, -62, -70,  10, -54, -56, -78, -69;
/M: SY='T';  M=   2, -68, -26, -64, -57, -25, -69,  26,  11,  36,   7, -61, -70, -24, -47, -54,  61,   5, -78, -61;
/M: SY='F';  M= -72, -72, -86, -82, 110, -83, -66,  -3, -78,  -1, -47, -77, -85, -84, -75, -73, -65,  -2, -44,  30;
/M: SY='R';  M= -41,  11,  19,  46, -73, -69,  47, -52, -21, -34, -16,   5, -68,  -3,  60,  19, -29, -13, -83, -63;
/M: SY='V';  M=  29, -67, -79, -73, -54, -74, -74,  37, -71,  23,  48, -72, -74, -69, -73, -29,  -8,  60, -79, -60;
/M: SY='E';  M= -23, -78,  -2,  40, -75,  32, -18,  -8,  33, -45, -17,   4,  18, -10, -29, -55,  16, -68,  38, -68;
/I:         I=-42; MD=-106;
/M: SY='V';  M= -14, -78, -85, -79, -19, -85, -84,  45, -75,  -3, -49, -81,  26, -77, -19, -71, -29,  61,  18, -64; D=-42;
/I:         I=-42; MD=-106;
/M: SY='T';  M=  -7, -80, -18,  21,  11, -13, -70, -36,   7, -74, -70, -29, -13,  -9,  15,   4,  35, -20, -83, -69; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='S';  M=   9, -76, -68,  -4,   3, -71,  16, -60, -15, -49,  -6, -21,  18, -62,  -2,  35,   9,  27, -84, -66;
/M: SY='V';  M= -14,  29, -75, -70, -15,  24, -75, -53, -25, -10, -60, -43, -79,  33, -26,  -3,  -1,  46, -84, -69;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_02 which contains 575'503 sequence entries.

Total number of hits	63 in 63 different sequences
Number of true positive hits	63 in 63 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	5-PPase
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

63 sequences

I5P1_CAEEL  (Q17848), I5P1_CANLF  (Q29467), I5P1_HUMAN  (Q14642),

I5P1_MOUSE  (Q7TNC9), I5P1_RAT(D3ZZX1), I5P2_CAEEL  (P34370), 
I5P2_HUMAN  (P32019), I5P2_MOUSE  (Q8K337), INP51_YEAST (P40559), 
INP52_YEAST (P50942), INP53_YEAST (Q12271), INP54_YEAST (Q08227), 
INP5E_DROME (Q9VTW2), INP5E_HUMAN (Q9NRR6), INP5E_MOUSE (Q9JII1), 
INP5E_PANTR (A0FI79), INP5E_RAT   (Q9WVR1), INP5K_HUMAN (Q9BT40), 
INP5K_MOUSE (Q8C5L6), IP5P1_ARATH (Q84MA2), IP5P2_ARATH (Q9FUR2), 
IP5P3_ARATH (Q8H0Z6), IP5P4_ARATH (Q8GTS0), IP5P5_ARATH (Q66GQ6), 
IP5P6_ARATH (Q9LR47), IP5P7_ARATH (Q0WQ41), IP5P8_ARATH (Q0WT19), 
IP5P9_ARATH (Q9SIS4), IP5PA_ARATH (A8MR21), IP5PB_ARATH (Q5EAF2), 
IP5PC_ARATH (O80560), IP5PD_ARATH (Q9SYK4), IP5PE_ARATH (Q9SKB7), 
IP5PF_ARATH (Q84W55), NP_CIMLE(O76745), OCRL_HUMAN  (Q01968), 
OCRL_MOUSE  (Q6NVF0), OCRL_RAT(D3ZGS3), PI5PA_HUMAN (Q15735), 
PI5PA_MOUSE (P59644), PI5PA_RAT   (Q9JMC1), SHIP1_HUMAN (Q92835), 
SHIP1_MOUSE (Q9ES52), SHIP1_RAT   (P97573), SHIP1_XENLA (Q6P4S2), 
SHIP2_CANLF (A0A8I3NFE2), SHIP2_HUMAN (O15357), SHIP2_MOUSE (Q6P549), 
SHIP2_PIG   (D7PF45), SHIP2_RAT   (Q9WVR3), SHP2A_DANRE (Q2I6J1), 
SHP2B_DANRE (Q2I6J0), SYJ1_SCHPO  (O43001), SYJ2_SCHPO  (Q9USQ6), 
SYNJ1_BOVIN (O18964), SYNJ1_HUMAN (O43426), SYNJ1_MOUSE (Q8CHC4), 
SYNJ1_RAT   (Q62910), SYNJ2_HUMAN (O15056), SYNJ2_MOUSE (Q9D2G5), 
SYNJ2_RAT   (O55207), SYNJ_CAEEL  (G5ECL2), YE8A_SCHPO  (O14306)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

127 PDB

pdb_00001i9y; pdb_00001i9z; pdb_00001ntf; pdb_00001si6; pdb_00001y21; pdb_00001yjh; pdb_00002imq; pdb_00002xsw; pdb_00003mtc; pdb_00003n9v; pdb_00003nr8; pdb_00004a9c; pdb_00004cml; pdb_00004cmn; pdb_00004l1y; pdb_00004l1z; pdb_00004l20; pdb_00004l21; pdb_00005a7i; pdb_00005a7j; pdb_00005okm; pdb_00005okn; pdb_00005oko; pdb_00005okp; pdb_00005rw2; pdb_00005rw3; pdb_00005rw4; pdb_00005rw5; pdb_00005rw6; pdb_00005rw7; pdb_00005rw8; pdb_00005rw9; pdb_00005rwa; pdb_00005rwb; pdb_00005rwc; pdb_00005rwd; pdb_00005rwe; pdb_00005rwf; pdb_00005rwg; pdb_00005rwh; pdb_00005rwi; pdb_00005rwj; pdb_00005rwk; pdb_00005rwl; pdb_00005rwm; pdb_00005rwn; pdb_00005rwo; pdb_00005rwp; pdb_00005rwq; pdb_00005rwr; pdb_00005rws; pdb_00005rwt; pdb_00005rwu; pdb_00005rwv; pdb_00005rww; pdb_00005rwx; pdb_00005rwy; pdb_00005rwz; pdb_00005rx0; pdb_00005rx1; pdb_00005rx2; pdb_00005rx3; pdb_00005rx4; pdb_00005rx5; pdb_00005rx6; pdb_00005rx7; pdb_00005rx8; pdb_00005rx9; pdb_00005rxa; pdb_00005rxb; pdb_00005rxc; pdb_00005rxd; pdb_00005rxe; pdb_00005rxf; pdb_00005rxg; pdb_00005rxh; pdb_00005rxi; pdb_00005rxj; pdb_00005rxk; pdb_00005rxl; pdb_00005rxm; pdb_00005rxo; pdb_00005rxp; pdb_00005rxq; pdb_00005rxr; pdb_00005rxs; pdb_00005rxt; pdb_00005rxu; pdb_00005rxv; pdb_00005rxw; pdb_00005rxx; pdb_00005rxy; pdb_00005rxz; pdb_00005ry0; pdb_00005ry1; pdb_00005ry2; pdb_00005ry3; pdb_00005ry4; pdb_00005ry5; pdb_00005ry6; pdb_00005ry7; pdb_00005ry8; pdb_00005ry9; pdb_00005rya; pdb_00005ryb; pdb_00005ryc; pdb_00005ryd; pdb_00005rye; pdb_00005ryf; pdb_00005ryg; pdb_00005ryh; pdb_00005ryi; pdb_00005ryj; pdb_00005ryk; pdb_00005ryl; pdb_00006dlg; pdb_00006ibd; pdb_00006squ; pdb_00006srr; pdb_00006xy7; pdb_00007a0v; pdb_00007a17; pdb_00008pdg; pdb_00008pdh; pdb_00008pdi; pdb_00008pdj; pdb_00008um5
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