ProRule PRU01427
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01427
General rule information
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| Accession | PRU01427 |
| Dates | -- (Created)
-- (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52082; 5_PPASE |
Name | 5-phosphatase (5-PPase) domain |
| Function | The inositol polyphosphate 5-phosphatases (5-phosphatases or 5- PPases) form a family of Mg(2+)-dependent enzymes that catalyse the hydrolytic removal of the phosphate group on the 5-position of lipid-bound and soluble inositol phosphates. Members of this family share the catalytic 5-PPase domain. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9BT40; |
Propagated annotation
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Comments
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| case <FTTag:act_site> and <FTTag:Mg> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
Keywords
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| Hydrolase | |
| Metal-binding | |
| Magnesium | |
| end case | |
Gene Ontology
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| GO:0046856; Biological process:phosphatidylinositol dephosphorylation |
| GO:0052745; Molecular function:inositol phosphate phosphatase activity |
Features
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| From: PS52082 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="5-PPase #" | |||||||||
| BINDING | 16 | 16 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" /ligand_label="#1" |
N | ||||||||
| BINDING | 46 | 46 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic" /ligand_label="#1" |
Mg | [ED] | |||||||
| ACT_SITE | 190 | 190 | /note="Proton acceptor" | act_site | D | |||||||
Additional information
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| Size range | 281-516 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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