PROSITE entry PS52085
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PURL: https://purl.expasy.org/prosite/signature/PS52085
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General information about the entry
| Entry name [info] | HERC2_LIKE |
| Accession [info] | PS52085 |
| Entry type [info] | MATRIX |
| Date [info] |
10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE; 10-JUN-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52085 |
| Associated ProRule [info] | PRU01430 |
Name and characterization of the entry
| Description [info] | HERC2-like domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=67; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=67; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8764880; R2=0.0078268; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1038; N_SCORE=11.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=463; N_SCORE=6.5; MODE=1; TEXT='R?'; /DEFAULT: M0=-58; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='V'; M= -28,-109,-118,-113, -95,-119, 13, 56,-109, -29, -83,-111,-115,-109, -7, 4, -92, 84,-122, -99; /I: I=-12; MD=-29; /M: SY='G'; M= -16,-117,-105,-114,-124, 103,-112,-130, -18,-126,-115, -92,-109,-107,-114, -90,-108,-123,-115,-118; D=-12; /I: I=-12; DM=-29; /M: SY='D'; M= -28,-124, 110, -19,-131,-108, -96,-127, -95,-124,-120, -82,-110, 58,-102, -97,-102,-124,-138,-112; D=-12; /I: I=-12; MD=-29; /M: SY='W'; M=-108,-122,-115, -18, 9,-119, -8, -20, 31, -1, -99,-110,-117,-101, 38, -18, -14, 17, 118, -90; D=-12; /I: I=-12; MD=-29; /M: SY='V'; M= -96,-110,-125,-120, -98,-127,-128, -12,-118, -83, -86,-120,-121,-120,-120,-108, -15, 103,-131,-105; D=-12; /I: I=-12; MD=-29; /M: SY='R'; M=-108, 39,-104, -95,-114,-117, 39,-118, 40,-115,-106, 0,-117, 13, 91,-103,-106, -27,-119, 2; D=-12; /I: I=-12; MD=-29; /M: SY='V'; M=-104, 38,-127,-121, 14,-126,-118, 49,-119, 37, 43,-119,-122,-117,-119, -25,-101, 52,-118, -97; D=-12; /I: I=-12; MD=-29; /M: SY='K'; M=-106, 30, -6, -94,-113,-116, 16, 6, 73, -18,-101, -96,-111, -10, 33, -99, 42,-103,-122,-106; D=-12; /I: I=-12; DM=-29; /M: SY='D'; M= 25, 18, 59, 6,-107, -38,-102,-103, -30, 14,-100, -97, 20, -14, 6, -96, 14, -29,-118, 15; D=-12; /I: I=-12; MD=-29; /M: SY='D'; M= -29,-114, 82, -43,-122, 22, -96,-122, -95,-123,-116, 57,-109, -94, -18, 54, -92,-117,-131,-112; D=-12; /I: I=-12; MD=-29; /M: SY='V'; M= -29,-114,-121,-116, -93,-122,-115, 51,-112, 30, 11,-115, -8,-111, -15, -19, -11, 54,-117, 5; D=-12; /I: I=-12; MD=-29; /M: SY='D'; M= -20,-145, 46, 46,-145, -34,-123,-142,-115, -38,-134,-117,-131, 2, -16,-122,-126,-138,-150,-136; D=-12; /I: I=-12; MD=-29; /M: SY='R'; M= -29,-139,-130,-124,-136, -18,-131, -2, 24,-129,-124,-121,-134,-119, 35,-119, 29, -25,-144,-131; D=-12; /I: I=-12; MD=-29; /M: SY='L'; M= -33, 17,-148,-142,-112,-147,-138, -9,-141, 34,-104,-144,-147,-138,-141,-135,-124, 31,-138, 4; D=-12; /I: I=-12; MD=-29; /M: SY='K'; M=-132,-149,-122, -7,-150,-140,-125,-149, 67,-146,-134,-119,-133, 31, 5,-125,-129,-145,-143,-135; D=-12; /I: I=-12; MD=-29; /M: SY='S'; M=-123,-142, 15, 7,-141, -28,-123,-139, 9, -29,-130,-116,-133, -1, 13, 24,-121,-137,-146,-132; D=-12; /I: I=-12; MD=-29; /M: SY='M'; M=-131,-136,-148,-139, -15,-148,-130,-101, -23, 45, 73,-142,-144,-131,-132,-139,-127, -25,-137,-117; D=-12; /I: I=-12; MD=-29; /M: SY='Q'; M= -2,-115,-100, -89,-117,-108, -99,-104, -2, -34, -99, -8,-108, 101, -92, -23, 60, -5,-120,-106; D=-12; /I: I=-12; DM=-29; /M: SY='E'; M= -23, 20, -91, 65,-117,-111, 21, 2, -90,-111,-105, 7, -11, 46, 18, -3, 37,-105,-124,-108; D=-12; /I: I=-12; MD=-29; /M: SY='P'; M= -9,-124,-108,-104,-126, 68,-111,-122, -17,-125,-114,-102, 95,-106, -15, -98,-105,-121,-119,-121; D=-12; /I: I=-12; MD=-29; /M: SY='H'; M=-109,-121,-102, -97, -9,-115, 119,-116, 18, -9, -97, -92,-114, -90, 63, -23, -26,-115,-126, -89; D=-12; /I: I=-12; MD=-29; /M: SY='G'; M= -99,-117,-107,-111, 26, 68, 37,-112,-105, -36,-103, -2,-114,-104, -12, 4, -14,-112, 62, 62; D=-12; /I: I=-12; MD=-29; /M: SY='G'; M= -1, 10, -15, 30,-120, 79,-106,-121, 4, -36,-110, -94, -5, -11,-105, -18,-103,-116,-117,-115; D=-12; /I: I=-12; MD=-29; /M: SY='W'; M=-114, 17,-134,-120, 15, -26,-134,-113,-112,-110,-113, -7,-120,-113,-116,-118,-123,-125, 174, -71; D=-12; /I: I=-12; MI=0; MD=-29; IM=0; DM=-29; /M: SY='N'; M= -16,-110, -94, -23,-114, 27, 19,-110, 32,-113,-105, 47,-106, 2, 21, 38, 44, -24,-121,-106; /M: SY='D'; M= -38,-114, 68, 42,-120, 28, -97,-117, -15,-117, 8, 21, 14, -90,-100, 41, -13,-113,-124,-110; /M: SY='Q'; M= 15,-115, 36, 45,-113, -22, 14, -26, 16,-104, -99, -95,-107, 54, 13, -95, -97, 40,-121,-105; /M: SY='M'; M= -27,-109,-108,-106,-101, 24,-100, -19, 2, -86, 118, -17,-107, -97, -18, -3, 45, -35,-117, -99; /M: SY='H'; M= 21,-114, -11, -97, -4,-107, 77, 4, -97, -4, -95, -97, 61, 1, 19, 8, 21, -99,-119, -97; /M: SY='E'; M= -5,-116, 0, 53,-117, 8, 37,-118, 25,-116,-108, -11, 44, 2, -14, 19, -2,-113, 35,-106; /M: SY='S'; M= 15, 17, -9,-101, 10,-100,-102, -97,-101,-103,-100, -94, -10, -99,-106, 73, 46, 19,-111, 38; /M: SY='I'; M= -17,-111,-120,-114, -90,-121,-115, 61, -26, 45, 2,-114,-115,-109, -27,-106, 4, 47, 43, -96; /M: SY='G'; M= -29,-115, -9,-111,-122, 104,-110,-127,-108,-124,-114, -89,-107,-106,-115, -88, -9,-120,-115,-116; /M: SY='Q'; M= -99, 31,-103, -16, -9,-115, 38, -6, 46, -52, -93, -98,-110, 54, 14, -97, 25, 51,-118, -98; /M: SY='V'; M= -26,-109,-118,-113, -94,-120,-115, 46,-106, -7, 53,-111,-115,-108, 12,-103, 16, 78,-121, -99; /M: SY='H'; M= -26,-113,-101,-103,-111, 72, 76,-112, -19, -55, 15, -90,-107, 1,-103, 30, 9, -32,-117, -12; /M: SY='T'; M= -3, 27,-100, -31,-111, -7,-102, -20, 25,-105,-100, -2,-108, -5, 46, 32, 47, 18,-120,-106; /M: SY='V'; M= -96,-109,-124,-119, -8,-125,-123, 64,-116, -33, 5,-117,-117,-116,-117,-109, -93, 90,-119, -97; /I: I=-24; MD=-60; /M: SY='H'; M=-125, 23,-132,-126,-133, -38, 35, 2, -20, -36,-121,-123,-139, 11, 12, 11,-123, -22,-147,-127; D=-24; /I: I=-24; MI=0; MD=-60; IM=0; DM=-60; /M: SY='D'; M=-108,-122, 70, 19, -4,-115, 38,-116, -23, -14,-109, -94,-114, -3, 8, 13, 5,-115,-123, 15; D=-24; /I: I=-24; DM=-60; /M: SY='E'; M= 30,-118, 8, 49,-120, 22,-106,-116, -99,-116, 14, 15, 11, -96, -18, 15,-100, -31, 34,-113; D=-24; /I: I=-24; DM=-60; /M: SY='D'; M=-108,-121, 101, 9,-122,-108, -95,-124, 10,-123,-118, 35,-110, -93, 5, -97, -17,-121,-132, -3; D=-24; /I: I=-24; DM=-60; /M: SY='G'; M= -99,-124, -11, -18,-129, 85, 21,-134, -18,-130,-119, -40,-114, 2,-113, 0,-110,-128,-124,-119; D=-24; /I: I=-24; DM=-60; /M: SY='D'; M=-110, 11, 71, -28,-122, 0,-105, -44, 21, -53,-117, 23,-117, 2,-105, -34, 9,-119,-131, -2; D=-24; /I: I=-24; MI=0; MD=-60; IM=0; DM=-60; /M: SY='V'; M=-100,-109,-122,-116, -87, -34,-115, 13,-115, 63, 17,-118,-119,-112,-115,-109, -20, 67, 41, -95; /M: SY='R'; M= -32, 5, 13, 5,-108, -34,-103, 18, 40, -47, -97, -96,-109, -92, 58, 4, -11, 35,-119,-104; /M: SY='V'; M= -27, 19,-122,-117, -93,-123,-123, 40,-115, -10, -81,-117,-118,-116,-117,-106, -92, 96,-124,-101; /M: SY='Q'; M= 42,-115, 44, 45,-116, -12, -96,-116, 8,-113,-106, -91,-105, 55, 28, -2, -97,-109,-115, 0; /M: SY='F'; M=-108, 14,-123,-120, 107,-122,-105, -30,-115, -41, -88,-114,-123,-121,-114,-109, -16, 34, -87, 52; /M: SY='C'; M= -8, 91, 15,-100, -22, -37,-107, 4, -18, -41,-103, 14, 76,-103, -12, -3, -13,-102,-122,-110; /I: I=-26; MD=-67; /M: SY='G'; M= -33,-137,-130,-136, 26, 58,-130,-132,-131,-131,-128, -23,-135,-130,-136, -21,-125, -34, 36, -14; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='R'; M= -51,-135, -11, 1,-128, 12, 18,-127,-107, 5,-117,-114,-130, -1, 44, -1,-119,-126,-137,-122; D=-26; /I: I=-26; DM=-67; /M: SY='Q'; M=-109,-129, 44, 41,-133, -23,-104,-129, -22,-129,-120, 22, 39, 56,-104, 13,-105,-127,-132,-120; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='Q'; M= -27,-113, -11, -23,-114, 22, 19, -36, 22,-108, 13, 19, -3, 50, 17, -18, 50, -25,-120,-105; /M: SY='R'; M= -26,-115,-103, -15,-108, -47, 16,-101, 9, 10, -96, -98, 40, -90, 76, 24, -15, 3,-118,-103; /M: SY='W'; M=-114,-134,-139,-120, 39,-115,-132,-105,-112,-104,-108,-131,-120,-113,-115,-120,-122, -27, 175, 2; /M: SY='T'; M= -34, 18,-104, -98,-104,-108, 0, -25, -3, 1, 13, -95,-108, 23, 43, 33, 66, -22, 45,-100; /I: I=-38; MD=-97; /M: SY='F'; M= -1, 52,-117,-118, 70, 40,-106, 8,-113, -10, -94,-108,-119,-114,-115,-102, -18, -23, -97, 57; D=-38; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='N'; M=-100,-113, 59, -29,-116,-100, 69,-117, -29, -38,-108, 77, -13, -92, -99, 47, -16,-115,-133,-104; D=-38; /I: I=-38; DM=-97; /M: SY='P'; M= -8,-123,-108, -99,-112,-108,-108, -18,-104, -37, 16,-110, 118,-105,-113, -24, -20, -31,-115, -2; /M: SY='A'; M= 58,-106, -95, 26,-115, 21,-101,-110, -17,-111, 15, 24,-104, -92,-101, 53, 9,-102,-119,-109; /M: SY='E'; M= 35, 48, 54, 60,-111,-108, 8, -97, -97, -10, -99, -96,-107, -3,-103, -95, -97, 35,-124,-107; /M: SY='L'; M= -28,-108,-123,-115, -86,-122,-111, -18,-115, 74, 49,-119,-120,-110,-114,-111, -98, 58,-115, -95; /M: SY='E'; M= -94,-112, -83, 91,-113,-111, -99,-101, -89,-106,-103, -95,-100, -2, -97, 22, 52, 30,-122,-108; /M: SY='K'; M= -2,-114,-108, -97,-104,-115,-105, -25, 78, 35, 11,-102, -21, -94, 8,-102, -16, -3,-116,-104; /M: SY='V'; M= 12, -18, -19, -31, -94,-117, 18, 38,-111, 2, 18, -8,-117,-108,-113,-104, -97, 66,-118, 22; /M: SY='P'; M= 26,-116, 9, 17,-119, -24, -19, -21, 3,-114,-106, 42, 57, -4, 11, -19, -19, -25,-123,-112; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 35 in 14 different sequences |
| Number of true positive hits | 35 in 14 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 12 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | HERC2-like |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
14 sequences
HERC2_DROME (Q9VR91), HERC2_HUMAN (O95714), HERC2_MOUSE (Q4U2R1), KEG_ARATH (Q9FY48), KOC1_ARATH (Q8RWX4), MIB1_DANRE (Q804S5), MIB1_HUMAN (Q86YT6), MIB1_MOUSE (Q80SY4), MIB1_XENLA (Q6GNY1), MIB2_CHICK (Q5ZIJ9), MIB2_HUMAN (Q96AX9), MIB2_MOUSE (Q8R516), MIB2_RAT(Q68LP1), MIB_DROME (Q9VUX2)» more
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| PDB [Detailed view] |
6 PDB
pdb_00004tse; pdb_00004xi6; pdb_00004xi7; pdb_00004xib; pdb_00009l8y; pdb_00009l93 |