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PROSITE entry PS52087


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PURL: https://purl.expasy.org/prosite/signature/PS52087

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General information about the entry

Entry name [info] LNS2
Accession [info] PS52087
Entry type [info] MATRIX
Date [info] 10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE;
10-JUN-2026 INFO UPDATE.
PROSITE Doc. [info] PDOC52087
Associated ProRule [info] PRU01432

Name and characterization of the entry

Description [info] Lipin/Ned1/Smp2 (LNS2) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=183;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=178;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7968993; R2=0.0080720; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=893; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=459; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-39; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='D';  M=  26, -70,  83, -45, -76, -64, -61, -68, -54, -71, -68, -45, -65, -57,  10, -47,  64, -15, -90, -68;
/M: SY='K';  M=  -3, -78,  15,  47,  25, -69, -60, -75,  73, -73, -67, -54,  46, -47, -42, -58, -59, -72, -72, -62;
/M: SY='A';  M=  55,  42, -77, -71,  -7, -68, -73,  32, -70,  15,  38, -70, -74, -68, -73, -27, -55,  35, -76, -60;
/M: SY='V';  M= -56, -68, -84, -79,  17, -85, -84,  46, -76, -38, -41, -78, -78, -78, -77, -68, -53,  91, -80, -56;
/M: SY='I';  M= -58, -71, -84, -80, -51, -87, -86,  79, -77, -36, -39, -77, -76, -77, -79, -70, -54,  77, -81, -59;
/M: SY='F';  M=  23, -66, -68, -66,  81, -60, -64, -58, -66, -57, -59, -58, -72, -63, -68,  74, -48, -14, -61, -42;
/M: SY='D';  M= -60, -76, 103, -37, -82, -61,  50, -83, -56, -81, -77, -38, -66, -52, -62,  48, -52, -79, -98, -65;
/M: SY='I';  M= -63, -75, -85, -81, -49, -88, -80,  92, -77,   9,  49, -76, -75, -73, -79, -73, -58,  30, -75, -56;
/M: SY='D';  M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -84, -35, -67, -54, -63, -56, -57, -83,-103, -70;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='T';  M=   8, -62, -58, -60, -70, -61, -66, -62, -58, -66, -62, -47, -61, -58, -65,  50,  99, -54, -85, -66;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='F';  M= -70, -77, -90, -86,  72, -91, -80,  63, -82,  19, -44, -82, -84, -83, -82, -77, -65,  26, -65, -44; D=-31;
/I:         I=-31; DM=-79;
/M: SY='T';  M=  -1, -64, -57,   7, -67, -69, -68,  13, -58, -60, -58, -50, -60, -60, -66, -40, 104, -48, -85, -65;
/M: SY='K';  M=  49, -72, -65, -56, -70,  -1, -66,  14,  62,  -1, -56, -59,  20, -54,  -3, -54, -57, -55, -74, -67;
/M: SY='S';  M= -45, -65,   4, -56, -66, -54, -58, -70, -57, -73, -68, -45, -64, -51, -62,  95,  38, -64, -76,  26;
/I:         I=-25; MD=-63;
/M: SY='D';  M= -81,  52,  79,   8, -99, -81, -72, -98, -71, -97, -93,  18,  18, -71, -80, -72, -72, -94,-112, -89; D=-25;
/I:         I=-25; MD=-63;
/M: SY='A';  M=  45, -79, -87, -82, -79, -79, -87, -56, -81, -66,  37, -80, -85, -80, -85, -65,  26,  43, -97, -80; D=-25;
/I:         I=-25; MD=-63;
/M: SY='K';  M=  -5, -86, -74,  22, -79, -15, -80, -68,  27,  15, -67, -75, -82, -69, -70, -70,  17,  -2, -92, -80; D=-25;
/I:         I=-25; MD=-63;
/M: SY='G';  M= -71, -95, -78,   2,-101,  70, -88,-104, -84,-101, -93, -71, -85, -81, -92, -68,  16, -97, -97, -96; D=-25;
/I:         I=-25; MD=-63;
/M: SY='H';  M=  -8, -97, -80, -75,  12,   5,  95, -97, -79, -87, -78, -70, -90,  34, -77, -75, -85, -95, -98, -65; D=-25;
/I:         I=-25; MD=-63;
/M: SY='I';  M= -83, -94, -98, -93, -72,-104, -93,  54, -83,  14, -60, -90, -95, -86,  16, -86,   7, -12, -96, -78; D=-25;
/I:         I=-25; MD=-63;
/M: SY='M';  M=  -2, -72, -74, -70, -63,  -1, -68, -48, -63,  18,  63, -65, -76, -62,  21,  43, -55,  34, -81, -64; D=-25;
/I:         I=-25; MD=-63;
/M: SY='T';  M= -16, -71,  13, -61,  24, -65, -65, -66, -63, -11, -64,  19,  36, -63, -69,  48,  55, -63, -81, -63; D=-25;
/I:         I=-25; MD=-63;
/M: SY='I';  M= -65, -77, -76, -70, -54, -83, -69,  61,  13,  10,  50, -69, -75,  21, -65, -66,  27,  -6, -72,  26; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='M';  M= -63, -71, -80, -72, -50, -83, -68,  41, -63,  50,  66, -73, -77, -64,  32, -69,  -5,  28, -75, -56;
/M: SY='G';  M= -53, -78, -66, -74,  15,  93, -67, -81, -69, -77, -70, -54,  19, -68, -76, -53, -67, -79, -65,  25;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='K';  M= -64, -81,  14,   9, -64, -70, -57, -77,  63, -76, -68, -56,  29, -50,  -1,  30, -58, -75, -66,  60; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -68, -81,  96,  33, -82, -71, -59, -79,   6, -14, -74, -45, -68, -54, -61, -58,  10, -76, -95, -72; D=-26;
/I:         I=-26; MI=0; MD=-67; IM=0; DM=-67;
/M: SY='W';  M=   5, -77,  12, -58, -51, -70, -63, -62,  48, -65, -62, -61, -70, -57, -53, -57,  36,  -1, 114,  61;
/M: SY='M';  M=  37, -64, -69, -66, -63, -65, -69,   0, -64, -51,  62, -60, -68, -62, -68,  31,  53,  44, -81, -63;
/M: SY='H';  M= -69, -82, -57, -54, -64, -73, 129, -82, -45, -69, -56, -48, -72, -46,  67, -60, -67, -80, -83,  29;
/M: SY='A';  M=  49, -72,  32,  34, -67, -61,  40, -68, -55, -24,  18, -54, -66,  41, -58,  15, -55, -63, -74,  26;
/M: SY='G';  M= -54, -78,  37, -64, -73,  89,  38, -86, -66, -81, -72, -48, -69, -63, -72, -52, -66, -82, -72,  25;
/M: SY='A';  M=  73, -66, -72, -67, -64, -60, -73,  61, -67, -52, -51, -65, -69, -63, -71,  17, -52,  -6, -76, -65;
/M: SY='C';  M=  53,  78, -72, -67, -67, -66,  38, -46, -68, -57, -55, -66,  19, -68, -71, -54,  -7,  56, -86, -66;
/M: SY='D';  M=  16, -76,  77,  33, -82, -63,  40, -80,  24, -77, -70,  21, -65,  25, -52, -11, -56, -75, -87, -66;
/M: SY='V';  M=  21, -67, -82, -75,  54, -77, -73, -33, -75,  51, -40, -77, -80, -74, -74, -66, -58,  54, -68, -48;
/M: SY='Y';  M= -64,  24, -79, -77,  60, -81, -59, -38, -72,  -3, -46, -76, -83, -73, -71, -68, -60,  57, -48,  89;
/M: SY='H';  M=   6, -72, -55, -55, -73, -62,  77, -76, -43, -73, -63,  45, -69, -48,  67,  37,  25, -70, -85, -59;
/M: SY='H';  M=  21, -73, -52,  -6, -71, -62,  79, -76,  56, -74, -63,  43, -67, -46,  14,  17, -55, -71, -79,   2;
/M: SY='W';  M= -68, -79, -86, -79, -39, -83, -71,  52, -75,  48, -41, -82, -80, -71, -75, -75, -66,  -8, 116,  55;
/M: SY='Q';  M=  51, -72, -58, -47, -79, -59,  28, -71, -48, -70, -60, -10, -66,  90,  13,  14,  11, -65, -77, -63;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='D';  M= -11, -77,  57,  56, -80, -66, -55, -77,  30, -30, -67, -48, -63,  49,  -1,  22, -56, -72, -81, -67;
/M: SY='N';  M= -61, -71,  16, -55, -68, -61, -53,  14,  31,   6, -58,  85, -71, -51,  13,  21, -51, -61, -84, -65;
/M: SY='G';  M= -49, -73, -60, -71, -80,  92, -67, -85, -65, -83, -73,  20, -67, -63, -73,  16,  10, -78, -77, -75;
/M: SY='Y';  M=   6, -77, -70, -71,  20, -74, -42, -57, -65, -54, -51, -69, -79, -62, -64, -60,  10, -59, -33, 123;
/M: SY='K';  M= -64, -77, -61, -51, -67, -73,  49, -64,  63,  16,  40,   3, -70,  26,  59, -60, -61, -65, -76, -58;
/I:         I=-26; MD=-67;
/M: SY='I';  M= -65, -77, -87, -81,  32, -88, -81,  71, -79, -12,  34, -80,  18, -78, -81, -74, -61,  46, -74, -55; D=-26;
/I:         I=-26; MI=-67; MD=-67; IM=-67; DM=-67;
/M: SY='V';  M= -63, -73, -88, -82,   8, -89, -80,  54, -79,  30,  39, -81, -81, -77, -80, -74, -60,  61, -78, -57; D=-26;
/I:         I=-26; DM=-67;
/M: SY='Y';  M= -75, -84, -75, -77,  25, -81, -42, -59, -70, -55, -53, -76, -87, -66, -67, -70, -69, -64, -31, 128; D=-26;
/I:         I=-26; DM=-67;
/M: SY='L';  M= -64,  60, -87, -81, -51, -88, -78,  -1, -80,  63, -39, -83, -86, -78, -80, -75, -62,  51, -82, -62; D=-26;
/I:         I=-26; DM=-67;
/M: SY='T';  M= -52, -65, -60, -63, -72, -65, -68, -65, -60, -70, -66, -49, -63, -61, -68,  52,  99, -57, -90, -69; D=-26;
/I:         I=-26; DM=-67;
/M: SY='A';  M=  68,  53, -69, -67, -80,  36, -72, -75, -67, -76, -69, -59, -71, -63, -72,  38, -55, -64, -82, -76; D=-26;
/I:         I=-26; DM=-67;
/M: SY='R';  M= -71, -86, -65, -55, -78, -80,  49, -86, -29, -77, -66, -58, -78, -44, 109, -64, -69, -80, -81, -62; D=-26;
/I:         I=-26; DM=-67;
/M: SY='P';  M=  11, -85, -70, -62, -84,   8, -74, -69, -67, -79, -70, -71, 106, -68, -77, -11, -60,  -2, -82, -81; D=-26;
/I:         I=-26; DM=-67;
/M: SY='D';  M= -20, -80,  57,   7, -58, -80, -65,  49, -63,  27, -51, -63, -76, -62,  10, -68, -63, -49, -76,  26; D=-26;
/I:         I=-26; DM=-67;
/M: SY='W';  M=   6, -74, -67, -66,  -6,  42, -61, -62, -62, -59,  76,  29, -71,  24, -66, -55,  10, -64,  96,  23;
/M: SY='W';  M= -64, -79, -73, -56,  12, -75, -62, -50, -58,  31,  54, -67, -74,  89, -58, -64, -65,   1, 103, -47;
/M: SY='A';  M=  63, -69, -63, -52, -68, -61, -61, -62,  53, -66, -59, -57, -67,  43, -48, -48,  11,   0, -70,  21;
/M: SY='N';  M= -12, -75,  43, -49, -75, -15,  57,  17,   7, -69, -62,  64, -69,  53, -54,   7, -54, -65, -85, -62;
/M: SY='R';  M= -60, -76,  12, -58,  15,  30, -58, -60, -10, -25,  36, -57, -73,  25,  61, -10, -61,   8, -68,  22;
/M: SY='T';  M= -53, -65, -66, -67, -61,  -2, -72,   9, -65,   1, -51, -57, -67, -65, -70,  17,  80,  44, -83, -63;
/M: SY='R';  M= -62, -78, -67, -55, -68, -77, -60, -54,  25,  -9,  13, -61,  20,  21,  83, -62, -60,  35, -77, -62;
/M: SY='G';  M=  23,  43,  39,   7, -75,  46, -66, -14, -62, -70, -66, -51, -67, -59, -68,  26,  20, -10, -83, -71;
/M: SY='W';  M= -72, -85, -80, -72,  44, -76,  51, -63, -62, -57,  37, -74, -79, -63,  19, -72, -73, -70, 137,  72;
/M: SY='L';  M= -68, -70, -85, -78,  49, -86, -69,  -1, -78,  82, -31, -82, -84, -73, -75, -77, -64, -40, -64, -45;
/M: SY='H';  M= -20, -75,  15,  34, -77, -64,  67, -79,  25, -75, -66, -48, -65,   7,  47,  50, -19, -73, -82, -61;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='W';  M=  22, -77, -58,  31, -66,  22, -59, -75, -51, -72, -65, -57, -67,  62,  12,  29, -59, -71,  85,  26;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='H';  M=   6, -75, -66, -63, -55, -74, 107,  20, -60,  16, -47, -58, -74, -56,  20, -62, -62,  16, -77,  28;
/M: SY='N';  M= -59, -73,  24,  -7, -73,   0,  40,  -2,   8, -70, -63,  75, -70, -51,  23,  21, -53,  -1, -86, -65;
/I:         I=-23; MD=-58;
/M: SY='Q';  M=  -8,-104, -22,  11,-110, -91, -78,-102,  13, -98, -88, -76, -90,  77, -67, -76, -85, -98,-100, -91; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='G';  M= -81, -98, -79, -16,  11,  33, -84,-102, -30, -99, -94,  32, -95, -81, -12,   1, -82, -99, -98, -86; D=-23;
/I:         I=-23; DM=-58;
/M: SY='G';  M=  -7,-100,  -1,  12,-101,  39, -90,  -2, -86, -96, -91,  -3, -92, -82, -93, -77, -86, -88,-104, -97; D=-23;
/I:         I=-23; DM=-58;
/M: SY='S';  M=   2,  18,  -1, -85,   7, -86, -88, -19, -87, -89, -87,  16, -95, -86, -92,  20,   7, -82,-103, -84; D=-23;
/I:         I=-23; DM=-58;
/M: SY='M';  M= -78, -94, -91, -87, -90, -23, -91, -29,  13, -80,  35, -81, -93, -82, -82,  24,   3,  14,-105, -88; D=-23;
/I:         I=-23; DM=-58;
/M: SY='F';  M= -69, -70, -79, -77,  81, -80, -65, -40, -74,  63,  35,  16, -83, -74, -73, -72, -63, -47, -58, -37;
/M: SY='P';  M= -67, -90, -68, -57,  13, -69, -70, -71, -64, -79, -69, -73, 124, -68, -75, -64, -60, -77, -75, -74;
/M: SY='H';  M= -66, -80,  10,   9, -62, -71,  79, -67,  22, -24,  47,   3,  59,   7, -16, -60, -61, -70, -72,  43;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/I:         I=-17; MD=-42;
/M: SY='P';  M= -36, -85, -74, -65, -73, -74, -75,  26, -69,  -6, -59, -74, 102, -70, -78,   4, -59,  -4, -82, -75; D=-17;
/I:         I=-17; MD=-42;
/M: SY='V';  M= -62, -75, -89, -84, -56, -91, -88,  49, -82,  18, -43, -84, -84, -81, -83, -75, -60,  76, -86, -64; D=-17;
/I:         I=-17; MD=-42;
/M: SY='H';  M= -64, -76, -75, -72, -58, -76,  67,  16, -73,  52,   6, -67, -79, -65, -72,  47, -59, -52, -84, -58; D=-17;
/I:         I=-17; MD=-42;
/M: SY='F';  M= -69, -75, -80, -78,  61,  -4,  48, -50, -77,  42, -49, -71, -82, -76, -76, -68,  29,   2, -71, -48; D=-17;
/I:         I=-17; MD=-42;
/M: SY='C';  M= -15,  72, -61, -66,  14,  15, -65, -74, -63, -74, -69,  40,  20, -62, -70,  60,  12, -69, -82, -67; D=-17;
/I:         I=-17; MD=-42;
/M: SY='P';  M= -79,-102, -84, -74, -95,  -4, -84, -87, -79, -16, -81, -83,  87,  22, -87,  -9, -76, -90, -95, -92; D=-17;
/I:         I=-17; MD=-42;
/M: SY='S';  M= -70, -89,  27,  14, -93,  -3, -75, -91, -74, -26, -86,  18, -84, -68, -80,  51, -66, -88,-102, -87; D=-17;
/I:         I=-17; MD=-42;
/M: SY='S';  M= -78, -97, -84, -77, -95, -15, -81, -93,   4, -16, -83, -75, -92,  17,  33,  37, -76, -91, -99, -87; D=-17;
/I:         I=-17; MD=-42;
/M: SY='L';  M= -88, -92,-102, -98,  14,-105, -93,   0, -97,  45, -60, -95,-100, -95, -97, -88,  25, -63, -92, -73; D=-17;
/I:         I=-17; MD=-42;
/M: SY='F';  M= -19, -98,-107,-102,  30,-102, -98,  -2,-100,  -3,  16, -99,-105, -98,-101,  -1, -84,  -3, -95, -76; D=-17;
/I:         I=-17; MI=-42; MD=-42; IM=-42; DM=-42;
/M: SY='S';  M= -22, -96, -86, -85,-105, -14, -90,-104,   1,-106, -99, -76, -93, -79, -84,  62, -71, -96,-108, -97; D=-17;
/I:         I=-17; DM=-42;
/M: SY='A';  M=  45, -91, -95, -91, -99, -85, -99, -84, -91, -91, -88, -87, -95, -89, -96,  -2,  17,  -4,-109, -97; D=-17;
/I:         I=-17; DM=-42;
/M: SY='L';  M=   0, -97,-110,-102, -20,-106, -98, -66,-104,  51, -63,-108,-110, -98,-103, -97, -90, -71, -99, -82; D=-17;
/I:         I=-17; DM=-42;
/M: SY='H';  M= -90,-102, -87, -86,   0, -95,  55, -94,   2, -16, -84,  11,-101, -81, -10,   9, -84, -95,-105, -79; D=-17;
/I:         I=-17; DM=-42;
/M: SY='R';  M= -93,-105,-100, -89, -90,-108, -87, -81, -68,  -5,  35, -93,-106, -79,  64, -95, -92, -15,-105, -88; D=-17;
/I:         I=-17; DM=-42;
/M: SY='E';  M= -63, -83,  72,  75, -87,  23, -59, -87, -52, -83, -78, -50,  21, -48, -62, -57, -62, -82, -87, -76; D=-17;
/I:         I=-17; DM=-42;
/M: SY='V';  M=  -3, -75, -73,   5, -68,  41, -78, -45, -72,  -8, -57, -71,  18, -71, -77, -63, -61,  63, -85, -72; D=-17;
/I:         I=-17; DM=-42;
/M: SY='W';  M= -68, -78,  11, -76, -53, -87, -80,  61, -77,  39, -44, -75, -80, -75, -80, -72,   9,  18,  66, -59; D=-17;
/I:         I=-17; DM=-42;
/M: SY='T';  M= -59, -75, -60,  22, -68,  -2,  51, -68, -62, -26, -64, -57,  19, -59, -67,  33,  58, -23, -81,  21; D=-17;
/I:         I=-17; DM=-42;
/M: SY='K';  M= -66, -81,  13, -50, -81, -72,  67, -83,  74, -80, -69, -52,  19, -49,  15,   5,  -6, -79, -85, -65; D=-17;
/I:         I=-17; DM=-42;
/M: SY='D';  M= -62, -76,  87, -41, -82,   0, -54, -82,  47, -82, -75,  53, -67, -50, -51,   7, -54, -79, -90, -70;
/M: SY='P';  M=  38, -77, -66, -58, -78, -63, -69, -67, -62, -32, -64, -66, 105, -64, -72, -53,  36, -65, -79, -76;
/M: SY='Q';  M=  -2, -76,  11,  51, -69, -70,  21, -59, -51,  25, -53,   8, -68,  77, -55, -56, -59,  -1, -79, -62;
/M: SY='K';  M=  -2, -76,  23,  47, -74, -17, -60, -12,  47, -67, -62, -55, -66, -47,  47, -57, -58,  22, -79, -67;
/M: SY='F';  M= -70, -74, -76, -69, 101, -79,  59, -50, -68, -46, -51, -67, -80,  39, -66, -67, -65,   9, -49,  32;
/M: SY='K';  M= -63, -76, -53, -42, -79, -67, -56, -79, 106, -79, -66,  29, -64, -40, -26, -55, -56, -75, -74, -66;
/M: SY='T';  M=  46, -66, -68, -64, -65,  -5, -69,  30,   6, -53,  47, -59, -66, -62, -64, -48,  61,   9, -79, -64;
/M: SY='A';  M=  69, -69,  39,   5, -78,  18, -61, -72, -55, -71,   8,  -4, -67,   6,  11, -47, -56, -63, -79, -70;
/M: SY='C';  M=   5,  90, -72,   5,  52, -76, -66,   7,   4,  -9, -53, -69, -78, -67, -66, -63, -60,  12, -62,  46;
/M: SY='L';  M= -66, -69, -84, -77, -41, -86, -69, -31, -78,  89, -29, -83, -84, -71, -75, -76, -62,   6, -72, -54;
/I:         I=-21; MD=-53;
/M: SY='D';  M= -86,-100,  43, -70,-107, -90, -82,-102,  -2,-103, -96,  17, -92,  21, -80, -18,  25, -98,-115, -95; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='R';  M= -65, -83, -58,   9, -82, -73, -56, -83,  46, -79, -68,   3, -71,  54,  77,   5, -62, -79, -79, -68; D=-21;
/I:         I=-21; DM=-53;
/M: SY='Q';  M= -17,  15, -56, -55, -75, -62,  40, -79, -50, -77, -67,  55, -73,  57,  35,  51, -54, -75, -82,   2; D=-21;
/I:         I=-21; DM=-53;
/M: SY='L';  M= -62, -68, -82, -75, -45, -84, -72,   1, -76,  77, -33, -78, -80, -71, -75, -70,  11,  38, -75, -56;
/M: SY='F';  M= -68, -76, -73,  -5,  85, -81, -61,  31, -60, -46, -50, -70, -78,  21,  30, -67, -63,   6, -51,  48;
/M: SY='P';  M= -15, -78,  60,  11,  21, -67, -59, -71,   7, -29, -66,  -3,  65,  38, -58, -14, -17, -71, -77, -63;
/M: SY='E';  M=  28, -77,  -5,  65, -79,  -1, -61, -70, -50, -73, -67,   2,  56, -49,  20, -54, -58,  -2, -80, -73;
/M: SY='C';  M=  12,  67,  -4,   3, -57, -70,  46, -59, -54, -59,  49,   0, -74, -55,  37, -23, -58,  13, -70,  53;
/M: SY='G';  M= -55, -75, -56,  42, -74,  42,  13, -60, -18, -66, -61, -56, -67,  40,  32,  -9,  -7,  36, -79, -66;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='W';  M= -58, -72, -66, -11, -59, -71, -66,  12, -62,   6,  53,  13,  19,  21, -66,  14,  28,  33,  67, -58;
/M: SY='P';  M= -35, -79, -62, -57,  26, -67, -62, -66, -15, -11, -62,  32,  94,   1,  11, -10,   1, -68, -74, -63;
/M: SY='F';  M= -67, -75, -85, -80,  75, -85, -77,  74, -77,   0, -42, -77,  18, -79, -79, -73, -61,  17, -61, -42;
/I:         I=-45; MD=-115;
/M: SY='Y';  M=  -5, -76, -80, -77,  44, -81,  14, -45, -74,  -5, -15, -75, -83, -73, -73, -67,  -6,  45, -56,  80; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='A';  M=  92, -64, -69, -60, -72, -52, -70, -67, -59, -68, -62, -64, -68, -58,  10, -44, -55, -55,  66, -65;
/M: SY='G';  M=  68, -68, -65, -66, -79,  69, -69, -75, -65, -75, -68, -55, -67, -61, -71,  16, -56, -65, -75, -74;
/M: SY='F';  M= -74, -74, -82, -80, 108, -81, -56, -51, -74, -44, -50, -75, -85, -79, -71, -72, -67, -56, -36,  85;
/M: SY='G';  M= -48, -75, -63, -74, -82,  99, -70, -89, -68, -85, -75, -49, -68, -65, -75,  16, -64, -82, -74, -77;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='N';  M=  -2, -66,  17, -55, -76, -52, -50, -73, -52, -79, -69,  99, -68, -51, -59,  49,  22, -70, -91, -70;
/I:         I=-45; MD=-115;
/M: SY='R';  M= -74, -88, -72, -69, -89, -83, -71, -89,   7, -89, -80,  17, -84, -62,  68,   4,  40, -83, -96, -80; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='P';  M=   3, -73,   8, -56, -69, -66, -64, -10, -60,  -9,  37, -58,  68,  33, -65,  23,  43, -18, -80, -66;
/M: SY='T';  M=  20, -65, -54, -55, -72, -62, -61, -66,  49, -70, -63,  45, -63, -53, -51,  -4,  82, -59, -83, -67;
/M: SY='D';  M=   4, -79, 115, -33, -87, -63, -54, -84, -55, -83, -81, -37, -67, -55, -64, -54, -57, -79,-100, -71;
/M: SY='I';  M=  30, -69, -71,   5,  17, -72, -74,  59, -68, -46, -48, -67, -71, -65, -72,  14,  -4,  46, -75, -58;
/M: SY='Q';  M=  11, -70, -62,   7,  -4, -66, -59,  13, -58,  -1,  26, -57, -68,  51, -61,  42,  34, -52, -69,  26;
/M: SY='A';  M=  72, -63, -70, -64, -67, -58, -72, -45, -65, -57, -55, -63, -70, -62, -69,  35, -48,  56, -80, -67;
/M: SY='Y';  M= -71,  37, -72, -75,  33, -78, -41, -57, -67, -53, -51, -72, -84, -64, -65, -67, -65, -61, -30, 127;
/M: SY='T';  M=  11, -70,  13, -54, -67, -65,  39, -64,  17,  11, -57, -51, -67, -52,  41,  32,  51, -60, -81, -61;
/M: SY='D';  M= -23, -74,  51,  29,  14, -63, -53, -73,  16, -71, -66,  38, -67,  41, -53,  32,  -4, -70, -73,  22;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='V';  M=  40, -68, -77, -73, -58,  24, -74,  33, -71,   9,  48, -69, -73, -68, -73, -58, -56,  51, -77, -63;
/M: SY='G';  M= -50, -77, -61,   5, -83, 100, -69, -90, -67, -85, -75, -51, -67, -64, -75, -50, -68, -84, -74, -77;
/M: SY='V';  M= -58, -69, -81, -76, -50, -84, -77,  44, -74,  39,  23, -76, -77, -73, -76, -67,  11,  69, -80, -58;
/M: SY='P';  M=   7, -77,   2, -55, -71, -66, -64,  32, -58, -45,  36, -60,  75,  40,  -6,  35, -54, -55, -78, -67;
/M: SY='P';  M= -11, -75, -18, -10, -68, -67, -64,   0,  47,  17, -56, -59,  66, -55, -55,  34,  -4, -59, -77, -67;
/M: SY='N';  M=  23,   6,  29,   9, -75,  10,  15, -69,   6, -73, -67,  50, -67, -53, -59,  42, -29,  -2, -85, -68;
/M: SY='R';  M=  13,  31, -54, -49, -78, -64,   0, -77,  19, -74, -63,  60, -71,  66,  67, -52, -58, -73, -80, -65;
/M: SY='I';  M= -12, -73, -77, -75, -54, -82, -79,  89, -67, -40, -42, -68, -71, -69,   8, -62,  37,  17, -77, -59;
/M: SY='F';  M= -74, -75, -79, -77, 101, -81, -54, -53, -67, -46, -51, -73, -84, -73,   9, -70, -67, -58, -37,  89;
/M: SY='M';  M=  -2, -69, -74, -72, -54, -76, -71,  63, -68,   7,  71, -65, -69, -67, -72, -57,  60,   8, -78, -58;
/M: SY='I';  M= -60, -71, -85, -80,  17, -87, -83,  74, -77,   1, -39, -78, -78, -77, -79, -71, -56,  70, -75, -54;
/M: SY='N';  M= -57, -74,  51, -54, -72,  54, -53, -80,   7, -81, -72,  74, -69, -55, -60,   7, -55, -78, -78,  25;
/M: SY='P';  M= -65, -83, -59,   5, -79, -71,  40, -77,  49, -78, -66, -58,  86, -49,  54, -59,  -6, -76, -78, -68;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='H';  M=   6, -78, -59,  25,  13, -18,  63, -72,  46, -71, -64, -57,  -6,  20,  -5, -57,   8, -18, -78, -59; D=-38;
/I:         I=-38; DM=-97;
/M: SY='G';  M= -53, -75,  12, -10, -79,  64, -69, -71, -66, -77, -72, -54,  -4, -62, -73,  49, -11,  13, -84, -75; D=-38;
/I:         I=-38; DM=-97;
/M: SY='K';  M= -58, -74,  15,  43, -73, -68, -57, -62,  45, -65,  36,  19, -65,  22,  13,  14,   2,  16, -81, -65;
/M: SY='K';  M=  -3, -71, -66,   7, -57, -76,  20,   8,  48,  43, -45, -63, -71, -57, -54, -61,  11,  24, -77, -59;
/I:         I=-45; MD=-115;
/M: SY='H';  M= -67, -80, -73,   4,  -7,  -4,  48,   3,   3,  17,  19, -69, -79, -66, -69,   3, -65,  16, -80,   3; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='Q';  M=  -3,  43, -52,  24, -77, -66,  78, -75, -50, -70, -61,  20, -66,  84, -52, -11,  31, -71, -84, -59;
/M: SY='Q';  M=   1, -73, -56,  23,  14,   0,  28,  -2, -13, -24, -59,  -2, -67,  64, -56,  48, -53, -62, -74, -58;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='Q';  M= -58, -75, -59, -56, -68,  24,  20, -63, -56,  29, -55,  37,  38,  60, -19,  31, -56, -65, -78, -64;
/M: SY='C';  M=   5,  72, -65, -10, -72,  54, -69,  25, -60, -65, -61, -56, -70,  23,   9, -52,  34, -58, -79, -70;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='Q';  M=  14, -77, -60, -49, -84,   8, -61, -79,  62, -77, -67, -53, -68,  74, -44,  17,  -5, -73, -78, -69; D=-33;
/I:         I=-33; DM=-84;
/M: SY='F';  M= -64, -80, -62,  38,  51,  28, -66,   3, -59, -64, -63,  -3,  19,  19,  11, -61,  -8, -16, -71, -57; D=-33;
/I:         I=-33; DM=-84;
/M: SY='F';  M= -14,  43, -71,   0,  48, -77,  16,  32, -71,  26, -50,  16, -79, -68, -73,   3, -61, -51, -69,  11; D=-33;
/I:         I=-33; DM=-84;
/M: SY='S';  M= -60, -74, -65, -59,  34, -69,  39,  20,  37,  -7, -55, -57,  -6, -53,  36,  47, -55, -57, -67,  17;
/M: SY='D';  M= -56, -73,  62,  34,  14,  17, -57, -76, -53, -75, -71,  21, -66, -51,   1,  46,  12, -72, -81, -63;
/M: SY='S';  M= -46, -68, -56,   7, -76,  54, -63, -77, -59, -78, -71, -47, -64, -53, -65,  81,  28, -69, -80, -70;
/M: SY='Y';  M= -71, -83, -71, -72, -22, -77,  42, -59, -65, -55, -51, -70, -82, -60, -62, -67, -67, -65,  70, 128;
/M: SY='Q';  M=  15,  23,  39,  -9, -72,  -1,   4, -10,   2, -64, -60, -53, -68,  45, -59,   7,  20,  27, -83, -66;
/M: SY='W';  M=  33, -72,  25,  34, -73, -60,  21, -76,   4, -75, -68, -52, -65, -48,  27,  55, -52, -69,  67, -62;
/M: SY='H';  M= -68, -77, -69, -66, -47, -78,  98,  20, -67,  40,  39, -63,  30, -60, -65, -67, -64, -52, -68,  55;
/M: SY='L';  M=  -4,  22, -68, -66,  42, -21, -63, -50,  22,  53, -46,  33, -77, -62,   1, -25, -59, -53, -69, -52;
/M: SY='E';  M=  48, -71,  24,  61, -79,  14, -61, -76,   8, -75, -69, -52, -62, -48, -57,  21,  -9, -67, -80, -71;
/M: SY='Q';  M= -22, -76, -61,  33,  15, -18, -61,   6,   4,  21, -51, -62, -71,  52,  42, -61, -61,   6, -72, -57;
/M: SY='M';  M= -60, -70, -84, -78, -48, -85, -75,  47, -75,  41,  67, -78, -78, -72, -75, -71, -57,  64, -78, -56;
/M: SY='W';  M= -62, -81,  72,  49, -67,  -1, -57, -70, -54, -71, -68, -51, -67,  40, -60, -57, -11,  -3,  79,  27;
/M: SY='H';  M=  47, -70, -63,   3,  15, -66,  58, -61, -57,  13, -54, -60,  20, -57,  20, -53,  30, -58, -72,   3;
/M: SY='M';  M=  -1, -72, -69,   6,  34,  12, -65, -45, -66,  39,  48,  -8,  19,   0, -69, -63, -60,  18, -70, -54;
/M: SY='F';  M= -34, -72, -71, -67,  89, -17, -67, -58, -67, -40, -57, -64,  53,  -4, -71,   6,  45, -59, -58, -39;
/M: SY='P';  M= -64, -85, -68, -61, -78,  16,  10, -20,  16, -11, -65, -66,  94, -63, -14,   4, -62, -72, -81, -75;
/M: SY='S';  M= -11, -74, -72, -65, -65, -73, -71,  17, -63,  14, -52, -66,  25,  23,   5,  31,  20,  31, -82, -66;
/M: SY='R';  M=  -5,  42, -72, -64, -66, -79,  56,  13,  17,  12, -54, -64, -78, -57,  61, -65, -64,   6, -83, -62;
/M: SY='Y';  M=  -2, -78,  12, -58, -61, -64, -58, -74,  22, -75, -68, -58,  56, -57, -60,  57, -54, -71, -66,  64;
/M: SY='C';  M=  12,  42, -84, -77, -92, -79, -83, -86,  13, -86,  35, -76,  28, -74, -77,  38, -69, -82, -99, -88;
/M: SY='K';  M= -82, -95, -87, -77, -88, -96, -86, -77,  47,  -5, -76, -79, -92, -74,  11, -25,   7,   0,-100, -86;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_02 which contains 575'503 sequence entries.


Total number of hits 19 in 19 different sequences
Number of true positive hits 19 in 19 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] LNS2
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

LPIN1_HUMAN (Q14693), LPIN1_MOUSE (Q91ZP3), LPIN2_HUMAN (Q92539), 
LPIN2_MOUSE (Q99PI5), LPIN3_HUMAN (Q9BQK8), LPIN3_MOUSE (Q99PI4), 
LPIN3_MUSSP (Q7TNN8), NED1_SCHPO  (Q9UUJ6), PAH1_ARATH  (Q9SF47), 
PAH1_YEAST  (P32567), PAH2_ARATH  (Q9FMN2), PITM1_HUMAN (O00562), 
PITM1_MOUSE (O35954), PITM1_RAT   (Q5U2N3), PITM2_HUMAN (Q9BZ72), 
PITM2_MOUSE (Q6ZPQ6), PITM3_HUMAN (Q9BZ71), PITM3_MOUSE (Q3UHE1), 
RDGB_DROME  (P43125)
» more

PDB
[Detailed view]
3 PDB

pdb_00009jtz; pdb_00009jz1; pdb_00009jzp