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ProRule PRU01432


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PURL: https://purl.expasy.org/prosite/rule/PRU01432
General rule information [?]

Accession PRU01432
Dates 09-MAR-2026 (Created)
09-MAR-2026 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS52087; LNS2
Name Lipin/Ned1/Smp2 (LNS2) domain
Function The lipin/Ned1/Smp2 (LNS2) domain of 180 amino acids, originally characterized as the Mg(2+)-dependent catalytic domain of PA phosphatases (lipins), is catalytically inactive in Nir proteins and RdgBalpha that exhibit substitutions for a critical catalytic aspartate residue and another Mg(2+)-coordinating residue. Nevertheless, the LNS2 domain retains the ability to bind PA, with two conserved lysine residues shown to be essential for this interaction.
Scope(s) Eukaryota
Example(s) Q5U2N3;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;

Keywords [?]

Magnesium
Metal-binding
end case

Gene Ontology [?]

GO:0000287; Molecular function:magnesium ion binding

Features [?]

From: PS52087
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="LNS2 #"
MOTIF 7 11 /note="DXDXT motif" D-x-D-x-T
MOTIF 18 22 /note="LXXIL motif" L-x(2)-I-L
BINDING 7 7 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 D 1
BINDING 9 9 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 D 1
BINDING 127 127 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"		 N 1

Additional information [?]

Size range 161-197 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]