PROSITE entry PS52098
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PURL: https://purl.expasy.org/prosite/signature/PS52098
Direct ScanProsite submission
General information about the entry
| Entry name [info] | PP1_BD |
| Accession [info] | PS52098 |
| Entry type [info] | MATRIX |
| Date [info] |
02-SEP-2026 CREATED;
02-SEP-2026 DATA UPDATE; 02-SEP-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52098 |
| Associated ProRule [info] | PRU01442 |
Name and characterization of the entry
| Description [info] | Protein phosphatase 1 (PP1)-binding domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=36; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=33; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.9559271; R2=0.0132364; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=608; N_SCORE=10.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=344; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-9; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='P'; M= -4, -9,-25, -7, -1,-23,-16,-15,-16, 10,-24,-12, -7, 13, -3, 0, 2, -1,-10,-29,-18, -3; /M: SY='R'; M=-16, -8,-12, -9, -1,-23,-21, -7,-30, 29,-23,-11, -2,-19, 5, 46,-10,-10,-19,-24,-12, -1; /M: SY='K'; M=-12, -6,-28, -6, 4,-22,-22,-10,-22, 35,-16, -5, -5,-15, 5, 29,-13,-10,-15,-20, -8, 4; /M: SY='R'; M=-12, -3,-28, -5, 6,-26,-20, -5,-26, 31,-23, -9, 0,-13, 15, 37, -5, -4,-19,-21,-10, 9; /M: SY='V'; M= 0,-30,-10,-30,-30, 0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10, 0, 50,-30,-10,-30; /M: SY='R'; M= -7, 1,-19, -5, -3,-17,-14, -7,-20, 6,-19,-13, 9,-15, 0, 21, 11, 17,-13,-29,-13, -3; /M: SY='F'; M=-20,-32,-25,-40,-30, 69,-28,-22, -3,-28, 5, -3,-23,-30,-37,-20,-23,-13, -5, 31, 30,-28; /M: SY='G'; M= 18,-10,-23,-14,-16,-26, 45,-20,-29,-16,-23,-16, -4,-16,-16,-20, 4,-13,-19,-20,-26,-16; /M: SY='E'; M= -7, -4,-33, 3, 20,-30, 7,-11,-30, -4,-26,-20, -5, 17, 0,-11, -3,-13,-30,-27,-26, 9; /M: SY='D'; M=-13, 12,-31, 16, 13,-29,-15, 11,-28, 3,-27,-17, 10, 13, 3, -3, -4,-10,-29,-32,-15, 6; /M: SY='L'; M=-10,-26,-21,-26,-15, 4,-29,-16, 15,-25, 42, 18,-26,-28,-10,-16,-26,-10, 5,-20, -1,-13; /M: SY='S'; M= 0, -5,-19, -7, -1,-21,-11, -8,-13, -3,-20,-10, 3,-13, 8, 3, 18, 7,-10,-31,-14, 2; /M: SY='P'; M= -9,-22,-34,-15, -6,-21,-22,-21, -9,-14,-15,-11,-22, 60,-14,-20,-12, -9,-15,-29,-24,-14; /M: SY='E'; M=-10, 10,-30, 20, 60,-30,-20, 0,-30, 10,-20,-20, 0, 0, 20, 0, 0,-10,-30,-30,-20, 40; /M: SY='L'; M= -8,-30,-18,-33,-26, 16,-31,-24, 24,-27, 28, 14,-27,-29,-26,-21,-21, -7, 24,-19, 1,-26; /M: SY='F'; M=-19,-28,-22,-35,-27, 64,-30,-11, 1,-25, 10, 1,-21,-30,-32,-18,-21,-10, -2, 13, 40,-27; /M: SY='D'; M=-17, 47,-27, 57, 15,-35, -7, 3,-35, 0,-30,-27, 30,-13, 0, -7, 3, -7,-30,-40,-20, 7; /M: SY='E'; M= -7, 6,-25, 9, 35,-25,-20, -7,-25, 11,-19,-16, 0, -4, 11, 2, 4, 6,-21,-29,-16, 23; /M: SY='N'; M= 0, 14,-16, 8, 8,-20, -5, -4,-20, -4,-26,-19, 22,-11, 2, -5, 22, 13,-18,-37,-19, 5; /M: SY='L'; M=-13, -2,-25, 3, -2,-13,-22,-12, -8, -2, 9, 0,-10,-20, -7, -5,-17,-10, -8,-25, -8, -5; /M: SY='P'; M=-10,-20,-40,-10, 0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10; /M: SY='P'; M= 0,-17,-33,-12, -2,-27,-16,-17,-20, -4,-25,-17,-15, 55, -7, -7, -6, -8,-23,-27,-25, -9; /M: SY='N'; M= 9, 4,-16, -7,-10,-15, -9,-10, -3,-10,-14, -9, 14,-17, -9,-13, 8, 2, -2,-31,-16,-10; /M: SY='T'; M= -1, -5,-15,-10, -8,-14,-17,-17,-10,-10,-13, -7, -3, 3, -8,-11, 15, 32, -5,-31,-14, -8; /M: SY='P'; M=-11,-19,-39,-10, 0,-29,-20,-17,-21, -4,-29,-19,-17, 74, -7, -7,-10,-10,-29,-29,-27, -9; /M: SY='L'; M= -8,-29, 2,-30,-23, 4,-30,-23, 14,-28, 34, 13,-29,-31,-23,-21,-24, -8, 13,-26, -6,-23; /M: SY='R'; M= -3, -5,-21, -7, 5,-28,-17, -5,-24, 22,-21, -8, -2,-14, 18, 25, -4, -8,-19,-21,-12, 10; /M: SY='K'; M=-13, -6,-30, -8, 2,-24,-23,-10,-20, 34,-21, -6, -3,-14, 6, 33,-11,-10,-14,-20, -9, 2; /M: SY='G'; M= -3, -9,-27,-10,-16,-26, 46,-17,-34,-12,-26,-17, 0,-19,-15, -7, 2, -9,-24,-21,-25,-16; /M: SY='E'; M= -8, 4,-28, 5, 19,-28, -6, -4,-25, 0,-23,-15, 5, 5, 12, -5, 2, -4,-27,-28,-20, 15; /M: SY='T'; M= -2, -8,-20,-13, -6, -8,-19,-13,-14, -3,-13, -8, -6, -3, -1, 2, 3, 13,-11,-21, -8, -4; /M: SY='P'; M= 5,-15,-24,-14, -7,-18,-15,-18, -6,-15,-12, -9,-12, 21,-10,-18, 3, 0, -9,-29,-19,-11; /M: SY='T'; M= -4,-15, 2,-18,-17,-12, -8,-20, -9,-15, -7, -7,-11,-23,-16, -9, 0, 4, 1,-30,-16,-17; /M: SY='T'; M= 1, -5, -8, -9, 1,-18,-18,-12,-17, 5,-13, -5, -5,-13, -1, 3, 1, 6, -9,-26,-14, 0; /M: SY='K'; M= 2,-11,-25,-13, 0,-14,-19, -9, -9, 5,-11, -6, -9,-10, -2, 4, -6, -8, -8,-16, -2, -3; /M: SY='R'; M= -9,-11,-26, -9, -1,-21,-18,-11,-20, 15,-22,-11, -6, 2, 0, 23, -3, -4,-12,-26,-15, -3; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 5 in 5 different sequences |
| Number of true positive hits | 5 in 5 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | PP1-binding |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
5 sequences
CDCA2_BOVIN (Q29RT4), CDCA2_HUMAN (Q69YH5), CDCA2_MOUSE (Q14B71), KI67_HUMAN (P46013), KI67_MOUSE (E9PVX6)» more
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| PDB [Detailed view] |
3 PDB
pdb_00005inb; pdb_00005ioh; pdb_00005j28 |