ProRule PRU01442
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01442
General rule information
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| Accession | PRU01442 |
| Dates | 14-APR-2026 (Created)
14-APR-2026 (Last updated, Version ) |
| Data class | Domain; |
| Predictors |
PROSITE; PS52098; PP1_BD |
Name | Protein phosphatase 1 (PP1)-binding domain |
| Function | Repo-Man and Ki-67 target PP1gamma to anaphase chromosomes through their PP1-binding domains. These proteins exhibit sequence similarity in only a very short region, of about 40 residues. This region includes the canonical RVxF small linear motif (SLiM) that is critical for PP1 binding. |
| Scope(s) |
Eukaryota Eutheria |
| Example(s) | E9PVX6 (KI67_MOUSE); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
| GO:0000793; Cellular component:condensed chromosome |
| GO:0007059; Biological process:chromosome segregation |
| GO:0140693; Molecular function:molecular condensate scaffold activity |
| GO:0051321; Biological process:meiotic cell cycle |
| GO:0007088; Biological process:regulation of mitotic nuclear division |
| GO:0005654; Cellular component:nucleoplasm |
| GO:0005694; Cellular component:chromosome |
Features
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| From: PS52098 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PP1-binding #" | |||||||||
| MOTIF | 4 | 7 | /note="RVxF #" | R-V-x-F | ||||||||
Additional information
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| Size range | 36-36 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [5] All [ 5 ]
- Retrieve set of proteins with 3D structure for this domain