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PROSITE entry PS52105


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PURL: https://purl.expasy.org/prosite/signature/PS52105

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General information about the entry

Entry name [info] HV_L_ENDO
Accession [info] PS52105
Entry type [info] MATRIX
Date [info] 02-SEP-2026 CREATED;
02-SEP-2026 DATA UPDATE;
02-SEP-2026 INFO UPDATE.
PROSITE Doc. [info] PDOC52105
Associated ProRule [info] PRU01449

Name and characterization of the entry

Description [info] Hantaviridae family large (L) protein endonuclease (ENDO) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=217;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=212;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0849490; R2=0.0072565; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=953; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=471; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-47; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='M';  M= -61, -69, -84, -73, -51, -75, -54, -35, -66, -28, 146, -70, -70, -57, -64, -71, -60, -42, -74, -50;
/M: SY='E';  M=  -8, -80,  35, 102, -83, -72, -54, -83, -22, -77, -73, -54, -57, -37, -53, -55, -59, -75, -82, -73;
/I:         I=-14; MD=-34;
/M: SY='K';  M= -65, -80, -56, -11, -82, -73, -61, -82, 106, -81, -69, -51, -65, -42, -27, -60, -60, -77, -75, -68; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='Y';  M= -73, -84, -74, -77,   3, -81, -41, -57, -69, -55, -52, -75, -86, -65, -66, -69, -68, -24, -31, 129; D=-14;
/I:         I=-14; DM=-34;
/M: SY='R';  M= -67, -81, -64, -56, -76, -78, -57, -78, -31, -39, -65,  -8, -76, -46, 104, -59,  30, -73, -80, -65; D=-14;
/I:         I=-14; DM=-34;
/M: SY='E';  M= -62, -83,  17, 103, -86, -76, -56, -87, -45, -80, -76,  -7, -59, -38, -55, -22, -61, -80, -85, -76; D=-14;
/I:         I=-14; DM=-34;
/M: SY='I';  M= -68, -80, -89, -87,  -8, -93, -87, 103, -81, -35,  10, -79, -77, -78, -85, -76, -62, -23, -74, -57; D=-14;
/I:         I=-14; DM=-34;
/M: SY='H';  M= -71, -83, -57, -57, -69, -74, 143, -79, -62, -68, -56, -47, -73, -51, -56, -62, -69, -10,-105, -41; D=-14;
/I:         I=-14; DM=-34;
/M: SY='Q';  M= -65, -81,  11,  33, -84, -68, -51, -82, -41, -79, -68,  66, -71,  77,  53, -54, -60, -80, -84, -69; D=-14;
/I:         I=-14; DM=-34;
/M: SY='R';  M= -69, -84,  55, -47, -81, -75,   7, -86,  36, -80, -70, -51, -74, -46,  91, -62, -65, -80, -83, -66; D=-14;
/I:         I=-14; DM=-34;
/M: SY='V';  M= -62, -70, -86, -79, -50, -86, -75, -29, -77,  55,  60, -82, -83, -74, -77, -74, -59,  67, -81, -59; D=-14;
/I:         I=-14; DM=-34;
/M: SY='K';  M= -66,   6, -62, -48, -80, -75, -58, -80,  78, -76,   6, -55, -71,  37,  69, -61, -63, -76, -77, -66; D=-14;
/I:         I=-14; DM=-34;
/M: SY='E';  M= -61, -80,  24,  96, -85, -73, -56, -85, -47, -80, -76,  -7, -60, -40, -56,  16, -18, -78, -86, -75; D=-14;
/I:         I=-14; DM=-34;
/M: SY='F';  M=  19,  66, -83, -79,  76, -77, -75,  40, -77,   1, -51, -73, -81, -78, -78, -25, -16, -47, -64, -45; D=-14;
/I:         I=-14; DM=-34;
/M: SY='P';  M=  31, -72, -19, -64, -72, -67, -74, -50, -67, -64, -61, -65,  63, -67, -73,  23,  29,  49, -86, -72; D=-14;
/I:         I=-14; DM=-34;
/M: SY='P';  M= -67, -89,   6, -60, -78, -74, -74,  21, -68, -70, -64, -73, 110, -70, -78, -67, -61,  10, -83, -78; D=-14;
/I:         I=-14; DM=-34;
/M: SY='G';  M= -53, -78, -62, -76, -85,  95, -69, -91, -69, -89, -77,  38, -71, -67, -77, -51, -67, -86, -79, -80; D=-14;
/I:         I=-14; DM=-34;
/M: SY='T';  M= -53, -71, -51,  57, -77,   7, -64, -74, -56, -75, -70, -52, -62, -52, -64,  51,  70, -66, -85, -72; D=-14;
/I:         I=-14; DM=-34;
/M: SY='L';  M=   4, -70, -78, -75, -56,   9, -76, -41, -74,  50, -45, -71, -77, -72, -76, -62,  35,  40,  29, -62; D=-14;
/I:         I=-14; DM=-34;
/M: SY='S';  M= -47, -66, -58, -59, -74, -58, -63, -70, -57, -73, -68, -47, -64,  -2, -28,  85,  70, -62, -86, -67; D=-14;
/I:         I=-14; DM=-34;
/M: SY='A';  M=  98, -62, -68, -60, -76, -49, -69, -65, -63, -67, -61, -63, -21, -59, -67, -41, -52, -52, -76, -72;
/M: SY='V';  M= -56, -67, -31, -73, -50, -82, -75, -26, -37,  41, -40, -75, -79, -72, -72, -34, -16,  82, -79,  -1;
/M: SY='E';  M= -36, -80,  30, 104, -83, -74, -54, -81, -43, -76, -72, -54, -57,  -8, -53, -56, -60, -40, -82, -73;
/M: SY='C';  M=   6, 149, -80, -79, -72, -73, -80, -77, -75, -69, -68, -67, -89, -82, -82, -61, -60, -64, -98, -81;
/M: SY='M';  M= -65, -72, -84, -78,   8, -84, -69,  60, -75,  54,  83, -76, -77, -69, -74, -73, -18, -34,  15, -50;
/M: SY='D';  M= -66, -80, 114, -13, -87, -64, -53, -85, -16, -84, -82,  11, -67, -53, -61, -28, -56, -82,-100, -70;
/I:         I=-45; MD=-115;
/M: SY='Y';  M= -31, -74, -78, -36, -34, -82, -55, -41, -72,  68,  13, -78, -83, -66, -70, -72, -64, -48, -52,  88; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='L';  M= -67, -70, -85, -77, -41, -87, -70,  19, -78,  88, -29, -83, -83, -71, -76, -77, -63, -37, -71, -53;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -66, -80, 116, -32, -87, -36, -54, -86, -19, -84, -83, -36, -67, -54, -62, -29, -57, -82,-101, -70;
/M: SY='R';  M= -66, -82, -63, -51, -76, -42, -53, -82,  -9, -75, -64, -55, -74, -10, 112, -59, -17, -75, -76, -63;
/M: SY='L';  M= -68, -69, -85, -77,  39, -86, -68, -34, -78,  86, -30, -83, -84, -73, -75, -77, -64, -41, -66, -47;
/M: SY='Y';  M= -71, -82, -71, -74,   0, -78, -37, -56, -66, -53, -50, -72, -83, -61, -63, -66, -66, -62, -27, 134;
/M: SY='A';  M=  95, -63, -64,   6, -74, -51, -67, -66, -61, -67, -61, -62, -66, -57, -66, -42, -53, -53, -74, -18;
/M: SY='V';  M= -54, -68, -81, -74, -54, -84, -80,  24, -71, -18,   9, -76, -78,   1, -33, -66, -52,  93, -84, -60;
/M: SY='R';  M= -67, -83, -63, -51, -76, -77, -52, -83, -24, -75, -64, -56, -75, -40, 117, -61, -66, -76, -76, -62;
/M: SY='H';  M= -69, -81, -53, -53, -68, -70, 148, -86, -58, -68, -54, -43, -70, -47, -52, -30, -67, -85,-103, -37;
/M: SY='D';  M= -67, -81, 117,   0, -88, -65, -53, -86, -53, -84, -83, -36, -66, -53, -28, -56, -58, -83,-101, -70;
/M: SY='V';  M= -13, -70, -83, -78, -50, -84, -81,  65, -76,  28, -38, -78, -77, -74, -78, -69, -55,  69, -79, -59;
/M: SY='V';  M= -52, -66, -83, -77, -53, -84, -85, -19, -75, -18, -42, -79, -79, -77, -76, -66, -51, 102, -88, -61;
/M: SY='D';  M= -39, -80, 114, -15, -85, -65,  11, -31, -55, -80, -78, -37, -67, -54, -63, -55, -25, -77,-100, -68;
/M: SY='Q';  M= -59, -83, -52,  -7, -88, -66, -47, -76, -40, -72, -59,  14, -66, 126, -42, -17, -60, -77, -74, -62;
/M: SY='M';  M= -61, -70, -79, -32, -53, -75,  11, -37, -15, -31, 140, -67, -70, -56, -61, -69, -60, -18, -75, -50;
/M: SY='I';  M= -65, -78, -86, -84, -49, -91, -86, 106, -79, -15, -35, -76, -74, -75, -82, -74, -58,  -7, -74, -56;
/M: SY='K';  M= -26, -76, -56, -43, -77, -70, -58, -76, 104, -39, -64, -49, -64, -41,  15, -57, -58, -72, -72, -65;
/M: SY='H';  M= -68, -80, -54, -18, -67, -71, 143, -80, -57, -32, -53, -45, -70, -48, -22, -31, -66, -44, -99, -39;
/M: SY='D';  M=  -9, -79, 108,  29, -85, -65,  -5, -42, -54, -80, -78, -39, -65, -51, -62, -27, -57, -77, -97, -69;
/M: SY='W';  M= -74, -97,-101, -80, -41, -74, -97, -68, -72, -15,   6, -94, -79, -71, -75, -82, -85, -81, 175, -29;
/M: SY='S';  M= -42, -65, -57, -58, -74,   4, -60, -74, -21, -48, -69, -45, -64, -50, -61, 103, -38, -67, -81, -67;
/M: SY='D';  M= -40, -80, 114, -34, -19, -65, -54, -79, -57, -31, -76, -38, -68, -56, -64, -57, -58, -77, -91,  -3;
/M: SY='N';  M= -37, -69, -12, -18, -77, -52, -44, -76, -48, -83, -70, 119, -10, -50, -25, -45, -48, -78, -94, -72;
/M: SY='K';  M= -63, -77, -56, -43, -74, -71, -58, -74, 104, -22, -62, -50, -64,  -1,  -8, -58, -58, -72, -71, -18;
/I:         I=-45; MD=-115;
/M: SY='D';  M= -69, -82, 115, -15, -87, -66, -54, -85, -56, -82,  -1, -10, -68, -55, -64, -57, -59, -82,-103, -71; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='S';  M= -24, -69, -62, -26, -67, -36, -61, -54,  50, -61,  45, -54, -68, -51,  11,  63, -48,  34, -77, -17;
/M: SY='E';  M= -60, -81, -31, 111, -84, -76, -53, -84, -41, -76, -72, -56, -56,   2, -51, -56, -61, -77, -80, -73;
/M: SY='Q';  M= -60, -80, -48,  66, -80, -73, -53, -76, -37, -72, -64, -54, -22,  77,  61, -53,  22, -40, -78, -66;
/M: SY='P';  M=  14, -81, -65, -56, -82, -62, -68, -72, -62, -80, -69, -65, 112, -62, -72,  28,   1, -71, -80, -78;
/M: SY='I';  M= -66, -78, -86, -84,   6, -90, -85, 105, -79, -20, -36, -76, -75, -76, -82, -74, -59, -20, -71, -53;
/M: SY='G';  M= -49, -75, -63, -35, -75,  92, -67, -83, -65, -41, -71, -51, -68, -62, -32,  30, -61, -78, -72,  -5;
/M: SY='Q';  M= -63, -78,  13, -44, -72, -70,  62, -69,  64,  13, -55,  -5, -68,  77, -16, -56, -60, -70, -77, -58;
/M: SY='V';  M= -31, -67, -83, -77, -19, -83, -85, -21, -74, -41, -43, -78, -79, -77, -76, -66, -52, 100,  29, -59;
/M: SY='L';  M= -67, -69, -85, -77, -41, -86, -69,  -8, -78,  91, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/I:         I=-25; MD=-63;
/M: SY='L';  M= -68, -70, -83, -76, -43, -86, -69, -35, -75,  87, -31, -81, -84, -70, -19, -75, -10, -42, -73, -55; D=-25;
/I:         I=-25; MD=-63;
/M: SY='M';  M= -69, -74, -36, -79,  76, -44, -62, -45, -74, -37, 120, -74, -79, -70, -72, -75, -66, -51, -63, -40; D=-25;
/I:         I=-25; MI=-63; MD=-63; IM=-63; DM=-63;
/M: SY='A';  M=  96, -63, -67, -28, -77, -51, -70, -67, -63, -69, -63, -24, -68, -59, -68, -43, -53, -54, -77, -73; D=-25;
/I:         I=-25; DM=-63;
/M: SY='G';  M= -51, -78, -65, -75, -84, 100, -71, -91, -25, -87, -76, -17, -70, -67, -75, -51, -69, -85, -75, -79; D=-25;
/I:         I=-25; DM=-63;
/M: SY='V';  M= -57, -70, -85, -80, -19, -87, -85,  47, -77,  -2, -41, -80, -80, -78, -79, -70, -55,  87, -83, -60; D=-25;
/I:         I=-25; DM=-63;
/M: SY='P';  M= -67, -91,   6, -55, -87, -69, -70, -76, -64, -85, -73, -70, 122, -66, -76, -24, -59, -80, -82, -83; D=-25;
/I:         I=-25; DM=-63;
/M: SY='N';  M= -60, -69, -41, -59, -76, -53, -48, -19, -52, -80, -69, 113, -13, -52, -60,  24, -20, -73, -94, -72; D=-25;
/I:         I=-25; DM=-63;
/M: SY='D';  M= -64, -75,  83,  30, -83, -61, -51, -81, -52, -83, -77,  79, -68, -51, -61, -10,  -1, -79, -97, -72; D=-25;
/I:         I=-25; DM=-63;
/M: SY='V';  M= -58, -72, -84, -80, -54, -86, -86,  65, -77, -25, -42, -78, -25, -77, -79, -36, -55,  81, -83, -62; D=-25;
/I:         I=-25; DM=-63;
/M: SY='I';  M= -67, -79, -88, -86,   5, -92, -86, 103, -80, -11, -37, -78, -76, -77, -83, -75, -61, -22, -72, -55; D=-25;
/I:         I=-25; DM=-63;
/M: SY='Q';  M= -57, -75, -13,  -4, -80, -68, -54, -70, -45, -69, -60, -48, -64, 105, -10, -22,  69, -66, -78, -63;
/M: SY='G';  M=  54, -68, -62, -64, -78,  68, -66, -76, -63, -76, -68, -19, -67,  -7, -68,  39, -23, -67, -76, -72;
/M: SY='M';  M= -62, -69, -84, -74, -48, -79, -59,  -7, -70,  43, 127, -74, -74, -62, -68, -72, -60,  -4, -74, -51;
/M: SY='E';  M= -59, -80, -34, 106, -80, -75,  11, -81, -42, -39, -70, -56, -57, -35, -23, -12, -60, -75, -81, -70;
/M: SY='K';  M= -29, -78, -58, -44, -73, -69, -61, -78, 104, -77, -66, -51, -64, -42, -27, -58, -59, -75,  77, -60;
/M: SY='K';  M= -63, -78, -55, -19, -78, -71, -56, -80,  98, -77, -66, -18, -65, -40,  54, -57, -59, -75, -73, -65;
/I:         I=-25; MD=-63;
/M: SY='I';  M= -64, -77, -85, -81, -54, -90,   6,  88, -28, -39, -41, -77, -77, -76, -79, -73, -59,  53, -81, -60; D=-25;
/I:         I=-25; MD=-63;
/M: SY='I';  M= -31, -80, -88, -86, -52, -91, -88, 103, -81, -36, -39, -78, -76, -78, -85, -75, -61,  -3, -77, -60; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='P';  M= -69, -93, -69, -57, -88, -71, -72, -77,  -1, -87, -73, -74, 122, -67, -72, -66, -62, -81, -81, -85; D=-25;
/I:         I=-25; DM=-63;
/M: SY='N';  M= -58, -73,  60, -24, -80,  53, -55, -80, -17, -82, -73,  75, -68, -55, -62, -25,  18, -77, -87, -72;
/M: SY='H';  M= -51, -71, -55, -55, -73, -16, 102, -79, -19, -74, -64, -44, -66, -12, -13,  83, -47, -73, -87, -54;
/M: SY='P';  M= -66, -91, -67, -55, -82, -36, -68, -38, -62, -81, -68, -72, 123,  -5, -74, -63, -59, -76, -77, -23;
/M: SY='S';  M= -44, -63, -56, -58, -72, -54,  -7, -68, -57, -72, -66, -45, -63, -52, -62,  94,  59, -33, -84, -65;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='G';  M= -50, -77, -61,   4, -82,  99, -69, -88, -67, -52, -73, -51, -67, -64, -75, -50, -67, -82, -74, -77;
/M: SY='Q';  M= -60, -81, -55, -17, -83, -38, -52, -75,  67, -35, -59, -50, -65, 108, -35, -52, -60, -75, -72, -63;
/M: SY='I';  M= -56, -71, -68, -21, -58, -74,  -8,  76, -65, -46, -47, -60, -68, -64, -32,  35,  52,  13, -80, -60;
/M: SY='L';  M= -67, -71, -85, -77, -41, -45, -71,  -8, -77,  86, -31, -83, -83, -71, -75, -77, -64, -41,  65, -51;
/M: SY='R';  M= -64, -79, -25, -47, -18, -72, -55, -79,  74, -75, -65, -52, -69, -41,  87,  -5, -60, -74, -73, -62;
/M: SY='S';  M=  17, -65,   2, -55, -29, -51, -60, -72, -18, -75, -69, -46, -64, -50, -60,  97, -17, -64, -81, -65;
/M: SY='F';  M= -75, -72, -87, -83, 120, -83, -66, -48, -78, -20, -50, -77, -86, -88, -75, -74, -67, -54, -41,  13;
/M: SY='F';  M= -34, -71, -86, -81, 118, -81, -67, -50, -74, -27, -51, -75, -85, -84, -11, -72, -67, -54, -43, -21;
/M: SY='K';  M= -29, -77, -55, -21, -78, -70, -56, -79,  95, -77, -65,  -5, -66, -40,  56, -57, -58, -74, -74, -65;
/M: SY='M';  M= -61, -70, -79, -68, -53, -75, -54, -39,  24, -32, 140, -66, -69, -55, -56, -69, -59, -45, -74, -51;
/M: SY='T';  M= -52, -61, -57, -61, -67, -68, -68, -58, -57, -63, -60, -47, -59, -62, -66, -35, 115, -50, -88, -65;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='D';  M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -84, -35, -67, -54, -63, -56, -57, -83,-103, -70;
/M: SY='N';  M= -37, -68, -38, -59, -71, -53, -45, -16, -50, -76, -66, 119, -74, -52, -58, -46, -48, -27, -90,  -7;
/M: SY='Y';  M= -70,   7, -73, -75,  44, -78, -42, -29, -67, -51,  -3, -72, -83, -64, -65, -35, -64, -59, -32, 124;
/M: SY='K';  M= -63, -77, -57, -11, -75, -72, -59, -11,  98, -46, -62, -51, -65, -42,  34, -59, -58, -38, -73, -64;
/M: SY='I';  M= -65, -77, -86, -84, -48, -90, -85, 104, -79,  -2, -35, -77, -75, -75, -82, -74, -58,   2, -74, -56;
/M: SY='T';  M= -52, -63, -11, -27, -69, -66, -65, -62,  -6, -66, -62, -46, -60, -58, -61,  26, 105, -54, -87, -66;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='G';  M= -50, -77, -16, -72, -83,  99, -69, -90, -66, -86, -75, -16, -68, -65, -12, -50, -67, -84, -75, -77;
/M: SY='N';  M=  17, -65, -20, -58, -74,  -8, -55, -71, -55, -48, -67,  78, -67, -53, -62,  65,  30, -66, -86, -69;
/M: SY='L';  M= -62, -69, -16, -63, -52, -78, -65, -43, -63,  68, -39, -65, -74,  36,  -9, -59,  56, -26, -76, -58;
/M: SY='I';  M= -66, -79, -87, -84,  -9, -89, -85, 103, -79, -11, -37, -77, -75, -75, -82, -74, -60, -22,  54, -53;
/M: SY='E';  M= -61, -80, -12, 106, -16, -76,   7, -78, -44, -45, -69, -57, -57, -36, -53, -58, -61, -41, -79, -68;
/M: SY='F';  M= -74, -71, -88, -83, 118, -83, -69,  -1, -79, -40, -49, -77, -85, -88, -76, -74, -66, -14, -43, -21;
/M: SY='I';  M= -60,  -6, -84, -81, -49, -87, -83,  85, -77, -16, -38, -77, -76, -76, -79, -71, -56,  62, -76,  -4;
/M: SY='E';  M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74;
/M: SY='V';  M= -53, -66, -83, -77,  12, -84, -84, -20, -75, -39, -43, -78, -79, -78, -76, -67, -51, 101, -83, -57;
/M: SY='T';  M= -51, -61, -57, -60, -68, -66, -67, -59, -57, -64, -60, -46, -59, -61, -65,  11, 112, -51, -88, -66;
/M: SY='V';  M= -52, -66, -83, -77, -54, -84, -86, -19, -75, -39, -42, -78, -79, -77, -76, -66, -50, 103, -88, -62;
/M: SY='T';  M= -52, -62, -57, -60, -68, -67, -67, -60, -56, -64, -60, -47, -60, -60, -19,   6, 111, -52, -87, -65;
/M: SY='A';  M=  91, -63, -70, -62, -70, -53, -71, -57, -64, -39, -58, -64, -68, -61, -68, -44, -24,  12,  34, -67;
/M: SY='D';  M= -66, -79, 114, -33, -86, -64, -53, -84,  -3, -83, -81,  -2, -67, -53, -60, -28, -24, -81,-100, -70;
/M: SY='V';  M= -53, -67, -82, -76, -55, -84, -85,  -1, -74, -40, -43, -78,  -3, -77, -76, -66, -51, 100, -87, -62;
/M: SY='D';  M=  68, -69,  73, -22, -79, -20,   6, -73, -59, -72, -11, -49, -66, -55, -65,  13, -53, -63, -84, -69;
/M: SY='R';  M=  -5, -79, -58,   0, -77, -71, -56, -80,  75, -76, -65, -53, -68, -40,  84, -57, -61, -73, -74, -65;
/M: SY='G';  M= -22, -75, -64, -74, -81,  98, -69, -85, -68, -81,   5, -51, -68, -65, -75,   2, -64, -79, -74, -76;
/M: SY='I';  M= -61, -73, -77, -74, -54, -84, -79,  88, -21, -40, -41, -68, -72, -69,   3, -63,  39,  30, -77, -59;
/M: SY='R';  M= -14, -81, -62,  -2, -76, -75, -53, -79, -26, -74, -64, -57, -74, -41, 111, -60, -64, -41, -76, -63;
/M: SY='E';  M= -34, -80, -33, 108, -82, -75, -54, -41,   1, -75, -71, -57, -56, -35, -50, -57, -60, -74, -80, -73;
/M: SY='K';  M= -63, -77, -55, -41, -79, -70, -58, -79, 110, -78, -66, -48, -63, -39, -24, -57, -57, -75, -72, -65;
/M: SY='K';  M= -64, -78, -27, -53, -67, -75, -62,  53,  73, -58,   5, -19, -68, -14,  51, -60, -15, -50, -75, -62;
/M: SY='L';  M= -66, -71, -79, -22, -44, -83, -65,  26, -73,  76,  59, -29, -79, -19, -72, -73, -62, -39, -71, -14;
/M: SY='K';  M= -63, -77, -55, -41, -79, -70, -58, -79, 110, -78, -66, -48, -63, -39, -24, -57, -57, -75, -72, -65;
/M: SY='Y';  M= -71, -82, -70, -74, -19, -78, -37, -56, -65, -53, -50, -72, -83, -61, -62, -66, -65, -62, -27, 135;
/M: SY='E';  M= -60, -82, -39,  91, -83, -73, -51, -79, -40, -72,   6, -55, -60,  80,  13, -55, -61, -75, -77, -68;
/M: SY='A';  M=  55, -68, -66, -63, -70,  43, -67, -65, -32,  12, -59, -58,  14, -59, -29,  41, -53, -60, -76, -69;
/M: SY='G';  M= -29, -76, -65, -76, -16, 100, -71, -85, -70, -41, -71, -52, -69, -68, -77, -50, -68, -80, -72, -73;
/M: SY='L';  M= -67, -69, -85, -77,  -3, -86, -69,   3, -78,  88, -29, -83, -84, -71, -75, -77, -63, -38, -70, -52;
/M: SY='E';  M= -25, -77, -10,  63, -80, -71,  -3, -77,  48, -74, -65, -51, -62,  60,  26, -52,  28, -72, -78, -66;
/M: SY='Y';  M= -41, -76, -74, -34,  86, -78, -50, -54, -22, -32, -51, -71, -82, -68, -65, -25, -64, -58, -36, 102;
/M: SY='I';  M= -61, -72, -81, -78, -50, -86, -80,  80, -75,  27, -37, -74, -75, -73, -78, -67,  22,  44, -77, -58;
/M: SY='E';  M= -19, -80, -34, 106, -83, -41, -54, -83, -11, -76, -72, -56, -57, -35, -14, -56, -60, -75, -79, -73;
/M: SY='Q';  M= -35, -80,  -9,  29, -84, -66,  47, -77, -43, -72, -61, -16, -65, 110, -11,  14, -58, -76, -77, -60;
/M: SY='L';  M= -36,   8, -57,  65, -53, -80, -63, -46, -61,  69, -41, -70, -71, -16, -65, -66, -28, -51, -75, -60;
/M: SY='L';  M= -67, -69, -85, -77, -14, -86, -69,  -7, -78,  90, -29, -83, -84, -71, -75, -77, -63, -39, -70, -52;
/M: SY='H';  M= -25, -77, -21,  43, -72, -37, 103, -73, -51, -64,  56,  -8, -66,  51, -22,  13, -59, -72, -85, -53;
/I:         I=-22; MD=-55;
/M: SY='Q';  M= -61, -74, -61, -56, -66, -72, -62,  42,  23,   3, -51,  30, -69,  67, -55, -53,  55, -49, -79, -63; D=-22;
/I:         I=-22; MD=-55;
/M: SY='E';  M= -66, -80, -18,  88,  61, -78,  51, -74, -50, -65, -65, -59, -65, -11, -13, -62, -64, -72, -69, -50; D=-22;
/I:         I=-22; MD=-55;
/M: SY='F';  M=  20, -73, -76, -73,  76, -71,  47, -59, -73, -59, -61, -66, -79, -71, -73,  44, -59,  11, -68, -45; D=-22;
/I:         I=-22; MI=-55; MD=-55; IM=-55; DM=-55;
/M: SY='H';  M= -70, -83, -62,  28, -72, -80,  59, -69,  42,  28, -57, -62, -74,  50,  19, -66, -68, -70, -82, -63; D=-22;
/I:         I=-22; DM=-55;
/M: SY='K';  M= -70, -85, -64, -50, -83, -78, -61, -86,  84, -82, -71, -57, -73, -45,  73, -64, -66, -81, -79, -70; D=-22;
/I:         I=-22; DM=-55;
/M: SY='G';  M= -55, -82, -70, -82, -89,  98, -77, -96, -75, -92, -81, -56, -74, -73, -83, -55, -74, -90, -79, -83; D=-22;
/I:         I=-22; DM=-55;
/M: SY='N';  M= -68, -78,  28,  52, -85, -63, -52, -85, -52, -87, -78,  99, -73, -51, -61, -54, -57, -84, -98, -78; D=-22;
/I:         I=-22; DM=-55;
/M: SY='C';  M= -71,  70, -90, -86, -54, -92, -83,  69, -84,  49, -42, -83, -86, -80, -85, -79, -66, -37, -81, -64; D=-22;
/I:         I=-22; DM=-55;
/M: SY='P';  M= -67, -90, -62, -50, -91, -70, -61, -79, -55, -83, -69,  26,  94,  88, -60, -59, -63, -83, -82, -76; D=-22;
/I:         I=-22; DM=-55;
/M: SY='Q';  M= -58, -79, -56, -47, -84,  20, -54, -78, -15, -39, -64,  38, -70, 101, -51,  30, -58, -77, -79, -67; D=-22;
/I:         I=-22; DM=-55;
/M: SY='P';  M=   4, -82, -70, -65, -82,  48, -73, -69, -24, -78, -69, -66,  91, -67, -19, -59, -62,   9, -80, -79; D=-22;
/I:         I=-22; DM=-55;
/M: SY='Y';  M= -74, -83, -76, -78,  46, -82, -45,   0, -71, -52, -51, -76, -86, -68, -68, -70, -68, -59, -33, 122; D=-22;
/I:         I=-22; DM=-55;
/M: SY='K';  M= -66, -81, -12, -47, -81, -74, -59, -83,  87, -80, -69, -52, -69, -43,  68, -22, -61, -78, -77, -67; D=-22;
/I:         I=-22; DM=-55;
/M: SY='I';  M= -65, -77, -86, -83, -48, -90, -82, 103, -78,  -5,   0, -76, -75, -74, -81, -73, -59,  -4, -72, -13;
/M: SY='T';  M= -54, -67, -55, -17, -72, -66, -62, -67,  60, -70, -63, -16, -61, -15, -47,  26,  87, -60, -82, -66;
/M: SY='F';  M= -75, -71, -88, -83, 120, -83, -67, -48, -79, -20, -50, -77, -86, -88, -76, -74, -67, -54, -41,   3;
/M: SY='N';  M= -61, -74,  68, -43, -79, -60,  34, -78,  25, -49, -69,  73, -68,  44, -51,  20, -52, -77, -89, -65;
/M: SY='V';  M= -52, -66, -82, -76, -54, -83, -85, -20, -74, -40, -43, -77, -78, -77, -76, -65, -11, 102, -88, -62;
/M: SY='V';  M= -53, -66, -83, -77, -53, -84, -85,   1, -75, -25, -42, -79, -79, -77, -76, -66, -51, 101, -87, -61;
/M: SY='A';  M=  89, -62, -66, -60, -75, -50, -68, -64, -62, -68, -62, -59, -66, -57, -66,  42, -48, -20, -77, -70;
/M: SY='V';  M= -30, -67, -82, -76, -53, -82, -83,  17, -74, -10, -42, -77, -78, -76, -76, -34, -51,  96, -86, -61;
/M: SY='R';  M= -65,  -8, -13, -48, -30, -74, -55, -80,  62, -75, -65, -53, -71, -41,  96, -30, -62, -75, -75, -62;
/M: SY='T';  M= -53, -63, -58, -60, -69, -68, -68, -60, -58, -65, -61, -48,  25, -62, -66, -17, 111, -52, -87, -67;
/M: SY='D';  M= -67, -81, 117,  -5, -88, -64, -53, -86, -54, -84, -83,  -9, -67, -53, -63, -55, -57, -83,-102, -71;
/M: SY='G';  M= -50, -76, -66, -76, -19, 100, -71, -83, -70, -24, -70, -52, -69, -68, -77, -51, -68, -79, -72, -73;
/M: SY='S';  M= -42, -64, -55, -26, -74, -51, -59, -74, -55, -77, -70, -45, -63, -48, -27, 105,  -5, -66, -82, -66;
/M: SY='N';  M= -62, -67, -13, -56, -77, -50, -43, -76, -48, -84, -70, 124, -73, -50, -56, -44, -47, -79, -96, -72;
/M: SY='I';  M= -65, -77, -85, -83, -47, -90, -82, 103, -78,   2, -35, -77, -75, -75, -81, -74, -59,  -9, -71,  -4;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='S';  M= -44, -65,  -5, -26, -74, -53, -59, -73, -20, -76, -70,  -3, -63, -49, -60,  97,  31, -65, -84, -66;
/M: SY='T';  M= -52, -62, -56, -28, -65, -67, -65, -60, -57, -64, -60, -16, -60, -60, -65,  -9, 111, -52, -84,  -6;
/M: SY='Q';  M= -59, -84, -12,  14, -89, -67, -48, -76, -40, -72, -59, -18, -66, 126, -41, -49, -61, -78, -74, -62;
/M: SY='W';  M= -75, -98,-101, -80, -13, -75, -97, -26, -72, -32, -68, -94, -79, -72, -76, -81, -85, -79, 174,  -2;
/M: SY='P';  M= -37, -89, -67, -56, -85, -38, -70, -73, -63, -83, -70, -71, 124, -66, -75, -61, -15, -77, -79, -82;
/M: SY='S';  M= -17, -65, -56, -57, -72, -28,   6, -74, -57, -76, -69, -14, -64, -49, -61, 103, -38, -66, -81, -18;
/M: SY='R';  M=  22, -79, -63, -50, -76, -70,  -5, -38,  -8, -71, -61, -56, -72,  47,  97, -56, -62, -37, -76, -63;
/M: SY='R';  M= -30, -82,   7, -51, -77, -28, -53, -83, -27, -76, -65, -55, -74, -42, 111, -60, -65, -76, -77, -63;
/M: SY='N';  M= -63, -69, -39, -58, -72, -53, -46, -74, -17, -38, -68, 119, -74, -51, -56, -47, -49, -77,  59, -67;
/M: SY='D';  M= -37, -80,  93,  77, -85, -68, -54, -85, -49, -80, -78, -44, -61, -44, -58, -29, -58, -79, -91, -72;
/M: SY='G';  M= -30, -76, -65, -74, -82,  99, -70, -86, -66, -83, -73, -51, -69, -65,  -4, -50, -67, -44, -74, -76;
/M: SY='V';  M= -53, -66, -80, -37, -54, -83, -83, -21, -73,  -5, -42, -77, -78, -75, -75, -34, -51,  99, -87, -61;
/M: SY='V';  M= -53, -67, -79, -74, -55, -82, -81, -21, -69, -42, -44, -16, -79, -73,  -2, -65, -51, 100, -88, -62;
/M: SY='Q';  M= -59, -83, -54,  -3, -84, -69, -49, -27, -41, -33, -56, -51, -66, 126, -42, -50, -27, -71, -73, -61;
/M: SY='Y';  M=  20, -75,   2, -10, -46, -69,  76, -65, -58, -33, -55, -56, -71,  37, -58, -53,  30, -64, -56,  88;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='M';  M= -28, -69, -83, -73, -51, -75, -56,   2, -66, -29, 141, -70, -71, -58, -65, -69, -59, -22, -74, -51;
/M: SY='R';  M= -38, -82, -64, -52, -75, -76, -53, -78, -25, -73, -63, -57, -75, -41, 114, -61, -65, -31, -76, -63;
/M: SY='L';  M= -66, -70, -82, -74, -42, -34, -67, -34, -74,  89, -30, -81, -83, -22, -31, -75, -63, -41, -71, -54;
/M: SY='V';  M= -57, -70, -84, -79, -52, -86, -84,  65, -76, -16,   9, -78, -77, -76, -78, -69, -54,  83, -82, -59;
/M: SY='Q';  M= -59, -82, -52,  -9, -88, -66, -48, -75, -40, -71, -58,  14, -66, 126, -42, -48, -15, -76, -74, -62;
/M: SY='A';  M=  94, -62, -62,   8, -76, -50, -67, -67, -60, -68, -62, -12, -66, -56, -65, -42, -52, -54, -76, -72;
/M: SY='D';  M= -29,  11,  94,  72, -85, -68, -54, -84, -49, -80, -78, -44, -63, -46, -26, -56, -59, -79, -92, -72;
/M: SY='I';  M= -64, -77, -85, -83, -49, -90, -85, 105, -78, -15, -36, -75, -74, -75, -82, -72, -14,  -8, -74, -57;
/M: SY='N';  M= -53, -67, -43, -28, -76,  -6, -49, -76, -17, -81, -70,  99, -69, -49, -26,  63, -44, -74, -88, -70;
/M: SY='Y';  M=  -1, -78, -72, -74,  46, -39, -43, -56, -67, -34, -50, -71, -82, -64, -65, -64, -64, -59, -32, 122;
/M: SY='V';  M= -53,   9, -82, -77, -54, -84, -84,  -7, -74, -18, -42, -77, -79, -77, -76, -66, -23,  99, -88, -62;
/M: SY='R';  M= -66, -82, -63, -51, -76, -76, -53, -82,  -2, -75, -64, -56, -74, -10, 113, -60, -20, -75, -76, -63;
/M: SY='E';  M= -60, -80, -34, 107, -79, -76, -54, -79, -14, -21, -68, -57, -57, -36, -51, -57, -28, -73, -80, -72;
/M: SY='H';  M= -69, -81, -13, -25, -69, -71, 143, -86,  -3, -69, -55, -43, -69, -46, -22, -59, -67, -84,-100, -39;
/M: SY='L';  M= -66, -69, -82, -37, -41, -86, -69, -14, -77,  89, -29, -83, -83, -70, -75, -76, -63, -13, -72, -54;
/M: SY='I';  M= -26, -76, -83, -80, -52, -85, -84,  98, -76, -36, -38, -74, -13, -74, -80, -36, -24,  26, -76, -58;
/M: SY='K';  M= -62, -76, -11, -21, -75, -70, -56, -72,  95, -69,  49, -18, -65, -42,  28, -29, -57, -70, -74, -64;
/I:         I=-45; MD=-115;
/M: SY='N';  M= -62, -74, -53, -27, -75, -66, -57, -67, -19,  -6, -61,  70,  36,  63, -58, -49,  55, -67, -85, -69; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M= -64, -81,  96,  75, -86, -68, -53, -85, -49, -81, -79, -14, -62, -45, -58, -56, -58, -80, -92, -72;
/M: SY='E';  M= -27, -80, -32, 108, -83, -74, -53, -83, -42, -76, -72, -19, -56,   5, -51, -55, -60, -76, -80, -73;
/M: SY='R';  M= -28, -81, -65, -53, -72, -76, -54, -76, -11, -12, -60, -58, -75, -42, 111, -61, -65, -71, -75, -62;
/M: SY='A';  M=  81, -64, -64, -30, -77,  26, -67, -69, -61, -71, -64, -57, -66,  -6, -66,  27, -12, -58, -76, -71;
/M: SY='A';  M=  78, -64, -64, -58, -30, -51, -65, -67, -29, -68, -10, -56, -11,  -3, -63,  56, -48, -57, -76, -67;
/M: SY='L';  M= -67, -69, -85, -77,  20, -86, -69, -32, -78,  87, -30, -83, -84, -72, -75, -77, -63, -15, -68, -50;
/M: SY='E';  M= -59, -79, -33, 107, -81, -74, -54, -81, -43, -39, -70, -21, -56, -35, -52, -18, -27, -74, -80, -72;
/M: SY='A';  M=  94, -62, -15, -59, -75, -50, -69, -32, -63, -66, -61, -61, -67, -59, -67, -14, -52, -29, -77, -71;
/M: SY='M';  M= -61, -69, -83, -73, -49, -76, -54, -36, -66,  -8, 143, -70, -71, -58, -64, -71, -60, -43, -71,  -2;
/M: SY='F';  M= -74, -71, -87, -83, 118, -83, -67, -46, -78, -40,  -5, -77, -85, -87, -75, -73, -66,  -8, -42,  10;
/M: SY='N';  M= -63, -69, -38, -57, -78, -53, -45, -78,   7, -85, -71, 119, -74, -50, -54, -22, -48, -79, -95, -73;
/M: SY='L';  M= -40, -70, -83, -77, -43, -45, -69, -35, -78,  88, -31, -28, -85, -71, -76, -76, -64, -42, -73, -56;
/M: SY='K';  M= -64, -78, -57, -44, -76, -72, -59, -77, 106, -40, -65, -50, -65, -42, -26, -59, -59, -74, -72, -18;
/M: SY='F';  M= -76, -73, -89, -85, 119, -84, -69, -18, -80, -41,  -6, -78, -87, -90, -77, -76, -68, -54, -43, -21;
/M: SY='H';  M= -65, -76, -48, -57, -73, -17, 123, -83, -56, -76, -62,  79, -72, -50, -56,  -6, -59, -83, -99, -50;
/M: SY='V';  M= -58, -72, -80, -26, -55, -86, -83,  65, -16, -40, -43, -76, -77, -23, -73, -69, -55,  79, -83, -62;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_03 which contains 575'748 sequence entries.


Total number of hits 9 in 9 different sequences
Number of true positive hits 9 in 9 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Cap-snatching endoN Hantaviridae-type
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
9 sequences

L_ANDV  (Q9E005), L_BCCV  (V5IVB1), L_DOBV  (Q806Y6), 
L_HANTV (P23456), L_PUUMG (P27176), L_PUUMS (P0C760), 
L_SEOU8 (P27314), L_SINV  (Q89709), L_TULV  (Q9YQR5)
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PDB
[Detailed view]
16 PDB

pdb_00005ize; pdb_00006q99; pdb_00008c4s; pdb_00008c4t; pdb_00008c4u; pdb_00008c4v; pdb_00008p1j; pdb_00008p1k; pdb_00008p1l; pdb_00008p1m; pdb_00008p1n; pdb_00008qe5; pdb_00008qgt; pdb_00008qgu; pdb_00008qh3; pdb_00008qhd
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