Most proteins which contain a 'homeobox' domain can be classified [1,2], on
the basis of their sequence characteristics, in three subfamilies: engrailed,
antennapedia and paired. Proteins currently known to belong to the engrailed
Drosophila segmentation polarity protein engrailed (en) which specifies the
body segmentation pattern and is required for the development of the
central nervous system.
Drosophila invected protein (inv).
Silk moth proteins engrailed and invected, which may be involved in the
compartmentalization of the silk gland.
Honeybee E30 and E60.
Grasshopper (Schistocerca americana) G-En.
Mammalian and birds En-1 and En-2.
Zebrafish Eng-1, -2 and -3.
Sea urchin (Tripneusteas gratilla) SU-HB-en.
Leech (Helobdella triserialis) Ht-En.
Caenorhabditis elegans ceh-16.
Engrailed homeobox proteins are characterized by the presence of a conserved
region of some 20 amino-acid residues located at the C-terminal of the
'homeobox' domain. As a signature pattern for this subfamily of proteins, we
have used a stretch of eight perfectly conserved residues in this region.
July 1999 / Pattern and text revised.
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