PROSITE documentation PDOC00033'Homeobox' engrailed-type protein signature
Most proteins which contain a 'homeobox' domain can be classified [1,2], on the basis of their sequence characteristics, in three subfamilies: engrailed, antennapedia and paired. Proteins currently known to belong to the engrailed subfamily are:
- Drosophila segmentation polarity protein engrailed (en) which specifies the body segmentation pattern and is required for the development of the central nervous system.
- Drosophila invected protein (inv).
- Silk moth proteins engrailed and invected, which may be involved in the compartmentalization of the silk gland.
- Honeybee E30 and E60.
- Grasshopper (Schistocerca americana) G-En.
- Mammalian and birds En-1 and En-2.
- Zebrafish Eng-1, -2 and -3.
- Sea urchin (Tripneusteas gratilla) SU-HB-en.
- Leech (Helobdella triserialis) Ht-En.
- Caenorhabditis elegans ceh-16.
Engrailed homeobox proteins are characterized by the presence of a conserved region of some 20 amino-acid residues located at the C-terminal of the 'homeobox' domain. As a signature pattern for this subfamily of proteins, we have used a stretch of eight perfectly conserved residues in this region.
Last update:July 1999 / Pattern and text revised.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Scott M.P. Tamkun J.W. Hartzell G.W. III |
Title | The structure and function of the homeodomain. | |
Source | Biochim. Biophys. Acta 989:25-48(1989). | |
PubMed ID | 2568852 |
2 | Authors | Gehring W.J. |
Title | Homeo boxes in the study of development. | |
Source | Science 236:1245-1252(1987). | |
PubMed ID | 2884726 |
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