Histone H2A is one of the four histones, along with H2B, H3 and H4, which
forms the eukaryotic nucleosome core. Using alignments of histone H2A
sequences [1,2,E1] we selected, as a signature pattern, a conserved region in
the N-terminal part of H2A. This region is conserved both in classical S-phase regulated H2A's and in variant histone H2A's which are synthesized
throughout the cell cycle.
November 1995 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
Wells D.E., Brown D.
Histone and histone gene compilation and alignment update.
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