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PROSITE documentation PDOC00045 [for PROSITE entry PS00046]

Histone H2A signature


Histone H2A is one of the four histones, along with H2B, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2A sequences [1,2,E1] we selected, as a signature pattern, a conserved region in the N-terminal part of H2A. This region is conserved both in classical S-phase regulated H2A's and in variant histone H2A's which are synthesized throughout the cell cycle.

Last update:

November 1995 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

HISTONE_H2A, PS00046; Histone H2A signature  (PATTERN)


1AuthorsWells D.E. Brown D.
TitleHistone and histone gene compilation and alignment update.
SourceNucleic Acids Res. 19:2173-2188(1991).
PubMed ID2041803

2AuthorsThatcher T.H. Gorovsky M.A.
TitlePhylogenetic analysis of the core histones H2A, H2B, H3, and H4.
SourceNucleic Acids Res. 22:174-179(1994).
PubMed ID8121801


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