PROSITE documentation PDOC00045 [for PROSITE entry PS00046]Histone H2A signature
Description
Histone H2A is one of the four histones, along with H2B, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2A sequences [1,2,E1] we selected, as a signature pattern, a conserved region in the N-terminal part of H2A. This region is conserved both in classical S-phase regulated H2A's and in variant histone H2A's which are synthesized throughout the cell cycle.
Last update:November 1995 / Pattern and text revised.
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References
1 | Authors | Wells D.E. Brown D. |
Title | Histone and histone gene compilation and alignment update. | |
Source | Nucleic Acids Res. 19:2173-2188(1991). | |
PubMed ID | 2041803 |
2 | Authors | Thatcher T.H. Gorovsky M.A. |
Title | Phylogenetic analysis of the core histones H2A, H2B, H3, and H4. | |
Source | Nucleic Acids Res. 22:174-179(1994). | |
PubMed ID | 8121801 |
E1 | Title | https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/ |
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