PROSITE documentation PDOC00045Histone H2A signature
Description
Histone H2A is one of the four histones, along with H2B, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2A sequences [1,2,E1] we selected, as a signature pattern, a conserved region in the N-terminal part of H2A. This region is conserved both in classical S-phase regulated H2A's and in variant histone H2A's which are synthesized throughout the cell cycle.
Last update:November 1995 / Pattern and text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Wells D.E. Brown D. |
| Title | Histone and histone gene compilation and alignment update. | |
| Source | Nucleic Acids Res. 19:2173-2188(1991). | |
| PubMed ID | 2041803 |
| 2 | Authors | Thatcher T.H. Gorovsky M.A. |
| Title | Phylogenetic analysis of the core histones H2A, H2B, H3, and H4. | |
| Source | Nucleic Acids Res. 22:174-179(1994). | |
| PubMed ID | 8121801 |
| E1 | Title | https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/ |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)