PROSITE documentation PDOC00045
Histone H2A signature


Histone H2A is one of the four histones, along with H2B, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2A sequences [1,2,E1] we selected, as a signature pattern, a conserved region in the N-terminal part of H2A. This region is conserved both in classical S-phase regulated H2A's and in variant histone H2A's which are synthesized throughout the cell cycle.

Last update:

November 1995 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HISTONE_H2A, PS00046; Histone H2A signature  (PATTERN)


1AuthorsWells D.E. Brown D.
TitleHistone and histone gene compilation and alignment update.
SourceNucleic Acids Res. 19:2173-2188(1991).
PubMed ID2041803

2AuthorsThatcher T.H. Gorovsky M.A.
TitlePhylogenetic analysis of the core histones H2A, H2B, H3, and H4.
SourceNucleic Acids Res. 22:174-179(1994).
PubMed ID8121801


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