Histone H4 is one of the four histones, along with H2A, H2B and H3, which
forms the eukaryotic nucleosome core. Along with H3, it plays a central role
in nucleosome formation. The sequence of histone H4 has remained almost
invariant in more then 2 billion years of evolution [1,E1]. The region we use
as a signature pattern is a pentapeptide found in positions 14 to 18 of all H4
sequences. It contains a lysine residue which is often acetylated  and a
histidine residue which is implicated in DNA-binding .
November 1995 / Text revised.
PROSITE method (with tools and information) covered by this documentation:
Thatcher T.H. Gorovsky M.A.
Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.
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