PROSITE documentation PDOC00046 [for PROSITE entry PS00047]Histone H4 signature
Description
Histone H4 is one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [1,E1]. The region we use as a signature pattern is a pentapeptide found in positions 14 to 18 of all H4 sequences. It contains a lysine residue which is often acetylated [2] and a histidine residue which is implicated in DNA-binding [3].
Last update:November 1995 / Text revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Thatcher T.H. Gorovsky M.A. |
| Title | Phylogenetic analysis of the core histones H2A, H2B, H3, and H4. | |
| Source | Nucleic Acids Res. 22:174-179(1994). | |
| PubMed ID | 8121801 |
| 2 | Authors | Doenecke D. Gallwitz D. |
| Title | Acetylation of histones in nucleosomes. | |
| Source | Mol. Cell. Biochem. 44:113-128(1982). | |
| PubMed ID | 6808351 |
| 3 | Authors | Ebralidse K.K. Grachev S.A. Mirzabekov A.D. |
| Title | A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA. | |
| Source | Nature 331:365-367(1988). | |
| PubMed ID | 3340182 | |
| DOI | 10.1038/331365a0 |
| E1 | Title | https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/ |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)