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PROSITE documentation PDOC00046 [for PROSITE entry PS00047]

Histone H4 signature


Histone H4 is one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core. Along with H3, it plays a central role in nucleosome formation. The sequence of histone H4 has remained almost invariant in more then 2 billion years of evolution [1,E1]. The region we use as a signature pattern is a pentapeptide found in positions 14 to 18 of all H4 sequences. It contains a lysine residue which is often acetylated [2] and a histidine residue which is implicated in DNA-binding [3].

Last update:

November 1995 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HISTONE_H4, PS00047; Histone H4 signature  (PATTERN)


1AuthorsThatcher T.H. Gorovsky M.A.
TitlePhylogenetic analysis of the core histones H2A, H2B, H3, and H4.
SourceNucleic Acids Res. 22:174-179(1994).
PubMed ID8121801

2AuthorsDoenecke D. Gallwitz D.
TitleAcetylation of histones in nucleosomes.
SourceMol. Cell. Biochem. 44:113-128(1982).
PubMed ID6808351

3AuthorsEbralidse K.K. Grachev S.A. Mirzabekov A.D.
TitleA highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA.
SourceNature 331:365-367(1988).
PubMed ID3340182


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