Mismatch repair contributes to the overall fidelity of DNA replication . It
involves the correction of mismatched base pairs that have been missed by the
proofreading element of the DNA polymerase complex. The sequence of some
proteins involved in mismatch repair in different organisms have been found to
be evolutionary related. These proteins are:
Escherichia coli and Salmonella typhimurium mutL protein . MutL is
required for dam-dependent methyl-directed DNA repair.
Streptococcus pneumoniae hexB protein . The Hex system is nick directed.
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