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PROSITE documentation PDOC00067 [for PROSITE entry PS00069]

Glucose-6-phosphate dehydrogenase active site





Description

Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PD) [1] catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.

Last update:

April 2006 / Pattern revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

G6P_DEHYDROGENASE, PS00069; Glucose-6-phosphate dehydrogenase active site  (PATTERN)


Reference

1AuthorsJeffery J. Persson B. Wood I. Bergman T. Jeffery R. Joernvall H.
TitleGlucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure.
SourceEur. J. Biochem. 212:41-49(1993).
PubMed ID8444164



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