PROSITE documentation PDOC00067
Glucose-6-phosphate dehydrogenase active site


Glucose-6-phosphate dehydrogenase (EC (G6PD) [1] catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

G6P_DEHYDROGENASE, PS00069; Glucose-6-phosphate dehydrogenase active site  (PATTERN)


1AuthorsJeffery J. Persson B. Wood I. Bergman T. Jeffery R. Joernvall H.
TitleGlucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure.
SourceEur. J. Biochem. 212:41-49(1993).
PubMed ID8444164

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