 |
|
| PROSITE documentation PDOC00067 |
Glucose-6-phosphate dehydrogenase active site
Description
Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PD) [1] catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.
Last update:April 2006 / Pattern revised.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Jeffery J. Persson B. Wood I. Bergman T. Jeffery R. Joernvall H. |
| Title | Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. | |
| Source | Eur. J. Biochem. 212:41-49(1993). | |
| PubMed ID | 8444164 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
Miscellaneous
View entry in original PROSITE document format
View entry in raw text format (no links)