PROSITE documentation PDOC00067Glucose-6-phosphate dehydrogenase active site
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00067
Description
Glucose-6-phosphate dehydrogenase (EC 1.1.1.49) (G6PD) [1] catalyzes the first step in the pentose pathway, the reduction of glucose-6-phosphate to gluconolactone 6-phosphate. A lysine residue has been identified as a reactive nucleophile associated with the activity of the enzyme. The sequence around this lysine is totally conserved from bacterial to mammalian G6PD's and can be used as a signature pattern.
Last update:April 2006 / Pattern revised.
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Technical section
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Reference
| 1 | Authors | Jeffery J. Persson B. Wood I. Bergman T. Jeffery R. Joernvall H. |
| Title | Glucose-6-phosphate dehydrogenase. Structure-function relationships and the Pichia jadinii enzyme structure. | |
| Source | Eur. J. Biochem. 212:41-49(1993). | |
| PubMed ID | 8444164 |
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