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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00079


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PURL: https://purl.expasy.org/prosite/signature/PS00079

Direct ScanProsite submission
General information about the entry

Entry name [info] MULTICOPPER_OXIDASE1
Accession [info] PS00079
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00076

Name and characterization of the entry

Description [info] Multicopper oxidases signature 1.
Pattern [info] 
G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x-{PR}-{K}-x(2)-{S}-x-{LFH}-G-[LM]-x(3)-
[LIVMFYW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 249 in 193 different sequences
Number of true positive hits 203 in 147 different sequences
Number of 'unknown' hits 1
Number of false positive hits 45 in 45 different sequences
Number of false negative sequences 19
Number of 'partial' sequences 8
Precision (true positives / (true positives + false positives)) 81.85 %
Recall (true positives / (true positives + false negatives)) 91.44 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 147 sequences 

ABR1_ASPFU  (Q4WZB4), ABR2_ASPFU  (E9RBR0), ASO_ARATH   (Q8LPL3), 

ASO_BRARP   (M4DUF2), ASO_CUCMA   (P24792), ASO_CUCPM   (P37064), 
ASO_CUCSA   (P14133), ASO_TOBAC   (Q40588), AURB_CHLAA  (P27197), 
AURL2_GIBZE (I1RF64), CERU_HUMAN  (P00450), CERU_MOUSE  (Q61147), 
CERU_RAT(P13635), CERU_SHEEP  (Q9XT27), COPA_PSESM  (P59571), 
COPA_PSEUB  (P12374), CTB12_CERBT (A0A2G5I8N8), ELCG_PHANO  (Q0UHZ8), 
FA5V_OXYMI  (Q58L90), FA5V_OXYSU  (Q58L91), FA5V_PSETE  (Q7SZN0), 
FA5_BOVIN   (Q28107), FA5_HUMAN   (P12259), FA5_MOUSE   (O88783), 
FA5_PIG (Q9GLP1), FA5_PSETE   (Q593B6), FA8_CANLF   (O18806), 
FA8_HUMAN   (P00451), FA8_MOUSE   (Q06194), FA8_PIG (P12263), 
FER1_MYCMD  (Q4PIF8), FET3_CANAX  (P78591), FET3_CANGA  (Q96WT3), 
FET3_GIBZE  (I1RMG9), FET3_KLULA  (Q6CII3), FET3_YEAST  (P38993), 
FET5_YEAST  (P43561), FETC_ASPFU  (E9R598), FETC_EPIFE  (K7NCS2), 
FIO1_SCHPO  (Q09920), GEDJ_ASPTN  (Q0CCX6), GIP1_GIBZE  (I1RF62), 
GMC1_YEAST  (Q04399), GME65_PESMI (A0A5B8YWJ2), HEPHL_ACRMI (B3EWZ9), 
HEPH_HUMAN  (Q9BQS7), HEPH_MOUSE  (Q9Z0Z4), HEPH_RAT(Q920H8), 
HPHL1_HUMAN (Q6MZM0), HPHL1_MOUSE (Q3V1H3), LAC10_ARATH (Q6ID18), 
LAC10_ORYSJ (Q10ND7), LAC11_ARATH (Q8VZA1), LAC11_ORYSJ (Q0DHL5), 
LAC12_ARATH (Q9FLB5), LAC12_ORYSJ (B9FJH4), LAC13_ARATH (Q9LYQ2), 
LAC13_ORYSJ (P0DKK6), LAC14_ARATH (Q9FY79), LAC15_ARATH (Q84J37), 
LAC15_ORYSJ (Q339K6), LAC16_ARATH (Q1PDH6), LAC16_ORYSJ (Q7XE50), 
LAC17_ARATH (Q9FJD5), LAC17_ORYSJ (Q2RBK2), LAC18_ORYSI (A2XCN6), 
LAC18_ORYSJ (Q53LU4), LAC19_ORYSI (A2Y9C5), LAC19_ORYSJ (Q2R0L2), 
LAC1_AGABI  (Q12541), LAC1_ARATH  (Q9LMS3), LAC1_ARTBC  (D4APX3), 
LAC1_BOTFU  (Q12570), LAC1_CRYPA  (Q03966), LAC1_FOMSC  (S8FIE4), 
LAC1_MELAO  (Q70KY3), LAC1_NEUCR  (P06811), LAC1_ORYSJ  (Q5ZCW1), 
LAC1_PHLRA  (Q01679), LAC1_PLEOS  (Q12729), LAC1_PYCCI  (O59896), 
LAC1_THACU  (P56193), LAC1_TRAHI  (Q02497), LAC1_TRAMX  (D0VWU3), 
LAC1_TRAVI  (Q99044), LAC20_ORYSI (A2Y9C2), LAC20_ORYSJ (Q2R0L0), 
LAC21_ORYSJ (Q2QZ80), LAC22_ORYSJ (Q0IQU1), LAC23_ORYSJ (Q2QYS3), 
LAC2_AGABI  (Q12542), LAC2_ARATH  (O81081), LAC2_BOTFU  (Q96WM9), 
LAC2_FOMSC  (S8FGV1), LAC2_ORYSJ  (Q8RYM9), LAC2_PLEOS  (Q12739), 
LAC2_PODAS  (P78722), LAC2_THACU  (Q02075), LAC2_TRAVE  (Q12718), 
LAC2_TRAVI  (Q99046), LAC3_ARATH  (Q56YT0), LAC3_BOTFU  (Q96UM2), 
LAC3_ORYSJ  (Q941X2), LAC3_THACU  (Q02079), LAC3_TRAVI  (Q99049), 
LAC4_ARATH  (O80434), LAC4_ORYSJ  (Q5N9X2), LAC4_TRAVE  (Q12719), 
LAC4_TRAVI  (Q99055), LAC5_ARATH  (Q9SIY8), LAC5_ORYSJ  (Q5N9W4), 
LAC5_TRAVE  (Q12717), LAC5_TRAVI  (Q99056), LAC6_ARATH  (Q9ZPY2), 
LAC6_ORYSJ  (Q5N7A3), LAC7_ORYSJ  (Q5N7B4), LAC9_ORYSJ  (Q6Z8L2), 
LACF_GANAU  (C0HLV7), LACS_TRAHI  (C0HLV6), LMCO1_THET4 (G2QFD0), 
MCE_TALPI   (A0A1S7IUL2), MCO_STAAR   (Q6GIX3), MCO_STAAU   (Q69HT9), 
MCO_STAES   (Q8CQF6), MCO_STAHJ   (Q4LAB0), MLAC1_METAF (A0A0B4F1I0), 
MLAC1_METAN (C3SAH7), MLAC1_METAQ (E9E686), MLAC1_METAS (A0A0B2WJN5), 
MLAC1_METBS (A0A0B4F5S2), MLAC1_METGA (A0A0B4GLB5), MLAC1_METMF (A0A0B4HQH6), 
MLAC1_METRA (E9F648), MMCO_MYCTU  (I6WZK7), NRHAO_KUEST (P0DV45), 
PCOA_ECOLX  (Q47452), PFMAD_PESFW (W3X7K0), PFMAY_PESFW (W3X732), 
PHSA_STRAT  (Q53692), RUS1_ACIFR  (P23742), RUS2_ACIFI  (P0C918), 
RUS_ACIF2   (B7JAQ0), SOXE_SULAC  (Q53765), TERE_ASPTN  (Q0D1P3), 
TPCJ_ASPFU  (Q4WQY8), USTL_USTVR  (A0A4Y6F0M8), VDTB1_BYSSP (A0A443HK79)
» more

UniProtKB/Swiss-Prot
False negative sequences		 19 sequences 

COTA_BACIT  (A0A7T1FRB0), COTA_BACSU  (P07788), LAC14_ORYSJ (Q69L99), 

LAC1_EMENI  (P17489), LAC24_ORYSJ (Q2QUN2), LAC25_ORYSJ (Q0IP28), 
LAC4_THACU  (Q02081), LAC7_ARATH  (Q9SR40), LAC8_ARATH  (Q9LFD2), 
LAC8_ORYSJ  (Q0JHP8), LAC9_ARATH  (Q9LFD1), LACC_HALVD  (D4GPK6), 
LPR1_ARATH  (F4I4K5), LPR1_ORYSJ  (Q9AWU4), LPR2_ARATH  (Q949X9), 
LPR2_ORYSJ  (Q5ZE07), LPR3_ORYSJ  (Q5ZE00), LPR4_ORYSJ  (Q7F757), 
LPR5_ORYSJ  (A2ZNT5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 8 sequences 

LAC1B_CERUI (P85308), LAC1_GALSP  (P86351), LAC2D_CERUI (P85430), 

LAC2_CERUI  (P85149), LACC1_CERUI (P86328), LACC2_CERUI (P86327), 
LAC_AGAPC   (B3EWI3), MCOL1_ZINEL (P85414)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

COPI_RUBGE  (W8FLH9)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			45 sequences
			


			
ACCD_CALFG  (Q7YIX5), AGRV1_DANRE (Q6JAN0), AL15_ASPFU  (O60022), 

			
AMP2_CAEEL  (Q22531), AUNC_ASPNA  (G3XSI4), AUNC_ASPNC  (A2QBE9), 
BFOC_ASPBC  (A0A1L9UQW4), BPT_GRABC   (Q0BTF8), CALI_BOVIN  (Q28068), 
CALI_HUMAN  (Q13939), CALI_MOUSE  (Q8CDE2), CALI_RAT(Q5XI58), 
DPO3A_STAEQ (Q5HNK2), DPO3A_STAES (Q8CNX0), DPOL1_SULOH (O50607), 
EXG1_YEAST  (P23776), EXG_SACU7   (Q876J3), FPOH_METAC  (Q8TQP1), 
HYAL4_HUMAN (Q2M3T9), HYAL_CONCN  (I0CME7), IMCL2_ORYSJ (Q5VNW5), 
MFS55_MYCLE (Q9CCP7), MGLA_CLOTE  (Q896Y2), NDVA_RHOP2  (Q2J0F4), 
NDVA_RHOPS  (Q13BH6), NUD17_ARATH (Q9ZU95), PEPT_PASMU  (Q9CP05), 
PTTBC_BACSU (P39794), RIR1_TRYBB  (O15909), S15A4_BOVIN (A6QQL0), 
S15A4_HUMAN (Q8N697), S15A4_MOUSE (Q91W98), S15A4_RAT   (O09014), 
S15A4_XENLA (Q68F72), SIM2_MOUSE  (Q61079), THII_COXBU  (Q83CD9), 
UT1_CAPHI   (D3INW7), UT1_HUMAN   (Q13336), UT1_MOUSE   (Q8VHL0), 
UT1_RAT (P97689), UT1_SHEEP   (C5MK33), UT2_HUMAN   (Q15849), 
UT2_MOUSE   (Q8R4T9), UT2_RAT (Q62668), Y3934_DICDI (Q54B29)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			57 PDB
			


			pdb_00001a3z; pdb_00001a8z; pdb_00001aoz; pdb_00001aso; pdb_00001asp; pdb_00001asq; pdb_00001cur; pdb_00001gw0; pdb_00001gy1; pdb_00001gy2; pdb_00001gyc; pdb_00001kcw; 
			
				pdb_00001ov8; pdb_00001qhq; pdb_00001rcy; pdb_00001sdd; pdb_00001zpu; pdb_00002cak; pdb_00002cal; pdb_00002h5u; pdb_00002ih8; pdb_00002ih9; pdb_00002j5w; pdb_00002q9o; 
				pdb_00002r7e; pdb_00003cdz; pdb_00003div; pdb_00003dkh; pdb_00003fu7; pdb_00003fu8; pdb_00003fu9; pdb_00003gyr; pdb_00003j2q; pdb_00003j2s; pdb_00003qpk; pdb_00004bdv; 
				pdb_00004bxs; pdb_00004ejx; pdb_00004enz; pdb_00005k8d; pdb_00005n0k; pdb_00005n4l; pdb_00006mf0; pdb_00006mf2; pdb_00007k66; pdb_00007kbt; pdb_00007kve; pdb_00007kvf; 
				pdb_00007kwo; pdb_00007kxy; pdb_00007tpp; pdb_00007zn6; pdb_00008fdg; pdb_00008g6i; pdb_00008tn9; pdb_00008ty1; pdb_00009cth
			
			

			» more