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PROSITE entry PS00094


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PURL: https://purl.expasy.org/prosite/signature/PS00094

Direct ScanProsite submission
General information about the entry

Entry name [info] C5_MTASE_1
Accession [info] PS00094
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00089
Associated ProRule [info] PRU10018

Name and characterization of the entry

Description [info] C-5 cytosine-specific DNA methylases active site.
Pattern [info] 
[DENKS]-x-[FLIV]-x(2)-[GSTC]-x-P-C-x-{V}-[FYWLIM]-S.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 99 in 99 different sequences
Number of true positive hits 88 in 88 different sequences
Number of 'unknown' hits 0
Number of false positive hits 11 in 11 different sequences
Number of false negative sequences 15
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 88.89 %
Recall (true positives / (true positives + false negatives)) 85.44 %

Comments [info]

Taxonomic range [info] Archaea, Bacteriophages, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 88 sequences 

CMT1_MAIZE  (Q9AXT8), CMT1_ORYSJ  (A0A0P0VUY4), CMT2_MAIZE  (Q9ARI6), 

CMT2_ORYSJ  (Q5KQL9), CMT3_ARATH  (Q94F88), CMT3_MAIZE  (Q8LPU5), 
CMT3_ORYSJ  (C0SQ89), DAM_BPP1(Q71TL0), DCM_ECO57   (P0AEE0), 
DCM_ECOLI   (P0AED9), DNM1A_ORYSJ (Q7Y1I7), DNM1B_ORYSJ (B1Q3J6), 
DNM3A_CHICK (Q4W5Z4), DNM3A_HUMAN (Q9Y6K1), DNM3A_MOUSE (O88508), 
DNM3A_RAT   (Q1LZ53), DNM3B_HUMAN (Q9UBC3), DNM3B_MOUSE (O88509), 
DNM3C_MOUSE (P0DOY1), DNMT1_ARATH (P34881), DNMT1_BOVIN (Q24K09), 
DNMT1_CHICK (Q92072), DNMT1_HUMAN (P26358), DNMT1_MOUSE (P13864), 
DNMT1_PARLI (Q27746), DNMT1_RAT   (Q9Z330), DNMT2_ARATH (Q9M0S8), 
DNMT3_ARATH (Q9T0I1), DNMT4_ARATH (O23273), DNMT_FRG3G  (Q67472), 
MT872_AERPE (Q9YDP3), MTA1_CELCE  (P31974), MTA1_THAGE  (P94147), 
MTAA_PICP2  (P34882), MTAP_ARTPN  (D4ZX35), MTB1_BACP9  (P0DW08), 
MTB1_BREBE  (P34905), MTB1_BREEP  (P10283), MTB1_HERAU  (P25262), 
MTB1_LYSSH  (P13906), MTB1_NEIGO  (Q59603), MTB5_NEIGO  (Q59605), 
MTB6_BACSF  (P43420), MTBA_ANEAE  (P19888), MTBB_BPSPB  (P09389), 
MTBF_BACIU  (P17044), MTBP_BACSU  (P68585), MTBP_BPPHT  (P68586), 
MTBR_BACIU  (P06530), MTBR_BPRH1  (P09915), MTBS_BPSPR  (P00476), 
MTC1_HERAU  (P25263), MTC1_PBCVI  (P36216), MTC2_HERAU  (P25264), 
MTD1_DESNO  (P05302), MTD1_HERAU  (P24600), MTD2_HERAU  (P25265), 
MTD5_DACSA  (P50185), MTE1_HERAU  (P25266), MTE2_ECOLX  (P05101), 
MTE8_ECOLX  (P50196), MTF1_FUSNU  (P34906), MTF7_NEIGO  (Q59606), 
MTG1_AVIVO  (P25282), MTG1_HERAU  (P25267), MTG2_AVIVO  (P25283), 
MTH1_HAEPH  (P05102), MTH2_HAEAE  (O30868), MTH2_HAEPA  (P15446), 
MTH3_HAEAE  (P20589), MTH5_HAEIN  (P45000), MTHA_HAEPH  (P50192), 
MTM1_MORSP  (P11408), MTM4_NEIGO  (P31033), MTN1_LENAE  (P50188), 
MTN4_NEILA  (P50182), MTNX_NEILA  (P24581), MTP1_PSYTA  (O33481), 
MTP2_NEIGO  (P08455), MTS1_SALIN  (P09795), MTS2_SHISO  (P34879), 
MTS3_STAAU  (P16668), MTS9_STAAU  (P23737), MTSA_LACLC  (P34877), 
MTSB_LACLC  (P34878), MTSI_SPISQ  (P15840), MTX2_XANOR  (P52311), 
YDIP_BACSU  (O34680)
» more

UniProtKB/Swiss-Prot
False negative sequences		 15 sequences 

DRM1L_ARATH (Q9LXE5), DRM2_ARATH  (Q9M548), MT36_OCEIH  (Q8EL95), 

MT51_METJA  (Q57983), MTA1_ACEPA  (O52702), MTD1_NEIMC  (Q9RLM4), 
MTHT_METTF  (P29567), MTM7_METJA  (Q58600), MTS1_STRAH  (O31073), 
PMT1M_SCHPO (P40999), TRDMT_BOVIN (Q7YS61), TRDMT_HUMAN (O14717), 
TRDMT_MOUSE (O55055), TRDMT_RAT   (Q4G073), YDIO_BACSU  (O34939)
» more

UniProtKB/Swiss-Prot
False positive sequences		 11 sequences 

AF111_ALTAL (Q50LG1), CCN5_HUMAN  (O76076), GATA_NEOSM  (Q2GEE7), 

MEND_PHOLL  (Q7N2K3), OOPDA_ARATH (Q94AM1), RTPR_LACAC  (Q5FMX8), 
RTPR_LACH4  (A8YW74), RTPR_LEVBA  (Q03PB4), SYA_METBU   (Q12U25), 
Y94X_SYNY3  (P77971), YME2_CANAL  (Q5A061)
» more

PDB
[Detailed view]		 96 PDB

pdb_000010mh; pdb_00001dct; pdb_00001fjx; pdb_00001hmy; pdb_00001m0e; pdb_00001mht; pdb_00001skm; pdb_00001svu; pdb_00002c7o; pdb_00002c7p; pdb_00002c7q; pdb_00002c7r; pdb_00002hmy; pdb_00002hr1; pdb_00002i9k; pdb_00002qrv; pdb_00002uyc; pdb_00002uyh; pdb_00002uz4; pdb_00002z6q; pdb_00002z6u; pdb_00002zcj; pdb_00003av4; pdb_00003av5; pdb_00003av6; pdb_00003eeo; pdb_00003mht; pdb_00003pt6; pdb_00003pt9; pdb_00003pta; pdb_00003swr; pdb_00004da4; pdb_00004fsx; pdb_00004ft2; pdb_00004ft4; pdb_00004mht; pdb_00004u7p; pdb_00004u7t; pdb_00004wxx; pdb_00004yoc; pdb_00005ciy; pdb_00005gut; pdb_00005guv; pdb_00005lod; pdb_00005mht; pdb_00005wy1; pdb_00005yx2; pdb_00006brr; pdb_00006f57; pdb_00006kda; pdb_00006kdb; pdb_00006kdl; pdb_00006kdp; pdb_00006kdt; pdb_00006mht; pdb_00006pa7; pdb_00006u8p; pdb_00006u8v; pdb_00006u8w; pdb_00006u8x; pdb_00006u90; pdb_00006u91; pdb_00006w89; pdb_00006w8b; pdb_00006w8d; pdb_00006w8j; pdb_00006w8v; pdb_00006w8w; pdb_00006x9i; pdb_00006x9j; pdb_00006x9k; pdb_00007mht; pdb_00007sfc; pdb_00007sfd; pdb_00007sfe; pdb_00007sff; pdb_00007sfg; pdb_00007ubu; pdb_00007v0e; pdb_00007x9d; pdb_00007xi9; pdb_00007xib; pdb_00008eih; pdb_00008eii; pdb_00008eij; pdb_00008eik; pdb_00008mht; pdb_00008qzm; pdb_00008tci; pdb_00008tdr; pdb_00008te1; pdb_00008te3; pdb_00008te4; pdb_00008xee; pdb_00008xqc; pdb_00009mht
» more