|PROSITE documentation PDOC00102 [for PROSITE entry PS00111]|
Phosphoglycerate kinase (EC 188.8.131.52) (PGK)  catalyzes the second step in the second phase of glycolysis, the reversible conversion of 1,3-diphospho-glycerate to 3-phosphoglycerate with generation of one molecule of ATP. PGK is found in all living organisms and its sequence has been highly conserved throughout evolution. It is a two-domain protein; each domain is composed of six repeats of an α/β structural motif. As a signature pattern for PGK's, we selected a conserved region in the N-terminal region.Last update:
July 1999 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Watson H.C., Littlechild J.A.|
|Title||Isoenzymes of phosphoglycerate kinase: evolutionary conservation of the structure of this glycolytic enzyme.|
|Source||Biochem. Soc. Trans. 18:187-190(1990).|