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PROSITE entry PS00136


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00136
Entry name [info] SUBTILASE_ASP
Accession [info] PS00136
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10080

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, aspartic acid active site.
Pattern [info] 
[STAIV]-{ERDL}-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-[DNH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 382 in 382 different sequences
Number of true positive hits 187 in 187 different sequences
Number of 'unknown' hits 0
Number of false positive hits 195 in 195 different sequences
Number of false negative sequences 7
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 48.95 %
Recall (true positives / (true positives + false negatives)) 96.39 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 187 sequences 

AEP_YARLI   (P09230), AEX5_CAEEL  (P91863), ALP_FUSCU   (P83610),
» more

UniProtKB/Swiss-Prot
False negative sequences		 7 sequences 

NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), SBT61_ARATH (Q0WUG6),
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 6 sequences 

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454),
» more

UniProtKB/Swiss-Prot
False positive sequences		 195 sequences 

ACDA1_ARCFU (O29165), AES1_THET4  (G2QJ27), AES1_THETO  (T2FKR1),
» more

PDB
[Detailed view]		 460 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU;
» more