PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00140


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00140

Direct ScanProsite submission
General information about the entry

Entry name [info] UCH_1
Accession [info] PS00140
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00127
Associated ProRule [info] PRU10091

Name and characterization of the entry

Description [info] Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site.
Pattern [info] 
Q-x(3)-N-[SA]-C-G-x(3)-[LIVM](2)-H-[SA]-[LIVM]-[SA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 17 in 17 different sequences
Number of true positive hits 17 in 17 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 29
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 36.96 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 17 sequences 

UBL1_YEAST  (P35127), UBLH1_SCHPO (Q10171), UCHL1_BOVIN (P23356), 

UCHL1_HORSE (Q9GM50), UCHL1_HUMAN (P09936), UCHL1_MACFA (Q60HC8), 
UCHL1_MONDO (P50103), UCHL1_MOUSE (Q9R0P9), UCHL1_PIG   (Q6SEG5), 
UCHL1_RAT   (Q00981), UCHL3_BOVIN (Q2TBG8), UCHL3_HUMAN (P15374), 
UCHL3_MOUSE (Q9JKB1), UCHL3_PIG   (Q06AB3), UCHL3_RAT   (Q91Y78), 
UCHL_APLCA  (O01391), UCHL_DROME  (P35122)
» more

UniProtKB/Swiss-Prot
False negative sequences		 29 sequences 

BAP1_BOVIN  (A2VDM8), BAP1_BRAFL  (C4A0D9), BAP1_CHICK  (Q5F3N6), 

BAP1_DANRE  (A1L2G3), BAP1_HUMAN  (Q92560), BAP1_MOUSE  (Q99PU7), 
BAP1_RAT(D3ZHS6), BAP1_XENLA  (Q52L14), BAP1_XENTR  (Q66JB6), 
CALYP_AEDAE (Q17N72), CALYP_CULQU (B0W2R4), CALYP_DROAN (B3MIV9), 
CALYP_DROER (B3NPV7), CALYP_DROGR (B4JW98), CALYP_DROME (Q7K5N4), 
CALYP_DROMO (B4KT51), CALYP_DROPE (B4GAM2), CALYP_DROPS (Q291J4), 
CALYP_DROSE (B4HST0), CALYP_DROSI (B4QHH0), CALYP_DROVI (B4LQ24), 
CALYP_DROYA (B4P6P6), UBH4_CAEEL  (Q09444), UBLH2_SCHPO (Q9UUB6), 
UCHL4_MOUSE (P58321), UCHL5_BOVIN (Q9XSJ0), UCHL5_DICDI (Q54N38), 
UCHL5_HUMAN (Q9Y5K5), UCHL5_MOUSE (Q9WUP7)
» more

PDB
[Detailed view]		 20 PDB

pdb_00001cmx; pdb_00001uch; pdb_00001xd3; pdb_00002etl; pdb_00002len; pdb_00003ifw; pdb_00003irt; pdb_00003kvf; pdb_00003kw5; pdb_00004dm9; pdb_00004jkj; pdb_00006isu; pdb_00006qml; pdb_00007en4; pdb_00007yv4; pdb_00007zm0; pdb_00008dy8; pdb_00008ede; pdb_00008pw1; pdb_00008xi7
» more