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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10091


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10091
General rule information [?]

Accession PRU10091
Dates 16-OCT-2006 (Created)
08-AUG-2024 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS00140; UCH_1
Name Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site
Function Undefined
Scope(s) Eukaryota
Example(s) Q9GM50;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Ubiquitin thiolesterase;
                 EC=3.4.19.12;

Comments [?]

CATALYTIC ACTIVITY Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;

Features [?]

From: PS00140
Key From To Description Tag Condition FTGroup
ACT_SITE 4 4 /note="Nucleophile"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]