Amino acid permeases are integral membrane proteins involved in the transport
of amino acids into the cell. A number of such proteins have been found to be
evolutionary related [1,2,3]. These proteins are:
Yeast general amino acid permeases (genes GAP1, AGP2 and AGP3).
Escherichia coli and Klebsiella pneumoniae hypothetical protein yeeF.
Escherichia coli and Salmonella typhimurium hypothetical protein yifK.
Bacillus subtilis permeases rocC and rocE which probably transports
arginine or ornithine.
These proteins seem to contain up to 12 transmembrane segments. As a signature
for this family of proteins we selected the best conserved region which is
located in the second transmembrane segment.
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