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PROSITE documentation PDOC00191 [for PROSITE entry PS00218]

Amino acid permeases signature





Description

Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to be evolutionary related [1,2,3]. These proteins are:

  • Yeast general amino acid permeases (genes GAP1, AGP2 and AGP3).
  • Yeast basic amino acid permease (gene ALP1).
  • Yeast Leu/Val/Ile permease (gene BAP2).
  • Yeast arginine permease (gene CAN1).
  • Yeast dicarboxylic amino acid permease (gene DIP5).
  • Yeast asparagine/glutamine permease (gene AGP1).
  • Yeast glutamine permease (gene GNP1).
  • Yeast histidine permease (gene HIP1).
  • Yeast lysine permease (gene LYP1).
  • Yeast proline permease (gene PUT4).
  • Yeast valine and tyrosine permease (gene VAL1/TAT1).
  • Yeast tryptophan permease (gene TAT2/SCM2).
  • Yeast choline transport protein (gene HNM1/CTR1).
  • Yeast GABA permease (gene UGA4).
  • Yeast hypothetical protein YKL174c.
  • Fission yeast protein isp5.
  • Fission yeast hypothetical protein SpAC8A4.11
  • Fission yeast hypothetical protein SpAC11D3.08c.
  • Emericella nidulans proline transport protein (gene prnB).
  • Trichoderma harzianum amino acid permease INDA1.
  • Salmonella typhimurium L-asparagine permease (gene ansP).
  • Escherichia coli aromatic amino acid transport protein (gene aroP).
  • Escherichia coli D-serine/D-alanine/glycine transporter (gene cycA).
  • Escherichia coli GABA permease (gene gabP).
  • Escherichia coli lysine-specific permease (gene lysP).
  • Escherichia coli phenylalanine-specific permease (gene pheP).
  • Salmonella typhimurium proline-specific permease (gene proY).
  • Escherichia coli and Klebsiella pneumoniae hypothetical protein yeeF.
  • Escherichia coli and Salmonella typhimurium hypothetical protein yifK.
  • Bacillus subtilis permeases rocC and rocE which probably transports arginine or ornithine.

These proteins seem to contain up to 12 transmembrane segments. As a signature for this family of proteins we selected the best conserved region which is located in the second transmembrane segment.

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Last update:

July 1999 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

?, PS00218;   (?)


References

1Source?
PubMed ID3146645

2Source?
PubMed ID2687114

3Title
Source?



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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