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PROSITE documentation PDOC00202 [for PROSITE entry PS00230]

Neuraxin and MAP1B proteins repeated region signature





Description

MAP1B [1], and neuraxin [2] are neuronal microtubule-binding proteins. Both proteins contain a region that consists of 12 tandem repeats of a 17 residues motif.

The pattern we developed to detect this repeated region corresponds to the N-terminal ten residues of the repeated region.

Expert(s) to contact by email:

Matus A.

Last update:

December 2004 / Pattern and text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

MAP1B_NEURAXIN, PS00230; Neuraxin and MAP1B proteins repeated region signature  (PATTERN)


References

1AuthorsNoble M. Lewis S.A. Cowan N.J.
TitleThe microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau.
SourceJ. Cell Biol. 109:3367-3376(1989).
PubMed ID2480963

2AuthorsRienitz A. Grenningloh G. Hermans-Borgmeyer I. Kirsch J. Littauer U.Z. Prior P. Gundelfinger E.D. Schmitt B. Betz H.
TitleNeuraxin, a novel putative structural protein of the rat central nervous system that is immunologically related to microtubule- associated protein 5.
SourceEMBO J. 8:2879-2888(1989).
PubMed ID2555150



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