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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00243


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PURL: https://purl.expasy.org/prosite/signature/PS00243

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General information about the entry

Entry name [info] I_EGF_1
Accession [info] PS00243
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-1990 DATA UPDATE;
27-NOV-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00216

Name and characterization of the entry

Description [info] Integrins beta chain EGF (I-EGF) domain signature.
Pattern [info] 
C-x-[GNQ]-x(1,3)-G-x-C-x-C-x(2)-C-x-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 155 in 51 different sequences
Number of true positive hits 154 in 50 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.35 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 10
Site [info] disulfide(?) at position 1
Site [info] disulfide(?) at position 7
Site [info] disulfide(?) at position 9
Site [info] disulfide(?) at position 11
Site [info] disulfide(?) at position 13
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 50 sequences 

ITB1A_XENLA (P12606), ITB1B_XENLA (P12607), ITB1_BOVIN  (P53712), 

ITB1_CAMBA  (A5Z1X6), ITB1_CHICK  (P07228), ITB1_FELCA  (P53713), 
ITB1_HUMAN  (P05556), ITB1_MOUSE  (P09055), ITB1_PIG(Q9GLP0), 
ITB1_PONAB  (Q5RCA9), ITB1_RAT(P49134), ITB1_SHEEP  (B0FYY4), 
ITB2L_MOUSE (Q3UV74), ITB2_BOVIN  (P32592), ITB2_CAPHI  (Q5VI41), 
ITB2_HUMAN  (P05107), ITB2_MOUSE  (P11835), ITB2_OVICA  (Q2VJ42), 
ITB2_PIG(P53714), ITB2_SHEEP  (Q6ECI6), ITB3_HUMAN  (P05106), 
ITB3_MOUSE  (O54890), ITB3_RAT(Q8R2H2), ITB4_HUMAN  (P16144), 
ITB4_MOUSE  (A2A863), ITB4_RAT(Q64632), ITB5_BOVIN  (P80747), 
ITB5_HUMAN  (P18084), ITB5_MOUSE  (O70309), ITB5_PAPCY  (Q07441), 
ITB6_BOVIN  (Q8SQB8), ITB6_CAVPO  (P18563), ITB6_HUMAN  (P18564), 
ITB6_MOUSE  (Q9Z0T9), ITB6_PIG(Q1RPR6), ITB6_RAT(Q6AYF4), 
ITB6_SHEEP  (Q863C4), ITB7_HUMAN  (P26010), ITB7_MOUSE  (P26011), 
ITB8_HUMAN  (P26012), ITB8_MOUSE  (Q0VBD0), ITB8_RABIT  (P26013), 
ITBL_CAEEL  (Q9GYK2), ITBN_DROME  (Q27591), ITBX_DROME  (P11584), 
ITGBL_HUMAN (O95965), ITGBL_MOUSE (Q8VDV0), ITGBL_RAT   (Q5PQQ8), 
ITGBL_XENLA (Q5M9B3), PAT3_CAEEL  (Q27874)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

C30_CONCL   (P0DTX8)


				
	

	

		PDB
[Detailed view]		
		
			68 PDB
			


			pdb_00001jv2; pdb_00001l3y; pdb_00001l5g; pdb_00001m1x; pdb_00001u8c; pdb_00002p26; pdb_00002p28; pdb_00003fcs; pdb_00003ije; pdb_00003k6s; pdb_00003k71; pdb_00003k72; 
			
				pdb_00004cak; pdb_00004g1e; pdb_00004g1m; pdb_00004mmx; pdb_00004mmy; pdb_00004mmz; pdb_00004neh; pdb_00004nen; pdb_00004o02; pdb_00004um8; pdb_00005e6w; pdb_00005e6x; 
				pdb_00005es4; pdb_00006avq; pdb_00006avr; pdb_00006avu; pdb_00006bxb; pdb_00006bxf; pdb_00006bxj; pdb_00006ckb; pdb_00006djp; pdb_00006mk0; pdb_00006msl; pdb_00006msu; 
				pdb_00006naj; pdb_00006uja; pdb_00006ujb; pdb_00006ujc; pdb_00006v4p; pdb_00007la4; pdb_00007nwl; pdb_00007nxd; pdb_00007usl; pdb_00007usm; pdb_00008gcd; pdb_00008gce; 
				pdb_00008oxz; pdb_00008t2u; pdb_00008t2v; pdb_00008vs6; pdb_00008xei; pdb_00008xek; pdb_00008xel; pdb_00008xen; pdb_00008xer; pdb_00008xez; pdb_00008xf6; pdb_00008xfg; 
				pdb_00008xfo; pdb_00008zjf; pdb_00009axl; pdb_00009b9j; pdb_00009b9k; pdb_00009ckv; pdb_00009deq; pdb_00009der
			
			

			» more