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PROSITE documentation PDOC00216 [for PROSITE entry PS00243]

Integrins beta chain cysteine-rich domain signature





Description

Integrins [1,2] are a large family of cell surface receptors that mediate cell to cell as well as cell to matrix adhesion. Some integrins recognize the R-G-D sequence in their extracellular matrix protein ligand. Structurally, integrins consist of a dimer of an α and a β chain. Each subunit has a large N-terminal extracellular domain followed by a transmembrane domain and a short C-terminal cytoplasmic region. Some receptors share a common β chain while having different α chains. The sequence of a number of different β chains has been determined and are listed below:

  • Integrin β-1, which associates with α-1 to form a laminin receptor, with α-2 to form a collagen receptor, with α-4 to interact with VCAM-1, with α-5 to form a fibronectin receptor, and with α-8.
  • Integrin β-2, which associates with α-L (LFA-1) to interact with ICAM-1, and with α-M (MAC-1) or α-X (p150,95) to form the receptor for the iC3b fragment of the third complement component.
  • Integrin β-3, which associates with α-IIB to form a receptor for fibrinogen, fibronectin, vitronectin and VWF, and with α-V to form a vitronectin receptor.
  • Integrin β-4, which associates with α-6.
  • Integrin β-5, which associates with α-V.
  • Integrin β-6 [3].
  • Integrin β-7 [4].
  • Integrin β-8, which associates with α-V [5].
  • The Drosophila myospheroid protein, a probable integrin β chain.

All the integrin β chains contain four repeats of a forty amino acid region in the C-terminal extremity of their extracellular domain. Each of the repeats contains eight cysteines. We have developed a pattern from a section of the repeated region that includes five of these conserved cysteines.

Note:

The pattern will not pick up the first of the four repeats, the spacing of the cysteine residues being different in that repeat.

Last update:

May 2004 / Text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

INTEGRIN_BETA, PS00243; Integrins beta chain cysteine-rich domain signature  (PATTERN)


References

1AuthorsHynes R.O.
TitleIntegrins: a family of cell surface receptors.
SourceCell 48:549-554(1987).
PubMed ID3028640

2AuthorsAlbelda S.M. Buck C.A.
TitleIntegrins and other cell adhesion molecules.
SourceFASEB J. 4:2868-2880(1990).
PubMed ID2199285

3AuthorsSheppard D. Rozzo C. Starr L. Quaranta V. Erle D.J. Pytela R.
TitleComplete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
SourceJ. Biol. Chem. 265:11502-11507(1990).
PubMed ID2365683

4AuthorsErle D.J. Rueegg C. Sheppard D. Pytela R.
TitleComplete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
SourceJ. Biol. Chem. 266:11009-11016(1991).
PubMed ID2040616

5AuthorsMoyle M. Napier M.A. McLean J.W.
TitleCloning and expression of a divergent integrin subunit beta 8.
SourceJ. Biol. Chem. 266:19650-19658(1991).
PubMed ID1918072



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