PROSITE documentation PDOC00216
Integrins beta chain cysteine-rich domain signature


Integrins [1,2] are a large family of cell surface receptors that mediate cell to cell as well as cell to matrix adhesion. Some integrins recognize the R-G-D sequence in their extracellular matrix protein ligand. Structurally, integrins consist of a dimer of an α and a β chain. Each subunit has a large N-terminal extracellular domain followed by a transmembrane domain and a short C-terminal cytoplasmic region. Some receptors share a common β chain while having different α chains. The sequence of a number of different β chains has been determined and are listed below:

  • Integrin β-1, which associates with α-1 to form a laminin receptor, with α-2 to form a collagen receptor, with α-4 to interact with VCAM-1, with α-5 to form a fibronectin receptor, and with α-8.
  • Integrin β-2, which associates with α-L (LFA-1) to interact with ICAM-1, and with α-M (MAC-1) or α-X (p150,95) to form the receptor for the iC3b fragment of the third complement component.
  • Integrin β-3, which associates with α-IIB to form a receptor for fibrinogen, fibronectin, vitronectin and VWF, and with α-V to form a vitronectin receptor.
  • Integrin β-4, which associates with α-6.
  • Integrin β-5, which associates with α-V.
  • Integrin β-6 [3].
  • Integrin β-7 [4].
  • Integrin β-8, which associates with α-V [5].
  • The Drosophila myospheroid protein, a probable integrin β chain.

All the integrin β chains contain four repeats of a forty amino acid region in the C-terminal extremity of their extracellular domain. Each of the repeats contains eight cysteines. We have developed a pattern from a section of the repeated region that includes five of these conserved cysteines.


The pattern will not pick up the first of the four repeats, the spacing of the cysteine residues being different in that repeat.

Last update:

May 2004 / Text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

INTEGRIN_BETA, PS00243; Integrins beta chain cysteine-rich domain signature  (PATTERN)


1AuthorsHynes R.O.
TitleIntegrins: a family of cell surface receptors.
SourceCell 48:549-554(1987).
PubMed ID3028640

2AuthorsAlbelda S.M. Buck C.A.
TitleIntegrins and other cell adhesion molecules.
SourceFASEB J. 4:2868-2880(1990).
PubMed ID2199285

3AuthorsSheppard D. Rozzo C. Starr L. Quaranta V. Erle D.J. Pytela R.
TitleComplete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
SourceJ. Biol. Chem. 265:11502-11507(1990).
PubMed ID2365683

4AuthorsErle D.J. Rueegg C. Sheppard D. Pytela R.
TitleComplete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes.
SourceJ. Biol. Chem. 266:11009-11016(1991).
PubMed ID2040616

5AuthorsMoyle M. Napier M.A. McLean J.W.
TitleCloning and expression of a divergent integrin subunit beta 8.
SourceJ. Biol. Chem. 266:19650-19658(1991).
PubMed ID1918072

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