Heparin-binding growth factors I and II (HBGF) [1,2] (also known as acidic and
basic fibroblast growth factors (FGF) are structurally related mitogens which
stimulate growth or differentiation of a wide variety of cells of mesodermal
or neuroectodermal origin. These two proteins belong to a family of growth
factors and oncogenes which is currently known [3,4] to include:
FGF-3 (int-2), induced by the integration of mouse mammary tumor virus
FGF-4 (hst-1; KS3), a transforming protein independently isolated from a
human stomach tumor (hst-1) and from Kaposi's sarcoma (KS3).
FGF-5, an oncogene expressed in neonatal brain.
FGF-6 (hst-2), a transforming protein that exhibits strong mitogenic and
FGF-7 or keratinocyte growth factor (KGF), a paracrine effector of normal
epithelial cell proliferation.
FGF-8 or androgen-induced growth factor (AIGF).
FGF-9 or glia-activating factor (GAF), a heparin-binding growth factor that
may have a role in glial cell growth and differentiation during
FGF-11 (FHF-3), FGF-12 (FHF-1), FGF-13 (FHF-2) and FGF-14 (FHF-4) ,
which seem to be involved in nervous system development and function.
FGF-15, which may play an important role in regulating cell division and
patterning within specific regions of the embryonic brain, spinal cord and
FGF-18, which stimulates hepatic and intestinal proliferation.
A FGF homolog of unknown function from Autographa californica nuclear
polyhedrosis virus .
From the sequences of these related proteins, we have derived a signature
pattern which includes one of the two conserved cysteine residues.
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