We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00220HBGF/FGF family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00220
Description
Heparin-binding growth factors I and II (HBGF) [1,2] (also known as acidic and basic fibroblast growth factors (FGF) are structurally related mitogens which stimulate growth or differentiation of a wide variety of cells of mesodermal or neuroectodermal origin. These two proteins belong to a family of growth factors and oncogenes which is currently known [3,4] to include:
- FGF-3 (int-2), induced by the integration of mouse mammary tumor virus (MMTV).
- FGF-4 (hst-1; KS3), a transforming protein independently isolated from a human stomach tumor (hst-1) and from Kaposi's sarcoma (KS3).
- FGF-5, an oncogene expressed in neonatal brain.
- FGF-6 (hst-2), a transforming protein that exhibits strong mitogenic and angiogenic properties.
- FGF-7 or keratinocyte growth factor (KGF), a paracrine effector of normal epithelial cell proliferation.
- FGF-8 or androgen-induced growth factor (AIGF).
- FGF-9 or glia-activating factor (GAF), a heparin-binding growth factor that may have a role in glial cell growth and differentiation during development.
- FGF-11 (FHF-3), FGF-12 (FHF-1), FGF-13 (FHF-2) and FGF-14 (FHF-4) [5], which seem to be involved in nervous system development and function.
- FGF-15, which may play an important role in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord and sensory organs.
- FGF-16.
- FGF-17.
- FGF-18, which stimulates hepatic and intestinal proliferation.
- FGF-19,
- A FGF homolog of unknown function from Autographa californica nuclear polyhedrosis virus [6].
From the sequences of these related proteins, we have derived a signature pattern which includes one of the two conserved cysteine residues.
Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Burgess W.H. Maciag T. |
| Title | The heparin-binding (fibroblast) growth factor family of proteins. | |
| Source | Annu. Rev. Biochem. 58:575-606(1989). | |
| PubMed ID | 2549857 | |
| DOI | 10.1146/annurev.bi.58.070189.003043 |
| 2 | Authors | Thomas K.A. |
| Title | Transforming potential of fibroblast growth factor genes. | |
| Source | Trends Biochem. Sci. 13:327-328(1988). | |
| PubMed ID | 3072709 |
| 3 | Authors | Benharroch D. Birnbaum D. |
| Title | Biology of the fibroblast growth factor gene family. | |
| Source | Isr. J. Med. Sci. 26:212-219(1990). | |
| PubMed ID | 1693362 |
| 4 | Authors | Miyamoto M. Naruo K.-I. Seko C. Matsumoto S. Kondo T. Kurokawa T. |
| Title | Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. | |
| Source | Mol. Cell. Biol. 13:4251-4259(1993). | |
| PubMed ID | 8321227 |
| 5 | Authors | Smallwood P.M. Munoz-Sanjuan I. Tong P. Macke J.P. Hendry S.H. Gilbert D.J. Copeland N.G. Jenkins N.A. Nathans J. |
| Title | Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996). | |
| PubMed ID | 8790420 |
| 6 | Authors | Ayres M.D. Howard S.C. Kuzio J. Lopez-Ferber M. Possee R.D. |
| Title | The complete DNA sequence of Autographa californica nuclear polyhedrosis virus. | |
| Source | Virology 202:586-605(1994). | |
| PubMed ID | 8030224 |
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