PROSITE documentation PDOC00220
HBGF/FGF family signature


Heparin-binding growth factors I and II (HBGF) [1,2] (also known as acidic and basic fibroblast growth factors (FGF) are structurally related mitogens which stimulate growth or differentiation of a wide variety of cells of mesodermal or neuroectodermal origin. These two proteins belong to a family of growth factors and oncogenes which is currently known [3,4] to include:

  • FGF-3 (int-2), induced by the integration of mouse mammary tumor virus (MMTV).
  • FGF-4 (hst-1; KS3), a transforming protein independently isolated from a human stomach tumor (hst-1) and from Kaposi's sarcoma (KS3).
  • FGF-5, an oncogene expressed in neonatal brain.
  • FGF-6 (hst-2), a transforming protein that exhibits strong mitogenic and angiogenic properties.
  • FGF-7 or keratinocyte growth factor (KGF), a paracrine effector of normal epithelial cell proliferation.
  • FGF-8 or androgen-induced growth factor (AIGF).
  • FGF-9 or glia-activating factor (GAF), a heparin-binding growth factor that may have a role in glial cell growth and differentiation during development.
  • FGF-11 (FHF-3), FGF-12 (FHF-1), FGF-13 (FHF-2) and FGF-14 (FHF-4) [5], which seem to be involved in nervous system development and function.
  • FGF-15, which may play an important role in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord and sensory organs.
  • FGF-16.
  • FGF-17.
  • FGF-18, which stimulates hepatic and intestinal proliferation.
  • FGF-19,
  • A FGF homolog of unknown function from Autographa californica nuclear polyhedrosis virus [6].

From the sequences of these related proteins, we have derived a signature pattern which includes one of the two conserved cysteine residues.

Last update:

December 2004 / Pattern and text revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HBGF_FGF, PS00247; HBGF/FGF family signature  (PATTERN)


1AuthorsBurgess W.H. Maciag T.
TitleThe heparin-binding (fibroblast) growth factor family of proteins.
SourceAnnu. Rev. Biochem. 58:575-606(1989).
PubMed ID2549857

2AuthorsThomas K.A.
TitleTransforming potential of fibroblast growth factor genes.
SourceTrends Biochem. Sci. 13:327-328(1988).
PubMed ID3072709

3AuthorsBenharroch D. Birnbaum D.
TitleBiology of the fibroblast growth factor gene family.
SourceIsr. J. Med. Sci. 26:212-219(1990).
PubMed ID1693362

4AuthorsMiyamoto M. Naruo K.-I. Seko C. Matsumoto S. Kondo T. Kurokawa T.
TitleMolecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property.
SourceMol. Cell. Biol. 13:4251-4259(1993).
PubMed ID8321227

5AuthorsSmallwood P.M. Munoz-Sanjuan I. Tong P. Macke J.P. Hendry S.H. Gilbert D.J. Copeland N.G. Jenkins N.A. Nathans J.
TitleFibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
SourceProc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
PubMed ID8790420

6AuthorsAyres M.D. Howard S.C. Kuzio J. Lopez-Ferber M. Possee R.D.
TitleThe complete DNA sequence of Autographa californica nuclear polyhedrosis virus.
SourceVirology 202:586-605(1994).
PubMed ID8030224

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