PROSITE documentation PDOC00220HBGF/FGF family signature
Description
Heparin-binding growth factors I and II (HBGF) [1,2] (also known as acidic and basic fibroblast growth factors (FGF) are structurally related mitogens which stimulate growth or differentiation of a wide variety of cells of mesodermal or neuroectodermal origin. These two proteins belong to a family of growth factors and oncogenes which is currently known [3,4] to include:
- FGF-3 (int-2), induced by the integration of mouse mammary tumor virus (MMTV).
- FGF-4 (hst-1; KS3), a transforming protein independently isolated from a human stomach tumor (hst-1) and from Kaposi's sarcoma (KS3).
- FGF-5, an oncogene expressed in neonatal brain.
- FGF-6 (hst-2), a transforming protein that exhibits strong mitogenic and angiogenic properties.
- FGF-7 or keratinocyte growth factor (KGF), a paracrine effector of normal epithelial cell proliferation.
- FGF-8 or androgen-induced growth factor (AIGF).
- FGF-9 or glia-activating factor (GAF), a heparin-binding growth factor that may have a role in glial cell growth and differentiation during development.
- FGF-11 (FHF-3), FGF-12 (FHF-1), FGF-13 (FHF-2) and FGF-14 (FHF-4) [5], which seem to be involved in nervous system development and function.
- FGF-15, which may play an important role in regulating cell division and patterning within specific regions of the embryonic brain, spinal cord and sensory organs.
- FGF-16.
- FGF-17.
- FGF-18, which stimulates hepatic and intestinal proliferation.
- FGF-19,
- A FGF homolog of unknown function from Autographa californica nuclear polyhedrosis virus [6].
From the sequences of these related proteins, we have derived a signature pattern which includes one of the two conserved cysteine residues.
Last update:December 2004 / Pattern and text revised.
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Technical section
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References
| 1 | Authors | Burgess W.H. Maciag T. |
| Title | The heparin-binding (fibroblast) growth factor family of proteins. | |
| Source | Annu. Rev. Biochem. 58:575-606(1989). | |
| PubMed ID | 2549857 | |
| DOI | 10.1146/annurev.bi.58.070189.003043 |
| 2 | Authors | Thomas K.A. |
| Title | Transforming potential of fibroblast growth factor genes. | |
| Source | Trends Biochem. Sci. 13:327-328(1988). | |
| PubMed ID | 3072709 |
| 3 | Authors | Benharroch D. Birnbaum D. |
| Title | Biology of the fibroblast growth factor gene family. | |
| Source | Isr. J. Med. Sci. 26:212-219(1990). | |
| PubMed ID | 1693362 |
| 4 | Authors | Miyamoto M. Naruo K.-I. Seko C. Matsumoto S. Kondo T. Kurokawa T. |
| Title | Molecular cloning of a novel cytokine cDNA encoding the ninth member of the fibroblast growth factor family, which has a unique secretion property. | |
| Source | Mol. Cell. Biol. 13:4251-4259(1993). | |
| PubMed ID | 8321227 |
| 5 | Authors | Smallwood P.M. Munoz-Sanjuan I. Tong P. Macke J.P. Hendry S.H. Gilbert D.J. Copeland N.G. Jenkins N.A. Nathans J. |
| Title | Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996). | |
| PubMed ID | 8790420 |
| 6 | Authors | Ayres M.D. Howard S.C. Kuzio J. Lopez-Ferber M. Possee R.D. |
| Title | The complete DNA sequence of Autographa californica nuclear polyhedrosis virus. | |
| Source | Virology 202:586-605(1994). | |
| PubMed ID | 8030224 |
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