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PROSITE documentation PDOC00228 [for PROSITE entry PS00255]

Interleukin-7 and -9 signature





Description

Interleukin-7 (IL-7) [1] is a cytokine that serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. Interleukin-9 (IL-9) [2] is a cytokine that supports IL-2 independent and IL-4 independent growth of helper T-cells.

Interleukin-7 and -9 seems to be evolutionary related [3]. As a signature pattern, we selected a conserved region located in the C-terminal section of the protein.

Expert(s) to contact by email:

Boulay J.-L.

Last update:

July 1998 / Pattern and text revised.

Technical section

PROSITE method (with tools and information) covered by this documentation:

INTERLEUKIN_7_9, PS00255; Interleukin-7 and -9 signature  (PATTERN)


References

1AuthorsHenney C.S.
TitleInterleukin 7: effects on early events in lymphopoiesis.
SourceImmunol. Today. 10:170-173(1989).
PubMed ID2663018

2AuthorsRenauld J.C. Goethals A. Houssiau F. Merz H. Van Roost E. Van Snick J.
TitleHuman P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.
SourceJ. Immunol. 144:4235-4241(1990).
PubMed ID1971295

3AuthorsBoulay J.-L. Paul W.E.
TitleHematopoietin sub-family classification based on size, gene organization and sequence homology.
SourceCurr. Biol. 3:573-581(1993).
PubMed ID15335670



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