|PROSITE documentation PDOC00228 [for PROSITE entry PS00255]|
Interleukin-7 (IL-7)  is a cytokine that serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. Interleukin-9 (IL-9)  is a cytokine that supports IL-2 independent and IL-4 independent growth of helper T-cells.
Interleukin-7 and -9 seems to be evolutionary related . As a signature pattern, we selected a conserved region located in the C-terminal section of the protein.Expert(s) to contact by email:
July 1998 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|Title||Interleukin 7: effects on early events in lymphopoiesis.|
|Source||Immunol. Today. 10:170-173(1989).|
|2||Authors||Renauld J.C., Goethals A., Houssiau F., Merz H., Van Roost E., Van Snick J.|
|Title||Human P40/IL-9. Expression in activated CD4+ T cells, genomic organization, and comparison with the mouse gene.|
|Source||J. Immunol. 144:4235-4241(1990).|
|3||Authors||Boulay J.-L., Paul W.E.|
|Title||Hematopoietin sub-family classification based on size, gene organization and sequence homology.|
|Source||Curr. Biol. 3:573-581(1993).|