|PROSITE documentation PDOC00264 [for PROSITE entry PS00292]|
Cyclins [1,2,3] are eukaryotic proteins which play an active role in controlling nuclear cell division cycles. Cyclins, together with the p34 (cdc2) or cdk2 kinases, form the Maturation Promoting Factor (MPF). There are two main groups of cyclins:
In most species, there are multiple forms of G1 and G2 cyclins. For example, in vertebrates, there are two G2 cyclins, A and B, and at least three G1 cyclins, C, D, and E.
A cyclin homolog has also been found in herpesvirus saimiri .
The best conserved region is in the central part of the cyclins' sequences, known as the 'cyclin-box', from which we have derived a 32 residue pattern.Last update:
November 1995 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|Title||Universal control mechanism regulating onset of M-phase.|
|2||Authors||Norbury C., Nurse P.|
|Title||Cyclins and cell cycle control.|
|Source||Curr. Biol. 1:23-24(1991).|
|3||Authors||Lew D.J., I Reed S.|
|Title||A proliferation of cyclins.|
|Source||Trends Cell Biol. 2:77-81(1992).|
|4||Authors||Nicholas J., Cameron K.R., Honess R.W.|
|Title||Herpesvirus saimiri encodes homologues of G protein-coupled receptors and cyclins.|