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PROSITE documentation PDOC00277 [for PROSITE entry PS00306]

Caseins alpha/beta signature





Description

Caseins [1] are the major protein constituent of milk. Caseins can be classified into two families; the first consists of the kappa-caseins, and the second groups the α-s1, α-s2, and β-caseins. The α/β caseins are a rapidly diverging family of proteins. However two regions are conserved: a cluster of phosphorylated serine residues and the signal sequence. The signature pattern we selected for this family of proteins is based on the last eight residues of the signal sequence.

Note:

α-s2 casein is known as epsilon-casein in mouse, γ-casein in rat and casein-A in guinea pig. α-s1 casein is known as α-casein in rat and rabbit and as casein-B in guinea-pig.

Last update:

December 1992 / Text revised.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

CASEIN_ALPHA_BETA, PS00306; Caseins alpha/beta signature  (PATTERN)


Reference

1AuthorsHolt C. Sawyer L.
TitlePrimary and predicted secondary structures of the caseins in relation to their biological functions.
SourceProtein Eng. 2:251-259(1988).
PubMed ID3074304



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