|PROSITE documentation PDOC00281 [for PROSITE entry PS00312]|
Glycophorin A is the major sialoglycoprotein of erythrocyte membrane . Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on serine and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain.
In human there are two closely related forms: glycophorin A which carries the blood group M/N antigen, and glycophorin B which carries the blood group S/s antigen.
The best conserved region of glycophorin A is the transmembrane domain and we have derived a consensus pattern from that region.Last update:
December 1991 / Pattern and text revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Murayama J.-I., Utsumi H., Hamada A.|
|Title||Amino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid sequence has a striking homology with that of human glycophorin A.|
|Source||Biochim. Biophys. Acta 999:273-280(1989).|