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PROSITE entry PS00381


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00381
Entry name [info] CLP_PROTEASE_SER
Accession [info] PS00381
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-JUL-1998 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00358
Associated ProRule [info] PRU10085

Name and characterization of the entry

Description [info] Endopeptidase Clp serine active site.
Pattern [info]
T-x(2)-[LIVMF]-G-x-A-[SAC]-S-[MSA]-[PAG]-[STA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 643 in 643 different sequences
Number of true positive hits 625 in 625 different sequences
Number of 'unknown' hits 0
Number of false positive hits 18 in 18 different sequences
Number of false negative sequences 134
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 97.20 %
Recall (true positives / (true positives + false negatives)) 82.35 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
625 sequences

CLPP1_BIFLO (Q8G5R0), CLPP1_BORBU (O51556), CLPP1_CAEBR (A8WPG6), 
» more

UniProtKB/Swiss-Prot
False negative sequences
134 sequences

CLPP1_AGRFC (Q8UEX6), CLPP1_ARATH (P56772), CLPP1_BACAN (Q81PL4), 
» more

UniProtKB/Swiss-Prot
'Partial' sequences
2 sequences

CLPPH_POPEU (P84982), CLPP_PINST  (P84723)

		
UniProtKB/Swiss-Prot
False positive sequences
18 sequences

PAN2_EMENI  (Q5BBL5), PKN2_MYXXA  (P54736), RPOC_ACTP2  (A3N326), 
» more

PDB
[Detailed view]
132 PDB

1TG6; 1TYF; 1Y7O; 1YG6; 1YG8; 2FZS; 2ZL0; 2ZL2; 3HLN; 3KTG; 3KTH; 3KTI;
» more