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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00396


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PURL: https://purl.expasy.org/prosite/signature/PS00396

Direct ScanProsite submission
General information about the entry

Entry name [info] TOPO_IA_1
Accession [info] PS00396
Entry type [info] PATTERN
Date [info] 01-NOV-1990 CREATED;
01-DEC-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00333
Associated ProRule [info] PRU10131

Name and characterization of the entry

Description [info] Topoisomerase (Topo) IA-type active site signature.
Pattern [info] 
[EQ]-x-L-Y-[DEQSTLM]-x(3,12)-[LIVST]-[ST]-Y-x-R-[ST]-[DEQSN].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 110 in 110 different sequences
Number of true positive hits 109 in 109 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 99.09 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 9
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 109 sequences 

TOP1P_MIMIV (Q5UQB5), TOP1P_XYLFA (Q9PHK2), TOP1_AERPE  (Q9YB01), 

TOP1_ALKPO  (P34184), TOP1_AQUAE  (O66893), TOP1_ARCFU  (O28469), 
TOP1_BACAN  (P40114), TOP1_BACSU  (P39814), TOP1_BORBU  (O51768), 
TOP1_BUCAI  (P57371), TOP1_BUCAP  (Q8K9P7), TOP1_CAMJE  (Q9PLZ2), 
TOP1_ECOLI  (P06612), TOP1_FERIS  (O34204), TOP1_HAEIN  (P43012), 
TOP1_HALH5  (Q9KA23), TOP1_HELPJ  (Q9ZMV7), TOP1_HELPY  (P55991), 
TOP1_LACLA  (Q9CG80), TOP1_METJA  (Q59046), TOP1_METTH  (O27661), 
TOP1_MYCBO  (P0A621), TOP1_MYCGA  (Q9JN65), TOP1_MYCGE  (P47368), 
TOP1_MYCLE  (O69548), TOP1_MYCPN  (P78032), TOP1_MYCS2  (A0R5D9), 
TOP1_MYCTA  (A5U8X0), TOP1_MYCTO  (P9WG48), TOP1_MYCTU  (P9WG49), 
TOP1_PASMU  (Q9CN30), TOP1_PSEAE  (Q9HZJ5), TOP1_PYRAB  (Q9UYS8), 
TOP1_PYRHO  (O58356), TOP1_RICBR  (Q1RIM1), TOP1_RICCN  (Q92IH1), 
TOP1_RICFE  (Q4UM42), TOP1_RICPR  (Q9ZDK2), TOP1_RICTY  (Q68X45), 
TOP1_SALTI  (P0A2I2), TOP1_SALTY  (P0A2I1), TOP1_STAA3  (Q2FHI8), 
TOP1_STAA8  (Q2FZ32), TOP1_STAAB  (Q2YXL8), TOP1_STAAC  (Q5HGI2), 
TOP1_STAAM  (Q99UM1), TOP1_STAAN  (Q7A5Y5), TOP1_STAAR  (Q6GHI5), 
TOP1_STAAS  (Q6G9W3), TOP1_STAAU  (Q06AK7), TOP1_STAAW  (Q8NWZ9), 
TOP1_STAEQ  (Q5HPU2), TOP1_STAES  (Q8CSU3), TOP1_STAHJ  (Q4L5V2), 
TOP1_STAS1  (Q49X35), TOP1_STRCO  (Q9X909), TOP1_SYNE7  (P34185), 
TOP1_SYNY3  (P73810), TOP1_THEAC  (Q9HM08), TOP1_THEMA  (P46799), 
TOP1_TREPA  (O83409), TOP1_VIBCH  (Q9KRB2), TOP1_XYLFA  (Q9PEV8), 
TOP1_XYLFT  (Q87AQ6), TOP1_ZYMMO  (Q9X3X7), TOP3A_ARATH (Q9LVP1), 
TOP3A_DROME (Q9NG98), TOP3A_HUMAN (Q13472), TOP3A_MOUSE (O70157), 
TOP3A_ORYSJ (C7J0A2), TOP3B_ARATH (F4ISQ7), TOP3B_DROME (O96651), 
TOP3B_HUMAN (O95985), TOP3B_MOUSE (Q9Z321), TOP3B_ORYSJ (Q0J0S6), 
TOP3_BACAH  (A0R979), TOP3_BACAN  (Q81Z97), TOP3_BACC1  (Q73E74), 
TOP3_BACCR  (Q81IH1), TOP3_BACCZ  (Q63GK5), TOP3_BACHK  (Q6HP19), 
TOP3_BACLD  (Q65N90), TOP3_BACSU  (P96583), TOP3_CAEEL  (O61660), 
TOP3_CANAR  (A0A0L0P6P7), TOP3_DICDI  (Q8T2T7), TOP3_ECOLI  (P14294), 
TOP3_HAEIN  (P43704), TOP3_PASMU  (Q9CP53), TOP3_SACS2  (Q97ZJ8), 
TOP3_SALTI  (Q8Z6F5), TOP3_SALTY  (P40687), TOP3_SCHPO  (O60126), 
TOP3_SHOC1  (Q5WAX6), TOP3_STAA3  (Q2FEN5), TOP3_STAA8  (Q2FW03), 
TOP3_STAAB  (P0C2W6), TOP3_STAAC  (Q5HDV4), TOP3_STAAM  (Q99S17), 
TOP3_STAAN  (Q7A455), TOP3_STAAR  (Q6GEH9), TOP3_STAAS  (Q6G767), 
TOP3_STAAW  (Q7A075), TOP3_STAEQ  (Q5HLZ4), TOP3_STAES  (Q8CRF7), 
TOP3_STAHJ  (Q4L8B8), TOP3_STAS1  (Q49ZH2), TOP3_VIBCH  (Q9KQF5), 
TOP3_YEAST  (P13099)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

TOP1_KLEAE  (P46155)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			1 sequence
			


			
SYSM_SCHPO  (Q9UTB2)


				
	

	

		PDB
[Detailed view]		
		
			42 PDB
			


			pdb_00001cy0; pdb_00001cy1; pdb_00001cy2; pdb_00001cy4; pdb_00001cy6; pdb_00001cy7; pdb_00001cy8; pdb_00001cy9; pdb_00001cyy; pdb_00001d6m; pdb_00001ecl; pdb_00001mw8; 
			
				pdb_00001mw9; pdb_00002gai; pdb_00002gaj; pdb_00002o19; pdb_00002o54; pdb_00002o59; pdb_00002o5c; pdb_00002o5e; pdb_00003pwt; pdb_00003px7; pdb_00004cgy; pdb_00004cht; 
				pdb_00004rul; pdb_00005d5h; pdb_00005gvc; pdb_00005gve; pdb_00005uj1; pdb_00005ujy; pdb_00006cq2; pdb_00006cqi; pdb_00006pcm; pdb_00008czq; pdb_00008tfg; pdb_00009c9w; 
				pdb_00009ca0; pdb_00009ca1; pdb_00009ca4; pdb_00009cah; pdb_00009cak; pdb_00009cal
			
			

			» more