The following mammalian lipid-binding serum glycoproteins belong to the same
Lipopolysaccharide-binding protein (LBP). LBP binds to the lipid A moiety
of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer
membrane of all Gram-negative bacteria. The LBP/LPS complex seems to
interact with the CD14 receptor and may be responsible for the secretion of
Bactericidal permeability-increasing protein (BPI). Like LBP, BPI binds LPS
and has a cytotoxic activity on Gram-negative bacteria.
Cholesteryl ester transfer protein (CETP). CETP is involved in the transfer
of insoluble cholesteryl esters in reverse cholesterol transport.
Phospholipid transfer protein (PLTP). May play a key role in extracellular
phospholipid transport and modulation of HDL particles.
These proteins are structurally related and share many regions of sequence
similarities. As a signature pattern we have selected one of these regions,
which is located in the N-terminal section of these proteins; a region which
could be involved in the binding to the lipids .
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