We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC00367LBP / BPI / CETP family signature
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PURL: https://purl.expasy.org/prosite/documentation/PDOC00367
Description
The following mammalian lipid-binding serum glycoproteins belong to the same family [1,2,3]:
- Lipopolysaccharide-binding protein (LBP). LBP binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. The LBP/LPS complex seems to interact with the CD14 receptor and may be responsible for the secretion of α-TNF.
- Bactericidal permeability-increasing protein (BPI). Like LBP, BPI binds LPS and has a cytotoxic activity on Gram-negative bacteria.
- Cholesteryl ester transfer protein (CETP). CETP is involved in the transfer of insoluble cholesteryl esters in reverse cholesterol transport.
- Phospholipid transfer protein (PLTP). May play a key role in extracellular phospholipid transport and modulation of HDL particles.
These proteins are structurally related and share many regions of sequence similarities. As a signature pattern we have selected one of these regions, which is located in the N-terminal section of these proteins; a region which could be involved in the binding to the lipids [2].
Expert(s) to contact by email: Last update:December 2004 / Pattern and text revised.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Schumann R.R. Leong S.R. Flaggs G.W. Gray P.W. Wright S.D. Mathison J.C. Tobias P.S. Ulevitch R.J. |
| Title | Structure and function of lipopolysaccharide binding protein. | |
| Source | Science 249:1429-1431(1990). | |
| PubMed ID | 2402637 |
| 2 | Authors | Gray P.W. Flaggs G. Leong S.R. Gumina R.J. Weiss J. Ooi C.E. Elsbach P. |
| Title | Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. | |
| Source | J. Biol. Chem. 264:9505-9509(1989). | |
| PubMed ID | 2722846 |
| 3 | Authors | Day J.R. Albers J.J. Lofton-Day C.E. Gilbert T.L. Ching A.F.T. Grant F.J. O'Hara P.J. Marcovina S.M. Adolphson J.L. |
| Title | Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. | |
| Source | J. Biol. Chem. 269:9388-9391(1994). | |
| PubMed ID | 8132678 |
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