PROSITE documentation PDOC00339 [for PROSITE entry PS00405]43 Kd postsynaptic protein signature
The 43 Kd postsynaptic protein [1,2] is a peripheral membrane protein thought to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying post-synaptic cytoskeleton, possibly by direct association with actin or spectrin.
The 43 Kd protein is highly conserved across species. Two highly conserved regions, one encompassing the N-terminus and the other near the C-terminus, may be important for interaction of the protein with other components of the postsynaptic membrane.
As a signature pattern we selected the N-terminus of the mature protein (after removal of the initiator methionine). The N-terminal glycine is thought to be myristoylated.
Last update:November 1990 / First entry.
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| 1 | Authors | Froehner S.C. |
| Source | Trends Neurosci. 9:37-41(1986). |
| 2 | Authors | Froehner S.C. |
| Title | Expression of RNA transcripts for the postsynaptic 43 kDa protein in innervated and denervated rat skeletal muscle. | |
| Source | FEBS Lett. 249:229-233(1989). | |
| PubMed ID | 2737281 |
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