|PROSITE documentation PDOC00368 [for PROSITE entry PS00417]|
Synaptobrevin  is an intrinsic membrane protein of small synaptic vesicles whose function is not yet known, but which is highly conserved in mammals, electric ray (where its is known as VAMP-1), Drosophila and yeast . In yeast there are two closely related forms of synaptobrevin (genes SNC1 and SNC2) while in mammals there is at least 4 (genes SYB1, SYB2, SYB3 and SYBL1).
Structurally synaptobrevin consist of a N-terminal cytoplasmic domain of from 90 to 110 residues, followed by a transmembrane region, and then by a short (from 2 to 22 residues) C-terminal intravesicular domain.
As a signature pattern for synaptobrevin we selected a highly conserved stretch of residues located in the central part of the sequence.Last update:
April 2006 / Pattern revised.
PROSITE method (with tools and information) covered by this documentation:
|1||Authors||Suedhof T.C. Baumert M. Perin M.S. Jahn R.|
|2||Authors||Gerst J.E. Rodgers L. Riggs M. Wigler M.|
|Title||SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.|
|Source||Proc. Natl. Acad. Sci. U.S.A. 89:4338-4342(1992).|