PROSITE documentation PDOC00368
Synaptobrevin signature


Synaptobrevin [1] is an intrinsic membrane protein of small synaptic vesicles whose function is not yet known, but which is highly conserved in mammals, electric ray (where its is known as VAMP-1), Drosophila and yeast [2]. In yeast there are two closely related forms of synaptobrevin (genes SNC1 and SNC2) while in mammals there is at least 4 (genes SYB1, SYB2, SYB3 and SYBL1).

Structurally synaptobrevin consist of a N-terminal cytoplasmic domain of from 90 to 110 residues, followed by a transmembrane region, and then by a short (from 2 to 22 residues) C-terminal intravesicular domain.

As a signature pattern for synaptobrevin we selected a highly conserved stretch of residues located in the central part of the sequence.

Last update:

April 2006 / Pattern revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SYNAPTOBREVIN, PS00417; Synaptobrevin signature  (PATTERN)


1AuthorsSuedhof T.C. Baumert M. Perin M.S. Jahn R.
SourceNeuron 2:1475-1481(1989).

2AuthorsGerst J.E. Rodgers L. Riggs M. Wigler M.
TitleSNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.
SourceProc. Natl. Acad. Sci. U.S.A. 89:4338-4342(1992).
PubMed ID1316605

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